GREMLIN Database
FliE - Flagellar hook-basal body complex protein FliE
PFAM: PF02049 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 88 (81)
Sequences: 27446 (17690)
Seq/√Len: 1965.5
META: 0.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_A48_E2.8421.00
82_E85_R2.7671.00
78_E81_Q2.5721.00
63_E67_Q2.5521.00
33_L65_A2.1681.00
39_A43_A2.1461.00
40_A58_A2.1281.00
31_N35_Q1.9341.00
42_Q46_T1.6681.00
29_E32_Q1.6211.00
40_A43_A1.6171.00
36_E40_A1.5861.00
30_V69_T1.5381.00
51_D54_D1.5371.00
25_D28_D1.5211.00
22_L26_A1.5051.00
36_E39_A1.4951.00
81_Q85_R1.4921.00
39_A42_Q1.4181.00
24_K28_D1.4071.00
21_D24_K1.3921.00
18_S21_D1.3831.00
44_L55_V1.3521.00
58_A61_K1.3221.00
19_F23_L1.3091.00
35_Q39_A1.2931.00
53_H57_I1.2461.00
20_G24_K1.2371.00
32_Q36_E1.2251.00
25_D29_E1.2191.00
26_A29_E1.2051.00
31_N34_Q1.1871.00
17_G21_D1.1821.00
60_Q63_E1.1791.00
36_E58_A1.1771.00
33_L36_E1.1711.00
29_E33_L1.1341.00
34_Q38_D1.0891.00
28_D32_Q1.0671.00
50_V54_D1.0581.00
38_D42_Q1.0391.00
19_F22_L1.0381.00
78_E82_E1.0141.00
41_A59_V1.0081.00
80_Y84_M0.9941.00
21_D25_D0.9831.00
23_L26_A0.9781.00
66_F70_V0.9751.00
35_Q38_D0.9601.00
32_Q35_Q0.9481.00
14_A17_G0.9251.00
73_R78_E0.9251.00
71_Q74_N0.9191.00
70_V74_N0.9151.00
40_A54_D0.9041.00
65_A69_T0.8771.00
49_P55_V0.8641.00
38_D41_A0.8471.00
55_V59_V0.8451.00
54_D58_A0.8451.00
12_A15_G0.8411.00
72_V76_L0.8301.00
8_A11_A0.8271.00
74_N78_E0.8241.00
34_Q66_F0.8191.00
36_E61_K0.8121.00
30_V34_Q0.8111.00
37_A62_A0.8101.00
75_K78_E0.7961.00
10_A13_A0.7851.00
22_L25_D0.7691.00
33_L61_K0.7671.00
34_Q37_A0.7651.00
11_A14_A0.7641.00
49_P54_D0.7631.00
13_A16_G0.7411.00
40_A50_V0.7401.00
77_V80_Y0.7311.00
81_Q84_M0.7301.00
78_E85_R0.7261.00
37_A41_A0.7211.00
43_A46_T0.7081.00
52_L55_V0.7061.00
68_L72_V0.7051.00
43_A49_P0.6971.00
69_T73_R0.6941.00
59_V72_V0.6901.00
17_G25_D0.6861.00
9_A12_A0.6781.00
53_H68_L0.6771.00
40_A44_L0.6701.00
43_A50_V0.6641.00
41_A45_A0.6631.00
79_A83_I0.6631.00
60_Q64_L0.6581.00
70_V73_R0.6411.00
37_A40_A0.6281.00
10_A14_A0.6251.00
57_I60_Q0.6251.00
9_A14_A0.6241.00
67_Q71_Q0.6141.00
54_D57_I0.6081.00
30_V65_A0.6011.00
40_A49_P0.5961.00
52_L56_M0.5891.00
8_A14_A0.5881.00
28_D31_N0.5821.00
27_L31_N0.5681.00
66_F69_T0.5621.00
11_A15_G0.5591.00
84_M87_Q0.5581.00
26_A30_V0.5551.00
57_I61_K0.5511.00
62_A66_F0.5471.00
26_A33_L0.5431.00
12_A16_G0.5201.00
9_A13_A0.5191.00
59_V63_E0.5081.00
30_V33_L0.5081.00
12_A17_G0.5031.00
56_M60_Q0.5021.00
45_A53_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ca5A 1 0.7386 10 0.872 Contact Map
3zqeA 1 0.8068 9.2 0.874 Contact Map
2g0uA 1 0.9659 6.1 0.884 Contact Map
2d4yA 1 0.9432 4.6 0.891 Contact Map
2fkcA 1 0.9432 4.2 0.893 Contact Map
4ut1A 1 0.5114 3.1 0.9 Contact Map
2p58B 1 0.3864 2.7 0.903 Contact Map
3a69A 3 0.8523 2.6 0.904 Contact Map
3v47C 1 0.875 2.4 0.905 Contact Map
3ghgA 2 0.8864 2 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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