GREMLIN Database
DUF92 - Integral membrane protein DUF92
PFAM: PF01940 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 230 (216)
Sequences: 5929 (4158)
Seq/√Len: 282.9
META: 0.827

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_A166_V3.8061.00
191_C194_C3.7801.00
114_A225_T3.5621.00
177_V227_I3.2111.00
34_G38_W3.0511.00
156_G175_S3.0171.00
130_R139_P2.9591.00
215_L219_A2.8461.00
52_L119_W2.7581.00
26_V86_A2.7461.00
119_W159_G2.6751.00
153_T176_L2.6421.00
120_A156_G2.6031.00
22_A75_A2.5531.00
56_G59_R2.4951.00
44_A162_L2.4631.00
88_L106_A2.4131.00
109_A228_G2.3761.00
108_A167_A2.3561.00
140_V147_G2.3271.00
85_A111_L2.3071.00
161_L168_A2.2661.00
15_L23_A2.2291.00
48_S119_W2.2241.00
41_L108_A2.0471.00
157_L172_F1.9601.00
190_Y195_G1.8781.00
88_L103_L1.8231.00
127_S151_L1.7961.00
10_Y17_L1.7611.00
7_L11_R1.7581.00
140_V144_T1.7441.00
29_L86_A1.7181.00
6_A24_A1.7061.00
56_G60_K1.6341.00
145_S187_A1.6301.00
131_P147_G1.6251.00
135_T184_T1.6221.00
132_R139_P1.6191.00
113_A224_S1.6041.00
3_L24_A1.5881.00
115_A163_I1.5861.00
133_L183_A1.5751.00
123_I155_A1.5681.00
131_P149_S1.5311.00
154_L158_A1.5191.00
141_P144_T1.5061.00
109_A170_A1.4841.00
38_W107_F1.4831.00
14_S50_S1.4741.00
13_R72_R1.4731.00
84_V226_L1.4401.00
172_F176_L1.4061.00
148_V153_T1.3821.00
58_A61_A1.3781.00
59_R63_L1.3691.00
120_A175_S1.3681.00
45_F49_S1.3641.00
133_L140_V1.3631.00
75_A79_L1.3381.00
31_F39_F1.3321.00
113_A228_G1.3141.00
24_A28_T1.3141.00
33_G93_A1.2941.00
48_S162_L1.2891.00
41_L167_A1.2891.00
181_L185_L1.2751.00
33_G89_A1.2731.00
134_I176_L1.2611.00
49_S119_W1.2411.00
48_S115_A1.2311.00
20_A24_A1.2261.00
53_T71_G1.2161.00
30_I107_F1.1971.00
135_T180_L1.1841.00
153_T156_G1.1781.00
22_A79_L1.1761.00
123_I151_L1.1671.00
85_A107_F1.1601.00
69_K74_D1.1511.00
74_D77_Q1.1311.00
130_R141_P1.1281.00
39_F43_L1.1151.00
133_L136_T1.1141.00
44_A48_S1.1101.00
215_L223_L1.1091.00
145_S182_G1.1091.00
45_F114_A1.1071.00
135_T183_A1.1051.00
23_A27_G1.1041.00
8_L12_A1.0921.00
170_A228_G1.0871.00
105_L109_A1.0861.00
116_A160_A1.0801.00
2_A39_F1.0751.00
115_A119_W1.0711.00
9_A14_S1.0501.00
224_S228_G1.0481.00
187_A214_W1.0321.00
18_S75_A1.0271.00
116_A175_S1.0161.00
130_R149_S1.0081.00
82_G111_L0.9931.00
160_A164_A0.9911.00
41_L107_F0.9881.00
88_L91_L0.9861.00
164_A171_G0.9861.00
17_L21_L0.9851.00
93_A96_P0.9741.00
92_Y96_P0.9701.00
53_T60_K0.9491.00
113_A174_G0.9461.00
156_G176_L0.9461.00
151_L154_L0.9421.00
156_G172_F0.9381.00
144_T147_G0.9361.00
44_A163_I0.9341.00
38_W89_A0.9281.00
115_A159_G0.9271.00
23_A82_G0.9231.00
129_R151_L0.9221.00
59_R62_A0.9131.00
15_L78_V0.9051.00
150_L153_T0.9041.00
219_A222_F0.8961.00
224_S227_I0.8941.00
43_L47_V0.8871.00
128_G151_L0.8871.00
164_A168_A0.8761.00
86_A89_A0.8661.00
81_N218_D0.8611.00
112_A171_G0.8591.00
66_A71_G0.8561.00
173_L227_I0.8531.00
111_L163_I0.8531.00
95_T103_L0.8511.00
76_G216_N0.8511.00
157_L168_A0.8481.00
41_L163_I0.8431.00
50_S53_T0.8411.00
29_L33_G0.8401.00
10_Y72_R0.8381.00
153_T175_S0.8281.00
188_R197_E0.8281.00
155_A158_A0.8271.00
84_V88_L0.8271.00
85_A110_A0.8241.00
129_R149_S0.8181.00
15_L82_G0.8160.99
84_V110_A0.8110.99
27_G42_L0.8090.99
34_G107_F0.8040.99
174_G178_D0.8040.99
57_Y61_A0.8010.99
6_A20_A0.7900.99
1_L4_L0.7890.99
107_F111_L0.7880.99
97_S100_W0.7870.99
112_A163_I0.7850.99
34_G89_A0.7830.99
145_S186_Q0.7790.99
150_L154_L0.7740.99
78_V82_G0.7690.99
214_W219_A0.7660.99
147_G179_S0.7660.99
60_K63_L0.7660.99
171_G178_D0.7640.99
57_Y66_A0.7640.99
219_A223_L0.7630.99
194_C199_E0.7630.99
3_L7_L0.7630.99
84_V222_F0.7610.99
133_L144_T0.7600.99
130_R142_P0.7520.99
225_T228_G0.7440.99
5_L43_L0.7440.99
15_L19_G0.7430.99
10_Y20_A0.7420.99
14_S54_R0.7420.99
26_V82_G0.7400.99
110_A225_T0.7380.99
22_A78_V0.7330.99
49_S52_L0.7320.99
133_L147_G0.7320.99
159_G163_I0.7290.99
46_F77_Q0.7240.99
45_F82_G0.7220.99
173_L177_V0.7170.99
65_I125_V0.7130.99
19_G22_A0.7120.99
63_L142_P0.7120.99
26_V78_V0.7090.99
132_R137_L0.7050.99
191_C199_E0.7050.99
49_S115_A0.7020.98
55_L59_R0.7020.98
67_E71_G0.7010.98
33_G86_A0.7010.98
20_A23_A0.6980.98
190_Y193_V0.6960.98
64_G67_E0.6960.98
92_Y103_L0.6920.98
134_I183_A0.6910.98
181_L184_T0.6900.98
52_L121_S0.6890.98
42_L111_L0.6880.98
16_T74_D0.6870.98
27_G30_I0.6820.98
121_S125_V0.6790.98
185_L215_L0.6790.98
49_S118_T0.6770.98
19_G23_A0.6750.98
76_G218_D0.6710.98
111_L225_T0.6680.98
222_F226_L0.6670.98
8_L11_R0.6600.98
127_S131_P0.6580.98
83_G87_L0.6530.98
45_F115_A0.6470.97
190_Y194_C0.6460.97
190_Y197_E0.6450.97
149_S176_L0.6430.97
18_S22_A0.6420.97
145_S178_D0.6380.97
121_S228_G0.6370.97
134_I147_G0.6360.97
177_V181_L0.6350.97
87_L91_L0.6340.97
172_F175_S0.6290.97
6_A10_Y0.6280.97
121_S145_S0.6240.97
66_A69_K0.6230.97
132_R136_T0.6220.97
136_T183_A0.6220.97
81_N174_G0.6190.97
38_W92_Y0.6180.97
81_N114_A0.6160.97
170_A174_G0.6160.97
151_L155_A0.6140.96
108_A164_A0.6120.96
181_L223_L0.6100.96
52_L123_I0.6050.96
58_A62_A0.6040.96
135_T179_S0.6040.96
53_T122_E0.6010.96
30_I35_G0.6010.96
67_E77_Q0.5980.96
91_L103_L0.5970.96
92_Y104_L0.5960.96
91_L95_T0.5960.96
95_T98_P0.5940.96
14_S46_F0.5930.96
56_G126_L0.5900.96
60_K126_L0.5900.96
30_I85_A0.5840.95
127_S149_S0.5830.95
89_A107_F0.5810.95
22_A26_V0.5790.95
109_A113_A0.5780.95
32_G39_F0.5770.95
79_L222_F0.5740.95
216_N219_A0.5740.95
109_A225_T0.5730.95
192_P195_G0.5730.95
41_L166_V0.5720.95
86_A111_L0.5680.95
181_L220_V0.5680.95
173_L176_L0.5670.95
85_A225_T0.5660.95
212_W215_L0.5640.94
2_A28_T0.5640.94
30_I89_A0.5630.94
68_E216_N0.5620.94
125_V128_G0.5620.94
9_A15_L0.5580.94
171_G174_G0.5570.94
67_E70_G0.5570.94
4_L7_L0.5560.94
24_A31_F0.5550.94
92_Y95_T0.5550.94
53_T74_D0.5540.94
38_W43_L0.5520.94
148_V176_L0.5520.94
77_Q119_W0.5480.94
131_P140_V0.5460.93
61_A64_G0.5440.93
123_I131_P0.5420.93
136_T139_P0.5410.93
42_L107_F0.5410.93
159_G171_G0.5400.93
67_E125_V0.5400.93
135_T140_V0.5390.93
121_S217_N0.5390.93
9_A46_F0.5360.93
109_A121_S0.5350.93
178_D182_G0.5350.93
55_L127_S0.5300.92
37_G40_L0.5300.92
98_P103_L0.5290.92
88_L107_F0.5260.92
31_F35_G0.5260.92
80_A222_F0.5240.92
94_L98_P0.5220.92
180_L184_T0.5210.92
77_Q218_D0.5210.92
29_L90_L0.5190.92
76_G186_Q0.5190.92
63_L67_E0.5160.91
97_S103_L0.5160.91
89_A92_Y0.5150.91
30_I86_A0.5150.91
114_A145_S0.5130.91
46_F82_G0.5120.91
18_S74_D0.5090.91
26_V42_L0.5080.91
97_S102_L0.5070.91
76_G79_L0.5070.91
92_Y97_S0.5070.91
30_I82_G0.5060.91
38_W41_L0.5050.90
185_L212_W0.5040.90
31_F34_G0.5030.90
63_L66_A0.5000.90
112_A164_A0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.5348 76.3 0.937 Contact Map
4q2eA 2 0.8652 45.1 0.949 Contact Map
3dh4A 3 0.4304 40.8 0.95 Contact Map
3l1lA 2 0.3 26.5 0.955 Contact Map
1dlcA 1 0.3217 16.1 0.959 Contact Map
3qnqA 2 0.3174 10.2 0.962 Contact Map
4czbA 2 0.813 9.5 0.963 Contact Map
2jwaA 2 0.1913 9.5 0.963 Contact Map
2c9kA 1 0.3087 9.3 0.963 Contact Map
4w6vA 1 0.2609 9.3 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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