GREMLIN Database
Ferric_reduct - Ferric reductase like transmembrane component
PFAM: PF01794 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 124 (120)
Sequences: 44235 (28946)
Seq/√Len: 2642.4
META: 0.849

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
49_L87_L3.6981.00
45_F91_L3.2891.00
108_R111_R3.0741.00
98_T101_A3.0571.00
5_A48_A2.7941.00
3_L7_V2.5431.00
45_F94_A2.4841.00
110_R114_R2.3461.00
39_M43_L2.2441.00
89_L119_A2.1651.00
52_V87_L2.1401.00
105_G108_R2.1251.00
115_L118_L2.0451.00
84_F88_L1.9401.00
114_R118_L1.9041.00
29_G32_R1.7641.00
69_V72_A1.7371.00
118_L121_V1.5551.00
12_T44_A1.5231.00
57_V62_F1.4851.00
4_V7_V1.4701.00
32_R35_R1.4301.00
78_P81_T1.4251.00
44_A90_L1.4241.00
86_A122_L1.3931.00
43_L46_F1.3911.00
99_D102_R1.3781.00
36_L39_M1.3781.00
7_V10_L1.3511.00
93_L116_V1.3471.00
111_R115_L1.3461.00
111_R114_R1.3251.00
66_D70_P1.3221.00
67_L70_P1.3141.00
66_D72_A1.3051.00
21_P24_P1.2971.00
108_R112_L1.2951.00
77_R80_I1.2371.00
42_L46_F1.1861.00
60_Y69_V1.1581.00
10_L14_L1.1561.00
107_R111_R1.1501.00
24_P29_G1.1501.00
12_T40_L1.1371.00
96_T112_L1.1241.00
7_V14_L1.1141.00
69_V73_D1.1041.00
73_D77_R1.1031.00
100_L104_L1.0901.00
71_F74_I1.0831.00
31_D35_R1.0731.00
53_L57_V1.0681.00
20_T23_R1.0641.00
75_Y78_P1.0621.00
58_D61_A1.0611.00
68_L72_A1.0591.00
7_V11_L1.0581.00
70_P73_D1.0531.00
10_L120_A1.0511.00
48_A52_V1.0401.00
8_L12_T1.0401.00
95_V101_A1.0351.00
42_L94_A1.0151.00
9_L44_A1.0131.00
26_R29_G1.0121.00
70_P74_I1.0041.00
71_F75_Y0.9791.00
57_V61_A0.9701.00
78_P82_L0.9591.00
115_L119_A0.9311.00
48_A123_A0.9261.00
89_L115_L0.9191.00
94_A97_S0.9161.00
93_L96_T0.9091.00
50_L54_T0.9041.00
37_H113_H0.9031.00
67_L71_F0.8971.00
49_L53_L0.8931.00
19_V22_L0.8911.00
79_F82_L0.8871.00
73_D80_I0.8731.00
4_V8_L0.8701.00
59_D62_F0.8571.00
54_T58_D0.8521.00
37_H93_L0.8491.00
76_K80_I0.8481.00
98_T102_R0.8431.00
82_L122_L0.8401.00
76_K79_F0.8401.00
66_D69_V0.8381.00
85_V88_L0.8301.00
55_Y58_D0.8041.00
23_R26_R0.8031.00
49_L52_V0.8021.00
75_Y81_T0.8011.00
63_D68_L0.7991.00
66_D71_F0.7981.00
30_L33_L0.7981.00
25_L29_G0.7951.00
10_L13_L0.7931.00
116_V119_A0.7881.00
106_Y110_R0.7881.00
89_L92_A0.7861.00
24_P30_L0.7761.00
63_D69_V0.7751.00
8_L47_Y0.7741.00
49_L91_L0.7641.00
85_V89_L0.7641.00
90_L97_S0.7601.00
37_H45_F0.7541.00
68_L73_D0.7521.00
48_A87_L0.7511.00
75_Y80_I0.7371.00
24_P28_L0.7371.00
28_L32_R0.7361.00
90_L94_A0.7201.00
6_L10_L0.7091.00
81_T84_F0.7041.00
66_D73_D0.7001.00
18_R22_L0.6991.00
27_G31_D0.6981.00
57_V60_Y0.6951.00
74_I81_T0.6861.00
39_M42_L0.6741.00
26_R31_D0.6731.00
26_R30_L0.6651.00
18_R21_P0.6591.00
19_V23_R0.6581.00
92_A95_V0.6571.00
35_R39_M0.6551.00
28_L33_L0.6441.00
77_R81_T0.6431.00
81_T85_V0.6411.00
74_I77_R0.6331.00
28_L31_D0.6311.00
72_A76_K0.6311.00
43_L47_Y0.6291.00
60_Y63_D0.6261.00
102_R106_Y0.6251.00
62_F66_D0.6211.00
63_D66_D0.6121.00
74_I78_P0.6091.00
118_L122_L0.6091.00
24_P27_G0.6081.00
55_Y63_D0.6061.00
31_D34_L0.6011.00
63_D67_L0.5981.00
5_A44_A0.5931.00
25_L28_L0.5891.00
87_L91_L0.5851.00
74_I80_I0.5831.00
55_Y70_P0.5751.00
112_L116_V0.5701.00
27_G32_R0.5651.00
48_A86_A0.5621.00
76_K81_T0.5561.00
70_P76_K0.5541.00
37_H97_S0.5491.00
114_R117_Y0.5461.00
112_L115_L0.5361.00
101_A105_G0.5341.00
8_L44_A0.5331.00
9_L120_A0.5331.00
59_D63_D0.5321.00
38_R42_L0.5311.00
52_V56_L0.5311.00
11_L14_L0.5211.00
52_V84_F0.5191.00
88_L92_A0.5181.00
44_A47_Y0.5181.00
12_T15_L0.5181.00
69_V76_K0.5171.00
26_R32_R0.5141.00
44_A48_A0.5131.00
100_L103_R0.5091.00
90_L119_A0.5071.00
82_L86_A0.5031.00
62_F67_L0.5031.00
9_L12_T0.5031.00
70_P77_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o6yA 2 0.7823 79 0.781 Contact Map
1kqfC 3 0.9919 7.5 0.879 Contact Map
2bs2C 2 0.8548 6.6 0.883 Contact Map
4i0uA 4 0.4516 4.6 0.891 Contact Map
4ev6A 3 0.75 3.5 0.897 Contact Map
4hyjA 2 0.4274 3.2 0.899 Contact Map
3j2wE 1 0.371 3 0.901 Contact Map
4jq6A 3 0.379 2.8 0.902 Contact Map
2l6wA 2 0.2984 2.8 0.902 Contact Map
3wt9A 1 0.4435 2.2 0.908 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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