GREMLIN Database
MarC - MarC family integral membrane protein
PFAM: PF01914 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 203 (199)
Sequences: 25787 (16241)
Seq/√Len: 1151.3
META: 0.882

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_F154_L3.2221.00
32_S35_E3.0281.00
41_R158_Y2.9181.00
70_P201_G2.7881.00
163_L166_R2.7181.00
59_E63_R2.3391.00
46_I113_V2.3381.00
48_F151_L2.3161.00
166_R169_R2.3071.00
193_Q197_D2.2981.00
44_A154_L2.2011.00
82_L85_L2.1851.00
158_Y162_R2.1671.00
31_L35_E2.1591.00
38_R42_R2.0841.00
73_R197_D2.0671.00
50_I118_I2.0371.00
74_I196_L2.0081.00
52_L147_L1.9991.00
31_L39_V1.9871.00
36_R165_D1.9651.00
71_A193_Q1.9071.00
77_G195_I1.8921.00
8_F156_L1.8791.00
51_L126_A1.8511.00
84_A188_A1.8491.00
51_L130_V1.8361.00
47_A154_L1.8321.00
33_P37_R1.8171.00
8_F152_L1.8121.00
172_G175_G1.8051.00
86_E91_K1.8001.00
56_L147_L1.7791.00
60_A63_R1.7391.00
73_R201_G1.7091.00
166_R170_L1.6941.00
37_R162_R1.6881.00
16_D19_G1.6731.00
51_L150_I1.6711.00
74_I198_G1.6291.00
46_I117_A1.5991.00
86_E89_F1.5981.00
51_L122_A1.5961.00
33_P165_D1.5851.00
34_A38_R1.5421.00
121_I157_T1.5341.00
70_P73_R1.4861.00
35_E38_R1.4861.00
130_V150_I1.4651.00
41_R45_L1.4611.00
71_A196_L1.4551.00
81_F195_I1.4351.00
4_F8_F1.4351.00
15_I153_V1.4321.00
57_A60_A1.4111.00
41_R162_R1.4101.00
48_F52_L1.4041.00
140_L143_L1.3821.00
74_I195_I1.3801.00
37_R41_R1.3801.00
78_I81_F1.3771.00
11_L130_V1.3751.00
44_A158_Y1.3721.00
53_V57_A1.3711.00
4_F152_L1.3571.00
45_L49_V1.3481.00
42_R110_D1.3351.00
75_A188_A1.3351.00
196_L200_K1.3331.00
74_I192_V1.3301.00
55_A130_V1.3281.00
140_L144_L1.3061.00
14_I129_T1.3011.00
142_E145_A1.2981.00
24_F40_A1.2931.00
78_I195_I1.2291.00
7_A133_L1.2021.00
55_A134_A1.1931.00
141_L144_L1.1831.00
49_V53_V1.1691.00
134_A143_L1.1691.00
68_S71_A1.1631.00
68_S193_Q1.1561.00
159_L163_L1.1361.00
4_F148_L1.1351.00
59_E135_A1.1301.00
33_P36_R1.1241.00
43_A116_L1.1151.00
43_A47_A1.1141.00
81_F188_A1.1111.00
55_A147_L1.1041.00
47_A117_A1.1031.00
99_P102_A1.0911.00
50_I122_A1.0901.00
82_L86_E1.0881.00
81_F191_A1.0721.00
144_L148_L1.0711.00
40_A44_A1.0701.00
168_E176_I1.0631.00
6_S9_V1.0511.00
145_A148_L1.0501.00
157_T161_L1.0491.00
34_A37_R1.0391.00
44_A157_T1.0161.00
153_V156_L1.0141.00
25_L168_E1.0121.00
44_A48_F1.0071.00
24_F28_T0.9991.00
98_T101_E0.9911.00
55_A146_V0.9841.00
22_P25_L0.9821.00
52_L151_L0.9801.00
46_I112_A0.9701.00
139_G142_E0.9651.00
95_T101_E0.9601.00
54_F131_I0.9601.00
54_F127_I0.9561.00
12_F156_L0.9491.00
42_R46_I0.9361.00
7_A149_A0.9361.00
10_T129_T0.9351.00
173_E177_N0.9341.00
196_L199_L0.9271.00
55_A150_I0.9231.00
155_L159_L0.9191.00
112_A117_A0.9121.00
21_I160_V0.9081.00
145_A149_A0.9001.00
4_F145_A0.8981.00
100_E103_E0.8941.00
197_D200_K0.8871.00
28_T36_R0.8781.00
6_S10_T0.8731.00
12_F153_V0.8661.00
97_E102_A0.8661.00
28_T31_L0.8641.00
35_E39_V0.8631.00
142_E146_V0.8541.00
144_L147_L0.8421.00
42_R112_A0.8341.00
29_A173_E0.8301.00
122_A126_A0.8301.00
91_K94_G0.8261.00
153_V157_T0.8241.00
149_A153_V0.8161.00
82_L89_F0.8101.00
143_L147_L0.8011.00
95_T98_T0.8001.00
12_F160_V0.7991.00
24_F164_A0.7911.00
3_E7_A0.7881.00
162_R166_R0.7851.00
79_L188_A0.7841.00
70_P198_G0.7831.00
50_I127_I0.7821.00
77_G198_G0.7771.00
104_E108_K0.7731.00
8_F149_A0.7691.00
168_E173_E0.7631.00
105_A108_K0.7621.00
97_E101_E0.7601.00
27_L111_I0.7591.00
15_I154_L0.7571.00
99_P103_E0.7551.00
35_E108_K0.7541.00
192_V195_I0.7521.00
157_T160_V0.7471.00
55_A143_L0.7421.00
71_A192_V0.7331.00
137_A142_E0.7301.00
78_I85_L0.7271.00
156_L160_V0.7211.00
15_I126_A0.7191.00
28_T39_V0.7141.00
24_F36_R0.7131.00
134_A146_V0.7101.00
76_G128_T0.7091.00
121_I161_L0.7091.00
38_R41_R0.7081.00
31_L108_K0.7061.00
20_N121_I0.7061.00
46_I50_I0.7051.00
14_I125_G0.6941.00
53_V61_I0.6891.00
164_A172_G0.6891.00
171_L176_I0.6861.00
3_E137_A0.6831.00
26_S29_A0.6811.00
164_A168_E0.6791.00
44_A47_A0.6791.00
11_L150_I0.6781.00
19_G22_P0.6761.00
107_D110_D0.6741.00
39_V43_A0.6741.00
47_A122_A0.6711.00
177_N181_R0.6711.00
130_V134_A0.6691.00
60_A64_F0.6661.00
13_V16_D0.6651.00
150_I154_L0.6631.00
197_D201_G0.6621.00
81_F85_L0.6611.00
88_L184_G0.6601.00
98_T102_A0.6581.00
40_A43_A0.6541.00
47_A121_I0.6521.00
72_F189_A0.6511.00
175_G179_L0.6501.00
4_F149_A0.6481.00
138_P142_E0.6451.00
133_L146_V0.6451.00
3_E145_A0.6441.00
98_T104_E0.6421.00
188_A191_A0.6391.00
15_I157_T0.6371.00
43_A117_A0.6351.00
33_P169_R0.6341.00
80_L191_A0.6311.00
43_A121_I0.6291.00
50_I117_A0.6231.00
160_V167_I0.6231.00
132_L135_A0.6191.00
154_L157_T0.6191.00
41_R44_A0.6051.00
187_L191_A0.6051.00
122_A150_I0.6041.00
103_E106_E0.6031.00
24_F116_L0.6011.00
195_I199_L0.5991.00
167_I175_G0.5961.00
126_A130_V0.5951.00
39_V42_R0.5951.00
39_V112_A0.5911.00
61_I64_F0.5891.00
152_L156_L0.5861.00
23_I120_L0.5801.00
128_T131_I0.5741.00
165_D169_R0.5731.00
134_A139_G0.5701.00
187_L190_I0.5681.00
94_G98_T0.5681.00
25_L164_A0.5631.00
86_E90_G0.5621.00
8_F12_F0.5621.00
110_D177_N0.5621.00
23_I26_S0.5571.00
146_V149_A0.5561.00
149_A152_L0.5551.00
81_F192_V0.5541.00
35_E109_E0.5531.00
117_A122_A0.5531.00
65_F186_I0.5521.00
20_N161_L0.5511.00
167_I172_G0.5481.00
20_N120_L0.5471.00
180_T183_M0.5461.00
98_T103_E0.5441.00
79_L185_L0.5431.00
165_D168_E0.5431.00
16_D183_M0.5421.00
46_I49_V0.5411.00
42_R45_L0.5411.00
118_I178_V0.5401.00
143_L146_V0.5391.00
96_K99_P0.5371.00
34_A41_R0.5341.00
112_A116_L0.5341.00
97_E100_E0.5341.00
11_L126_A0.5321.00
193_Q196_L0.5301.00
137_A146_V0.5271.00
192_V196_L0.5251.00
110_D173_E0.5251.00
155_L158_Y0.5251.00
131_I134_A0.5241.00
87_M90_G0.5231.00
95_T103_E0.5231.00
23_I27_L0.5231.00
72_F185_L0.5231.00
102_A106_E0.5221.00
15_I47_A0.5221.00
123_G126_A0.5221.00
25_L176_I0.5211.00
12_F18_I0.5201.00
9_V13_V0.5191.00
51_L55_A0.5181.00
108_K111_I0.5161.00
78_I82_L0.5161.00
171_L175_G0.5151.00
95_T102_A0.5121.00
10_T133_L0.5121.00
51_L127_I0.5111.00
75_A192_V0.5101.00
90_G93_S0.5091.00
50_I54_F0.5081.00
32_S36_R0.5051.00
43_A112_A0.5001.00
103_E107_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a65A 2 0.8325 14.2 0.932 Contact Map
1pw4A 1 0.5172 14.1 0.932 Contact Map
2cfqA 1 0.5222 13.8 0.932 Contact Map
4k0jA 3 0.8473 12 0.934 Contact Map
3j1zP 8 0.8374 11.8 0.934 Contact Map
4w6vA 1 0.4729 9.1 0.938 Contact Map
4c7rA 3 0.468 6.5 0.941 Contact Map
4ikvA 1 0.4631 5.5 0.943 Contact Map
3l1lA 2 0.4483 5.1 0.944 Contact Map
3mktA 1 0.8079 5.1 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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