GREMLIN Database
DUF131 - Protein of unknown function DUF131
PFAM: PF01998 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 62 (49)
Sequences: 731 (592)
Seq/√Len: 84.5
META: 0.884

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_K40_D4.9401.00
26_G37_F3.6191.00
43_S47_A3.0741.00
40_D43_S2.1171.00
39_S44_A2.0151.00
24_G39_S1.8921.00
54_L58_A1.7461.00
25_G49_I1.6511.00
55_M58_A1.6391.00
25_G39_S1.5341.00
27_V51_A1.4510.99
29_M51_A1.4240.99
26_G36_V1.3110.99
36_V48_L1.2190.98
29_M55_M1.2120.98
27_V44_A1.2100.98
36_V51_A1.2030.97
15_E21_K1.2010.97
39_S43_S1.1890.97
14_E17_E1.1850.97
28_I37_F1.1830.97
36_V44_A1.1660.97
27_V47_A1.1010.96
23_K42_K1.0800.95
35_I48_L0.9570.91
15_E60_L0.9510.91
28_I41_K0.9500.91
48_L58_A0.8960.88
40_D46_I0.8840.87
15_E49_I0.8610.86
14_E56_I0.7820.80
16_E19_K0.7800.80
26_G35_I0.7630.79
13_S53_I0.7600.78
23_K39_S0.7370.76
55_M61_L0.7320.76
46_I58_A0.7160.74
21_K57_L0.7030.73
39_S47_A0.7020.73
45_K48_L0.6840.71
38_G47_A0.6770.70
14_E20_T0.6700.69
18_E59_L0.6700.69
55_M59_L0.6510.67
46_I49_I0.6360.65
25_G40_D0.6340.65
29_M45_K0.6340.65
14_E18_E0.6330.65
18_E53_I0.6320.65
29_M50_L0.6320.65
16_E21_K0.6260.64
25_G35_I0.6170.63
50_L54_L0.6130.62
46_I55_M0.6010.61
19_K45_K0.6000.61
39_S42_K0.5960.60
27_V49_I0.5940.60
19_K41_K0.5910.59
31_G34_P0.5860.59
26_G32_P0.5620.56
57_L60_L0.5600.55
13_S18_E0.5410.53
48_L51_A0.5370.52
16_E22_V0.5360.52
38_G44_A0.5320.52
17_E57_L0.5240.51
17_E41_K0.5220.50
33_I59_L0.5210.50
15_E19_K0.5150.49
33_I61_L0.5140.49
14_E19_K0.5100.49
26_G59_L0.5060.48
28_I35_I0.5060.48
17_E20_T0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e84A 1 0 9.1 0.857 Contact Map
1z1nX 1 0 7.4 0.862 Contact Map
3mk7C 2 0.9032 7.3 0.862 Contact Map
2cvcA 1 0 3.8 0.88 Contact Map
4he8J 1 0.1613 3.2 0.884 Contact Map
3qnqA 2 0.9516 3 0.885 Contact Map
3j6dA 3 0 2 0.895 Contact Map
2j7aC 2 0.2742 2 0.896 Contact Map
4xtrG 1 0.2903 2 0.897 Contact Map
4rp9A 2 0.2742 1.8 0.898 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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