GREMLIN Database
DUF123 - Domain of unknown function DUF123
PFAM: PF01986 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 93 (86)
Sequences: 5995 (4859)
Seq/√Len: 523.9
META: 0.933

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_C85_C4.0061.00
65_C87_C3.8751.00
68_A92_F2.7471.00
11_V68_A2.6181.00
38_L47_A2.4491.00
15_L62_R2.2731.00
45_L91_L2.1911.00
76_P89_S2.1641.00
16_G19_G2.1471.00
59_S63_L2.1441.00
15_L59_S1.9101.00
22_A25_A1.8651.00
80_F91_L1.7511.00
78_P88_P1.6601.00
30_R36_K1.6481.00
11_V71_L1.6131.00
63_L66_E1.5971.00
11_V92_F1.5881.00
87_C90_H1.5631.00
49_A53_I1.5301.00
27_H36_K1.4711.00
20_L24_I1.4601.00
53_I56_V1.4231.00
19_G22_A1.4171.00
26_R38_L1.3831.00
41_H83_S1.3591.00
38_L44_Y1.3161.00
15_L61_E1.2911.00
21_E25_A1.2341.00
46_L51_V1.2221.00
15_L63_L1.0881.00
28_L31_S1.0801.00
13_S16_G1.0601.00
25_A29_R1.0471.00
30_R46_L1.0451.00
82_S89_S1.0311.00
9_V71_L1.0231.00
45_L80_F1.0131.00
25_A28_L1.0071.00
71_L92_F1.0001.00
4_P76_P0.9981.00
7_Y54_V0.9891.00
3_F8_Y0.9391.00
11_V67_L0.9391.00
36_K46_L0.9341.00
32_K36_K0.9271.00
41_H44_Y0.9171.00
3_F45_L0.9091.00
59_S62_R0.9091.00
28_L53_I0.8871.00
57_I67_L0.8801.00
16_G22_A0.8751.00
62_R67_L0.8641.00
49_A55_W0.8631.00
65_C90_H0.8621.00
51_V54_V0.8531.00
28_L56_V0.8531.00
14_A19_G0.8211.00
13_S61_E0.8181.00
42_I47_A0.8181.00
85_C90_H0.8141.00
27_H46_L0.8111.00
3_F44_Y0.8071.00
68_A90_H0.8051.00
23_R40_W0.7981.00
26_R32_K0.7941.00
28_L51_V0.7811.00
55_W58_Y0.7791.00
46_L49_A0.7661.00
32_K46_L0.7591.00
45_L49_A0.7591.00
3_F77_V0.7501.00
82_S85_C0.7461.00
14_A20_L0.7391.00
71_L75_A0.7381.00
24_I56_V0.7361.00
82_S92_F0.7331.00
29_R36_K0.7321.00
20_L58_Y0.7301.00
66_E69_R0.7271.00
63_L67_L0.7171.00
29_R32_K0.7141.00
48_H51_V0.7061.00
77_V89_S0.6991.00
57_I63_L0.6901.00
52_E56_V0.6731.00
26_R36_K0.6661.00
6_G10_Y0.6601.00
13_S62_R0.6561.00
69_R88_P0.6481.00
8_Y77_V0.6391.00
79_G82_S0.6331.00
49_A52_E0.6271.00
31_S38_L0.6251.00
53_I58_Y0.6251.00
3_F80_F0.6241.00
27_H30_R0.6191.00
42_I46_L0.6161.00
89_S92_F0.6031.00
59_S67_L0.5860.99
36_K47_A0.5810.99
23_R27_H0.5800.99
30_R51_V0.5750.99
72_A75_A0.5740.99
65_C68_A0.5720.99
50_E53_I0.5620.99
76_P82_S0.5610.99
54_V57_I0.5570.99
46_L53_I0.5520.99
77_V80_F0.5500.99
16_G20_L0.5460.99
24_I54_V0.5450.99
24_I42_I0.5280.99
79_G88_P0.5250.99
26_R37_K0.5250.99
47_A50_E0.5250.99
3_F65_C0.5230.99
68_A85_C0.5220.99
42_I45_L0.5190.99
41_H91_L0.5180.99
3_F90_H0.5140.99
38_L46_L0.5130.99
81_G84_D0.5120.98
16_G63_L0.5100.98
27_H31_S0.5090.98
15_L19_G0.5070.98
2_D5_A0.5040.98
21_E24_I0.5030.98
28_L54_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yd0A 1 0.6882 59.6 0.886 Contact Map
2wshA 4 0.7957 49.9 0.892 Contact Map
1yd6A 5 0.7742 45.6 0.895 Contact Map
1mk0A 1 0.8172 41.3 0.897 Contact Map
3mx1A 2 0.9032 9.5 0.924 Contact Map
2wnwA 2 0.6344 9.1 0.925 Contact Map
4b0hA 3 0.828 6.6 0.93 Contact Map
4egcB 1 0.4301 5 0.933 Contact Map
3clwA 1 0.3333 4.8 0.934 Contact Map
1ufiA 3 0.2258 4.8 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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