GREMLIN Database
CbiZ - Adenosylcobinamide amidohydrolase
PFAM: PF01955 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 192 (187)
Sequences: 3867 (2736)
Seq/√Len: 200.1
META: 0.787

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_A184_I4.0551.00
108_I138_L3.5881.00
84_V191_A3.4011.00
9_L124_V2.8381.00
7_R120_D2.7491.00
112_V184_I2.7091.00
73_E190_E2.5021.00
140_D189_R2.4831.00
84_V110_I2.3841.00
91_N155_G2.3471.00
123_L163_A2.3081.00
68_A83_V2.2961.00
82_A112_V2.2801.00
73_E186_R2.2711.00
70_V81_T2.1831.00
28_Q63_A2.0591.00
24_V111_I2.0471.00
112_V130_A2.0291.00
9_L18_L2.0141.00
155_G177_H2.0121.00
72_T81_T1.9941.00
124_V127_V1.9431.00
22_R55_D1.9361.00
135_T139_Q1.9291.00
130_A159_V1.9121.00
82_A187_A1.8921.00
41_Y45_L1.8121.00
21_A57_V1.7381.00
74_S79_T1.7341.00
27_H45_L1.7271.00
59_L160_V1.7171.00
71_A190_E1.6741.00
65_M68_A1.6381.00
117_P164_P1.5751.00
128_I131_T1.5701.00
7_R20_E1.5651.00
33_Y41_Y1.5321.00
28_Q65_M1.5221.00
127_V159_V1.5161.00
42_L58_G1.4831.00
74_S77_D1.4571.00
97_D145_S1.4531.00
93_V176_P1.4511.00
8_V21_A1.4391.00
11_S124_V1.4141.00
126_A161_V1.4041.00
136_A152_T1.4011.00
24_V162_A1.3861.00
25_L58_G1.3861.00
116_A171_L1.3771.00
131_T159_V1.3721.00
59_L158_A1.3661.00
127_V131_T1.3591.00
18_L120_D1.3581.00
131_T135_T1.3501.00
38_P42_L1.3081.00
126_A174_A1.2441.00
70_V83_V1.2401.00
45_L49_L1.2381.00
110_I192_V1.2331.00
133_A137_A1.2231.00
129_T176_P1.2121.00
95_A129_T1.2031.00
93_V155_G1.2001.00
180_L183_L1.1981.00
18_L123_L1.1911.00
97_D148_S1.1901.00
39_E172_T1.1801.00
4_E166_R1.1781.00
145_S148_S1.1711.00
51_L56_T1.1701.00
179_K183_L1.1641.00
123_L161_V1.1611.00
114_V180_L1.1571.00
40_A43_A1.1491.00
92_A151_A1.1341.00
182_E186_R1.1301.00
94_R139_Q1.1241.00
57_V160_V1.1121.00
45_L48_E1.1011.00
8_V162_A1.0991.00
6_L113_L1.0981.00
78_L183_L1.0871.00
59_L111_I1.0801.00
15_G19_R1.0711.00
72_T79_T1.0671.00
95_A185_G1.0591.00
132_E176_P1.0521.00
133_A188_V1.0451.00
44_E48_E1.0291.00
14_L42_L1.0281.00
42_L46_A1.0181.00
136_A189_R1.0171.00
130_A188_V1.0041.00
64_D67_N0.9951.00
38_P41_Y0.9901.00
37_D40_A0.9841.00
5_P22_R0.9841.00
119_T122_A0.9791.00
92_A143_V0.9781.00
118_L122_A0.9710.99
94_R150_G0.9680.99
137_A189_R0.9630.99
88_V92_A0.9530.99
6_L164_P0.9530.99
136_A140_D0.9520.99
125_N129_T0.9510.99
26_N59_L0.9500.99
94_R140_D0.9460.99
23_A55_D0.9430.99
40_A44_E0.9420.99
8_V57_V0.9410.99
175_G178_T0.9310.99
143_V151_A0.9270.99
116_A164_P0.9210.99
174_A184_I0.9200.99
24_V160_V0.9190.99
29_V60_L0.9190.99
127_V130_A0.9180.99
31_E62_A0.9080.99
183_L187_A0.9050.99
43_A47_A0.9010.99
7_R18_L0.8990.99
88_V138_L0.8930.99
171_L180_L0.8910.99
46_A56_T0.8830.99
20_E165_P0.8800.99
7_R117_P0.8740.99
6_L162_A0.8710.99
138_L143_V0.8690.99
8_V24_V0.8610.99
92_A154_T0.8600.99
125_N128_I0.8570.99
38_P46_A0.8550.99
135_T152_T0.8360.98
93_V147_Y0.8290.98
38_P60_L0.8110.98
5_P20_E0.8090.98
107_T156_T0.8080.98
42_L60_L0.8050.98
179_K182_E0.8030.98
137_A141_L0.7990.98
80_V183_L0.7970.98
62_A107_T0.7920.98
41_Y46_A0.7850.98
26_N111_I0.7820.98
28_Q31_E0.7810.98
10_S57_V0.7760.98
95_A135_T0.7700.97
186_R190_E0.7690.97
98_D102_P0.7650.97
117_P169_P0.7620.97
110_I130_A0.7560.97
136_A139_Q0.7550.97
175_G181_G0.7510.97
79_T115_N0.7490.97
118_L174_A0.7470.97
132_E153_G0.7390.97
12_A57_V0.7360.97
30_P33_Y0.7350.97
130_A184_I0.7300.96
25_L46_A0.7290.96
82_A188_V0.7290.96
23_A51_L0.7280.96
53_P56_T0.7270.96
73_E187_A0.7270.96
98_D101_A0.7270.96
185_G189_R0.7270.96
130_A161_V0.7230.96
80_V114_V0.7150.96
85_T107_T0.7120.96
39_E43_A0.7120.96
94_R189_R0.7120.96
29_V33_Y0.7100.96
111_I162_A0.7090.96
12_A16_G0.7010.95
88_V143_V0.6950.95
44_E47_A0.6910.95
80_V180_L0.6780.95
155_G176_P0.6770.95
84_V192_V0.6740.94
75_F179_K0.6730.94
137_A192_V0.6730.94
85_T109_N0.6720.94
60_L158_A0.6710.94
26_N156_T0.6670.94
11_S158_A0.6640.94
76_G179_K0.6570.94
9_L127_V0.6560.94
13_V158_A0.6560.94
78_L116_A0.6550.94
100_G105_P0.6530.93
81_T113_L0.6520.93
118_L180_L0.6470.93
69_A83_V0.6460.93
99_P103_P0.6410.93
90_S146_R0.6390.93
29_V158_A0.6370.93
100_G103_P0.6370.93
134_K158_A0.6330.92
97_D147_Y0.6320.92
125_N174_A0.6320.92
114_V184_I0.6290.92
11_S128_I0.6280.92
119_T172_T0.6270.92
98_D104_R0.6240.92
8_V160_V0.6230.92
31_E34_D0.6220.92
69_A190_E0.6190.92
38_P173_Y0.6150.91
95_A176_P0.6140.91
114_V118_L0.6140.91
115_N164_P0.6090.91
113_L162_A0.6070.91
109_N156_T0.6050.91
73_E183_L0.6050.91
94_R136_A0.6030.90
46_A49_L0.5980.90
120_D123_L0.5980.90
147_Y150_G0.5970.90
132_E152_T0.5950.90
12_A59_L0.5950.90
11_S127_V0.5910.90
166_R169_P0.5830.89
91_N156_T0.5800.89
177_H182_E0.5780.88
110_I188_V0.5780.88
114_V164_P0.5770.88
46_A58_G0.5770.88
27_H60_L0.5760.88
47_A117_P0.5750.88
114_V174_A0.5730.88
42_L45_L0.5720.88
117_P163_A0.5700.88
63_A69_A0.5680.88
75_F78_L0.5650.87
33_Y38_P0.5650.87
42_L48_E0.5650.87
128_I156_T0.5650.87
118_L126_A0.5610.87
101_A105_P0.5610.87
31_E35_R0.5610.87
25_L56_T0.5590.87
82_A110_I0.5590.87
173_Y178_T0.5590.87
80_V187_A0.5560.87
40_A50_G0.5540.86
96_G152_T0.5520.86
113_L121_A0.5500.86
125_N177_H0.5460.86
145_S151_A0.5460.86
143_V154_T0.5460.86
117_P166_R0.5450.85
174_A178_T0.5440.85
43_A53_P0.5430.85
29_V173_Y0.5400.85
73_E80_V0.5390.85
63_A68_A0.5380.85
92_A155_G0.5370.85
158_A173_Y0.5350.84
27_H41_Y0.5290.84
72_T100_G0.5290.84
26_N65_M0.5260.83
35_R41_Y0.5250.83
153_G157_D0.5250.83
43_A54_G0.5250.83
33_Y62_A0.5230.83
13_V39_E0.5200.83
47_A53_P0.5160.82
41_Y44_E0.5140.82
79_T114_V0.5130.82
101_A104_R0.5120.82
14_L43_A0.5110.82
30_P62_A0.5110.82
83_V111_I0.5070.81
24_V57_V0.5060.81
93_V156_T0.5040.81
36_D47_A0.5040.81
92_A96_G0.5030.81
88_V154_T0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eo2A 1 0.3698 19.4 0.945 Contact Map
3frrA 1 0.3177 9 0.953 Contact Map
2lekA 1 0.3646 6.1 0.956 Contact Map
4r84A 1 0.3177 5.7 0.957 Contact Map
1f0zA 1 0.3281 5.5 0.957 Contact Map
4ffjA 2 0.3594 5.3 0.958 Contact Map
2cu3A 2 0.3177 5.1 0.958 Contact Map
2k5pA 1 0.375 3.5 0.961 Contact Map
4wlrB 1 0.25 3.2 0.962 Contact Map
3mioA 2 0.349 3.1 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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