GREMLIN Database
TauE - Sulfite exporter TauE/SafE
PFAM: PF01925 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 236 (234)
Sequences: 92132 (61877)
Seq/√Len: 4045.0
META: 0.807

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_R223_R3.3461.00
220_L223_R3.2661.00
217_P220_L2.7121.00
76_G133_F2.6981.00
62_D65_L2.6761.00
10_F212_L2.6041.00
83_L137_F2.5411.00
62_D164_R2.5011.00
4_A26_L2.3721.00
66_L171_A2.3521.00
46_F199_A2.2961.00
207_L211_R2.2021.00
161_P164_R2.1761.00
64_R67_L2.1561.00
105_L109_L2.1431.00
56_R63_W2.1341.00
63_W67_L2.1141.00
191_D194_L2.0541.00
211_R215_R2.0291.00
32_P35_V1.9951.00
64_R68_P1.8681.00
104_A233_G1.8571.00
104_A226_A1.8371.00
72_G129_L1.8081.00
53_L56_R1.8001.00
82_L86_L1.7901.00
73_S176_T1.7861.00
90_A93_K1.7821.00
70_A175_V1.7681.00
71_L75_P1.7471.00
6_F205_G1.7421.00
227_V231_L1.7291.00
101_L233_G1.7151.00
90_A94_L1.7051.00
193_P197_L1.7001.00
75_P78_L1.6821.00
104_A230_L1.6671.00
97_G233_G1.6581.00
2_L201_G1.6461.00
65_L160_L1.6461.00
102_L106_L1.6291.00
82_L85_L1.6141.00
58_R214_R1.6061.00
50_S203_L1.5741.00
55_H60_N1.5621.00
124_S127_L1.5491.00
88_P91_V1.5271.00
50_S207_L1.5271.00
76_G80_G1.5181.00
89_G93_K1.4931.00
98_V102_L1.4551.00
91_V94_L1.4541.00
78_L183_G1.4511.00
41_L180_G1.4511.00
94_L98_V1.4391.00
211_R214_R1.4211.00
68_P71_L1.4191.00
54_A210_A1.4161.00
200_V204_L1.4001.00
66_L168_T1.3911.00
72_G75_P1.3901.00
28_L33_P1.3701.00
45_I178_L1.3601.00
162_L218_A1.3551.00
204_L207_L1.3541.00
192_W195_A1.3491.00
223_R227_V1.3471.00
72_G76_G1.3451.00
81_A183_G1.3421.00
67_L70_A1.3311.00
123_P126_L1.3301.00
67_L71_L1.3241.00
189_L193_P1.3231.00
182_L186_L1.3061.00
126_L129_L1.2931.00
49_L53_L1.2691.00
105_L230_L1.2621.00
53_L57_R1.2531.00
108_L226_A1.2481.00
126_L130_L1.2411.00
78_L82_L1.2271.00
129_L132_G1.2021.00
54_A58_R1.2011.00
49_L174_L1.1971.00
52_A171_A1.1881.00
120_R123_P1.1811.00
51_G170_L1.1691.00
68_P72_G1.1451.00
184_F189_L1.1381.00
46_F49_L1.1321.00
8_A23_T1.1271.00
39_T195_A1.1221.00
201_G205_G1.1191.00
83_L86_L1.1171.00
205_G208_L1.1161.00
5_G201_G1.1141.00
218_A222_R1.1121.00
193_P196_L1.1071.00
91_V95_L1.1061.00
208_L211_R1.0971.00
84_L184_F1.0971.00
77_A180_G1.0961.00
196_L200_V1.0921.00
220_L224_L1.0891.00
35_V38_G1.0821.00
94_L97_G1.0821.00
166_V169_S1.0801.00
219_R222_R1.0751.00
109_L112_R1.0701.00
182_L185_A1.0661.00
135_I149_L1.0641.00
106_L110_R1.0621.00
178_L182_L1.0611.00
185_A192_W1.0571.00
144_I148_F1.0551.00
205_G209_G1.0541.00
24_V36_A1.0541.00
52_A56_R1.0491.00
74_L179_A1.0431.00
97_G101_L1.0411.00
42_V195_A1.0401.00
35_V191_D1.0311.00
60_N214_R1.0201.00
33_P93_K1.0181.00
127_L130_L1.0181.00
194_L197_L1.0161.00
151_V165_A1.0131.00
206_A210_A1.0071.00
6_F208_L1.0061.00
54_A57_R1.0051.00
203_L207_L1.0041.00
230_L234_L0.9911.00
123_P127_L0.9901.00
15_A224_L0.9871.00
147_G152_P0.9831.00
8_A22_L0.9811.00
87_L141_L0.9781.00
160_L164_R0.9751.00
103_A106_L0.9671.00
216_L220_L0.9631.00
197_L200_V0.9631.00
122_R125_R0.9601.00
192_W196_L0.9571.00
75_P79_L0.9561.00
122_R126_L0.9421.00
68_P129_L0.9421.00
125_R129_L0.9411.00
51_G206_A0.9401.00
14_L216_L0.9391.00
68_P125_R0.9341.00
164_R167_G0.9291.00
77_A81_A0.9281.00
163_K213_A0.9251.00
5_G23_T0.9241.00
101_L105_L0.9181.00
99_L142_F0.9141.00
6_F204_L0.9111.00
55_H167_G0.9101.00
61_V171_A0.9101.00
121_R124_S0.9071.00
130_L133_F0.9031.00
161_P218_A0.8951.00
60_N163_K0.8901.00
12_N20_G0.8881.00
5_G198_L0.8871.00
153_A157_L0.8851.00
210_A214_R0.8841.00
121_R125_R0.8831.00
131_L153_A0.8821.00
135_I150_L0.8811.00
35_V39_T0.8801.00
63_W66_L0.8741.00
150_L154_L0.8731.00
155_V162_L0.8731.00
231_L235_K0.8651.00
31_L35_V0.8621.00
42_V181_L0.8611.00
79_L133_F0.8611.00
106_L109_L0.8541.00
79_L82_L0.8541.00
54_A211_R0.8531.00
119_S122_R0.8451.00
183_G187_L0.8451.00
102_L105_L0.8361.00
71_L74_L0.8351.00
73_S172_I0.8341.00
81_A85_L0.8281.00
133_F137_F0.8271.00
173_I176_T0.8231.00
81_A184_F0.8231.00
55_H210_A0.8211.00
80_G137_F0.8191.00
10_F208_L0.8161.00
120_R124_S0.8101.00
149_L152_P0.8091.00
110_R113_L0.8091.00
150_L172_I0.8061.00
183_G186_L0.8051.00
60_N167_G0.8041.00
85_L189_L0.8001.00
204_L208_L0.7991.00
3_L7_L0.7971.00
146_G150_L0.7931.00
150_L153_A0.7851.00
15_A228_V0.7841.00
174_L178_L0.7831.00
45_I181_L0.7821.00
100_L229_L0.7811.00
101_L234_L0.7801.00
109_L113_L0.7631.00
114_S117_R0.7571.00
169_S173_I0.7541.00
5_G9_G0.7511.00
23_T40_S0.7511.00
177_S180_G0.7431.00
37_V184_F0.7421.00
56_R59_G0.7401.00
130_L134_L0.7391.00
25_P28_L0.7331.00
52_A174_L0.7301.00
56_R61_V0.7261.00
76_G79_L0.7251.00
224_L228_V0.7241.00
212_L215_R0.7181.00
54_A207_L0.7051.00
24_V28_L0.7051.00
33_P37_V0.7031.00
47_T202_S0.7031.00
79_L83_L0.7021.00
125_R128_L0.6971.00
50_S54_A0.6971.00
196_L199_A0.6951.00
77_A179_A0.6951.00
223_R226_A0.6941.00
45_I49_L0.6901.00
69_L154_L0.6901.00
72_G132_G0.6891.00
225_F229_L0.6891.00
50_S53_L0.6861.00
152_P156_L0.6851.00
12_N19_G0.6821.00
2_L6_F0.6811.00
181_L185_A0.6811.00
55_H213_A0.6791.00
29_L235_K0.6761.00
138_L144_I0.6731.00
9_G13_G0.6681.00
24_V40_S0.6671.00
110_R222_R0.6651.00
199_A203_L0.6621.00
23_T27_L0.6621.00
175_V178_L0.6571.00
119_S124_S0.6551.00
163_K218_A0.6511.00
58_R211_R0.6501.00
6_F9_G0.6471.00
224_L227_V0.6461.00
79_L137_F0.6441.00
60_N164_R0.6431.00
121_R127_L0.6421.00
107_M226_A0.6401.00
43_A198_L0.6401.00
104_A108_L0.6401.00
151_V166_V0.6391.00
200_V203_L0.6381.00
82_L183_G0.6371.00
69_L172_I0.6301.00
61_V168_T0.6291.00
101_L230_L0.6291.00
155_V165_A0.6291.00
128_L131_L0.6271.00
12_N17_V0.6271.00
10_F205_G0.6261.00
139_S176_T0.6261.00
108_L223_R0.6251.00
44_V177_S0.6231.00
173_I177_S0.6231.00
31_L194_L0.6221.00
40_S44_V0.6181.00
74_L78_L0.6081.00
217_P223_R0.6081.00
131_L134_L0.6051.00
73_S150_L0.6051.00
145_G149_L0.6041.00
85_L187_L0.6031.00
62_D168_T0.6031.00
23_T198_L0.6021.00
104_A229_L0.5981.00
28_L36_A0.5981.00
118_G121_R0.5941.00
222_R226_A0.5931.00
120_R125_R0.5931.00
231_L234_L0.5901.00
65_L68_P0.5901.00
34_A84_L0.5901.00
26_L30_L0.5881.00
13_G51_G0.5871.00
127_L131_L0.5851.00
6_F10_F0.5851.00
135_I146_G0.5831.00
27_L198_L0.5821.00
208_L212_L0.5781.00
28_L93_K0.5771.00
188_G191_D0.5741.00
95_L98_V0.5701.00
34_A89_G0.5701.00
104_A107_M0.5661.00
144_I147_G0.5641.00
146_G149_L0.5631.00
70_A172_I0.5611.00
6_F201_G0.5591.00
33_P92_L0.5591.00
43_A202_S0.5571.00
162_L166_V0.5561.00
78_L186_L0.5561.00
165_A169_S0.5551.00
55_H166_V0.5511.00
62_D67_L0.5511.00
187_L191_D0.5511.00
148_F152_P0.5501.00
175_V179_A0.5501.00
216_L221_L0.5481.00
103_A107_M0.5471.00
7_L10_F0.5431.00
33_P89_G0.5431.00
148_F151_V0.5381.00
179_A182_L0.5371.00
197_L201_G0.5331.00
139_S145_G0.5331.00
13_G210_A0.5321.00
76_G137_F0.5301.00
12_N15_A0.5291.00
8_A26_L0.5281.00
66_L71_L0.5281.00
171_A175_V0.5271.00
128_L132_G0.5251.00
162_L225_F0.5231.00
49_L52_A0.5201.00
122_R127_L0.5191.00
34_A37_V0.5171.00
33_P96_F0.5161.00
129_L133_F0.5141.00
68_P128_L0.5141.00
95_L99_L0.5091.00
78_L81_A0.5091.00
126_L132_G0.5061.00
232_V235_K0.5051.00
8_A12_N0.5041.00
3_L6_F0.5031.00
152_P155_V0.5011.00
56_R60_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o7qA 1 0.8602 37.1 0.911 Contact Map
3llqA 3 0.7373 32.3 0.914 Contact Map
1pw4A 1 0.8517 32.3 0.914 Contact Map
2f2bA 4 0.75 27 0.917 Contact Map
2gfpA 2 0.839 22 0.921 Contact Map
3l1lA 2 0.4831 19 0.923 Contact Map
4tphA 2 0.3729 9.5 0.933 Contact Map
4j05A 3 0.7797 9.3 0.933 Contact Map
2a65A 2 0.4746 9.2 0.933 Contact Map
4ldsA 2 0.3517 9.2 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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