GREMLIN Database
MatK_N - MatK/TrnK amino terminal region
PFAM: PF01824 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 331 (331)
Sequences: 1661 (454)
Seq/√Len: 24.9
META: 0.031

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
288_G324_N4.3201.00
148_I288_G3.8251.00
54_L111_V3.3741.00
25_Q288_G3.1331.00
157_E177_R2.5860.99
158_I238_G2.5690.99
30_A34_D2.4960.99
168_K202_R2.4680.99
10_L16_H2.4370.98
101_I259_N2.3990.98
54_L120_V2.3520.98
168_K227_N2.2960.98
314_P317_I2.2640.98
25_Q204_Q2.2440.97
91_S237_S2.2060.97
148_I204_Q2.1370.96
303_F307_H2.1340.96
148_I324_N2.0870.96
33_H301_V2.0760.96
167_V300_L2.0750.96
204_Q223_V2.0750.96
234_S262_Q2.0350.95
311_W314_P2.0340.95
255_E258_A2.0330.95
117_K238_G2.0080.95
263_A327_L1.9900.95
156_L181_H1.9700.94
142_L285_A1.9620.94
309_Y315_G1.9610.94
165_Y218_Y1.8820.93
85_H264_I1.8730.93
56_I152_Y1.8700.93
84_G304_W1.8430.92
32_A35_H1.8400.92
21_P24_F1.8370.92
4_F9_E1.8340.92
14_R196_I1.8330.92
288_G303_F1.8330.92
156_L280_G1.8210.92
33_H228_Q1.7990.91
148_I223_V1.7740.91
172_S228_Q1.7670.90
117_K267_L1.7480.90
78_N167_V1.7340.90
162_T180_L1.7320.89
165_Y244_I1.7270.89
31_L255_E1.7210.89
170_A216_C1.7020.89
39_R231_H1.6690.88
255_E315_G1.6660.88
100_V138_K1.6640.87
39_R42_L1.6580.87
227_N255_E1.6250.86
118_E154_I1.6060.86
102_V162_T1.5750.84
204_Q288_G1.5710.84
121_K175_L1.5610.84
164_R327_L1.5480.83
43_L258_A1.5460.83
61_I163_L1.5410.83
42_L45_N1.5320.83
116_G267_L1.5310.83
54_L117_K1.5300.83
4_F111_V1.5230.82
244_I315_G1.5170.82
167_V202_R1.5020.81
147_D175_L1.4980.81
194_K200_S1.4840.81
33_H213_S1.4780.80
36_G197_S1.4610.79
168_K258_A1.4530.79
54_L138_K1.4510.79
8_L19_L1.4380.78
55_L164_R1.4350.78
181_H309_Y1.4200.77
100_V172_S1.4190.77
117_K140_S1.4030.77
170_A197_S1.4030.77
222_F226_R1.4020.77
54_L85_H1.3980.76
165_Y227_N1.3950.76
234_S285_A1.3940.76
158_I253_L1.3860.76
303_F330_L1.3740.75
5_Q197_S1.3710.75
210_L219_E1.3670.75
216_C227_N1.3670.75
262_Q267_L1.3660.75
4_F16_H1.3600.74
158_I170_A1.3570.74
147_D323_S1.3490.74
9_E313_Q1.3430.73
47_G50_N1.3410.73
204_Q303_F1.3390.73
56_I221_I1.3380.73
25_Q148_I1.3340.73
174_H177_R1.3310.73
207_F210_L1.3230.72
135_L327_L1.3190.72
223_V288_G1.3130.72
168_K244_I1.3110.72
243_R246_F1.3040.71
29_Y275_Y1.2940.71
43_L327_L1.2820.70
164_R170_A1.2820.70
211_Y219_E1.2770.69
115_E175_L1.2750.69
117_K303_F1.2670.69
188_S191_T1.2620.69
91_S217_E1.2600.68
131_I137_D1.2490.68
181_H302_N1.2430.67
230_S316_R1.2320.67
152_Y254_V1.2310.67
5_Q30_A1.2220.66
31_L156_L1.2210.66
304_W315_G1.2180.66
92_Q99_A1.2150.66
227_N263_A1.2150.66
124_N295_K1.2140.65
146_L290_P1.2120.65
111_V259_N1.2090.65
88_N282_S1.2080.65
158_I304_W1.2070.65
31_L315_G1.2070.65
215_V274_H1.2070.65
175_L318_H1.1930.64
10_L14_R1.1910.64
49_D52_S1.1900.64
100_V313_Q1.1890.64
117_K262_Q1.1830.63
97_G317_I1.1830.63
213_S262_Q1.1790.63
260_D282_S1.1780.63
93_M288_G1.1780.63
258_A264_I1.1770.63
165_Y291_L1.1700.63
84_G312_S1.1680.62
267_L285_A1.1680.62
227_N245_Y1.1670.62
216_C309_Y1.1620.62
12_R17_D1.1570.62
162_T170_A1.1570.62
35_H239_V1.1560.62
171_S255_E1.1550.62
99_A133_P1.1510.61
214_Y300_L1.1470.61
272_F298_Y1.1450.61
165_Y168_K1.1450.61
183_Y214_Y1.1380.60
97_G191_T1.1290.60
167_V327_L1.1240.59
139_F238_G1.1200.59
41_I222_F1.1150.59
65_Y257_F1.1130.59
93_M102_V1.1130.59
85_H238_G1.1010.58
43_L168_K1.0990.58
5_Q110_L1.0980.58
194_K229_S1.0960.57
146_L198_I1.0930.57
30_A158_I1.0790.56
220_S260_D1.0770.56
69_H116_G1.0700.56
232_L243_R1.0660.55
83_F89_L1.0620.55
212_N219_E1.0620.55
150_I283_I1.0550.54
44_E201_K1.0470.54
53_S61_I1.0410.53
96_E241_L1.0360.53
292_L321_Q1.0350.53
24_F27_Y1.0340.53
167_V310_V1.0320.53
146_L310_V1.0300.53
190_I283_I1.0200.52
320_N323_S1.0200.52
153_P280_G1.0170.52
50_N273_M1.0100.51
69_H214_Y1.0080.51
96_E189_L1.0050.51
170_A316_R1.0020.51
121_K183_Y1.0000.51
131_I185_N1.0000.51
20_Y24_F0.9970.50
204_Q222_F0.9950.50
316_R327_L0.9910.50
268_F280_G0.9880.50
270_D280_G0.9870.50
25_Q223_V0.9850.49
39_R52_S0.9780.49
85_H313_Q0.9750.49
109_R184_H0.9710.48
264_I294_N0.9710.48
181_H325_H0.9700.48
167_V255_E0.9650.48
198_I285_A0.9630.48
14_R198_I0.9620.48
84_G315_G0.9610.48
83_F180_L0.9590.48
95_S301_V0.9560.47
54_L149_L0.9520.47
314_P320_N0.9520.47
30_A316_R0.9500.47
71_I154_I0.9480.47
142_L287_K0.9430.46
171_S263_A0.9420.46
164_R177_R0.9390.46
171_S227_N0.9380.46
138_K313_Q0.9370.46
95_S101_I0.9360.46
223_V324_N0.9360.46
120_V162_T0.9350.46
86_N255_E0.9300.45
106_F285_A0.9280.45
185_N222_F0.9260.45
167_V288_G0.9220.45
147_D183_Y0.9200.45
197_S214_Y0.9180.45
263_A294_N0.9180.45
255_E264_I0.9130.44
1_M4_F0.9060.44
223_V244_I0.9060.44
31_L291_L0.9050.44
202_R288_G0.9000.43
2_E329_F0.8990.43
280_G292_L0.8980.43
99_A102_V0.8890.43
4_F23_I0.8880.42
10_L83_F0.8850.42
117_K304_W0.8850.42
161_Q179_F0.8850.42
56_I164_R0.8800.42
184_H234_S0.8800.42
56_I120_V0.8770.42
14_R181_H0.8750.42
282_S325_H0.8700.41
167_V192_P0.8700.41
264_I300_L0.8690.41
63_R71_I0.8680.41
148_I178_F0.8660.41
309_Y328_D0.8650.41
262_Q273_M0.8630.41
220_S306_C0.8550.40
94_I102_V0.8550.40
10_L120_V0.8420.39
44_E60_L0.8420.39
168_K294_N0.8410.39
52_S183_Y0.8370.39
234_S267_L0.8360.39
32_A96_E0.8360.39
93_M248_G0.8350.39
188_S192_P0.8340.39
152_Y324_N0.8320.39
141_H228_Q0.8320.39
16_H32_A0.8300.38
31_L172_S0.8300.38
190_I273_M0.8280.38
204_Q324_N0.8280.38
162_T183_Y0.8280.38
146_L201_K0.8280.38
255_E328_D0.8270.38
100_V264_I0.8230.38
202_R263_A0.8200.38
116_G152_Y0.8150.37
10_L227_N0.8120.37
74_A263_A0.8110.37
33_H173_L0.8100.37
227_N244_I0.8090.37
165_Y258_A0.8060.37
160_V318_H0.8050.37
5_Q37_L0.8010.36
20_Y26_E0.8000.36
140_S178_F0.7990.36
14_R180_L0.7910.36
147_D309_Y0.7910.36
154_I324_N0.7910.36
6_R162_T0.7840.35
83_F328_D0.7790.35
184_H300_L0.7740.35
113_S276_V0.7710.34
260_D264_I0.7690.34
259_N288_G0.7660.34
178_F209_F0.7650.34
19_L24_F0.7650.34
227_N315_G0.7610.34
30_A223_V0.7580.34
168_K290_P0.7580.34
215_V246_F0.7580.34
111_V114_L0.7550.33
235_T238_G0.7540.33
83_F244_I0.7520.33
72_I101_I0.7490.33
40_S101_I0.7470.33
4_F144_Y0.7470.33
18_F22_L0.7430.33
109_R262_Q0.7430.33
156_L306_C0.7420.33
30_A260_D0.7400.32
160_V247_Y0.7390.32
29_Y32_A0.7370.32
29_Y34_D0.7340.32
148_I259_N0.7330.32
259_N303_F0.7330.32
226_R229_S0.7300.32
164_R231_H0.7260.32
100_V154_I0.7260.32
12_R251_E0.7250.32
239_V288_G0.7250.32
154_I195_S0.7240.31
232_L247_Y0.7210.31
111_V139_F0.7190.31
162_T315_G0.7170.31
111_V122_S0.7170.31
116_G315_G0.7170.31
202_R327_L0.7160.31
184_H244_I0.7160.31
255_E263_A0.7160.31
66_Q78_N0.7140.31
272_F280_G0.7130.31
133_P192_P0.7100.31
117_K254_V0.7080.30
72_I120_V0.7080.30
151_P157_E0.7060.30
184_H288_G0.7040.30
5_Q19_L0.7040.30
154_I330_L0.7030.30
121_K188_S0.7020.30
81_P86_N0.7010.30
69_H72_I0.7000.30
205_R208_L0.6980.30
175_L255_E0.6940.30
164_R310_V0.6930.30
151_P155_H0.6930.30
84_G158_I0.6930.30
72_I257_F0.6920.29
196_I252_H0.6900.29
91_S96_E0.6900.29
149_L228_Q0.6880.29
117_K266_W0.6870.29
158_I236_S0.6860.29
141_H237_S0.6840.29
167_V172_S0.6840.29
19_L48_Y0.6840.29
202_R255_E0.6830.29
4_F202_R0.6800.29
306_C309_Y0.6790.29
317_I325_H0.6780.29
9_E310_V0.6780.29
276_V327_L0.6780.29
54_L330_L0.6760.29
57_V126_R0.6740.28
197_S310_V0.6730.28
6_R267_L0.6690.28
68_N71_I0.6670.28
55_L306_C0.6670.28
4_F100_V0.6640.28
109_R301_V0.6630.28
154_I303_F0.6620.28
6_R12_R0.6610.28
148_I303_F0.6580.27
147_D152_Y0.6570.27
67_Q82_F0.6560.27
10_L72_I0.6540.27
147_D319_I0.6520.27
78_N133_P0.6520.27
164_R174_H0.6500.27
279_Q320_N0.6500.27
147_D265_L0.6490.27
144_Y328_D0.6490.27
268_F272_F0.6490.27
23_I306_C0.6480.27
4_F264_I0.6460.27
46_V244_I0.6460.27
31_L222_F0.6410.27
166_W234_S0.6410.27
144_Y315_G0.6400.26
156_L268_F0.6390.26
167_V315_G0.6380.26
164_R216_C0.6380.26
53_S59_R0.6370.26
120_V164_R0.6360.26
237_S273_M0.6350.26
87_K259_N0.6350.26
77_S259_N0.6340.26
220_S282_S0.6340.26
223_V303_F0.6330.26
208_L214_Y0.6330.26
123_H288_G0.6330.26
144_Y167_V0.6310.26
244_I255_E0.6260.26
63_R95_S0.6250.26
46_V100_V0.6240.26
158_I276_V0.6210.25
4_F11_D0.6210.25
50_N290_P0.6200.25
4_F258_A0.6190.25
101_I255_E0.6160.25
133_P269_K0.6160.25
164_R257_F0.6150.25
42_L108_L0.6130.25
323_S327_L0.6130.25
43_L180_L0.6060.25
4_F312_S0.6060.25
136_E155_H0.6060.25
68_N148_I0.6020.24
139_F237_S0.6010.24
4_F316_R0.6000.24
84_G113_S0.5970.24
79_Q85_H0.5970.24
45_N55_L0.5960.24
4_F138_K0.5940.24
175_L245_Y0.5930.24
174_H212_N0.5910.24
164_R208_L0.5910.24
133_P322_L0.5880.24
150_I304_W0.5880.24
140_S152_Y0.5870.24
69_H221_I0.5860.24
123_H262_Q0.5850.23
227_N258_A0.5840.23
68_N216_C0.5830.23
32_A307_H0.5820.23
1_M16_H0.5820.23
230_S237_S0.5780.23
31_L181_H0.5770.23
209_F219_E0.5740.23
43_L328_D0.5730.23
138_K154_I0.5690.23
32_A67_Q0.5690.23
289_T316_R0.5680.23
93_M241_L0.5650.22
25_Q324_N0.5630.22
53_S107_S0.5600.22
22_L26_E0.5590.22
171_S245_Y0.5590.22
35_H70_L0.5580.22
110_L216_C0.5570.22
142_L226_R0.5570.22
241_L298_Y0.5550.22
81_P202_R0.5530.22
25_Q303_F0.5520.22
260_D267_L0.5520.22
68_N74_A0.5510.22
288_G315_G0.5500.22
100_V252_H0.5470.22
117_K236_S0.5450.21
80_N106_F0.5450.21
11_D31_L0.5450.21
181_H317_I0.5450.21
218_Y244_I0.5420.21
202_R227_N0.5420.21
99_A192_P0.5420.21
84_G110_L0.5410.21
5_Q143_N0.5410.21
263_A290_P0.5400.21
179_F320_N0.5390.21
89_L183_Y0.5380.21
147_D239_V0.5380.21
16_H43_L0.5370.21
50_N81_P0.5370.21
95_S110_L0.5330.21
11_D102_V0.5320.21
17_D39_R0.5310.21
44_E291_L0.5310.21
84_G216_C0.5310.21
158_I216_C0.5300.21
162_T250_I0.5290.21
138_K144_Y0.5280.21
156_L328_D0.5270.21
68_N82_F0.5260.21
196_I264_I0.5260.21
285_A298_Y0.5250.21
140_S191_T0.5240.20
84_G254_V0.5240.20
93_M110_L0.5210.20
172_S181_H0.5210.20
44_E238_G0.5210.20
100_V120_V0.5190.20
4_F10_L0.5190.20
46_V327_L0.5180.20
191_T283_I0.5170.20
99_A162_T0.5160.20
127_S132_F0.5140.20
13_S30_A0.5120.20
240_F310_V0.5120.20
181_H228_Q0.5110.20
305_Q311_W0.5090.20
111_V330_L0.5090.20
221_I303_F0.5090.20
69_H170_A0.5090.20
3_E8_L0.5040.20
236_S324_N0.5040.20
166_W246_F0.5030.19
29_Y127_S0.5030.19
10_L146_L0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kylA 1 0.7915 99.2 0.883 Contact Map
4wfzA 1 0.7976 97.8 0.926 Contact Map
1xr5A 1 0.7915 97.7 0.928 Contact Map
3mmiA 2 0.142 4.1 0.981 Contact Map
2ju0B 1 0.1571 2.3 0.983 Contact Map
1z2tA 1 0.0665 2.1 0.984 Contact Map
4xaiA 2 0.2024 1.9 0.984 Contact Map
4ll8A 1 0.1782 1.8 0.984 Contact Map
2ky8A 1 0.0755 1.8 0.984 Contact Map
2v6vA 1 0.1239 1.6 0.984 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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