GREMLIN Database
DAD - DAD family
PFAM: PF02109 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 108 (107)
Sequences: 520 (326)
Seq/√Len: 31.5
META: 0.308

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_T92_F5.8611.00
26_L66_V3.4501.00
25_F65_T3.3201.00
36_Q54_G3.2911.00
25_F61_Q3.1771.00
30_V34_V2.8651.00
57_S100_H2.6291.00
73_N76_N2.2990.99
86_E91_D1.9990.97
29_L61_Q1.9170.97
96_S100_H1.8660.96
9_K13_K1.8340.96
33_G62_F1.7990.95
49_N52_L1.7430.94
48_F67_S1.7190.94
64_L95_A1.6320.92
9_K12_L1.6260.92
9_K14_T1.6110.92
87_R91_D1.5970.91
8_W12_L1.5720.91
61_Q96_S1.5220.89
60_G88_A1.5020.88
44_G52_L1.5010.88
43_V46_F1.4910.88
101_F105_N1.4730.87
26_L62_F1.3570.83
68_L71_Q1.3120.80
25_F29_L1.3020.80
17_Q21_L1.2990.80
61_Q100_H1.2270.76
45_T56_I1.1930.74
55_F62_F1.1820.73
5_S8_W1.1700.72
25_F92_F1.1640.72
105_N108_G1.1460.71
66_V70_L1.1450.70
102_V105_N1.1390.70
29_L33_G1.1190.69
33_G55_F1.1120.68
63_V67_S1.0990.67
55_F59_V1.0810.66
2_S35_I1.0780.66
92_F96_S1.0750.66
60_G96_S1.0710.65
56_I59_V1.0450.63
37_F55_F1.0410.63
25_F96_S1.0370.63
27_V31_L1.0160.61
15_T39_Y1.0040.60
4_L78_S0.9870.59
76_N80_F0.9860.59
12_L42_L0.9840.59
7_L15_T0.9780.58
6_K10_E0.9660.57
3_V7_L0.9630.57
32_T108_G0.9560.56
37_F40_C0.9510.56
29_L58_C0.9460.56
39_Y91_D0.9450.55
94_F98_I0.9430.55
22_I92_F0.9190.53
26_L33_G0.9160.53
2_S13_K0.9120.53
21_L97_L0.9060.52
63_V87_R0.8950.51
38_V41_V0.8880.51
71_Q87_R0.8820.50
75_E81_K0.8800.50
36_Q46_F0.8650.49
21_L57_S0.8410.47
12_L78_S0.8400.47
24_A28_F0.8280.46
103_V108_G0.8150.45
86_E90_A0.8120.45
28_F32_T0.8110.45
64_L99_L0.8080.44
87_R90_A0.8070.44
66_V95_A0.7920.43
10_E31_L0.7920.43
53_S56_I0.7830.42
85_P98_I0.7800.42
51_F62_F0.7730.42
28_F61_Q0.7700.41
56_I62_F0.7550.40
37_F62_F0.7490.40
75_E79_E0.7440.39
57_S63_V0.7380.39
71_Q83_I0.7350.39
72_V107_I0.7320.38
15_T90_A0.7280.38
55_F100_H0.7240.38
4_L12_L0.7220.38
70_L93_I0.7220.38
49_N54_G0.7120.37
26_L37_F0.7090.37
10_E14_T0.7070.36
51_F55_F0.7010.36
4_L8_W0.6970.36
83_I104_V0.6950.36
37_F41_V0.6760.34
33_G37_F0.6750.34
59_V62_F0.6680.34
18_R21_L0.6680.34
18_R58_C0.6640.33
40_C64_L0.6640.33
36_Q44_G0.6630.33
13_K82_G0.6620.33
5_S12_L0.6600.33
7_L19_L0.6550.33
29_L94_F0.6540.33
3_V10_E0.6530.32
93_I97_L0.6500.32
35_I93_I0.6460.32
33_G59_V0.6350.31
60_G75_E0.6270.31
12_L38_V0.6180.30
2_S7_L0.6170.30
97_L101_F0.6160.30
19_L77_K0.6150.30
14_T75_E0.6130.30
5_S9_K0.6120.30
41_V67_S0.6060.29
70_L76_N0.6040.29
25_F57_S0.6010.29
29_L34_V0.5990.29
68_L93_I0.5950.29
44_G54_G0.5930.28
30_V35_I0.5890.28
7_L16_P0.5880.28
64_L96_S0.5860.28
7_L108_G0.5830.28
7_L73_N0.5800.28
31_L35_I0.5800.28
39_Y105_N0.5780.27
7_L39_Y0.5760.27
42_L55_F0.5730.27
23_D69_R0.5700.27
53_S104_V0.5670.27
3_V28_F0.5640.26
93_I107_I0.5620.26
16_P39_Y0.5550.26
21_L41_V0.5550.26
89_F100_H0.5530.26
73_N85_P0.5380.25
85_P91_D0.5360.25
71_Q91_D0.5360.25
3_V17_Q0.5350.25
81_K98_I0.5280.24
14_T79_E0.5270.24
52_L90_A0.5260.24
19_L42_L0.5220.24
10_E75_E0.5180.24
46_F85_P0.5170.24
5_S78_S0.5140.23
50_A108_G0.5110.23
3_V81_K0.5090.23
24_A48_F0.5090.23
76_N94_F0.5070.23
34_V38_V0.5000.23
82_G85_P0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mcoA 1 0.3333 5 0.945 Contact Map
2lkgA 1 0.463 4.9 0.945 Contact Map
4e17B 1 0.1204 4.8 0.946 Contact Map
4fc4A 3 0.9259 3.7 0.948 Contact Map
2xwvA 1 0.3056 2.8 0.952 Contact Map
4pe3A 1 0.3426 2.6 0.953 Contact Map
3udcA 3 0.8704 2.5 0.953 Contact Map
4hfiA 3 0.7407 2.2 0.954 Contact Map
4x5mA 2 0.7222 2.2 0.954 Contact Map
2wx4A 3 0.1944 2.1 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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