GREMLIN Database
DUF61 - Protein of unknown function DUF61
PFAM: PF01886 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 127 (126)
Sequences: 932 (663)
Seq/√Len: 59.0
META: 0.897

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_K28_E5.9591.00
26_L48_L2.9001.00
50_Y118_K2.7131.00
56_P59_E2.7121.00
23_S61_D2.6851.00
91_V115_L2.6681.00
25_L28_E2.3181.00
56_P60_Q2.2511.00
119_L122_T2.1811.00
6_K9_R2.1561.00
47_E121_T2.1521.00
43_F65_L2.1031.00
25_L31_P2.1011.00
28_E31_P2.0521.00
16_P47_E1.9981.00
31_P48_L1.9441.00
33_V41_H1.9411.00
17_R34_V1.9061.00
32_H40_T1.8661.00
45_R49_E1.8581.00
7_E10_R1.7970.99
114_E118_K1.6540.99
63_L90_V1.6050.99
79_A106_R1.5930.99
20_K25_L1.5530.98
52_A60_Q1.5430.98
49_E53_S1.5040.98
50_Y53_S1.4620.98
84_G87_E1.4540.98
116_R123_T1.4540.98
34_V40_T1.3840.97
43_F122_T1.3670.96
18_E34_V1.3610.96
71_I80_Y1.3320.96
21_S64_R1.3300.96
33_V43_F1.3180.96
50_Y119_L1.3150.96
59_E89_K1.3090.95
63_L86_V1.3090.95
4_L10_R1.3030.95
97_M111_Q1.3000.95
116_R119_L1.3000.95
119_L123_T1.2880.95
57_E60_Q1.2620.94
115_L123_T1.2470.94
51_L110_P1.1900.92
21_S24_E1.1820.92
68_L126_V1.1680.92
50_Y94_I1.1680.92
23_S27_E1.1530.91
51_L90_V1.1460.91
19_R44_D1.1420.91
35_T41_H1.1390.91
46_E49_E1.1320.90
69_I80_Y1.1200.90
116_R122_T1.1170.90
69_I82_V1.1100.90
75_L78_G1.1010.89
116_R121_T1.0910.89
26_L52_A1.0820.88
88_A92_S1.0810.88
47_E116_R1.0700.88
37_D107_I1.0660.88
110_P114_E1.0590.87
17_R21_S1.0240.85
8_L20_K1.0170.85
67_I82_V1.0040.84
25_L29_E0.9590.81
22_L48_L0.9370.80
16_P124_Q0.9180.78
12_N15_L0.9110.78
84_G91_V0.9100.78
71_I125_Y0.8950.77
74_D126_V0.8880.76
43_F107_I0.8830.76
54_L93_K0.8720.75
26_L31_P0.8700.75
14_H76_G0.8460.72
5_R73_P0.8430.72
92_S97_M0.8390.72
19_R67_I0.8330.71
108_Y111_Q0.8220.70
115_L119_L0.8100.69
15_L19_R0.8060.69
70_E83_R0.8060.69
57_E67_I0.7950.68
29_E32_H0.7940.68
74_D110_P0.7930.68
11_L14_H0.7880.67
56_P89_K0.7810.66
3_W7_E0.7600.64
69_I91_V0.7530.64
11_L68_L0.7500.63
20_K26_L0.7420.62
84_G97_M0.7410.62
46_E52_A0.7410.62
69_I117_R0.7380.62
13_A37_D0.7320.61
89_K93_K0.7290.61
16_P19_R0.7280.61
30_K42_R0.7170.60
20_K52_A0.7170.60
17_R36_R0.7160.60
73_P80_Y0.7150.59
11_L46_E0.7120.59
59_E62_R0.7110.59
72_D126_V0.7100.59
67_I78_G0.7070.59
88_A98_E0.7060.59
81_R84_G0.7030.58
109_R112_L0.7030.58
20_K24_E0.7010.58
27_E53_S0.6970.58
9_R36_R0.6960.57
35_T39_S0.6910.57
14_H37_D0.6850.56
72_D80_Y0.6820.56
24_E32_H0.6790.56
31_P121_T0.6760.55
24_E64_R0.6720.55
85_K103_G0.6660.54
18_E24_E0.6640.54
50_Y54_L0.6600.53
69_I107_I0.6600.53
46_E50_Y0.6540.53
46_E53_S0.6520.53
7_E35_T0.6510.52
113_A120_P0.6510.52
9_R35_T0.6450.52
27_E102_E0.6440.52
48_L52_A0.6410.51
91_V112_L0.6350.51
60_Q106_R0.6330.50
11_L30_K0.6300.50
30_K34_V0.6270.50
8_L108_Y0.6230.49
85_K115_L0.6220.49
6_K10_R0.6210.49
89_K96_G0.6190.49
47_E119_L0.6180.49
120_P123_T0.6140.48
28_E32_H0.6130.48
8_L15_L0.6120.48
33_V48_L0.6060.47
12_N65_L0.6020.47
75_L79_A0.5990.47
33_V39_S0.5980.47
19_R114_E0.5940.46
7_E11_L0.5920.46
8_L14_H0.5790.44
47_E95_L0.5790.44
20_K65_L0.5780.44
80_Y125_Y0.5770.44
61_D93_K0.5740.44
8_L13_A0.5720.44
112_L119_L0.5670.43
93_K96_G0.5660.43
92_S99_R0.5650.43
50_Y96_G0.5640.43
24_E72_D0.5600.42
11_L44_D0.5550.42
54_L119_L0.5550.42
55_L90_V0.5510.41
16_P95_L0.5510.41
108_Y112_L0.5500.41
51_L122_T0.5490.41
87_E90_V0.5490.41
88_A91_V0.5480.41
20_K31_P0.5450.41
16_P68_L0.5400.40
79_A108_Y0.5340.40
72_D77_E0.5340.40
44_D114_E0.5290.39
44_D127_F0.5290.39
88_A120_P0.5280.39
40_T79_A0.5230.38
95_L101_R0.5220.38
14_H78_G0.5210.38
94_I115_L0.5200.38
84_G105_L0.5160.38
24_E118_K0.5140.37
14_H21_S0.5080.37
9_R48_L0.5060.37
96_G117_R0.5050.37
74_D96_G0.5040.36
37_D116_R0.5030.36
2_R34_V0.5010.36
37_D68_L0.5010.36
109_R120_P0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2egzA 1 0.8504 15.3 0.921 Contact Map
1mukA 1 0.8425 14.1 0.922 Contact Map
3t0pA 2 0.7008 8.9 0.929 Contact Map
4k3lA 2 0.6457 7.5 0.931 Contact Map
4j2nA 4 0.4094 7.1 0.932 Contact Map
2oczA 2 0.8976 7 0.932 Contact Map
2o7sA 2 0.9291 6.9 0.932 Contact Map
3l9cA 1 0.8583 6.9 0.932 Contact Map
1sflA 2 0.8976 6.5 0.933 Contact Map
1rypF 1 0.4094 6.2 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0062 seconds.