GREMLIN Database
WSC - WSC domain
PFAM: PF01822 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 82 (81)
Sequences: 7213 (6085)
Seq/√Len: 676.1
META: 0.416

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_C52_C4.2221.00
27_V44_L4.1131.00
31_A42_A4.0211.00
71_P79_T2.5211.00
48_G73_S2.4781.00
47_G70_M2.3201.00
75_N78_E2.1061.00
40_T54_N2.0761.00
46_Y49_E2.0081.00
27_V78_E2.0031.00
24_N29_S1.7781.00
33_A37_K1.7611.00
28_E78_E1.5931.00
39_Y54_N1.5351.00
46_Y70_M1.5101.00
25_M29_S1.4921.00
30_C50_C1.4571.00
7_D45_E1.4241.00
72_C80_C1.4141.00
62_P65_D1.3921.00
64_P67_D1.3701.00
42_A52_C1.3531.00
39_Y52_C1.2551.00
53_G57_P1.2501.00
18_S33_A1.2281.00
45_E49_E1.2251.00
56_L60_G1.2051.00
63_A67_D1.1981.00
6_T63_A1.1731.00
43_G53_G1.1581.00
22_S25_M1.1561.00
25_M74_G1.1231.00
31_A35_A1.1151.00
23_S48_G1.0731.00
34_C42_A1.0401.00
5_Y62_P1.0401.00
71_P76_S1.0381.00
13_R16_G1.0331.00
2_L5_Y1.0101.00
28_E32_A1.0011.00
45_E51_Y1.0001.00
33_A36_A0.9871.00
22_S29_S0.9521.00
12_R15_L0.9321.00
56_L59_G0.9281.00
69_N82_G0.9111.00
29_S32_A0.9071.00
27_V31_A0.9041.00
23_S73_S0.8741.00
25_M44_L0.8651.00
32_A35_A0.8641.00
2_L41_Y0.8591.00
57_P60_G0.8551.00
29_S33_A0.8541.00
20_T29_S0.8131.00
19_S33_A0.8041.00
27_V42_A0.7941.00
20_T33_A0.7881.00
70_M82_G0.7721.00
25_M73_S0.7721.00
19_S37_K0.7531.00
58_N61_A0.7501.00
32_A36_A0.7301.00
26_T74_G0.7291.00
5_Y56_L0.7251.00
7_D46_Y0.7221.00
33_A52_C0.7191.00
69_N79_T0.7091.00
21_S48_G0.7081.00
4_C68_C0.7041.00
28_E31_A0.7011.00
7_D13_R0.6881.00
20_T25_M0.6881.00
5_Y65_D0.6861.00
11_G15_L0.6851.00
17_G20_T0.6751.00
26_T75_N0.6601.00
59_G62_P0.6501.00
14_L17_G0.6491.00
16_G53_G0.6491.00
60_G63_A0.6391.00
15_L18_S0.6351.00
6_T67_D0.6331.00
13_R17_G0.6321.00
63_A66_S0.6321.00
58_N62_P0.6311.00
8_S12_R0.6271.00
15_L53_G0.6261.00
5_Y60_G0.6231.00
26_T29_S0.6171.00
47_G73_S0.6151.00
10_G14_L0.6121.00
19_S49_E0.6121.00
8_S59_G0.6111.00
21_S24_N0.6081.00
60_G64_P0.6061.00
62_P67_D0.6051.00
62_P66_S0.6021.00
21_S25_M0.5961.00
41_Y56_L0.5961.00
71_P77_S0.5911.00
76_S79_T0.5901.00
18_S37_K0.5801.00
12_R16_G0.5801.00
17_G33_A0.5731.00
41_Y54_N0.5621.00
6_T59_G0.5561.00
28_E75_N0.5501.00
74_G78_E0.5471.00
16_G57_P0.5381.00
17_G21_S0.5341.00
41_Y57_P0.5341.00
43_G51_Y0.5331.00
22_S48_G0.5311.00
8_S11_G0.5301.00
7_D14_L0.5271.00
65_D79_T0.5261.00
61_A67_D0.5230.99
11_G16_G0.5190.99
6_T60_G0.5170.99
11_G14_L0.5160.99
3_G41_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kozA 1 0.4024 6.3 0.857 Contact Map
1pz7A 1 0.4024 4.1 0.87 Contact Map
1r1gA 1 0.3049 3.7 0.873 Contact Map
2e3eA 1 0.5488 3.2 0.877 Contact Map
1d5qA 1 0.3293 2.9 0.88 Contact Map
3v64A 2 0.4024 2.8 0.881 Contact Map
2meoA 1 0.4024 2.8 0.881 Contact Map
1pnhA 1 0.378 2.7 0.881 Contact Map
1pjvA 1 0.3902 2.6 0.882 Contact Map
3pveA 1 0.3902 2.5 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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