MarC - PFAM28P - GREMLIN Contacts

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MarC - MarC family integral membrane protein

PFAM:	PF01914	Sequences: FKEFLSAFVTLFVIIDPIGNIPIFLSLTAGLSPAERRRVARRAALIAFVILLVFALAGEAILRFFGISLPAFRIAGGILLFLIALEMLFGKRSGTKETPEEAEEAEDKEDIAVVPLAIPLIAGPGAITTVILLAAQAPGLLELLAVLLAILLVLLLTYLVLRLADRIERLLGETGINVLTRLMGLILAAIAVQFILDGLKGLF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	203 (199)
Sequences:	25787 (16241)
Seq/√Len:	1151.3
META:	0.882

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
48_F	154_L	3.222	1.00
32_S	35_E	3.028	1.00
41_R	158_Y	2.918	1.00
70_P	201_G	2.788	1.00
163_L	166_R	2.718	1.00
59_E	63_R	2.339	1.00
46_I	113_V	2.338	1.00
48_F	151_L	2.316	1.00
166_R	169_R	2.307	1.00
193_Q	197_D	2.298	1.00
44_A	154_L	2.201	1.00
82_L	85_L	2.185	1.00
158_Y	162_R	2.167	1.00
31_L	35_E	2.159	1.00
38_R	42_R	2.084	1.00
73_R	197_D	2.067	1.00
50_I	118_I	2.037	1.00
74_I	196_L	2.008	1.00
52_L	147_L	1.999	1.00
31_L	39_V	1.987	1.00
36_R	165_D	1.965	1.00
71_A	193_Q	1.907	1.00
77_G	195_I	1.892	1.00
8_F	156_L	1.879	1.00
51_L	126_A	1.851	1.00
84_A	188_A	1.849	1.00
51_L	130_V	1.836	1.00
47_A	154_L	1.832	1.00
33_P	37_R	1.817	1.00
8_F	152_L	1.812	1.00
172_G	175_G	1.805	1.00
86_E	91_K	1.800	1.00
56_L	147_L	1.779	1.00
60_A	63_R	1.739	1.00
73_R	201_G	1.709	1.00
166_R	170_L	1.694	1.00
37_R	162_R	1.688	1.00
16_D	19_G	1.673	1.00
51_L	150_I	1.671	1.00
74_I	198_G	1.629	1.00
46_I	117_A	1.599	1.00
86_E	89_F	1.598	1.00
51_L	122_A	1.596	1.00
33_P	165_D	1.585	1.00
34_A	38_R	1.542	1.00
121_I	157_T	1.534	1.00
70_P	73_R	1.486	1.00
35_E	38_R	1.486	1.00
130_V	150_I	1.465	1.00
41_R	45_L	1.461	1.00
71_A	196_L	1.455	1.00
81_F	195_I	1.435	1.00
4_F	8_F	1.435	1.00
15_I	153_V	1.432	1.00
57_A	60_A	1.411	1.00
41_R	162_R	1.410	1.00
48_F	52_L	1.404	1.00
140_L	143_L	1.382	1.00
74_I	195_I	1.380	1.00
37_R	41_R	1.380	1.00
78_I	81_F	1.377	1.00
11_L	130_V	1.375	1.00
44_A	158_Y	1.372	1.00
53_V	57_A	1.371	1.00
4_F	152_L	1.357	1.00
45_L	49_V	1.348	1.00
42_R	110_D	1.335	1.00
75_A	188_A	1.335	1.00
196_L	200_K	1.333	1.00
74_I	192_V	1.330	1.00
55_A	130_V	1.328	1.00
140_L	144_L	1.306	1.00
14_I	129_T	1.301	1.00
142_E	145_A	1.298	1.00
24_F	40_A	1.293	1.00
78_I	195_I	1.229	1.00
7_A	133_L	1.202	1.00
55_A	134_A	1.193	1.00
141_L	144_L	1.183	1.00
49_V	53_V	1.169	1.00
134_A	143_L	1.169	1.00
68_S	71_A	1.163	1.00
68_S	193_Q	1.156	1.00
159_L	163_L	1.136	1.00
4_F	148_L	1.135	1.00
59_E	135_A	1.130	1.00
33_P	36_R	1.124	1.00
43_A	116_L	1.115	1.00
43_A	47_A	1.114	1.00
81_F	188_A	1.111	1.00
55_A	147_L	1.104	1.00
47_A	117_A	1.103	1.00
99_P	102_A	1.091	1.00
50_I	122_A	1.090	1.00
82_L	86_E	1.088	1.00
81_F	191_A	1.072	1.00
144_L	148_L	1.071	1.00
40_A	44_A	1.070	1.00
168_E	176_I	1.063	1.00
6_S	9_V	1.051	1.00
145_A	148_L	1.050	1.00
157_T	161_L	1.049	1.00
34_A	37_R	1.039	1.00
44_A	157_T	1.016	1.00
153_V	156_L	1.014	1.00
25_L	168_E	1.012	1.00
44_A	48_F	1.007	1.00
24_F	28_T	0.999	1.00
98_T	101_E	0.991	1.00
55_A	146_V	0.984	1.00
22_P	25_L	0.982	1.00
52_L	151_L	0.980	1.00
46_I	112_A	0.970	1.00
139_G	142_E	0.965	1.00
95_T	101_E	0.960	1.00
54_F	131_I	0.960	1.00
54_F	127_I	0.956	1.00
12_F	156_L	0.949	1.00
42_R	46_I	0.936	1.00
7_A	149_A	0.936	1.00
10_T	129_T	0.935	1.00
173_E	177_N	0.934	1.00
196_L	199_L	0.927	1.00
55_A	150_I	0.923	1.00
155_L	159_L	0.919	1.00
112_A	117_A	0.912	1.00
21_I	160_V	0.908	1.00
145_A	149_A	0.900	1.00
4_F	145_A	0.898	1.00
100_E	103_E	0.894	1.00
197_D	200_K	0.887	1.00
28_T	36_R	0.878	1.00
6_S	10_T	0.873	1.00
12_F	153_V	0.866	1.00
97_E	102_A	0.866	1.00
28_T	31_L	0.864	1.00
35_E	39_V	0.863	1.00
142_E	146_V	0.854	1.00
144_L	147_L	0.842	1.00
42_R	112_A	0.834	1.00
29_A	173_E	0.830	1.00
122_A	126_A	0.830	1.00
91_K	94_G	0.826	1.00
153_V	157_T	0.824	1.00
149_A	153_V	0.816	1.00
82_L	89_F	0.810	1.00
143_L	147_L	0.801	1.00
95_T	98_T	0.800	1.00
12_F	160_V	0.799	1.00
24_F	164_A	0.791	1.00
3_E	7_A	0.788	1.00
162_R	166_R	0.785	1.00
79_L	188_A	0.784	1.00
70_P	198_G	0.783	1.00
50_I	127_I	0.782	1.00
77_G	198_G	0.777	1.00
104_E	108_K	0.773	1.00
8_F	149_A	0.769	1.00
168_E	173_E	0.763	1.00
105_A	108_K	0.762	1.00
97_E	101_E	0.760	1.00
27_L	111_I	0.759	1.00
15_I	154_L	0.757	1.00
99_P	103_E	0.755	1.00
35_E	108_K	0.754	1.00
192_V	195_I	0.752	1.00
157_T	160_V	0.747	1.00
55_A	143_L	0.742	1.00
71_A	192_V	0.733	1.00
137_A	142_E	0.730	1.00
78_I	85_L	0.727	1.00
156_L	160_V	0.721	1.00
15_I	126_A	0.719	1.00
28_T	39_V	0.714	1.00
24_F	36_R	0.713	1.00
134_A	146_V	0.710	1.00
76_G	128_T	0.709	1.00
121_I	161_L	0.709	1.00
38_R	41_R	0.708	1.00
31_L	108_K	0.706	1.00
20_N	121_I	0.706	1.00
46_I	50_I	0.705	1.00
14_I	125_G	0.694	1.00
53_V	61_I	0.689	1.00
164_A	172_G	0.689	1.00
171_L	176_I	0.686	1.00
3_E	137_A	0.683	1.00
26_S	29_A	0.681	1.00
164_A	168_E	0.679	1.00
44_A	47_A	0.679	1.00
11_L	150_I	0.678	1.00
19_G	22_P	0.676	1.00
107_D	110_D	0.674	1.00
39_V	43_A	0.674	1.00
47_A	122_A	0.671	1.00
177_N	181_R	0.671	1.00
130_V	134_A	0.669	1.00
60_A	64_F	0.666	1.00
13_V	16_D	0.665	1.00
150_I	154_L	0.663	1.00
197_D	201_G	0.662	1.00
81_F	85_L	0.661	1.00
88_L	184_G	0.660	1.00
98_T	102_A	0.658	1.00
40_A	43_A	0.654	1.00
47_A	121_I	0.652	1.00
72_F	189_A	0.651	1.00
175_G	179_L	0.650	1.00
4_F	149_A	0.648	1.00
138_P	142_E	0.645	1.00
133_L	146_V	0.645	1.00
3_E	145_A	0.644	1.00
98_T	104_E	0.642	1.00
188_A	191_A	0.639	1.00
15_I	157_T	0.637	1.00
43_A	117_A	0.635	1.00
33_P	169_R	0.634	1.00
80_L	191_A	0.631	1.00
43_A	121_I	0.629	1.00
50_I	117_A	0.623	1.00
160_V	167_I	0.623	1.00
132_L	135_A	0.619	1.00
154_L	157_T	0.619	1.00
41_R	44_A	0.605	1.00
187_L	191_A	0.605	1.00
122_A	150_I	0.604	1.00
103_E	106_E	0.603	1.00
24_F	116_L	0.601	1.00
195_I	199_L	0.599	1.00
167_I	175_G	0.596	1.00
126_A	130_V	0.595	1.00
39_V	42_R	0.595	1.00
39_V	112_A	0.591	1.00
61_I	64_F	0.589	1.00
152_L	156_L	0.586	1.00
23_I	120_L	0.580	1.00
128_T	131_I	0.574	1.00
165_D	169_R	0.573	1.00
134_A	139_G	0.570	1.00
187_L	190_I	0.568	1.00
94_G	98_T	0.568	1.00
25_L	164_A	0.563	1.00
86_E	90_G	0.562	1.00
8_F	12_F	0.562	1.00
110_D	177_N	0.562	1.00
23_I	26_S	0.557	1.00
146_V	149_A	0.556	1.00
149_A	152_L	0.555	1.00
81_F	192_V	0.554	1.00
35_E	109_E	0.553	1.00
117_A	122_A	0.553	1.00
65_F	186_I	0.552	1.00
20_N	161_L	0.551	1.00
167_I	172_G	0.548	1.00
20_N	120_L	0.547	1.00
180_T	183_M	0.546	1.00
98_T	103_E	0.544	1.00
79_L	185_L	0.543	1.00
165_D	168_E	0.543	1.00
16_D	183_M	0.542	1.00
46_I	49_V	0.541	1.00
42_R	45_L	0.541	1.00
118_I	178_V	0.540	1.00
143_L	146_V	0.539	1.00
96_K	99_P	0.537	1.00
34_A	41_R	0.534	1.00
112_A	116_L	0.534	1.00
97_E	100_E	0.534	1.00
11_L	126_A	0.532	1.00
193_Q	196_L	0.530	1.00
137_A	146_V	0.527	1.00
192_V	196_L	0.525	1.00
110_D	173_E	0.525	1.00
155_L	158_Y	0.525	1.00
131_I	134_A	0.524	1.00
87_M	90_G	0.523	1.00
95_T	103_E	0.523	1.00
23_I	27_L	0.523	1.00
72_F	185_L	0.523	1.00
102_A	106_E	0.522	1.00
15_I	47_A	0.522	1.00
123_G	126_A	0.522	1.00
25_L	176_I	0.521	1.00
12_F	18_I	0.520	1.00
9_V	13_V	0.519	1.00
51_L	55_A	0.518	1.00
108_K	111_I	0.516	1.00
78_I	82_L	0.516	1.00
171_L	175_G	0.515	1.00
95_T	102_A	0.512	1.00
10_T	133_L	0.512	1.00
51_L	127_I	0.511	1.00
75_A	192_V	0.510	1.00
90_G	93_S	0.509	1.00
50_I	54_F	0.508	1.00
32_S	36_R	0.505	1.00
43_A	112_A	0.500	1.00
103_E	107_D	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2a65A	2	0.8325	14.2	0.932	Contact Map
1pw4A	1	0.5172	14.1	0.932	Contact Map
2cfqA	1	0.5222	13.8	0.932	Contact Map
4k0jA	3	0.8473	12	0.934	Contact Map
3j1zP	8	0.8374	11.8	0.934	Contact Map
4w6vA	1	0.4729	9.1	0.938	Contact Map
4c7rA	3	0.468	6.5	0.941	Contact Map
4ikvA	1	0.4631	5.5	0.943	Contact Map
3l1lA	2	0.4483	5.1	0.944	Contact Map
3mktA	1	0.8079	5.1	0.944	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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