GREMLIN Database
FTH - FTH domain
PFAM: PF01827 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 142 (130)
Sequences: 922 (874)
Seq/√Len: 76.6
META: 0.01

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_A91_F4.9311.00
94_F122_C4.9171.00
45_E71_K4.6751.00
47_I70_A4.1161.00
71_K92_E4.0361.00
33_L37_P3.2001.00
18_K40_D2.6161.00
42_G69_N2.5891.00
20_K45_E2.5791.00
73_L88_F2.5061.00
72_E93_K2.4001.00
19_V39_L2.3831.00
67_W91_F2.3571.00
62_V67_W2.2981.00
73_L91_F2.2821.00
86_E108_K2.2611.00
46_K72_E2.0921.00
40_D69_N2.0511.00
87_N109_L1.7001.00
21_K46_K1.6661.00
58_I61_I1.6611.00
126_S129_N1.6381.00
113_L119_F1.5450.99
65_E69_N1.4540.99
41_P65_E1.4390.99
85_I89_F1.4380.99
67_W90_H1.4250.99
105_D108_K1.4110.99
119_F122_C1.3880.99
19_V22_L1.3800.99
107_L111_E1.3160.98
129_N132_P1.3080.98
87_N90_H1.2880.98
16_K40_D1.2690.97
91_F94_F1.2460.97
8_E12_K1.2200.97
56_L109_L1.1900.96
130_L134_E1.1880.96
35_I58_I1.1830.96
91_F109_L1.1800.96
66_Q70_A1.1790.96
131_D134_E1.1550.96
6_K10_I1.1470.95
47_I66_Q1.1240.95
73_L94_F1.1170.95
16_K41_P1.1140.95
127_F132_P1.0990.94
128_K132_P1.0830.94
116_S119_F1.0690.93
126_S130_L1.0410.92
60_E63_E1.0390.92
17_L126_S1.0240.92
130_L133_E0.9840.90
41_P70_A0.9750.90
11_L19_V0.9740.90
35_I43_T0.9680.89
51_D100_S0.9680.89
117_P124_I0.9670.89
110_K114_L0.9660.89
107_L110_K0.9640.89
59_E63_E0.9640.89
29_Q59_E0.9580.89
92_E120_E0.9480.88
41_P44_L0.9470.88
64_L75_I0.9290.87
9_E103_V0.9270.87
42_G45_E0.9060.86
85_I88_F0.8990.86
17_L39_L0.8990.86
94_F113_L0.8970.86
22_L39_L0.8950.85
37_P66_Q0.8930.85
49_I70_A0.8810.84
85_I102_S0.8740.84
26_V106_L0.8600.83
84_P87_N0.8530.83
53_E61_I0.8490.82
93_K110_K0.8440.82
74_E95_E0.8360.81
63_E87_N0.8310.81
101_I108_K0.8290.81
56_L94_F0.8250.80
27_F109_L0.8220.80
13_S17_L0.7990.78
8_E37_P0.7970.78
22_L109_L0.7940.78
30_D40_D0.7850.77
24_L39_L0.7830.77
84_P109_L0.7810.77
22_L47_I0.7760.76
7_L10_I0.7730.76
129_N134_E0.7560.74
127_F130_L0.7540.74
49_I75_I0.7450.73
99_E111_E0.7450.73
66_Q86_E0.7430.73
43_T98_L0.7380.72
102_S105_D0.7370.72
73_L101_I0.7350.72
44_L66_Q0.7290.72
109_L119_F0.7140.70
86_E116_S0.7110.70
25_E97_T0.7080.69
17_L40_D0.7070.69
4_L94_F0.7050.69
48_E75_I0.6990.68
16_K38_Y0.6980.68
47_I122_C0.6940.68
7_L17_L0.6890.67
95_E123_K0.6770.66
6_K9_E0.6740.66
33_L60_E0.6720.65
10_I22_L0.6710.65
51_D61_I0.6700.65
36_L64_L0.6640.64
22_L35_I0.6620.64
30_D60_E0.6600.64
35_I112_I0.6500.63
115_K119_F0.6480.62
53_E59_E0.6470.62
45_E68_K0.6460.62
94_F119_F0.6460.62
31_E34_S0.6460.62
128_K133_E0.6440.62
89_F112_I0.6400.62
34_S72_E0.6400.62
88_F96_I0.6340.61
3_F7_L0.6270.60
101_I106_L0.6230.59
9_E28_S0.6200.59
22_L61_I0.6190.59
67_W87_N0.6120.58
7_L12_K0.6110.58
18_K88_F0.6080.58
44_L90_H0.6080.58
23_E48_E0.6000.57
37_P61_I0.6000.57
64_L67_W0.5990.56
23_E26_V0.5960.56
11_L62_V0.5940.56
76_S98_L0.5940.56
55_E102_S0.5930.56
88_F118_N0.5870.55
85_I108_K0.5850.55
29_Q33_L0.5830.54
14_K32_V0.5820.54
86_E89_F0.5810.54
24_L41_P0.5790.54
72_E97_T0.5720.53
58_I89_F0.5720.53
110_K119_F0.5710.53
27_F106_L0.5700.53
114_L121_S0.5680.53
32_V57_E0.5670.52
74_E79_V0.5630.52
124_I129_N0.5610.52
26_V80_V0.5600.52
74_E77_G0.5580.51
34_S37_P0.5570.51
110_K113_L0.5560.51
54_E64_L0.5520.51
19_V54_E0.5520.51
92_E109_L0.5520.51
116_S120_E0.5470.50
10_I24_L0.5470.50
33_L38_Y0.5450.50
90_H119_F0.5440.50
49_I103_V0.5410.49
69_N74_E0.5380.49
19_V117_P0.5360.49
62_V87_N0.5360.49
71_K91_F0.5350.48
26_V31_E0.5350.48
19_V66_Q0.5340.48
27_F121_S0.5330.48
27_F88_F0.5290.48
39_L82_S0.5280.48
76_S97_T0.5270.47
63_E73_L0.5260.47
34_S81_S0.5240.47
28_S41_P0.5200.47
11_L115_K0.5170.46
55_E65_E0.5170.46
47_I104_E0.5170.46
65_E68_K0.5150.46
9_E81_S0.5140.46
51_D79_V0.5100.45
17_L32_V0.5050.45
94_F124_I0.5050.45
80_V105_D0.5040.44
126_S132_P0.5030.44
112_I116_S0.5020.44
79_V97_T0.5010.44
108_K119_F0.5000.44
80_V112_I0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ca6A 1 0.9648 26.4 0.891 Contact Map
1io0A 1 0.9718 22.5 0.895 Contact Map
4pkiG 1 0.9718 21 0.896 Contact Map
4im6A 2 0.9789 20 0.897 Contact Map
3gozA 1 0.9859 16.9 0.901 Contact Map
4perA 1 0.9718 14 0.904 Contact Map
1pgvA 1 0.9859 12 0.907 Contact Map
4wwuA 1 0 9.6 0.911 Contact Map
4r6gA 1 0.9085 9.3 0.911 Contact Map
1ds9A 1 0.9296 9 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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