GREMLIN Database
Haemolytic - Haemolytic domain
PFAM: PF01809 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 65 (64)
Sequences: 60368 (34496)
Seq/√Len: 4312.0
META: 0.937

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
31_A47_A3.7221.00
5_I32_I2.4761.00
4_L40_A2.4091.00
9_R32_I2.3331.00
39_G43_G2.1381.00
12_Q29_E1.9481.00
32_I36_E1.9201.00
45_W49_K1.9001.00
23_F59_P1.8021.00
12_Q32_I1.6881.00
10_F14_T1.6581.00
24_Y29_E1.5651.00
29_E33_E1.4531.00
49_K53_R1.4411.00
29_E32_I1.4161.00
35_I47_A1.3891.00
23_F58_G1.3881.00
5_I36_E1.3591.00
35_I44_G1.3531.00
55_H58_G1.3481.00
38_H42_R1.3361.00
4_L35_I1.3331.00
9_R13_R1.3131.00
33_E37_K1.3011.00
48_L52_L1.2641.00
24_Y62_Y1.2111.00
35_I40_A1.2011.00
38_H46_L1.1951.00
14_T17_P1.1621.00
6_A10_F1.1441.00
9_R12_Q1.1131.00
8_I12_Q1.1011.00
43_G47_A1.0261.00
41_L44_G1.0111.00
52_L55_H0.9731.00
23_F53_R0.9701.00
8_I31_A0.9631.00
35_I43_G0.9391.00
15_I19_L0.9371.00
31_A35_I0.9201.00
21_C27_C0.8931.00
44_G48_L0.8651.00
5_I9_R0.8631.00
31_A44_G0.8601.00
42_R46_L0.8381.00
58_G61_G0.8361.00
10_F13_R0.8111.00
22_R58_G0.7981.00
49_K55_H0.7801.00
33_E36_E0.7731.00
6_A9_R0.7651.00
15_I20_S0.7501.00
2_R6_A0.7481.00
49_K52_L0.7461.00
14_T18_L0.7361.00
34_A46_L0.7321.00
46_L49_K0.7171.00
47_A51_I0.7111.00
12_Q28_S0.7101.00
33_E64_P0.7081.00
4_L44_G0.7061.00
53_R58_G0.6961.00
25_P30_Y0.6961.00
45_W52_L0.6751.00
34_A38_H0.6661.00
7_L40_A0.6591.00
16_S29_E0.6571.00
9_R36_E0.6511.00
16_S19_L0.6311.00
44_G47_A0.6271.00
8_I32_I0.6201.00
25_P33_E0.6161.00
3_L7_L0.6081.00
7_L10_F0.5981.00
11_Y15_I0.5981.00
41_L45_W0.5951.00
14_T20_S0.5941.00
3_L6_A0.5931.00
45_W48_L0.5921.00
46_L65_V0.5811.00
22_R55_H0.5751.00
35_I39_G0.5741.00
20_S24_Y0.5641.00
2_R9_R0.5581.00
15_I18_L0.5501.00
39_G47_A0.5411.00
25_P53_R0.5371.00
13_R17_P0.5301.00
34_A65_V0.5261.00
8_I35_I0.5251.00
44_G52_L0.5231.00
22_R56_P0.5231.00
31_A51_I0.5231.00
5_I35_I0.5181.00
17_P20_S0.5121.00
40_A44_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4at7B 1 0.9077 4.1 0.891 Contact Map
4okzA 1 0.7846 3.2 0.897 Contact Map
2r17C 1 1 2.9 0.899 Contact Map
4uz1A 1 0.4615 2.8 0.9 Contact Map
2xwcA 2 0.8462 2.7 0.901 Contact Map
3qpiA 1 0.4308 2.4 0.903 Contact Map
2h9aA 1 0 1.9 0.909 Contact Map
1lkiA 1 0.3385 1.8 0.909 Contact Map
3j8eG 3 0.9231 1.8 0.91 Contact Map
4mc3A 1 0.7846 1.7 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0041 seconds.