FTH - PFAM28P - GREMLIN Contacts

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FTH - FTH domain

PFAM:	PF01827	Sequences: DKFLEKLEEILKSKHKLKVKKLELEVFSQDEVLSILPYLDPGTLEKIEISDEEEELEIEEIVELEQWKNAKELEISGFVVSSFPIENFFHFEKFEITLESISVEDLLKLKEILLKSPNFESCKIFSFKNLDPEEIAKVFGPD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	142 (130)
Sequences:	922 (874)
Seq/√Len:	76.6
META:	0.01

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
70_A	91_F	4.931	1.00
94_F	122_C	4.917	1.00
45_E	71_K	4.675	1.00
47_I	70_A	4.116	1.00
71_K	92_E	4.036	1.00
33_L	37_P	3.200	1.00
18_K	40_D	2.616	1.00
42_G	69_N	2.589	1.00
20_K	45_E	2.579	1.00
73_L	88_F	2.506	1.00
72_E	93_K	2.400	1.00
19_V	39_L	2.383	1.00
67_W	91_F	2.357	1.00
62_V	67_W	2.298	1.00
73_L	91_F	2.282	1.00
86_E	108_K	2.261	1.00
46_K	72_E	2.092	1.00
40_D	69_N	2.051	1.00
87_N	109_L	1.700	1.00
21_K	46_K	1.666	1.00
58_I	61_I	1.661	1.00
126_S	129_N	1.638	1.00
113_L	119_F	1.545	0.99
65_E	69_N	1.454	0.99
41_P	65_E	1.439	0.99
85_I	89_F	1.438	0.99
67_W	90_H	1.425	0.99
105_D	108_K	1.411	0.99
119_F	122_C	1.388	0.99
19_V	22_L	1.380	0.99
107_L	111_E	1.316	0.98
129_N	132_P	1.308	0.98
87_N	90_H	1.288	0.98
16_K	40_D	1.269	0.97
91_F	94_F	1.246	0.97
8_E	12_K	1.220	0.97
56_L	109_L	1.190	0.96
130_L	134_E	1.188	0.96
35_I	58_I	1.183	0.96
91_F	109_L	1.180	0.96
66_Q	70_A	1.179	0.96
131_D	134_E	1.155	0.96
6_K	10_I	1.147	0.95
47_I	66_Q	1.124	0.95
73_L	94_F	1.117	0.95
16_K	41_P	1.114	0.95
127_F	132_P	1.099	0.94
128_K	132_P	1.083	0.94
116_S	119_F	1.069	0.93
126_S	130_L	1.041	0.92
60_E	63_E	1.039	0.92
17_L	126_S	1.024	0.92
130_L	133_E	0.984	0.90
41_P	70_A	0.975	0.90
11_L	19_V	0.974	0.90
35_I	43_T	0.968	0.89
51_D	100_S	0.968	0.89
117_P	124_I	0.967	0.89
110_K	114_L	0.966	0.89
107_L	110_K	0.964	0.89
59_E	63_E	0.964	0.89
29_Q	59_E	0.958	0.89
92_E	120_E	0.948	0.88
41_P	44_L	0.947	0.88
64_L	75_I	0.929	0.87
9_E	103_V	0.927	0.87
42_G	45_E	0.906	0.86
85_I	88_F	0.899	0.86
17_L	39_L	0.899	0.86
94_F	113_L	0.897	0.86
22_L	39_L	0.895	0.85
37_P	66_Q	0.893	0.85
49_I	70_A	0.881	0.84
85_I	102_S	0.874	0.84
26_V	106_L	0.860	0.83
84_P	87_N	0.853	0.83
53_E	61_I	0.849	0.82
93_K	110_K	0.844	0.82
74_E	95_E	0.836	0.81
63_E	87_N	0.831	0.81
101_I	108_K	0.829	0.81
56_L	94_F	0.825	0.80
27_F	109_L	0.822	0.80
13_S	17_L	0.799	0.78
8_E	37_P	0.797	0.78
22_L	109_L	0.794	0.78
30_D	40_D	0.785	0.77
24_L	39_L	0.783	0.77
84_P	109_L	0.781	0.77
22_L	47_I	0.776	0.76
7_L	10_I	0.773	0.76
129_N	134_E	0.756	0.74
127_F	130_L	0.754	0.74
49_I	75_I	0.745	0.73
99_E	111_E	0.745	0.73
66_Q	86_E	0.743	0.73
43_T	98_L	0.738	0.72
102_S	105_D	0.737	0.72
73_L	101_I	0.735	0.72
44_L	66_Q	0.729	0.72
109_L	119_F	0.714	0.70
86_E	116_S	0.711	0.70
25_E	97_T	0.708	0.69
17_L	40_D	0.707	0.69
4_L	94_F	0.705	0.69
48_E	75_I	0.699	0.68
16_K	38_Y	0.698	0.68
47_I	122_C	0.694	0.68
7_L	17_L	0.689	0.67
95_E	123_K	0.677	0.66
6_K	9_E	0.674	0.66
33_L	60_E	0.672	0.65
10_I	22_L	0.671	0.65
51_D	61_I	0.670	0.65
36_L	64_L	0.664	0.64
22_L	35_I	0.662	0.64
30_D	60_E	0.660	0.64
35_I	112_I	0.650	0.63
115_K	119_F	0.648	0.62
53_E	59_E	0.647	0.62
45_E	68_K	0.646	0.62
94_F	119_F	0.646	0.62
31_E	34_S	0.646	0.62
128_K	133_E	0.644	0.62
89_F	112_I	0.640	0.62
34_S	72_E	0.640	0.62
88_F	96_I	0.634	0.61
3_F	7_L	0.627	0.60
101_I	106_L	0.623	0.59
9_E	28_S	0.620	0.59
22_L	61_I	0.619	0.59
67_W	87_N	0.612	0.58
7_L	12_K	0.611	0.58
18_K	88_F	0.608	0.58
44_L	90_H	0.608	0.58
23_E	48_E	0.600	0.57
37_P	61_I	0.600	0.57
64_L	67_W	0.599	0.56
23_E	26_V	0.596	0.56
11_L	62_V	0.594	0.56
76_S	98_L	0.594	0.56
55_E	102_S	0.593	0.56
88_F	118_N	0.587	0.55
85_I	108_K	0.585	0.55
29_Q	33_L	0.583	0.54
14_K	32_V	0.582	0.54
86_E	89_F	0.581	0.54
24_L	41_P	0.579	0.54
72_E	97_T	0.572	0.53
58_I	89_F	0.572	0.53
110_K	119_F	0.571	0.53
27_F	106_L	0.570	0.53
114_L	121_S	0.568	0.53
32_V	57_E	0.567	0.52
74_E	79_V	0.563	0.52
124_I	129_N	0.561	0.52
26_V	80_V	0.560	0.52
74_E	77_G	0.558	0.51
34_S	37_P	0.557	0.51
110_K	113_L	0.556	0.51
54_E	64_L	0.552	0.51
19_V	54_E	0.552	0.51
92_E	109_L	0.552	0.51
116_S	120_E	0.547	0.50
10_I	24_L	0.547	0.50
33_L	38_Y	0.545	0.50
90_H	119_F	0.544	0.50
49_I	103_V	0.541	0.49
69_N	74_E	0.538	0.49
19_V	117_P	0.536	0.49
62_V	87_N	0.536	0.49
71_K	91_F	0.535	0.48
26_V	31_E	0.535	0.48
19_V	66_Q	0.534	0.48
27_F	121_S	0.533	0.48
27_F	88_F	0.529	0.48
39_L	82_S	0.528	0.48
76_S	97_T	0.527	0.47
63_E	73_L	0.526	0.47
34_S	81_S	0.524	0.47
28_S	41_P	0.520	0.47
11_L	115_K	0.517	0.46
55_E	65_E	0.517	0.46
47_I	104_E	0.517	0.46
65_E	68_K	0.515	0.46
9_E	81_S	0.514	0.46
51_D	79_V	0.510	0.45
17_L	32_V	0.505	0.45
94_F	124_I	0.505	0.45
80_V	105_D	0.504	0.44
126_S	132_P	0.503	0.44
112_I	116_S	0.502	0.44
79_V	97_T	0.501	0.44
108_K	119_F	0.500	0.44
80_V	112_I	0.500	0.44

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ca6A	1	0.9648	26.4	0.891	Contact Map
1io0A	1	0.9718	22.5	0.895	Contact Map
4pkiG	1	0.9718	21	0.896	Contact Map
4im6A	2	0.9789	20	0.897	Contact Map
3gozA	1	0.9859	16.9	0.901	Contact Map
4perA	1	0.9718	14	0.904	Contact Map
1pgvA	1	0.9859	12	0.907	Contact Map
4wwuA	1	0	9.6	0.911	Contact Map
4r6gA	1	0.9085	9.3	0.911	Contact Map
1ds9A	1	0.9296	9	0.912	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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