GREMLIN Database
DUF39 - Domain of unknown function DUF39
PFAM: PF01837 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 342 (342)
Sequences: 2590 (1261)
Seq/√Len: 68.2
META: 0.871

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
189_R264_N4.0141.00
228_V256_I3.5231.00
238_E326_E3.5221.00
4_V12_I3.2681.00
100_V240_L3.2391.00
16_K24_E3.2241.00
104_D127_T3.1541.00
14_K274_S3.1131.00
276_E301_A3.0521.00
231_D234_Q3.0071.00
305_K312_E2.9291.00
188_Y224_G2.9151.00
279_F299_S2.7861.00
238_E323_K2.6501.00
148_V171_A2.6191.00
63_P79_E2.5521.00
153_S286_S2.5331.00
171_A306_I2.5331.00
93_G242_G2.4871.00
106_R123_E2.4701.00
9_M268_A2.4581.00
184_N273_V2.4171.00
319_S324_A2.3781.00
207_A229_I2.3371.00
97_E241_R2.3051.00
202_G234_Q2.2741.00
243_A253_A2.2121.00
288_D293_P2.2041.00
152_L168_L2.2031.00
7_E325_R2.1881.00
133_Q209_E2.1621.00
53_K111_A2.1421.00
282_V296_G2.1391.00
57_V73_L2.1201.00
20_K24_E2.0731.00
60_N90_Y2.0711.00
57_V66_A2.0391.00
239_W330_I2.0371.00
108_R123_E2.0371.00
41_A75_I2.0141.00
45_F54_M2.0081.00
203_I334_W2.0071.00
137_F207_A2.0021.00
189_R266_E1.9701.00
262_I271_T1.9621.00
208_W229_I1.9181.00
220_L297_E1.9151.00
178_Q321_Y1.8831.00
196_R205_Y1.8691.00
264_N267_I1.8661.00
58_W108_R1.8621.00
243_A251_S1.8311.00
119_R122_L1.8111.00
43_L131_L1.7801.00
150_V168_L1.7651.00
19_E265_E1.7531.00
54_M57_V1.7331.00
100_V232_L1.7281.00
148_V280_T1.7131.00
20_K23_K1.7101.00
307_E312_E1.7031.00
184_N271_T1.6971.00
104_D125_T1.6931.00
102_G129_D1.6570.99
9_M271_T1.6490.99
245_F251_S1.6460.99
263_L267_I1.6440.99
240_L254_V1.6160.99
137_F227_A1.6140.99
98_D103_K1.6130.99
299_S302_E1.6120.99
12_I21_A1.5680.99
56_K82_E1.5640.99
281_P294_S1.5550.99
59_L105_V1.5520.99
101_A237_P1.5350.99
97_E101_A1.5250.99
188_Y215_P1.5160.99
189_R270_Y1.5130.99
330_I334_W1.4930.99
268_A272_A1.4920.99
196_R341_L1.4790.99
137_F229_I1.4740.99
191_I206_V1.4660.99
42_F68_L1.4600.99
42_F135_V1.4600.99
198_F334_W1.4410.98
61_D108_R1.4360.98
178_Q275_D1.4350.98
10_I274_S1.4310.98
60_N98_D1.4300.98
9_M21_A1.4080.98
5_T325_R1.3630.98
108_R121_E1.3570.98
142_A256_I1.3550.98
307_E310_G1.3440.97
325_R329_E1.3400.97
80_L250_V1.3240.97
49_D289_Y1.2980.97
333_E337_K1.2850.97
90_Y98_D1.2820.97
34_G174_S1.2770.97
128_L134_A1.2710.96
134_A232_L1.2710.96
296_G302_E1.2550.96
10_I178_Q1.2470.96
48_S52_I1.2380.96
163_T246_T1.2360.96
136_L240_L1.2350.96
287_V291_N1.2320.96
45_F73_L1.2260.96
154_D167_N1.2150.95
321_Y325_R1.2080.95
219_P223_A1.2070.95
93_G250_V1.2050.95
7_E10_I1.2020.95
56_K110_T1.1970.95
124_T132_N1.1970.95
126_I131_L1.1920.95
148_V306_I1.1890.95
42_F137_F1.1860.95
150_V171_A1.1810.95
213_H224_G1.1810.95
40_G74_Y1.1740.94
226_L258_I1.1720.94
13_V17_G1.1710.94
189_R267_I1.1670.94
135_V227_A1.1640.94
267_I270_Y1.1620.94
308_I313_V1.1550.94
197_I228_V1.1540.94
127_T130_D1.1450.94
338_G341_L1.1450.94
187_Y270_Y1.1380.93
295_L308_I1.1360.93
10_I184_N1.1350.93
330_I333_E1.1330.93
9_M184_N1.1180.93
54_M73_L1.1180.93
262_I267_I1.1160.93
207_A228_V1.1130.93
281_P297_E1.1050.92
61_D106_R1.1030.92
55_S79_E1.1010.92
266_E270_Y1.1000.92
202_G231_D1.0970.92
257_G327_I1.0960.92
191_I258_I1.0960.92
322_K326_E1.0940.92
239_W323_K1.0850.92
35_P174_S1.0770.91
279_F297_E1.0740.91
51_P292_R1.0650.91
66_A73_L1.0620.91
48_S122_L1.0610.91
99_L131_L1.0610.91
273_V278_I1.0490.90
66_A111_A1.0470.90
203_I234_Q1.0460.90
333_E336_E1.0450.90
99_L105_V1.0370.90
113_G120_K1.0370.90
128_L232_L1.0360.90
4_V9_M1.0290.89
190_T260_I1.0280.89
41_A232_L1.0270.89
61_D81_S1.0260.89
147_N283_V1.0240.89
97_E242_G1.0240.89
58_W110_T1.0160.89
55_S58_W1.0150.89
329_E333_E1.0090.89
61_D83_D1.0070.88
75_I98_D1.0010.88
18_V268_A1.0000.88
9_M272_A0.9970.88
157_I286_S0.9940.88
106_R125_T0.9940.88
10_I272_A0.9920.88
198_F257_G0.9920.88
128_L131_L0.9880.87
150_V295_L0.9850.87
9_M12_I0.9780.87
241_R323_K0.9740.87
323_K326_E0.9730.87
59_L126_I0.9720.87
232_L240_L0.9540.86
287_V293_P0.9530.86
13_V272_A0.9520.85
266_E269_R0.9470.85
56_K79_E0.9430.85
59_L107_L0.9350.84
175_S183_L0.9350.84
218_P221_G0.9320.84
17_G21_A0.9290.84
74_Y139_P0.9280.84
68_L73_L0.9260.84
282_V298_V0.9250.84
47_H71_V0.9250.84
214_N217_V0.9240.84
16_K20_K0.9220.84
254_V327_I0.9200.83
45_F57_V0.9190.83
11_D15_E0.9170.83
296_G307_E0.9160.83
58_W82_E0.9150.83
57_V64_A0.9120.83
47_H51_P0.9120.83
274_S277_D0.9090.83
54_M109_A0.9060.82
269_R272_A0.9020.82
12_I16_K0.9000.82
39_S252_L0.8990.82
142_A258_I0.8990.82
41_A136_L0.8950.82
49_D290_P0.8900.81
145_N223_A0.8870.81
199_L228_V0.8740.80
138_N141_N0.8670.80
276_E299_S0.8670.80
289_Y292_R0.8660.80
5_T329_E0.8650.79
236_S323_K0.8620.79
21_A268_A0.8600.79
267_I271_T0.8590.79
288_D292_R0.8580.79
275_D321_Y0.8560.79
64_A105_V0.8550.79
19_E23_K0.8540.79
41_A99_L0.8510.78
22_A262_I0.8510.78
282_V308_I0.8440.78
168_L308_I0.8430.78
55_S80_L0.8420.78
55_S111_A0.8390.77
175_S319_S0.8360.77
137_F208_W0.8310.77
306_I315_T0.8290.77
9_M262_I0.8260.76
42_F74_Y0.8240.76
64_A73_L0.8230.76
9_M13_V0.8150.75
217_V223_A0.8150.75
87_G244_S0.8140.75
329_E336_E0.8120.75
43_L75_I0.8090.75
184_N274_S0.8090.75
75_I95_V0.8090.75
196_R203_I0.8040.74
262_I268_A0.8020.74
195_T259_P0.8000.74
13_V21_A0.7950.73
174_S319_S0.7880.73
188_Y213_H0.7790.72
168_L282_V0.7780.72
80_L83_D0.7750.72
199_L230_G0.7750.72
145_N183_L0.7740.71
164_L170_N0.7730.71
237_P241_R0.7710.71
12_I25_V0.7700.71
100_V128_L0.7690.71
193_I229_I0.7680.71
68_L139_P0.7680.71
230_G235_M0.7660.71
127_T131_L0.7650.71
62_V95_V0.7620.70
273_V277_D0.7590.70
214_N222_P0.7570.70
43_L73_L0.7570.70
110_T121_E0.7570.70
218_P297_E0.7530.69
150_V296_G0.7520.69
42_F45_F0.7500.69
34_G239_W0.7490.69
14_K276_E0.7490.69
218_P223_A0.7480.69
100_V237_P0.7470.69
1_A27_V0.7440.68
10_I14_K0.7430.68
175_S223_A0.7430.68
203_I339_E0.7420.68
217_V221_G0.7390.68
168_L313_V0.7380.68
150_V282_V0.7370.68
49_D292_R0.7350.67
190_T267_I0.7270.67
334_W339_E0.7270.67
19_E269_R0.7260.67
236_S240_L0.7220.66
80_L112_Y0.7200.66
41_A135_V0.7180.66
206_V226_L0.7170.66
221_G297_E0.7140.65
88_E246_T0.7130.65
200_G240_L0.7120.65
56_K63_P0.7120.65
126_I130_D0.7110.65
9_M18_V0.7070.64
96_I232_L0.7060.64
215_P224_G0.7050.64
35_P253_A0.7010.64
81_S86_P0.6980.63
172_N316_A0.6940.63
104_D128_L0.6920.63
64_A95_V0.6920.63
71_V78_T0.6910.63
18_V272_A0.6890.62
11_D14_K0.6850.62
55_S250_V0.6840.62
152_L286_S0.6840.62
208_W227_A0.6810.62
152_L295_L0.6790.61
188_Y223_A0.6770.61
99_L128_L0.6760.61
55_S112_Y0.6760.61
158_Y247_G0.6730.61
332_K336_E0.6710.60
10_I268_A0.6690.60
77_A252_L0.6670.60
43_L134_A0.6670.60
58_W79_E0.6660.60
302_E307_E0.6650.60
188_Y217_V0.6620.59
193_I208_W0.6600.59
124_T133_Q0.6590.59
51_P290_P0.6580.59
184_N219_P0.6570.59
221_G293_P0.6560.59
168_L295_L0.6540.58
53_K112_Y0.6520.58
169_G314_P0.6500.58
1_A4_V0.6480.58
98_D101_A0.6480.58
270_Y273_V0.6460.58
296_G308_I0.6460.58
180_S183_L0.6460.58
23_K265_E0.6440.57
280_T300_Y0.6390.57
152_L157_I0.6390.57
7_E178_Q0.6330.56
43_L130_D0.6300.56
268_A271_T0.6290.56
156_T165_K0.6290.56
58_W61_D0.6280.55
326_E330_I0.6280.55
274_S299_S0.6270.55
222_P292_R0.6240.55
129_D309_N0.6240.55
112_Y244_S0.6230.55
298_V302_E0.6230.55
202_G334_W0.6230.55
145_N175_S0.6220.55
288_D291_N0.6220.55
80_L88_E0.6210.55
9_M25_V0.6200.54
296_G313_V0.6200.54
5_T8_E0.6170.54
15_E20_K0.6160.54
171_A282_V0.6150.54
14_K301_A0.6140.54
100_V252_L0.6140.54
152_L313_V0.6130.54
63_P82_E0.6100.53
221_G281_P0.6090.53
214_N219_P0.6090.53
135_V209_E0.6080.53
259_P335_I0.6070.53
41_A131_L0.6060.53
152_L287_V0.6040.53
42_F54_M0.6030.52
221_G294_S0.6030.52
280_T297_E0.6030.52
236_S330_I0.6020.52
21_A271_T0.6020.52
22_A268_A0.6020.52
172_N315_T0.6010.52
36_M39_S0.6000.52
101_A232_L0.5990.52
184_N270_Y0.5990.52
145_N218_P0.5970.52
135_V208_W0.5960.52
173_Y275_D0.5940.51
42_F79_E0.5940.51
55_S66_A0.5930.51
52_I122_L0.5930.51
298_V306_I0.5930.51
23_K337_K0.5910.51
129_D262_I0.5910.51
202_G230_G0.5900.51
142_A216_G0.5900.51
43_L59_L0.5890.51
19_E264_N0.5890.51
93_G246_T0.5880.51
11_D178_Q0.5880.51
125_T128_L0.5870.51
245_F286_S0.5860.50
97_E237_P0.5830.50
222_P280_T0.5830.50
197_I256_I0.5830.50
3_V6_A0.5810.50
193_I205_Y0.5790.50
135_V232_L0.5780.49
4_V25_V0.5770.49
335_I340_F0.5760.49
125_T153_S0.5760.49
331_L335_I0.5730.49
271_T278_I0.5730.49
43_L128_L0.5690.48
56_K121_E0.5680.48
157_I290_P0.5680.48
269_R273_V0.5670.48
82_E108_R0.5660.48
175_S275_D0.5650.48
83_D86_P0.5650.48
48_S124_T0.5640.48
171_A296_G0.5640.48
209_E229_I0.5630.48
199_L256_I0.5630.48
65_Y95_V0.5620.48
13_V176_A0.5620.48
44_N70_A0.5600.47
283_V294_S0.5600.47
104_D122_L0.5570.47
135_V229_I0.5570.47
207_A227_A0.5550.47
46_G51_P0.5550.47
12_I18_V0.5550.47
179_L328_A0.5540.47
290_P293_P0.5530.46
68_L135_V0.5500.46
224_G244_S0.5500.46
165_K246_T0.5500.46
190_T195_T0.5500.46
51_P289_Y0.5490.46
109_A122_L0.5490.46
242_G264_N0.5470.46
86_P112_Y0.5470.46
150_V308_I0.5460.46
86_P244_S0.5440.45
184_N278_I0.5430.45
165_K316_A0.5420.45
54_M79_E0.5420.45
203_I206_V0.5420.45
119_R124_T0.5420.45
49_D293_P0.5410.45
104_D155_R0.5410.45
67_G139_P0.5380.45
45_F67_G0.5380.45
323_K330_I0.5380.45
174_S318_L0.5380.45
322_K325_R0.5370.45
197_I258_I0.5370.45
82_E110_T0.5370.45
193_I207_A0.5360.44
336_E339_E0.5360.44
40_G44_N0.5350.44
237_P278_I0.5340.44
148_V282_V0.5340.44
45_F107_L0.5330.44
161_M172_N0.5330.44
188_Y214_N0.5320.44
199_L202_G0.5320.44
136_L202_G0.5310.44
20_K106_R0.5300.44
75_I100_V0.5300.44
220_L279_F0.5280.44
133_Q245_F0.5270.43
83_D88_E0.5260.43
49_D84_D0.5220.43
156_T163_T0.5200.43
331_L342_L0.5190.42
245_F318_L0.5190.42
2_V16_K0.5170.42
65_Y75_I0.5170.42
337_K341_L0.5160.42
296_G309_N0.5150.42
197_I206_V0.5150.42
68_L79_E0.5140.42
79_E82_E0.5140.42
45_F68_L0.5140.42
296_G306_I0.5120.42
13_V271_T0.5120.42
124_T292_R0.5120.42
47_H50_P0.5120.42
287_V292_R0.5110.42
147_N281_P0.5110.42
228_V254_V0.5110.42
97_E136_L0.5100.41
105_V125_T0.5100.41
183_L223_A0.5100.41
289_Y293_P0.5080.41
236_S258_I0.5070.41
317_P320_S0.5070.41
105_V127_T0.5060.41
59_L75_I0.5060.41
103_K242_G0.5060.41
240_L252_L0.5060.41
24_E316_A0.5050.41
125_T322_K0.5050.41
9_M267_I0.5050.41
105_V128_L0.5040.41
75_I96_I0.5030.41
283_V289_Y0.5030.41
294_S297_E0.5020.40
155_R166_P0.5020.40
147_N285_Y0.5020.40
16_K21_A0.5020.40
176_A179_L0.5010.40
192_G195_T0.5010.40
35_P251_S0.5010.40
171_A298_V0.5000.40
29_T32_T0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3canA 2 0.4064 17.3 0.98 Contact Map
1veeA 1 0.2427 16.7 0.98 Contact Map
3p1xA 2 0.2018 15.5 0.98 Contact Map
1q16B 2 0.1988 12.7 0.981 Contact Map
3g98A 1 0.117 12 0.981 Contact Map
3ewtE 1 0.0205 11.8 0.981 Contact Map
4u0yA 1 0.0877 11.4 0.982 Contact Map
4l4yA 2 0.1404 8.7 0.983 Contact Map
1c5eA 3 0.2485 8.2 0.983 Contact Map
2eb4A 5 0.1754 7.6 0.983 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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