GREMLIN Database
PXA - PXA domain
PFAM: PF02194 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (171)
Sequences: 1299 (947)
Seq/√Len: 72.4
META: 0.164

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_A101_Y3.7411.00
15_L19_V3.3911.00
125_E147_R3.1831.00
97_L101_Y3.1521.00
97_L100_K3.1111.00
23_Y27_S3.0961.00
13_L16_R3.0391.00
104_G107_H2.8091.00
166_D169_N2.7501.00
98_A102_R2.6611.00
121_R148_E2.2881.00
158_V163_S2.1521.00
136_D142_V2.1081.00
162_L171_L2.0511.00
104_G108_P2.0501.00
124_V155_L2.0031.00
167_F171_L1.9821.00
94_D98_A1.9561.00
148_E169_N1.9531.00
112_S116_E1.9151.00
3_V7_L1.8831.00
125_E143_R1.8581.00
132_L137_L1.8451.00
127_L131_L1.8241.00
148_E152_C1.8211.00
162_L167_F1.7581.00
23_Y32_F1.7141.00
12_D37_R1.6831.00
150_L154_V1.6130.99
46_E50_R1.6120.99
7_L105_K1.5520.99
47_L131_L1.5490.99
100_K103_E1.5340.99
37_R40_I1.4620.99
31_E34_N1.4620.99
120_L155_L1.4620.99
139_S142_V1.4520.99
43_A131_L1.4200.99
71_H119_Y1.4130.99
169_N173_V1.4090.98
8_D41_R1.4070.98
43_A142_V1.3400.98
32_F36_V1.3370.98
112_S134_P1.3340.98
153_A157_P1.3340.98
142_V145_L1.3330.98
8_D12_D1.3140.98
10_L17_D1.3100.98
9_E13_L1.2990.97
124_V127_L1.2870.97
103_E154_V1.2720.97
94_D97_L1.2600.97
99_S102_R1.2580.97
114_E159_I1.2560.97
92_E96_A1.2560.97
4_D8_D1.2480.97
14_I154_V1.2450.97
35_E38_Q1.2360.96
95_L98_A1.2350.96
93_L96_A1.2270.96
19_V102_R1.2270.96
166_D170_Q1.2170.96
26_I164_D1.2170.96
73_R136_D1.1950.96
59_L64_L1.1840.96
13_L17_D1.1700.95
15_L33_P1.1530.95
105_K108_P1.1520.95
11_L40_I1.1510.95
96_A102_R1.1410.95
91_E95_L1.1340.94
92_E97_L1.1290.94
102_R106_L1.1290.94
76_R97_L1.1250.94
75_F79_E1.1170.94
91_E94_D1.0930.93
117_L121_R1.0890.93
79_E82_V1.0750.93
92_E99_S1.0710.92
20_L33_P1.0680.92
21_S25_K1.0630.92
3_V65_V1.0560.92
76_R136_D1.0550.92
81_A113_K1.0530.92
71_H75_F1.0510.92
104_G109_A1.0320.91
78_A111_S1.0100.90
12_D40_I0.9930.89
45_R48_S0.9860.89
112_S126_G0.9850.89
4_D10_L0.9820.89
6_A10_L0.9790.89
155_L158_V0.9750.88
5_A19_V0.9740.88
168_I172_I0.9700.88
92_E95_L0.9590.88
136_D139_S0.9570.87
66_P69_T0.9550.87
97_L102_R0.9480.87
31_E99_S0.9450.87
123_L133_P0.9380.86
90_S93_L0.9360.86
95_L100_K0.9360.86
94_D100_K0.9320.86
158_V161_K0.9230.85
70_A103_E0.9200.85
68_L154_V0.9190.85
90_S94_D0.9180.85
43_A60_L0.9180.85
96_A101_Y0.9100.85
19_V22_W0.9070.84
156_L159_I0.8950.84
7_L70_A0.8900.83
22_W27_S0.8820.83
50_R116_E0.8770.82
18_F27_S0.8760.82
36_V162_L0.8660.82
61_T132_L0.8550.81
81_A84_G0.8500.80
31_E158_V0.8500.80
11_L15_L0.8470.80
19_V23_Y0.8410.80
124_V150_L0.8330.79
46_E131_L0.8320.79
24_S28_P0.8310.79
90_S95_L0.8220.78
164_D169_N0.8190.78
101_Y104_G0.8170.78
96_A100_K0.8070.77
17_D157_P0.8040.77
143_R151_A0.7990.76
78_A82_V0.7960.76
67_L75_F0.7920.75
94_D99_S0.7910.75
47_L52_R0.7880.75
159_I168_I0.7840.75
72_L85_K0.7830.75
48_S137_L0.7770.74
6_A161_K0.7740.74
106_L110_L0.7730.74
170_Q173_V0.7700.73
95_L99_S0.7680.73
143_R147_R0.7540.72
93_L98_A0.7510.72
21_S29_D0.7410.71
114_E158_V0.7390.70
18_F22_W0.7360.70
10_L134_P0.7350.70
99_S103_E0.7290.69
62_T159_I0.7250.69
98_A105_K0.7230.69
13_L163_S0.7150.68
50_R130_L0.7140.68
73_R127_L0.7120.67
20_L24_S0.7080.67
19_V46_E0.7060.67
79_E98_A0.7060.67
13_L18_F0.7050.67
63_R66_P0.6970.66
18_F21_S0.6830.64
145_L149_I0.6800.64
22_W29_D0.6800.64
6_A69_T0.6720.63
11_L20_L0.6720.63
128_L132_L0.6680.63
39_T136_D0.6670.62
95_L101_Y0.6660.62
85_K103_E0.6650.62
138_E143_R0.6620.62
49_Q108_P0.6610.62
68_L80_A0.6600.62
42_H47_L0.6580.61
105_K151_A0.6580.61
11_L41_R0.6530.61
53_K138_E0.6520.61
77_Q171_L0.6520.61
16_R165_P0.6510.61
152_C157_P0.6490.60
79_E83_R0.6490.60
66_P168_I0.6370.59
39_T147_R0.6320.58
105_K118_A0.6290.58
54_V137_L0.6280.58
74_D77_Q0.6190.57
68_L108_P0.6140.56
103_E159_I0.6130.56
93_L101_Y0.6100.56
157_P169_N0.6070.55
64_L134_P0.6070.55
76_R167_F0.6030.55
23_Y60_L0.5970.54
81_A135_E0.5970.54
135_E158_V0.5960.54
51_L54_V0.5900.53
151_A160_D0.5880.53
158_V162_L0.5870.53
4_D11_L0.5820.52
3_V6_A0.5800.52
32_F141_P0.5780.52
27_S156_L0.5770.52
153_A168_I0.5760.51
65_V167_F0.5750.51
60_L163_S0.5730.51
115_A172_I0.5680.50
109_A119_Y0.5660.50
157_P161_K0.5650.50
127_L134_P0.5650.50
2_E5_A0.5650.50
163_S173_V0.5630.50
61_T166_D0.5630.50
44_L132_L0.5610.50
129_P150_L0.5590.49
25_K153_A0.5580.49
4_D119_Y0.5520.49
16_R78_A0.5510.48
85_K96_A0.5490.48
55_D67_L0.5470.48
61_T66_P0.5450.48
12_D60_L0.5450.48
17_D148_E0.5430.47
74_D78_A0.5420.47
15_L36_V0.5410.47
19_V161_K0.5400.47
80_A150_L0.5400.47
5_A52_R0.5390.47
47_L111_S0.5360.47
124_V151_A0.5350.46
93_L97_L0.5320.46
71_H146_L0.5320.46
55_D70_A0.5280.46
26_I154_V0.5270.45
53_K127_L0.5260.45
167_F174_K0.5250.45
59_L65_V0.5250.45
83_R173_V0.5240.45
66_P79_E0.5240.45
14_I125_E0.5230.45
121_R166_D0.5170.44
130_L134_P0.5170.44
40_I147_R0.5140.44
73_R118_A0.5140.44
74_D81_A0.5100.43
9_E12_D0.5100.43
66_P107_H0.5090.43
34_N160_D0.5080.43
35_E119_Y0.5080.43
163_S171_L0.5070.43
19_V113_K0.5050.43
4_D61_T0.5030.43
151_A157_P0.5020.42
115_A175_L0.5010.42
29_D159_I0.5010.42
121_R152_C0.5010.42
45_R49_Q0.5000.42
50_R132_L0.5000.42
136_D143_R0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fji1 1 0.9773 9.6 0.934 Contact Map
3v3tA 1 0.0909 6.7 0.939 Contact Map
3r9rA 1 0.3409 6.2 0.94 Contact Map
2a7oA 1 0.5 3.9 0.945 Contact Map
2p7vA 1 0.5966 3.9 0.945 Contact Map
3o4zA 2 0.9375 3.8 0.945 Contact Map
1h3lA 1 0.4375 3.7 0.946 Contact Map
1fp3A 2 0.375 3 0.948 Contact Map
4qikA 2 0.8466 2.8 0.949 Contact Map
1vsy5 1 0.858 2.8 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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