GREMLIN Database
MNHE - Na+/H+ ion antiporter subunit
PFAM: PF01899 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 146 (142)
Sequences: 17316 (12879)
Seq/√Len: 1080.8
META: 0.826

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_Y98_S3.7631.00
63_D67_R3.0191.00
55_W59_K2.9591.00
66_R70_S2.9511.00
81_R116_T2.9381.00
81_R118_Y2.8131.00
5_F25_A2.5641.00
78_G124_V2.5221.00
39_P42_L2.3691.00
88_S91_G2.2771.00
79_I108_V2.1801.00
70_S74_P2.1101.00
133_R137_G2.0811.00
70_S73_L2.0551.00
56_E59_K1.9691.00
47_L51_L1.9161.00
51_L55_W1.9081.00
107_T117_L1.8761.00
53_F57_I1.8431.00
85_D144_L1.8281.00
83_P116_T1.8041.00
12_S17_N1.7051.00
85_D136_K1.6801.00
86_L91_G1.6601.00
5_F18_L1.6001.00
128_P132_I1.5691.00
129_E133_R1.5611.00
67_R123_D1.5471.00
62_L66_R1.5311.00
5_F22_L1.5181.00
64_V122_L1.4781.00
79_I118_Y1.4711.00
16_G20_L1.4651.00
38_P41_R1.4301.00
96_A107_T1.4171.00
44_L48_R1.3481.00
67_R122_L1.3421.00
48_R142_R1.3391.00
136_K140_E1.3361.00
52_W56_E1.3221.00
81_R114_R1.2891.00
37_L40_R1.2871.00
82_V136_K1.2751.00
131_A134_E1.2731.00
130_A134_E1.2571.00
63_D66_R1.2541.00
138_R142_R1.2441.00
129_E132_I1.2421.00
59_K63_D1.2411.00
19_L23_V1.2061.00
48_R51_L1.1801.00
45_R48_R1.1761.00
92_I115_G1.1661.00
82_V117_L1.1641.00
76_R124_V1.1611.00
17_N20_L1.1381.00
80_V121_A1.1381.00
9_L18_L1.1311.00
53_F98_S1.1171.00
38_P42_L1.1131.00
52_W55_W1.1011.00
132_I136_K1.0991.00
48_R52_W1.0941.00
14_S17_N1.0881.00
87_K115_G1.0651.00
130_A133_R1.0631.00
76_R123_D1.0571.00
53_F101_L1.0411.00
52_W142_R1.0381.00
65_A69_L1.0301.00
32_S36_L1.0241.00
137_G141_R1.0211.00
111_D114_R1.0201.00
90_L94_L1.0191.00
121_A124_V1.0121.00
25_A29_A1.0051.00
109_D118_Y1.0031.00
63_D123_D0.9871.00
7_L11_L0.9851.00
5_F21_G0.9771.00
5_F9_L0.9751.00
76_R125_D0.9691.00
61_N65_A0.9571.00
82_V95_L0.9461.00
97_N107_T0.9321.00
128_P131_A0.9311.00
16_G19_L0.9271.00
20_L24_L0.9111.00
56_E138_R0.9051.00
84_L92_I0.9021.00
33_R36_L0.8871.00
133_R136_K0.8851.00
71_P74_P0.8831.00
66_R73_L0.8821.00
9_L14_S0.8761.00
46_L50_L0.8641.00
67_R74_P0.8611.00
43_P47_L0.8591.00
85_D140_E0.8571.00
66_R69_L0.8481.00
99_I119_V0.8431.00
23_V26_L0.8361.00
99_I102_T0.8341.00
15_P19_L0.8271.00
83_P114_R0.8261.00
86_L144_L0.8181.00
24_L28_V0.8141.00
83_P115_G0.8051.00
4_L28_V0.7971.00
86_L92_I0.7961.00
56_E139_F0.7961.00
30_L34_R0.7811.00
52_W138_R0.7781.00
58_V61_N0.7771.00
62_L65_A0.7761.00
100_T107_T0.7751.00
22_L26_L0.7671.00
80_V131_A0.7631.00
3_L7_L0.7611.00
86_L95_L0.7601.00
58_V62_L0.7571.00
51_L54_L0.7451.00
126_D130_A0.7441.00
65_A68_V0.7401.00
26_L30_L0.7311.00
123_D126_D0.7191.00
67_R70_S0.7171.00
19_L22_L0.7031.00
61_N64_V0.7011.00
5_F29_A0.7001.00
57_I101_L0.6991.00
27_L30_L0.6931.00
31_L34_R0.6931.00
134_E137_G0.6901.00
44_L47_L0.6871.00
26_L29_A0.6841.00
30_L33_R0.6771.00
132_I135_I0.6711.00
14_S18_L0.6671.00
9_L12_S0.6641.00
131_A135_I0.6631.00
84_L117_L0.6621.00
86_L140_E0.6541.00
102_T105_T0.6481.00
93_T97_N0.6371.00
125_D130_A0.6341.00
95_L135_I0.6331.00
49_Y53_F0.6311.00
28_V32_S0.6311.00
75_I123_D0.6301.00
18_L22_L0.6261.00
111_D115_G0.6231.00
54_L58_V0.6201.00
110_V117_L0.6191.00
93_T96_A0.6191.00
56_E60_A0.6141.00
4_L25_A0.6131.00
97_N101_L0.6111.00
131_A136_K0.6101.00
28_V31_L0.6081.00
67_R75_I0.6061.00
141_R144_L0.6061.00
60_A102_T0.6051.00
96_A117_L0.6041.00
66_R74_P0.6001.00
107_T119_V0.5981.00
92_I112_D0.5941.00
42_L45_R0.5941.00
32_S35_L0.5931.00
12_S20_L0.5931.00
16_G24_L0.5921.00
14_S19_L0.5921.00
82_V119_V0.5911.00
55_W138_R0.5851.00
97_N106_L0.5831.00
40_R43_P0.5821.00
111_D116_T0.5801.00
57_I61_N0.5801.00
98_S143_L0.5791.00
97_N119_V0.5751.00
21_G29_A0.5731.00
84_L95_L0.5661.00
37_L42_L0.5651.00
6_L10_L0.5621.00
85_D141_R0.5601.00
56_E102_T0.5601.00
94_L143_L0.5561.00
38_P43_P0.5551.00
92_I117_L0.5551.00
50_L54_L0.5541.00
125_D128_P0.5431.00
92_I114_R0.5431.00
95_L143_L0.5391.00
92_I110_V0.5391.00
29_A33_R0.5391.00
64_V68_V0.5371.00
135_I139_F0.5331.00
89_D93_T0.5311.00
82_V135_I0.5301.00
48_R55_W0.5291.00
121_A131_A0.5271.00
59_K66_R0.5241.00
23_V27_L0.5241.00
89_D92_I0.5231.00
43_P46_L0.5191.00
92_I113_D0.5181.00
20_L23_V0.5181.00
87_K91_G0.5161.00
4_L29_A0.5131.00
101_L106_L0.5081.00
83_P113_D0.5061.00
67_R71_P0.5051.00
81_R111_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ookA 2 0.3151 11.1 0.912 Contact Map
1rl6A 1 0.4384 4.7 0.925 Contact Map
4tp9G 1 0.4795 4.7 0.925 Contact Map
3zf7y 1 0.5274 3.9 0.928 Contact Map
3aqpA 1 0.4589 3.9 0.928 Contact Map
4dx5A 3 0.4726 3.8 0.929 Contact Map
4pwwA 2 0.4247 3.7 0.929 Contact Map
2mgyA 1 0.5479 3.4 0.931 Contact Map
4mt1A 3 0.4315 3.2 0.931 Contact Map
4qkvA 3 0.2671 3.1 0.932 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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