GREMLIN Database
VIT1 - VIT family
PFAM: PF01988 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 214 (209)
Sequences: 22883 (13275)
Seq/√Len: 918.3
META: 0.873

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_R76_E4.6741.00
84_R106_E3.5111.00
88_A102_R3.3551.00
77_D82_E2.9121.00
67_L120_A2.8961.00
92_E98_P2.8611.00
100_L103_Q2.8051.00
177_F195_G2.7691.00
98_P102_R2.3541.00
177_F199_L2.3371.00
102_R106_E2.3131.00
181_A191_P2.3011.00
18_L40_G2.2871.00
185_R191_P2.2771.00
84_R109_T2.2711.00
29_S32_A2.2621.00
68_A71_R2.1991.00
99_E103_Q2.1431.00
88_A92_E2.0381.00
190_S193_R2.0221.00
85_E89_L2.0191.00
173_L199_L2.0171.00
75_E112_P2.0071.00
173_L203_A1.9571.00
50_A201_I1.9531.00
67_L71_R1.9011.00
154_P171_L1.8971.00
100_L107_Q1.8471.00
74_L116_L1.8251.00
89_L92_E1.7681.00
97_S107_Q1.7321.00
84_R88_A1.7171.00
66_E69_R1.6811.00
103_Q107_Q1.6701.00
166_P170_V1.6661.00
118_A122_E1.6521.00
84_R102_R1.6501.00
103_Q106_E1.6441.00
78_P84_R1.6331.00
111_D114_A1.6151.00
113_D117_D1.5991.00
138_L142_A1.5871.00
164_A168_S1.5821.00
163_A167_V1.5651.00
96_L104_V1.5201.00
60_R64_E1.5031.00
25_A35_L1.4671.00
181_A195_G1.4651.00
71_R113_D1.4601.00
72_R75_E1.4521.00
46_L50_A1.4471.00
163_A166_P1.4311.00
68_A72_R1.4231.00
104_V108_L1.4181.00
32_A36_A1.4171.00
134_L138_L1.4091.00
88_A98_P1.3841.00
97_S100_L1.3791.00
41_L148_A1.3701.00
158_A167_V1.3541.00
26_G29_S1.3401.00
71_R75_E1.3331.00
183_K194_S1.3241.00
71_R116_L1.3171.00
98_P101_A1.3031.00
90_I122_E1.2941.00
150_I175_A1.2761.00
94_R122_E1.2601.00
176_L202_G1.2541.00
189_A193_R1.2511.00
81_E84_R1.2311.00
162_S166_P1.2291.00
107_Q110_A1.2241.00
78_P81_E1.2231.00
91_Y118_A1.2121.00
89_L93_A1.2091.00
85_E102_R1.2061.00
85_E88_A1.2041.00
19_V155_Y1.2001.00
49_A141_A1.1801.00
106_E110_A1.1731.00
117_D121_R1.1501.00
70_E86_E1.1481.00
69_R73_E1.1421.00
64_E68_A1.1361.00
207_A211_G1.1291.00
184_A194_S1.1271.00
37_G152_L1.1101.00
96_L100_L1.0981.00
171_L175_A1.0961.00
46_L208_V1.0911.00
52_E140_S1.0891.00
132_R135_Q1.0841.00
92_E101_A1.0671.00
26_G32_A1.0641.00
22_V36_A1.0431.00
192_L196_L1.0401.00
73_E123_E1.0391.00
66_E124_L1.0381.00
67_L117_D1.0381.00
27_A32_A1.0371.00
8_A179_L1.0191.00
96_L107_Q1.0111.00
97_S103_Q1.0061.00
191_P195_G1.0011.00
101_A105_A1.0011.00
97_S101_A0.9981.00
41_L145_A0.9931.00
73_E86_E0.9901.00
27_A36_A0.9891.00
105_A108_L0.9891.00
16_A172_S0.9771.00
31_S35_L0.9751.00
119_H123_E0.9621.00
154_P158_A0.9611.00
161_G164_A0.9411.00
57_S197_R0.9401.00
184_A187_T0.9361.00
106_E109_T0.9261.00
178_L182_L0.9211.00
65_A69_R0.9091.00
61_D64_E0.9091.00
200_L203_A0.9071.00
57_S60_R0.9051.00
15_T18_L0.9031.00
86_E123_E0.9021.00
83_E86_E0.9011.00
44_G144_F0.8941.00
177_F181_A0.8861.00
67_L116_L0.8851.00
92_E102_R0.8811.00
69_R124_L0.8801.00
24_G210_Y0.8751.00
158_A164_A0.8701.00
166_P169_V0.8671.00
50_A205_A0.8601.00
178_L181_A0.8581.00
49_A137_A0.8551.00
167_V170_V0.8541.00
196_L200_L0.8531.00
72_R77_D0.8481.00
164_A167_V0.8471.00
155_Y168_S0.8451.00
70_E83_E0.8431.00
82_E85_E0.8401.00
192_L195_G0.8391.00
104_V107_Q0.8391.00
3_A52_E0.8221.00
109_T115_W0.8211.00
135_Q138_L0.8191.00
182_L185_R0.8171.00
33_V36_A0.8131.00
167_V171_L0.8091.00
71_R112_P0.8021.00
170_V174_V0.7991.00
195_G199_L0.7931.00
34_L156_L0.7901.00
20_A165_L0.7871.00
14_S40_G0.7851.00
6_L140_S0.7821.00
3_A6_L0.7821.00
73_E124_L0.7791.00
142_A146_V0.7781.00
19_V33_V0.7741.00
114_A117_D0.7691.00
127_D130_E0.7641.00
91_Y122_E0.7631.00
91_Y104_V0.7571.00
165_L169_V0.7561.00
19_V168_S0.7491.00
32_A35_L0.7481.00
20_A210_Y0.7461.00
114_A118_A0.7451.00
105_A109_T0.7441.00
54_V201_I0.7431.00
139_A143_S0.7381.00
38_L152_L0.7351.00
77_D81_E0.7321.00
81_E85_E0.7291.00
84_R110_A0.7271.00
94_R121_R0.7261.00
184_A191_P0.7251.00
45_A145_A0.7231.00
74_L115_W0.7191.00
150_I171_L0.7091.00
52_E55_S0.7081.00
58_S183_K0.7061.00
8_A147_G0.7031.00
146_V149_L0.7031.00
203_A207_A0.7021.00
96_L108_L0.7001.00
52_E56_V0.6991.00
126_I129_D0.6991.00
86_E119_H0.6981.00
94_R117_D0.6931.00
83_E123_E0.6871.00
19_V37_G0.6861.00
87_L109_T0.6811.00
191_P194_S0.6771.00
88_A101_A0.6721.00
9_N14_S0.6691.00
208_V211_G0.6681.00
22_V32_A0.6671.00
204_L207_A0.6661.00
33_V155_Y0.6621.00
30_R34_L0.6621.00
63_E126_I0.6601.00
61_D189_A0.6601.00
84_R105_A0.6591.00
15_T41_L0.6531.00
87_L118_A0.6521.00
17_S206_A0.6501.00
165_L168_S0.6481.00
16_A169_V0.6481.00
201_I205_A0.6471.00
91_Y94_R0.6461.00
204_L211_G0.6451.00
20_A24_G0.6411.00
12_L175_A0.6401.00
164_A169_V0.6401.00
88_A105_A0.6401.00
163_A168_S0.6391.00
83_E119_H0.6301.00
4_A139_A0.6291.00
101_A109_T0.6291.00
67_L128_P0.6281.00
100_L104_V0.6261.00
12_L172_S0.6241.00
199_L203_A0.6171.00
110_A114_A0.6161.00
22_V35_L0.6151.00
91_Y101_A0.6131.00
56_V136_A0.6121.00
99_E102_R0.6111.00
153_L157_L0.6081.00
181_A185_R0.6081.00
200_L207_A0.6071.00
90_I124_L0.6071.00
57_S61_D0.6061.00
17_S43_A0.6061.00
87_L119_H0.6051.00
173_L177_F0.6041.00
20_A169_V0.6011.00
3_A136_A0.6001.00
14_S144_F0.6001.00
190_S194_S0.6001.00
38_L42_V0.5971.00
52_E136_A0.5971.00
90_I123_E0.5961.00
183_K198_V0.5941.00
60_R133_P0.5941.00
45_A141_A0.5931.00
90_I94_R0.5921.00
181_A194_S0.5901.00
42_V208_V0.5891.00
74_L112_P0.5891.00
176_L179_L0.5881.00
183_K197_R0.5881.00
67_L126_I0.5881.00
42_V212_I0.5881.00
193_R200_L0.5871.00
154_P167_V0.5851.00
112_P117_D0.5831.00
53_Y57_S0.5821.00
34_L38_L0.5811.00
172_S175_A0.5791.00
59_Q63_E0.5741.00
169_V203_A0.5711.00
15_T40_G0.5691.00
195_G198_V0.5681.00
121_R125_G0.5671.00
108_L115_W0.5671.00
158_A163_A0.5651.00
169_V207_A0.5641.00
208_V212_I0.5611.00
26_G30_R0.5601.00
135_Q139_A0.5601.00
138_L141_A0.5581.00
107_Q114_A0.5551.00
88_A106_E0.5531.00
19_V152_L0.5521.00
92_E97_S0.5511.00
200_L204_L0.5501.00
55_S59_Q0.5481.00
153_L156_L0.5461.00
16_A206_A0.5451.00
193_R196_L0.5441.00
70_E119_H0.5441.00
6_L14_S0.5431.00
15_T148_A0.5411.00
13_V205_A0.5411.00
57_S64_E0.5371.00
70_E123_E0.5351.00
23_A155_Y0.5311.00
108_L111_D0.5301.00
38_L156_L0.5301.00
145_A149_L0.5301.00
134_L137_A0.5291.00
90_I118_A0.5291.00
85_E98_P0.5261.00
94_R104_V0.5231.00
136_A140_S0.5231.00
117_D128_P0.5231.00
90_I119_H0.5231.00
73_E77_D0.5221.00
174_V178_L0.5211.00
196_L199_L0.5151.00
112_P116_L0.5151.00
149_L152_L0.5131.00
4_A143_S0.5071.00
12_L15_T0.5041.00
54_V58_S0.5031.00
4_A8_A0.5031.00
90_I93_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aurA 1 0.5701 19.3 0.944 Contact Map
3wdoA 1 0.5421 17.4 0.945 Contact Map
1z96A 1 0.1776 14.4 0.947 Contact Map
4j05A 3 0.6636 14 0.948 Contact Map
3d31C 2 0.3131 11.4 0.95 Contact Map
1vegA 1 0.3879 10.8 0.95 Contact Map
3effK 4 0.3879 10.4 0.951 Contact Map
1dv0A 1 0.2103 9.2 0.952 Contact Map
3b9wA 3 0.3785 8.6 0.952 Contact Map
4un2B 1 0.1963 8 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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