GREMLIN Database
SpoIIM - Stage II sporulation protein M
PFAM: PF01944 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 156 (148)
Sequences: 19736 (14198)
Seq/√Len: 1167.1
META: 0.875

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_R50_L3.4801.00
48_A108_A3.2941.00
48_A144_L3.0361.00
120_R128_E2.8431.00
58_L62_G2.7541.00
41_F145_V2.7221.00
41_F148_A2.5931.00
121_S124_E2.5921.00
18_E25_E2.5401.00
104_A143_L2.3131.00
37_F152_G2.2421.00
67_L109_G2.1451.00
100_L143_L1.9441.00
123_R127_R1.9111.00
82_A91_L1.9021.00
42_T46_R1.8921.00
52_F133_A1.8901.00
96_P150_I1.8601.00
82_A87_G1.8241.00
78_A90_F1.7631.00
100_L103_P1.7011.00
131_R135_K1.6711.00
8_G12_G1.6281.00
129_A132_D1.6111.00
100_L104_A1.5671.00
124_E127_R1.5581.00
124_E128_E1.5091.00
90_F94_I1.5021.00
65_F69_Y1.4841.00
80_L84_A1.4671.00
99_I103_P1.4191.00
37_F149_L1.4171.00
51_A66_L1.4101.00
149_L153_F1.4091.00
54_L62_G1.4051.00
32_S35_A1.3901.00
70_N73_M1.3781.00
9_A13_A1.3601.00
130_G133_A1.3401.00
64_L113_L1.3341.00
95_L99_I1.3271.00
79_G83_Q1.3261.00
87_G91_L1.3211.00
104_A144_L1.3191.00
78_A91_L1.3181.00
127_R131_R1.3161.00
93_F155_T1.2851.00
132_D135_K1.2821.00
36_M40_I1.2821.00
118_A129_A1.2741.00
38_L42_T1.2631.00
102_L106_F1.2491.00
97_H101_E1.2331.00
40_I152_G1.2271.00
114_R117_W1.2181.00
145_V149_L1.1991.00
100_L146_V1.1891.00
13_A17_A1.1771.00
37_F153_F1.1771.00
108_A140_V1.1711.00
50_L66_L1.1581.00
133_A136_L1.1581.00
74_L94_I1.1361.00
59_F62_G1.1221.00
128_E132_D1.1031.00
92_L96_P1.1021.00
105_I144_L1.1021.00
114_R129_A1.1001.00
125_A128_E1.0891.00
95_L102_L1.0831.00
86_L89_L1.0551.00
26_G29_S1.0311.00
48_A105_I1.0301.00
79_G82_A1.0261.00
6_L9_A1.0241.00
136_L139_G1.0211.00
88_L92_L1.0171.00
129_A133_A1.0101.00
37_F41_F0.9921.00
114_R118_A0.9891.00
8_G16_A0.9821.00
44_N101_E0.9711.00
89_L93_F0.9571.00
4_L8_G0.9551.00
60_G117_W0.9491.00
60_G63_T0.9471.00
39_F42_T0.9401.00
150_I154_V0.9271.00
12_G16_A0.9231.00
8_G68_F0.9141.00
103_P106_F0.9011.00
111_A136_L0.8991.00
45_I141_V0.8941.00
114_R132_D0.8891.00
4_L64_L0.8821.00
13_A79_G0.8781.00
41_F45_I0.8761.00
100_L150_I0.8681.00
28_Y31_G0.8651.00
47_V66_L0.8601.00
5_F8_G0.8451.00
59_F119_L0.8431.00
3_L7_L0.8351.00
8_G14_L0.8281.00
132_D136_L0.8221.00
50_L54_L0.8161.00
111_A140_V0.8131.00
51_A109_G0.8101.00
11_I14_L0.8081.00
28_Y33_A0.8051.00
96_P100_L0.8021.00
13_A16_A0.8001.00
135_K142_P0.7991.00
120_R125_A0.7931.00
120_R123_R0.7921.00
34_A38_L0.7901.00
110_A114_R0.7871.00
58_L116_G0.7861.00
137_L140_V0.7841.00
28_Y32_S0.7831.00
40_I43_N0.7811.00
78_A82_A0.7661.00
134_L142_P0.7641.00
51_A67_L0.7631.00
77_V90_F0.7611.00
5_F12_G0.7611.00
11_I68_F0.7611.00
91_L95_L0.7611.00
27_V30_S0.7531.00
10_L14_L0.7511.00
133_A137_L0.7511.00
134_L138_L0.7461.00
123_R126_L0.7461.00
122_R125_A0.7461.00
140_V144_L0.7411.00
43_N70_N0.7351.00
62_G65_F0.7331.00
78_A94_I0.7331.00
68_F72_L0.7291.00
74_L102_L0.7271.00
2_F6_L0.7211.00
89_L92_L0.7191.00
6_L10_L0.7171.00
36_M39_F0.7091.00
122_R126_L0.7081.00
49_F137_L0.7081.00
100_L147_A0.7071.00
7_L14_L0.7061.00
101_E144_L0.6941.00
104_A147_A0.6931.00
98_G101_E0.6921.00
131_R134_L0.6781.00
31_G35_A0.6711.00
29_S33_A0.6671.00
71_G75_G0.6641.00
80_L83_Q0.6511.00
77_V81_F0.6511.00
125_A129_A0.6471.00
35_A38_L0.6461.00
36_M152_G0.6441.00
29_S32_S0.6341.00
8_G15_L0.6311.00
130_G134_L0.6301.00
96_P99_I0.6301.00
51_A63_T0.6281.00
2_F106_F0.6271.00
127_R130_G0.6261.00
81_F84_A0.6251.00
135_K139_G0.6241.00
7_L11_I0.6201.00
138_L142_P0.6171.00
85_G89_L0.6171.00
26_G30_S0.6131.00
120_R124_E0.6101.00
73_M77_V0.6091.00
2_F5_F0.6041.00
91_L96_P0.6001.00
69_Y72_L0.5961.00
43_N46_R0.5921.00
11_I15_L0.5901.00
103_P107_I0.5891.00
117_W129_A0.5891.00
5_F106_F0.5891.00
7_L10_L0.5891.00
30_S33_A0.5851.00
70_N74_L0.5821.00
9_A12_G0.5821.00
69_Y73_M0.5811.00
54_L63_T0.5781.00
6_L14_L0.5771.00
40_I101_E0.5731.00
98_G102_L0.5721.00
49_F141_V0.5711.00
118_A125_A0.5651.00
136_L142_P0.5651.00
12_G15_L0.5651.00
52_F111_A0.5641.00
148_A152_G0.5611.00
66_L70_N0.5591.00
70_N98_G0.5551.00
51_A105_I0.5491.00
126_L129_A0.5481.00
90_F93_F0.5471.00
136_L140_V0.5471.00
64_L68_F0.5391.00
43_N47_V0.5361.00
11_I16_A0.5351.00
42_T45_I0.5341.00
55_G63_T0.5261.00
74_L98_G0.5221.00
121_S125_A0.5211.00
60_G116_G0.5141.00
78_A83_Q0.5111.00
92_L95_L0.5091.00
48_A51_A0.5091.00
33_A37_F0.5071.00
35_A39_F0.5061.00
66_L69_Y0.5041.00
121_S127_R0.5011.00
143_L147_A0.5011.00
113_L116_G0.5011.00
48_A140_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1scfA 4 0 4.7 0.914 Contact Map
4httA 1 0.7115 1.8 0.931 Contact Map
4ogqF 1 0.1346 0.9 0.943 Contact Map
4b4aA 1 0.7115 0.9 0.943 Contact Map
3rkoL 1 0.8333 0.9 0.943 Contact Map
2kv5A 1 0.2115 0.8 0.945 Contact Map
4lz6A 1 0.75 0.8 0.946 Contact Map
2onkC 2 0.7115 0.7 0.946 Contact Map
4p6vD 1 0.6603 0.7 0.947 Contact Map
1pfiA 7 0.2885 0.6 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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