GREMLIN Database
LysE - LysE type translocator
PFAM: PF01810 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 193 (190)
Sequences: 87348 (61664)
Seq/√Len: 4473.5
META: 0.782

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_L100_F5.1851.00
75_I79_R3.3701.00
173_W176_R2.7291.00
74_G183_I2.7051.00
39_V104_F2.5731.00
72_Y76_K2.5441.00
60_T63_K2.4471.00
97_R101_L2.4001.00
150_W154_L2.3611.00
172_R176_R2.2061.00
13_L29_A2.1911.00
10_D33_I2.1471.00
28_A96_L2.1131.00
17_R21_R2.0761.00
132_P135_Q2.0111.00
57_L60_T1.9531.00
71_L186_G1.8521.00
78_L176_R1.8431.00
25_A99_A1.8341.00
67_A190_A1.8201.00
59_F63_K1.8051.00
76_K79_R1.7241.00
151_F154_L1.7161.00
64_L68_A1.6661.00
11_N154_L1.6491.00
17_R29_A1.6281.00
101_L105_L1.6281.00
60_T64_L1.6121.00
126_D129_A1.6011.00
154_L158_A1.5951.00
176_R180_L1.5781.00
36_G108_L1.5631.00
31_L100_F1.5061.00
21_R25_A1.5031.00
184_G188_R1.4901.00
17_R102_Q1.4801.00
29_A103_G1.4671.00
16_A20_R1.4311.00
57_L61_V1.4231.00
81_A176_R1.4131.00
4_A146_G1.4091.00
24_R28_A1.4071.00
133_L136_L1.3991.00
180_L184_G1.3961.00
162_R166_R1.3841.00
131_P134_L1.3821.00
147_S151_F1.3651.00
173_W177_V1.3341.00
82_P176_R1.3271.00
78_L179_G1.3161.00
153_L157_L1.3131.00
71_L183_I1.2961.00
26_G30_A1.2931.00
18_G26_G1.2911.00
98_R101_L1.2841.00
76_K80_S1.2801.00
38_L144_V1.2691.00
40_H114_I1.2481.00
26_G155_A1.2471.00
160_R164_R1.2331.00
133_L137_L1.2251.00
36_G104_F1.1941.00
100_F104_F1.1921.00
95_S98_R1.1891.00
64_L67_A1.1731.00
23_R159_S1.1591.00
67_A186_G1.1591.00
13_L17_R1.1551.00
98_R102_Q1.1531.00
41_I140_G1.1511.00
164_R167_R1.1491.00
74_G179_G1.1451.00
130_G133_L1.1421.00
117_F143_F1.1321.00
79_R83_R1.1141.00
69_Y72_Y1.1051.00
50_A53_A1.0941.00
79_R82_P1.0901.00
24_R96_L1.0881.00
61_V65_A1.0881.00
160_R163_R1.0871.00
23_R156_L1.0861.00
69_Y73_L1.0801.00
167_R170_A1.0631.00
27_L152_L1.0591.00
142_G146_G1.0471.00
152_L156_L1.0451.00
157_L160_R1.0431.00
58_A61_V1.0421.00
131_P135_Q1.0381.00
132_P136_L1.0351.00
32_G104_F1.0221.00
27_L30_A1.0211.00
28_A99_A1.0211.00
21_R99_A1.0201.00
177_V180_L1.0181.00
35_L104_F1.0171.00
37_D113_A1.0041.00
150_W153_L1.0011.00
68_A72_Y1.0011.00
71_L75_I0.9941.00
82_P85_A0.9931.00
55_S58_A0.9731.00
156_L160_R0.9711.00
72_Y75_I0.9671.00
130_G135_Q0.9661.00
169_R173_W0.9631.00
158_A161_L0.9631.00
50_A54_A0.9621.00
18_G155_A0.9621.00
151_F155_A0.9561.00
80_S175_N0.9531.00
143_F147_S0.9521.00
10_D37_D0.9501.00
11_N15_L0.9481.00
6_T11_N0.9351.00
34_A148_L0.9331.00
174_L177_V0.9271.00
134_L137_L0.9271.00
161_L164_R0.9261.00
15_L158_A0.9241.00
77_A179_G0.9191.00
148_L152_L0.9131.00
168_P171_L0.9111.00
126_D130_G0.9071.00
2_V5_L0.9071.00
138_L142_G0.9011.00
141_A144_V0.9001.00
10_D107_N0.8881.00
17_R20_R0.8861.00
137_L140_G0.8851.00
37_D107_N0.8831.00
170_A173_W0.8761.00
137_L141_A0.8761.00
46_L50_A0.8621.00
187_L191_L0.8621.00
140_G144_V0.8601.00
177_V181_L0.8591.00
130_G134_L0.8581.00
143_F146_G0.8581.00
38_L42_L0.8571.00
32_G100_F0.8541.00
119_A123_Q0.8491.00
40_H108_L0.8491.00
47_G52_L0.8451.00
164_R168_P0.8451.00
102_Q106_V0.8441.00
149_L152_L0.8411.00
31_L34_A0.8351.00
23_R155_A0.8341.00
183_I187_L0.8331.00
5_L150_W0.8331.00
40_H44_A0.8331.00
13_L106_V0.8281.00
99_A102_Q0.8211.00
42_L46_L0.8201.00
61_V64_L0.8151.00
25_A28_A0.8121.00
52_L55_S0.8111.00
188_R191_L0.8071.00
37_D117_F0.8041.00
30_A34_A0.7971.00
14_V33_I0.7951.00
149_L153_L0.7941.00
30_A155_A0.7941.00
154_L157_L0.7931.00
49_G53_A0.7901.00
39_V42_L0.7811.00
169_R172_R0.7811.00
174_L178_S0.7801.00
23_R27_L0.7791.00
10_D106_V0.7791.00
34_A37_D0.7771.00
33_I107_N0.7761.00
141_A145_L0.7761.00
27_L156_L0.7751.00
140_G143_F0.7711.00
2_V6_T0.7701.00
14_V151_F0.7691.00
67_A71_L0.7661.00
56_P60_T0.7651.00
33_I37_D0.7631.00
153_L156_L0.7611.00
171_L175_N0.7531.00
81_A84_P0.7451.00
145_L149_L0.7421.00
89_A92_P0.7411.00
144_V148_L0.7381.00
54_A57_L0.7381.00
34_A144_V0.7361.00
14_V18_G0.7351.00
55_S59_F0.7341.00
75_I183_I0.7331.00
135_Q139_L0.7301.00
116_F121_L0.7271.00
36_G107_N0.7251.00
32_G36_G0.7211.00
146_G149_L0.7201.00
165_L168_P0.7171.00
17_R26_G0.7141.00
37_D40_H0.7141.00
39_V108_L0.7121.00
146_G150_W0.7061.00
147_S150_W0.7051.00
163_R167_R0.6981.00
78_L183_I0.6941.00
134_L138_L0.6921.00
105_L109_L0.6921.00
163_R166_R0.6891.00
85_A88_A0.6861.00
3_L116_F0.6841.00
136_L140_G0.6841.00
35_L39_V0.6801.00
25_A96_L0.6761.00
151_F158_A0.6761.00
17_R99_A0.6731.00
162_R165_L0.6701.00
166_R169_R0.6671.00
183_I186_G0.6641.00
22_G25_A0.6581.00
11_N150_W0.6551.00
107_N113_A0.6551.00
95_S99_A0.6461.00
96_L99_A0.6451.00
47_G54_A0.6431.00
144_V147_S0.6421.00
78_L82_P0.6391.00
142_G147_S0.6391.00
129_A132_P0.6361.00
40_H113_A0.6361.00
104_F108_L0.6341.00
6_T112_K0.6301.00
82_P172_R0.6261.00
94_R102_Q0.6211.00
80_S83_R0.6181.00
146_G151_F0.6171.00
65_A68_A0.6171.00
11_N151_F0.6121.00
29_A106_V0.6101.00
135_Q138_L0.6021.00
14_V29_A0.6021.00
14_V30_A0.6011.00
74_G186_G0.5941.00
159_S162_R0.5921.00
97_R100_F0.5911.00
129_A135_Q0.5881.00
87_A91_A0.5871.00
145_L148_L0.5851.00
30_A152_L0.5841.00
178_S182_L0.5831.00
85_A89_A0.5791.00
17_R25_A0.5751.00
13_L16_A0.5751.00
129_A133_L0.5731.00
4_A11_N0.5661.00
33_I103_G0.5621.00
139_L143_F0.5601.00
172_R175_N0.5601.00
126_D135_Q0.5591.00
88_A91_A0.5551.00
123_Q126_D0.5541.00
30_A151_F0.5521.00
86_A89_A0.5481.00
41_I117_F0.5451.00
179_G183_I0.5441.00
158_A165_L0.5431.00
137_L142_G0.5421.00
144_V151_F0.5401.00
11_N14_V0.5391.00
64_L190_A0.5381.00
127_P130_G0.5371.00
12_L16_A0.5361.00
23_R152_L0.5351.00
32_G103_G0.5311.00
96_L100_F0.5291.00
84_P87_A0.5281.00
155_A159_S0.5251.00
161_L165_L0.5181.00
3_L37_D0.5131.00
18_G158_A0.5101.00
27_L31_L0.5051.00
62_L66_G0.5041.00
49_G52_L0.5001.00
4_A37_D0.5001.00
21_R24_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwzA 2 0.4404 9 0.922 Contact Map
3wdoA 1 0.9016 8.4 0.923 Contact Map
3o7qA 1 0.9223 8 0.923 Contact Map
2gfpA 2 0.9223 7.1 0.925 Contact Map
2kncA 1 0.2487 6.6 0.926 Contact Map
1pw4A 1 0.9016 6.1 0.927 Contact Map
2xq2A 2 0.3886 6 0.928 Contact Map
3j1zP 8 0.8705 4.9 0.931 Contact Map
2cfqA 1 0.9119 4.5 0.932 Contact Map
4ldsA 2 0.4145 4.3 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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