GREMLIN Database
TctA - Tripartite tricarboxylate transporter TctA family
PFAM: PF01970 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 409 (409)
Sequences: 17118 (10151)
Seq/√Len: 501.9
META: 0.81

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_R89_R4.9061.00
262_K267_A4.5121.00
353_K356_R4.2201.00
259_H262_K3.9241.00
93_I268_I3.1871.00
89_R216_D2.9741.00
378_N383_D2.9011.00
81_M268_I2.8871.00
205_E399_K2.8811.00
80_P83_K2.7771.00
99_F341_L2.6881.00
93_I272_A2.6331.00
218_K221_W2.5581.00
64_N75_T2.5151.00
108_L232_F2.5131.00
101_G276_A2.4891.00
262_K265_K2.4511.00
102_G337_N2.4181.00
252_V255_R2.4121.00
215_K219_R2.4111.00
215_K218_K2.4061.00
317_L321_E2.3681.00
230_I252_V2.3411.00
202_R398_R2.3021.00
259_H267_A2.2421.00
61_I78_G2.2371.00
223_P227_G2.2291.00
97_G276_A2.2171.00
43_I332_S2.2121.00
160_L407_L2.1991.00
180_E382_F2.1671.00
3_L40_S2.1621.00
198_S202_R2.1591.00
26_I299_T2.1511.00
403_P406_P2.0611.00
205_E395_Y2.0441.00
103_L334_L2.0241.00
381_V384_V2.0231.00
84_Q262_K2.0071.00
110_I334_L1.9501.00
249_S273_A1.9471.00
37_D40_S1.9441.00
219_R269_E1.9371.00
124_G127_E1.9041.00
104_I108_L1.9011.00
221_W225_L1.9011.00
100_I224_I1.8951.00
381_V385_W1.8811.00
104_I232_F1.8611.00
229_L233_F1.8601.00
214_R218_K1.8441.00
197_I367_L1.8411.00
220_S272_A1.8281.00
222_P226_R1.7651.00
226_R256_L1.7641.00
226_R253_A1.7621.00
178_I182_L1.7451.00
39_V328_G1.7261.00
225_L229_L1.7211.00
33_T310_H1.7211.00
64_N80_P1.7151.00
317_L320_T1.7061.00
385_W389_V1.7061.00
252_V256_L1.6851.00
57_S61_I1.6741.00
185_I190_V1.6691.00
82_A87_A1.6581.00
74_T271_V1.6541.00
220_S223_P1.6511.00
139_I154_G1.6491.00
156_L407_L1.6341.00
79_Y83_K1.6281.00
98_S278_N1.6201.00
92_G212_P1.6121.00
118_E122_K1.6081.00
389_V393_L1.5921.00
186_D189_P1.5751.00
200_I363_Y1.5261.00
153_A397_M1.5251.00
257_S269_E1.5241.00
72_A247_F1.5191.00
104_I228_S1.5111.00
253_A263_F1.5091.00
153_A407_L1.5061.00
397_M402_F1.5001.00
185_I386_V1.4941.00
143_S150_G1.4891.00
64_N398_R1.4671.00
297_S300_T1.4651.00
257_S261_E1.4631.00
22_P52_A1.4601.00
371_V387_M1.4541.00
5_L339_L1.4531.00
189_P386_V1.4501.00
13_L17_L1.4421.00
213_T216_D1.4371.00
119_V122_K1.4361.00
374_A387_M1.4361.00
112_L115_P1.4351.00
223_P253_A1.4351.00
240_A244_I1.4041.00
84_Q265_K1.3981.00
396_L400_L1.3961.00
110_I330_I1.3891.00
397_M407_L1.3861.00
227_G276_A1.3801.00
190_V390_F1.3781.00
14_V25_A1.3741.00
232_F284_G1.3671.00
76_L80_P1.3601.00
145_G401_G1.3561.00
4_L47_G1.3561.00
93_I220_S1.3391.00
163_V185_I1.3321.00
197_I387_M1.3301.00
319_F326_V1.3291.00
105_G283_G1.3281.00
57_S94_A1.3241.00
14_V20_L1.3191.00
51_G55_G1.3171.00
81_M84_Q1.3091.00
103_L107_L1.3061.00
289_L304_L1.3031.00
245_A281_A1.3001.00
172_P175_T1.2891.00
160_L185_I1.2851.00
79_Y82_A1.2741.00
43_I47_G1.2741.00
338_V342_I1.2661.00
100_I104_I1.2631.00
390_F394_G1.2611.00
108_L112_L1.2591.00
285_A297_S1.2471.00
115_P119_V1.2421.00
382_F385_W1.2411.00
220_S269_E1.2401.00
360_R364_P1.2391.00
199_E203_N1.2301.00
7_G44_M1.2271.00
172_P182_L1.2271.00
393_L397_M1.2241.00
361_I365_I1.2131.00
371_V384_V1.2051.00
262_K269_E1.2011.00
53_M70_A1.2011.00
97_G224_I1.2001.00
347_L351_F1.1931.00
16_A59_T1.1921.00
113_A291_T1.1841.00
88_G92_G1.1611.00
348_I352_V1.1551.00
318_L326_V1.1521.00
392_V396_L1.1431.00
25_A48_I1.1291.00
54_Y344_N1.1231.00
233_F237_L1.1221.00
197_I391_G1.1211.00
4_L43_I1.1201.00
76_L247_F1.1201.00
194_L407_L1.1181.00
9_L343_L1.1181.00
8_V47_G1.1131.00
148_L152_I1.1091.00
194_L394_G1.1061.00
159_L163_V1.1041.00
156_L393_L1.1031.00
2_L6_L1.0971.00
200_I367_L1.0961.00
106_T334_L1.0891.00
136_L154_G1.0871.00
226_R252_V1.0831.00
398_R404_L1.0821.00
221_W224_I1.0821.00
223_P226_R1.0801.00
151_L155_L1.0791.00
74_T275_E1.0791.00
203_N363_Y1.0721.00
202_R205_E1.0681.00
219_R262_K1.0671.00
349_R353_K1.0661.00
149_K402_F1.0631.00
253_A273_A1.0631.00
312_I318_L1.0621.00
153_A402_F1.0591.00
93_I97_G1.0561.00
342_I346_P1.0521.00
179_P182_L1.0511.00
371_V388_L1.0501.00
397_M404_L1.0471.00
193_G390_F1.0441.00
257_S267_A1.0431.00
46_A329_L1.0341.00
197_I201_L1.0321.00
222_P225_L1.0301.00
322_N325_L1.0301.00
106_T333_M1.0291.00
73_A76_L1.0291.00
227_G252_V1.0261.00
180_E380_S1.0261.00
51_G340_L1.0251.00
91_L348_I1.0241.00
216_D219_R1.0231.00
98_S279_N1.0231.00
257_S260_P1.0231.00
106_T110_I1.0221.00
234_I248_L1.0201.00
382_F386_V1.0201.00
223_P269_E1.0191.00
95_A344_N1.0111.00
214_R217_L1.0101.00
334_L338_V1.0081.00
77_D271_V1.0051.00
68_T71_S1.0031.00
152_I402_F1.0021.00
3_L6_L1.0021.00
350_L353_K1.0001.00
186_D383_D0.9961.00
93_I271_V0.9961.00
47_G51_G0.9911.00
347_L350_L0.9871.00
116_L236_I0.9821.00
89_R213_T0.9811.00
249_S277_A0.9801.00
166_D169_T0.9801.00
196_A370_C0.9681.00
218_K222_P0.9671.00
199_E202_R0.9671.00
45_L303_L0.9621.00
253_A256_L0.9591.00
192_I370_C0.9561.00
29_L48_I0.9551.00
199_E398_R0.9511.00
234_I245_A0.9441.00
186_D378_N0.9401.00
259_H265_K0.9381.00
64_N83_K0.9371.00
5_L343_L0.9341.00
385_W388_L0.9311.00
11_G15_G0.9291.00
132_M135_G0.9281.00
406_P409_L0.9241.00
54_Y57_S0.9241.00
352_V355_L0.9231.00
56_G68_T0.9231.00
89_R268_I0.9221.00
213_T218_K0.9221.00
203_N359_Y0.9211.00
228_S276_A0.9201.00
308_M314_P0.9181.00
191_L408_V0.9141.00
73_A247_F0.9131.00
12_T51_G0.9121.00
23_T27_A0.9121.00
165_L172_P0.9111.00
81_M267_A0.9091.00
386_V389_V0.9091.00
249_S252_V0.9071.00
104_I229_L0.9061.00
240_A297_S0.9051.00
156_L160_L0.9001.00
290_L312_I0.9001.00
257_S262_K0.8991.00
185_I389_V0.8971.00
323_P326_V0.8951.00
213_T217_L0.8941.00
313_Q321_E0.8931.00
370_C387_M0.8931.00
59_T68_T0.8921.00
70_A242_A0.8891.00
275_E278_N0.8881.00
65_I196_A0.8861.00
53_M71_S0.8831.00
104_I225_L0.8821.00
228_S280_A0.8801.00
141_S251_A0.8801.00
346_P350_L0.8781.00
42_L307_L0.8731.00
395_Y399_K0.8731.00
326_V330_I0.8731.00
50_Y102_G0.8721.00
251_A255_R0.8721.00
341_L345_L0.8671.00
21_G24_M0.8671.00
221_W229_L0.8661.00
99_F103_L0.8651.00
290_L329_L0.8601.00
38_P41_A0.8591.00
289_L300_T0.8591.00
61_I90_A0.8561.00
23_T302_V0.8551.00
46_A286_L0.8541.00
202_R206_E0.8531.00
45_L306_A0.8521.00
49_Y299_T0.8511.00
285_A300_T0.8511.00
159_L174_F0.8501.00
41_A310_H0.8491.00
260_P267_A0.8451.00
96_I341_L0.8421.00
242_A281_A0.8401.00
386_V390_F0.8391.00
227_G249_S0.8371.00
24_M28_L0.8371.00
61_I94_A0.8371.00
8_V339_L0.8361.00
198_S404_L0.8361.00
81_M90_A0.8331.00
140_A147_L0.8331.00
3_L44_M0.8331.00
159_L162_T0.8321.00
303_L307_L0.8311.00
257_S265_K0.8261.00
192_I374_A0.8241.00
113_A319_F0.8221.00
323_P328_G0.8201.00
57_S275_E0.8191.00
4_L8_V0.8191.00
89_R93_I0.8181.00
202_R399_K0.8161.00
54_Y95_A0.8161.00
380_S383_D0.8141.00
267_A271_V0.8121.00
224_I276_A0.8091.00
80_P265_K0.8091.00
10_L14_V0.8091.00
50_Y336_A0.8081.00
158_L162_T0.8041.00
374_A384_V0.8011.00
155_L159_L0.7981.00
234_I240_A0.7961.00
96_I217_L0.7931.00
95_A348_I0.7881.00
109_L113_A0.7861.00
91_L95_A0.7851.00
72_A76_L0.7841.00
224_I272_A0.7831.00
81_M86_R0.7811.00
240_A409_L0.7791.00
357_I362_L0.7781.00
144_G147_L0.7751.00
259_H269_E0.7731.00
257_S263_F0.7701.00
220_S224_I0.7691.00
260_P269_E0.7681.00
236_I287_I0.7681.00
227_G253_A0.7671.00
40_S43_I0.7661.00
92_G345_L0.7631.00
97_G272_A0.7621.00
200_I366_I0.7611.00
260_P263_F0.7611.00
223_P273_A0.7581.00
398_R401_G0.7581.00
153_A403_P0.7571.00
190_V407_L0.7561.00
189_P374_A0.7541.00
377_V383_D0.7511.00
114_P117_A0.7491.00
42_L329_L0.7431.00
362_L366_I0.7411.00
151_L154_G0.7411.00
140_A154_G0.7401.00
146_S149_K0.7401.00
74_T278_N0.7401.00
208_G211_P0.7381.00
3_L7_G0.7381.00
339_L342_I0.7371.00
105_G282_A0.7371.00
14_V21_G0.7361.00
29_L44_M0.7341.00
129_F133_L0.7341.00
24_M27_A0.7341.00
308_M313_Q0.7311.00
115_P118_E0.7311.00
363_Y367_L0.7311.00
50_Y333_M0.7241.00
44_M47_G0.7231.00
304_L308_M0.7231.00
162_T174_F0.7231.00
160_L390_F0.7221.00
205_E208_G0.7191.00
192_I387_M0.7161.00
147_L151_L0.7151.00
333_M337_N0.7141.00
216_D268_I0.7131.00
359_Y363_Y0.7121.00
33_T36_M0.7111.00
56_G59_T0.7071.00
223_P256_L0.7061.00
77_D274_P0.7061.00
223_P272_A0.7041.00
137_T141_S0.7011.00
365_I369_F0.7011.00
255_R260_P0.7001.00
160_L163_V0.6981.00
4_L339_L0.6971.00
130_A133_L0.6961.00
5_L9_L0.6951.00
328_G332_S0.6941.00
320_T323_P0.6931.00
158_L161_G0.6871.00
217_L221_W0.6851.00
3_L36_M0.6851.00
81_M93_I0.6851.00
69_P243_T0.6811.00
234_I296_G0.6791.00
113_A117_A0.6781.00
14_V52_A0.6771.00
16_A21_G0.6771.00
110_I331_A0.6761.00
324_D328_G0.6751.00
39_V43_I0.6731.00
99_F338_V0.6721.00
243_T298_A0.6701.00
261_E265_K0.6691.00
90_A271_V0.6681.00
40_S44_M0.6681.00
245_A248_L0.6671.00
135_G237_L0.6661.00
165_L182_L0.6661.00
390_F393_L0.6621.00
222_P269_E0.6621.00
296_G300_T0.6611.00
212_P216_D0.6611.00
227_G273_A0.6611.00
246_S274_P0.6601.00
111_L115_P0.6601.00
343_L347_L0.6581.00
153_A156_L0.6571.00
128_Y132_M0.6561.00
81_M89_R0.6541.00
340_L344_N0.6531.00
50_Y337_N0.6521.00
80_P267_A0.6511.00
247_F405_A0.6481.00
388_L392_V0.6471.00
143_S147_L0.6471.00
117_A319_F0.6461.00
327_W330_I0.6431.00
92_G96_I0.6421.00
198_S398_R0.6421.00
169_T172_P0.6421.00
23_T298_A0.6411.00
281_A297_S0.6401.00
96_I224_I0.6381.00
50_Y282_A0.6381.00
356_R359_Y0.6381.00
100_I225_L0.6371.00
46_A332_S0.6361.00
34_F309_I0.6351.00
87_A271_V0.6341.00
16_A58_I0.6331.00
283_G286_L0.6321.00
226_R230_I0.6321.00
330_I334_L0.6321.00
243_T246_S0.6291.00
274_P277_A0.6291.00
370_C374_A0.6271.00
27_A302_V0.6251.00
312_I325_L0.6251.00
99_F340_L0.6221.00
52_A68_T0.6221.00
229_L232_F0.6191.00
183_D186_D0.6181.00
258_K261_E0.6161.00
160_L389_V0.6161.00
220_S268_I0.6141.00
190_V194_L0.6141.00
384_V387_M0.6121.00
72_A75_T0.6101.00
12_T58_I0.6090.99
109_L330_I0.6050.99
245_A277_A0.6030.99
14_V22_P0.6020.99
313_Q322_N0.6020.99
260_P265_K0.6000.99
116_L291_T0.5990.99
58_I61_I0.5990.99
150_G154_G0.5970.99
198_S201_L0.5970.99
189_P383_D0.5960.99
103_L106_T0.5960.99
143_S154_G0.5960.99
4_L336_A0.5950.99
279_N340_L0.5940.99
42_L303_L0.5940.99
143_S403_P0.5930.99
106_T283_G0.5920.99
116_L119_V0.5910.99
147_L150_G0.5910.99
175_T178_I0.5900.99
120_A316_P0.5900.99
94_A271_V0.5880.99
80_P84_Q0.5870.99
246_S277_A0.5870.99
331_A335_I0.5860.99
42_L325_L0.5840.99
243_T281_A0.5830.99
352_V356_R0.5820.99
8_V336_A0.5810.99
300_T303_L0.5800.99
207_G211_P0.5800.99
397_M400_L0.5790.99
94_A275_E0.5780.99
17_L369_F0.5760.99
165_L179_P0.5740.99
78_G90_A0.5740.99
9_L13_L0.5730.99
306_A310_H0.5730.99
313_Q317_L0.5730.99
214_R221_W0.5730.99
156_L397_M0.5720.99
153_A406_P0.5710.99
171_V175_T0.5710.99
177_G180_E0.5710.99
14_V29_L0.5700.99
105_G284_G0.5690.99
88_G212_P0.5670.99
149_K153_A0.5660.99
268_I271_V0.5650.99
7_G11_G0.5650.99
249_S253_A0.5650.99
10_L29_L0.5640.99
321_E324_D0.5630.99
375_Y379_N0.5600.99
339_L343_L0.5590.99
84_Q267_A0.5580.99
402_F406_P0.5570.99
163_V181_L0.5570.99
137_T154_G0.5570.99
20_L24_M0.5560.99
96_I100_I0.5540.99
241_G296_G0.5520.99
41_A309_I0.5520.99
96_I345_L0.5520.99
134_L137_T0.5510.99
6_L10_L0.5500.99
268_I272_A0.5480.99
70_A243_T0.5480.99
302_V305_G0.5450.99
43_I46_A0.5450.99
298_A308_M0.5450.99
22_P299_T0.5430.99
53_M282_A0.5430.99
290_L297_S0.5430.99
216_D220_S0.5420.99
358_P361_I0.5400.99
53_M279_N0.5400.99
180_E386_V0.5390.99
224_I228_S0.5390.99
332_S336_A0.5380.99
195_F391_G0.5380.99
62_L88_G0.5380.99
144_G403_P0.5370.99
201_L395_Y0.5370.99
212_P217_L0.5360.99
375_Y384_V0.5360.99
39_V324_D0.5360.99
240_A246_S0.5350.99
78_G271_V0.5340.99
10_L44_M0.5330.99
276_A280_A0.5310.99
78_G87_A0.5300.99
367_L371_V0.5300.99
89_R220_S0.5290.99
194_L390_F0.5290.99
145_G149_K0.5280.99
289_L307_L0.5280.99
46_A303_L0.5270.99
23_T299_T0.5270.99
22_P53_M0.5270.99
14_V17_L0.5270.99
319_F330_I0.5250.99
153_A393_L0.5240.98
86_R268_I0.5240.98
149_K400_L0.5220.98
153_A161_G0.5220.98
172_P176_F0.5210.98
235_G288_P0.5210.98
258_K262_K0.5190.98
2_L5_L0.5170.98
89_R212_P0.5160.98
123_F127_E0.5160.98
10_L25_A0.5140.98
253_A269_E0.5140.98
141_S147_L0.5130.98
93_I224_I0.5130.98
240_A296_G0.5130.98
84_Q89_R0.5110.98
135_G244_I0.5110.98
154_G158_L0.5110.98
197_I370_C0.5110.98
318_L322_N0.5100.98
186_D190_V0.5100.98
261_E267_A0.5080.98
318_L323_P0.5060.98
12_T343_L0.5050.98
322_N326_V0.5050.98
226_R255_R0.5050.98
128_Y131_L0.5050.98
109_L283_G0.5040.98
240_A245_A0.5040.98
15_G18_P0.5030.98
120_A292_L0.5030.98
175_T179_P0.5030.98
214_R225_L0.5030.98
42_L312_I0.5030.98
228_S232_F0.5020.98
8_V340_L0.5020.98
57_S274_P0.5010.98
6_L44_M0.5010.98
266_G270_G0.5010.98
53_M242_A0.5000.98
31_P34_F0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nd0A 2 0.5941 16.8 0.968 Contact Map
4cz8A 2 0.6284 16.2 0.968 Contact Map
4czbA 2 0.5892 15.3 0.969 Contact Map
3orgA 2 0.5208 9.6 0.971 Contact Map
2ksfA 1 0.2616 9.2 0.972 Contact Map
4bwzA 2 0.5795 8.5 0.972 Contact Map
2jwaA 2 0.1076 4.8 0.975 Contact Map
4xnjA 1 0.198 4.6 0.975 Contact Map
4eneA 2 0.6284 4.2 0.976 Contact Map
4tphA 2 0.1883 2.5 0.978 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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