GREMLIN Database
SURF1 - SURF1 family
PFAM: PF02104 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (160)
Sequences: 19556 (15318)
Seq/√Len: 1211.0
META: 0.794

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_G157_F3.2691.00
70_W83_N3.1491.00
12_F157_F3.0631.00
18_A22_E2.7751.00
52_T101_T2.7591.00
56_D76_R2.6871.00
9_G12_F2.4561.00
56_D59_R2.3281.00
50_T101_T2.2341.00
60_E73_T2.2121.00
145_L148_N2.0271.00
76_R79_A2.0161.00
9_G16_Q2.0021.00
45_E107_R1.9751.00
54_R76_R1.9451.00
56_D79_A1.9231.00
18_A150_L1.8941.00
53_G75_L1.8791.00
12_F16_Q1.8331.00
74_P79_A1.8231.00
55_F75_L1.7941.00
15_L19_A1.6961.00
16_Q20_W1.6891.00
68_G86_W1.6501.00
73_T84_R1.6481.00
128_D131_A1.6401.00
15_L157_F1.6341.00
50_T103_T1.6191.00
95_D99_R1.6141.00
20_W23_A1.6071.00
148_N151_G1.6011.00
7_L159_L1.5741.00
27_R31_R1.5721.00
150_L154_I1.5591.00
22_E150_L1.5581.00
8_V160_A1.5511.00
144_D148_N1.5391.00
4_V8_V1.5351.00
16_Q19_A1.5331.00
8_V12_F1.5291.00
151_G155_Q1.4931.00
44_D47_R1.4751.00
19_A22_E1.4721.00
5_A9_G1.4531.00
23_A27_R1.4511.00
154_I158_A1.4401.00
72_L81_L1.4171.00
116_D119_A1.3971.00
15_L153_A1.3971.00
25_I29_E1.3781.00
62_L71_V1.3561.00
51_V75_L1.3401.00
22_E26_A1.3291.00
26_A30_A1.3221.00
2_V5_A1.3171.00
7_L160_A1.2931.00
4_V7_L1.2861.00
95_D98_V1.2841.00
38_P50_T1.2791.00
155_Q159_L1.2741.00
55_F84_R1.2481.00
55_F82_V1.2251.00
96_P100_G1.2221.00
3_A7_L1.2151.00
132_L136_L1.2121.00
144_D147_N1.2101.00
3_A6_L1.1951.00
61_V132_L1.1541.00
60_E64_D1.1531.00
57_P60_E1.1401.00
22_E147_N1.1311.00
52_T78_D1.1301.00
17_R20_W1.1031.00
129_L133_A1.0941.00
81_L132_L1.0861.00
31_R34_A1.0731.00
48_R103_T1.0541.00
34_A47_R1.0421.00
49_V106_L1.0311.00
24_L27_R1.0241.00
18_A149_H1.0151.00
60_E71_V0.9991.00
21_K24_L0.9961.00
6_L9_G0.9811.00
51_V80_V0.9671.00
66_R70_W0.9541.00
112_T115_N0.9521.00
11_G15_L0.9481.00
69_Y89_A0.9461.00
26_A29_E0.9451.00
126_S129_L0.9441.00
37_V47_R0.9331.00
51_V77_L0.9311.00
57_P73_T0.9041.00
55_F102_V0.9041.00
61_V64_D0.9011.00
54_R75_L0.8891.00
21_K149_H0.8831.00
20_W24_L0.8831.00
131_A134_A0.8751.00
28_I32_L0.8661.00
19_A23_A0.8641.00
131_A135_A0.8571.00
7_L10_L0.8541.00
17_R21_K0.8541.00
44_D106_L0.8381.00
22_E25_I0.8281.00
29_E33_A0.8261.00
69_Y87_V0.8261.00
15_L18_A0.8211.00
6_L10_L0.8201.00
48_R105_R0.8191.00
69_Y123_Q0.8171.00
117_P120_G0.8101.00
63_L72_L0.8101.00
108_P111_G0.8091.00
60_E84_R0.8061.00
28_I145_L0.8041.00
5_A8_V0.8021.00
61_V135_A0.8021.00
89_A92_R0.8011.00
77_L80_V0.8011.00
36_P50_T0.7991.00
43_D47_R0.7971.00
4_V160_A0.7961.00
39_L51_V0.7941.00
24_L28_I0.7911.00
104_G143_I0.7911.00
63_L70_W0.7831.00
51_V143_I0.7831.00
130_A134_A0.7771.00
12_F15_L0.7691.00
120_G136_L0.7591.00
128_D134_A0.7571.00
61_V136_L0.7501.00
29_E32_L0.7491.00
72_L127_L0.7381.00
25_I146_P0.7361.00
52_T100_G0.7331.00
28_I46_Y0.7301.00
133_A136_L0.7291.00
126_S131_A0.7271.00
72_L83_N0.7241.00
35_P39_L0.7221.00
55_F73_T0.7221.00
59_R74_P0.7211.00
2_V6_L0.7181.00
27_R45_E0.7131.00
27_R30_A0.7091.00
36_P48_R0.7081.00
79_A138_L0.7081.00
71_V87_V0.7051.00
81_L136_L0.7041.00
25_I28_I0.7021.00
8_V157_F0.7011.00
109_P115_N0.7001.00
54_R100_G0.7001.00
30_A34_A0.6931.00
23_A26_A0.6901.00
18_A25_I0.6881.00
66_R86_W0.6831.00
74_P81_L0.6821.00
30_A33_A0.6761.00
75_L102_V0.6721.00
74_P77_L0.6691.00
49_V143_I0.6631.00
151_G154_I0.6631.00
69_Y90_G0.6621.00
124_V135_A0.6601.00
78_D100_G0.6591.00
151_G159_L0.6581.00
51_V102_V0.6561.00
60_E63_L0.6561.00
36_P103_T0.6561.00
62_L69_Y0.6531.00
49_V104_G0.6451.00
17_R149_H0.6421.00
32_L105_R0.6351.00
151_G158_A0.6321.00
71_V84_R0.6311.00
119_A122_W0.6301.00
125_Q132_L0.6301.00
96_P99_R0.6261.00
12_F19_A0.6231.00
82_V102_V0.6191.00
71_V74_P0.6191.00
153_A157_F0.6141.00
10_L13_W0.6081.00
80_V104_G0.6031.00
31_R47_R0.6031.00
63_L124_V0.5981.00
132_L135_A0.5961.00
89_A123_Q0.5941.00
18_A21_K0.5931.00
36_P39_L0.5911.00
91_A94_R0.5901.00
64_D123_Q0.5851.00
24_L46_Y0.5851.00
8_V11_G0.5771.00
20_W25_I0.5731.00
11_G158_A0.5721.00
104_G107_R0.5651.00
150_L158_A0.5641.00
62_L87_V0.5571.00
117_P122_W0.5561.00
127_L132_L0.5561.00
124_V131_A0.5521.00
59_R62_L0.5511.00
15_L150_L0.5501.00
21_K25_I0.5501.00
138_L141_V0.5461.00
42_P45_E0.5451.00
81_L133_A0.5421.00
130_A133_A0.5421.00
39_L49_V0.5411.00
138_L143_I0.5411.00
108_P113_P0.5401.00
124_V132_L0.5371.00
90_G94_R0.5361.00
61_V124_V0.5361.00
46_Y107_R0.5361.00
72_L142_V0.5331.00
69_Y121_R0.5321.00
128_D133_A0.5271.00
63_L66_R0.5241.00
75_L78_D0.5201.00
155_Q158_A0.5201.00
110_G115_N0.5191.00
65_N89_A0.5181.00
118_A121_R0.5131.00
149_H155_Q0.5131.00
51_V55_F0.5131.00
140_P148_N0.5131.00
152_Y156_W0.5111.00
59_R64_D0.5101.00
18_A147_N0.5091.00
125_Q131_A0.5061.00
138_L142_V0.5061.00
81_L84_R0.5051.00
112_T126_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lx0A 1 0.1304 10 0.934 Contact Map
2ks1B 1 0.1491 3.1 0.948 Contact Map
2jwaA 2 0.1429 2.6 0.95 Contact Map
2l2tA 2 0.1553 2.2 0.952 Contact Map
2m20A 2 0.2857 2.2 0.952 Contact Map
2mc7A 1 0.1056 2.1 0.953 Contact Map
1qleD 1 0.0932 2 0.953 Contact Map
3j9tb 1 0.6149 1.5 0.956 Contact Map
1v54L 1 0.1118 1.5 0.956 Contact Map
4tq0B 1 0.118 1.4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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