GREMLIN Database
DUF116 - Protein of unknown function DUF116
PFAM: PF01976 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 154 (148)
Sequences: 3832 (2405)
Seq/√Len: 197.7
META: 0.911

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_R105_D5.0311.00
71_S144_T4.6341.00
44_L110_V3.7181.00
66_R80_E3.6561.00
145_V150_V3.1741.00
66_R77_E3.0381.00
66_R76_L2.8951.00
52_D69_K2.8561.00
149_E152_E2.6611.00
85_K102_G2.5331.00
81_K151_E2.3141.00
51_S142_N2.2591.00
44_L86_V2.0271.00
73_G77_E1.9871.00
75_L150_V1.9461.00
14_D17_D1.8301.00
42_L84_Y1.8211.00
72_I88_V1.8061.00
71_S74_D1.8041.00
66_R73_G1.7861.00
137_K144_T1.7851.00
78_L151_E1.7711.00
97_K101_E1.7511.00
93_T115_E1.7281.00
136_P146_D1.7251.00
36_P39_R1.6141.00
48_L72_I1.5631.00
139_G143_T1.5071.00
106_A129_P1.5031.00
35_V106_A1.4631.00
96_R122_D1.4481.00
42_L79_A1.4431.00
78_L81_K1.4381.00
58_T63_N1.4311.00
56_K65_K1.4301.00
29_R33_A1.4211.00
50_N69_K1.4191.00
74_D147_L1.4141.00
87_Y98_I1.3871.00
146_D149_E1.3741.00
77_E81_K1.3661.00
24_N28_V1.3421.00
148_E151_E1.3191.00
55_A65_K1.3151.00
35_V40_R1.3061.00
111_A116_L1.3041.00
43_L89_A1.2981.00
76_L80_E1.2881.00
62_L79_A1.2561.00
92_G118_S1.2551.00
54_P65_K1.2341.00
111_A115_E1.2321.00
99_I107_I1.2311.00
43_L95_A1.1921.00
137_K142_N1.1751.00
87_Y102_G1.1641.00
15_H18_M1.1551.00
21_I113_E1.1531.00
79_A84_Y1.1361.00
37_P40_R1.1201.00
17_D117_E1.1151.00
22_E26_R1.0941.00
20_F24_N1.0941.00
93_T96_R1.0881.00
32_F35_V1.0711.00
131_Q153_A1.0451.00
74_D77_E1.0221.00
14_D18_M1.0091.00
108_V131_Q1.0071.00
75_L86_V1.0051.00
37_P84_Y0.9871.00
25_N32_F0.9851.00
78_L82_L0.9740.99
39_R85_K0.9670.99
54_P69_K0.9670.99
148_E152_E0.9510.99
65_K69_K0.9280.99
31_K35_V0.9220.99
62_L80_E0.9190.99
68_G73_G0.9170.99
114_R118_S0.9100.99
38_E105_D0.9060.99
29_R106_A0.9050.99
51_S141_V0.9010.99
82_L151_E0.8950.99
92_G115_E0.8810.99
24_N120_I0.8720.99
134_P144_T0.8700.99
110_V150_V0.8630.99
37_P106_A0.8540.99
7_R13_K0.8530.99
91_G95_A0.8430.98
89_A95_A0.8430.98
134_P146_D0.8420.98
135_L138_G0.8370.98
26_R29_R0.8370.98
61_G86_V0.8360.98
6_G16_L0.8320.98
43_L109_G0.8190.98
89_A94_L0.8160.98
46_H91_G0.8160.98
44_L72_I0.8120.98
26_R30_E0.8110.98
60_D63_N0.8050.98
19_S23_L0.8040.98
134_P149_E0.8000.98
46_H57_I0.7990.98
46_H115_E0.7980.98
16_L19_S0.7900.98
117_E121_Q0.7890.98
24_N27_L0.7770.97
92_G122_D0.7730.97
72_I143_T0.7500.97
61_G88_V0.7490.97
64_C112_C0.7480.97
6_G19_S0.7480.97
7_R16_L0.7460.97
30_E33_A0.7330.96
11_I15_H0.7320.96
114_R138_G0.7240.96
13_K17_D0.7200.96
46_H97_K0.7180.96
107_I126_L0.7020.95
120_I130_G0.7010.95
90_P94_L0.7010.95
147_L151_E0.6970.95
9_L14_D0.6930.95
6_G12_D0.6920.95
30_E34_K0.6880.95
48_L61_G0.6760.94
91_G115_E0.6720.94
91_G143_T0.6690.94
61_G79_A0.6650.94
75_L147_L0.6610.94
92_G96_R0.6590.94
95_A119_G0.6560.93
99_I104_P0.6540.93
18_M113_E0.6540.93
32_F108_V0.6440.93
117_E120_I0.6430.93
7_R14_D0.6420.93
114_R122_D0.6390.92
46_H111_A0.6360.92
123_L130_G0.6360.92
8_L13_K0.6250.92
41_L99_I0.6240.92
74_D78_L0.6230.92
41_L87_Y0.6190.91
74_D151_E0.6180.91
77_E82_L0.6160.91
11_I14_D0.6150.91
122_D130_G0.6130.91
116_L132_G0.6120.91
32_F36_P0.6100.91
21_I132_G0.6100.91
92_G104_P0.6090.91
47_C64_C0.6080.91
68_G95_A0.6050.90
75_L145_V0.6020.90
112_C140_C0.5990.90
17_D106_A0.5980.90
94_L97_K0.5980.90
49_R104_P0.5970.90
41_L98_I0.5930.89
144_T148_E0.5890.89
64_C70_C0.5890.89
15_H19_S0.5880.89
120_I132_G0.5850.89
57_I88_V0.5820.89
78_L147_L0.5810.88
49_R139_G0.5780.88
45_P107_I0.5770.88
50_N54_P0.5770.88
12_D15_H0.5760.88
29_R153_A0.5750.88
108_V153_A0.5750.88
19_S22_E0.5740.88
28_V31_K0.5720.88
46_H93_T0.5690.87
71_S147_L0.5680.87
8_L14_D0.5670.87
6_G9_L0.5670.87
93_T114_R0.5600.87
48_L75_L0.5600.87
93_T122_D0.5590.86
21_I91_G0.5560.86
47_C112_C0.5540.86
89_A132_G0.5540.86
111_A120_I0.5500.86
55_A63_N0.5490.86
92_G95_A0.5480.85
95_A122_D0.5480.85
98_I102_G0.5480.85
52_D77_E0.5480.85
53_C70_C0.5470.85
40_R84_Y0.5460.85
103_R126_L0.5450.85
16_L20_F0.5430.85
65_K73_G0.5420.85
119_G123_L0.5370.84
138_G143_T0.5360.84
115_E137_K0.5340.84
25_N34_K0.5310.84
144_T147_L0.5310.84
18_M22_E0.5300.83
135_L139_G0.5270.83
95_A99_I0.5250.83
91_G111_A0.5210.82
115_E119_G0.5200.82
133_V153_A0.5190.82
91_G98_I0.5180.82
96_R115_E0.5180.82
149_E153_A0.5170.82
114_R119_G0.5150.82
109_G132_G0.5150.82
116_L130_G0.5090.81
6_G15_H0.5080.81
111_A130_G0.5070.81
111_A122_D0.5040.80
41_L104_P0.5040.80
67_C70_C0.5010.80
35_V108_V0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m9wA 1 0.6558 57.2 0.914 Contact Map
2rgyA 2 0.6558 55.4 0.915 Contact Map
3clkA 2 0.6234 54.2 0.915 Contact Map
3cs3A 2 0.6753 50.1 0.917 Contact Map
2qu7A 2 0.6429 49.8 0.918 Contact Map
4rk6A 2 0.6429 49.1 0.918 Contact Map
3l6uA 2 0.6558 49.1 0.918 Contact Map
3c3kA 2 0.6558 48.1 0.918 Contact Map
3o74A 2 0.6688 48.1 0.918 Contact Map
4rk4A 2 0.6494 47.7 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0066 seconds.