GREMLIN Database
LGT - Prolipoprotein diacylglyceryl transferase
PFAM: PF01790 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 205 (202)
Sequences: 49679 (33450)
Seq/√Len: 2353.5
META: 0.889

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_H138_Y5.0191.00
142_E173_G3.5421.00
146_L169_L3.1371.00
176_F180_L2.8191.00
70_A73_E2.6981.00
67_E73_E2.6701.00
103_D160_G2.5171.00
67_E70_A2.5151.00
5_S9_A2.5001.00
164_G202_L2.4621.00
118_I140_A2.4541.00
120_N125_E2.3251.00
175_F179_F2.2781.00
158_R161_Q2.2601.00
113_Q166_Y2.2011.00
31_R154_R2.1741.00
168_I196_I2.0751.00
148_A152_W2.0721.00
100_R159_P1.9941.00
164_G199_G1.9701.00
84_G88_A1.8851.00
14_G18_A1.8351.00
171_G196_I1.7851.00
168_I199_G1.7641.00
26_W30_R1.7511.00
107_P110_P1.7511.00
120_N126_L1.7271.00
31_R34_R1.7161.00
102_A163_F1.6951.00
153_L165_L1.6791.00
50_L88_A1.6601.00
3_L15_L1.6471.00
28_A108_A1.5921.00
161_Q203_L1.5821.00
97_P159_P1.5811.00
30_R33_K1.5801.00
97_P100_R1.5491.00
111_L147_F1.5291.00
54_G84_G1.5241.00
135_T177_I1.5221.00
93_A101_L1.5181.00
114_A144_L1.5041.00
16_M119_G1.5011.00
113_Q143_G1.4991.00
98_F102_A1.4701.00
179_F189_Q1.4601.00
3_L12_W1.4491.00
110_P146_L1.4261.00
142_E146_L1.4011.00
110_P166_Y1.3991.00
121_F137_L1.3881.00
50_L84_G1.3781.00
25_L44_L1.3741.00
164_G203_L1.3711.00
29_R41_D1.3401.00
127_Y132_R1.3381.00
99_L160_G1.3381.00
153_L161_Q1.3291.00
30_R34_R1.3251.00
26_W29_R1.3221.00
118_I122_I1.3201.00
27_L151_W1.3201.00
90_L98_F1.3201.00
46_W50_L1.3131.00
151_W154_R1.3121.00
96_L101_L1.3081.00
39_D96_L1.3071.00
114_A140_A1.3001.00
38_D41_D1.2901.00
140_A144_L1.2821.00
46_W88_A1.2531.00
135_T180_L1.2521.00
147_F151_W1.2441.00
12_W122_I1.2311.00
29_R33_K1.2291.00
78_F82_L1.2161.00
168_I203_L1.2121.00
163_F167_L1.1981.00
186_T189_Q1.1801.00
16_M122_I1.1801.00
168_I200_L1.1541.00
172_L176_F1.1321.00
137_L141_L1.1271.00
43_L92_Y1.1241.00
169_L173_G1.1231.00
149_I153_L1.1211.00
157_R161_Q1.1171.00
175_F189_Q1.1151.00
144_L148_A1.1031.00
149_I152_W1.0991.00
154_R162_L1.0891.00
66_P69_F1.0891.00
150_L162_L1.0831.00
32_A40_V1.0811.00
78_F113_Q1.0601.00
106_A163_F1.0541.00
200_L204_I1.0521.00
60_V68_I1.0451.00
25_L41_D1.0391.00
175_F196_I1.0291.00
21_F48_V1.0251.00
87_L91_L1.0241.00
121_F136_Q1.0031.00
79_H188_G1.0011.00
16_M19_L0.9961.00
88_A92_Y0.9831.00
201_A204_I0.9791.00
89_A93_A0.9771.00
172_L196_I0.9741.00
39_D42_D0.9681.00
149_I169_L0.9681.00
190_L194_P0.9641.00
141_L145_L0.9621.00
198_A201_A0.9481.00
79_H192_S0.9471.00
194_P198_A0.9391.00
117_R174_R0.9251.00
22_L26_W0.9231.00
3_L10_I0.9231.00
43_L101_L0.9211.00
165_L203_L0.9201.00
165_L169_L0.9141.00
23_L115_I0.9101.00
173_G177_I0.9031.00
27_L108_A0.9021.00
65_N70_A0.8971.00
145_L149_I0.8971.00
167_L199_G0.8961.00
114_A147_F0.8921.00
129_G132_R0.8921.00
197_L201_A0.8911.00
139_E177_I0.8871.00
167_L195_M0.8831.00
19_L23_L0.8811.00
93_A98_F0.8761.00
187_M191_L0.8701.00
54_G80_G0.8701.00
71_I74_G0.8691.00
149_I165_L0.8671.00
164_G168_I0.8651.00
27_L147_F0.8621.00
124_G136_Q0.8581.00
114_A148_A0.8421.00
43_L47_A0.8381.00
153_L162_L0.8381.00
28_A104_A0.8311.00
13_Y120_N0.8291.00
64_Y67_E0.8271.00
176_F179_F0.8211.00
146_L173_G0.8191.00
81_G85_G0.8161.00
99_L164_G0.8151.00
4_F10_I0.8141.00
50_L54_G0.8121.00
161_Q165_L0.8001.00
20_G115_I0.7991.00
125_E136_Q0.7991.00
31_R107_P0.7981.00
171_G195_M0.7951.00
42_D46_W0.7941.00
25_L29_R0.7911.00
171_G199_G0.7901.00
70_A74_G0.7871.00
28_A40_V0.7851.00
44_L48_V0.7821.00
177_I180_L0.7771.00
83_I87_L0.7761.00
93_A96_L0.7741.00
46_W92_Y0.7721.00
127_Y135_T0.7631.00
23_L111_L0.7591.00
84_G87_L0.7551.00
47_A89_A0.7531.00
42_D92_Y0.7501.00
106_A166_Y0.7461.00
6_I9_A0.7371.00
113_Q116_G0.7361.00
148_A151_W0.7351.00
111_L114_A0.7321.00
43_L89_A0.7301.00
88_A91_L0.7261.00
24_G47_A0.7261.00
20_G23_L0.7251.00
59_Y77_S0.7231.00
143_G146_L0.7231.00
127_Y136_Q0.7201.00
23_L26_W0.7101.00
4_F9_A0.7081.00
150_L166_Y0.7081.00
31_R35_R0.7061.00
192_S195_M0.7021.00
199_G202_L0.7001.00
104_A108_A0.6951.00
58_G80_G0.6821.00
193_L197_L0.6781.00
114_A143_G0.6741.00
24_G108_A0.6731.00
58_G77_S0.6731.00
106_A109_L0.6731.00
12_W15_L0.6721.00
174_R178_E0.6711.00
173_G176_F0.6681.00
132_R136_Q0.6661.00
65_N68_I0.6651.00
86_L89_A0.6641.00
113_Q139_E0.6641.00
156_R161_Q0.6571.00
47_A85_G0.6481.00
195_M199_G0.6461.00
86_L98_F0.6451.00
60_V64_Y0.6451.00
56_R74_G0.6451.00
19_L115_I0.6441.00
20_G112_G0.6431.00
90_L93_A0.6401.00
143_G173_G0.6401.00
120_N123_N0.6351.00
79_H171_G0.6341.00
86_L90_L0.6331.00
42_D45_L0.6331.00
56_R60_V0.6321.00
161_Q164_G0.6311.00
185_L189_Q0.6281.00
139_E174_R0.6261.00
62_F65_N0.6261.00
153_L157_R0.6211.00
20_G116_G0.6201.00
39_D92_Y0.6171.00
188_G192_S0.6161.00
13_Y126_L0.6151.00
168_I172_L0.6141.00
45_L49_I0.6101.00
110_P150_L0.6081.00
100_R104_A0.6071.00
143_G166_Y0.6071.00
13_Y125_E0.6031.00
58_G191_L0.6021.00
86_L102_A0.6001.00
56_R59_Y0.5991.00
69_F72_W0.5981.00
185_L190_L0.5961.00
32_A104_A0.5961.00
3_L9_A0.5951.00
55_A76_L0.5951.00
31_R151_W0.5921.00
5_S8_L0.5891.00
110_P143_G0.5881.00
124_G134_P0.5851.00
198_A202_L0.5851.00
179_F186_T0.5831.00
164_G167_L0.5821.00
27_L31_R0.5821.00
142_E145_L0.5791.00
13_Y17_Y0.5781.00
117_R120_N0.5781.00
112_G116_G0.5771.00
99_L102_A0.5771.00
119_G122_I0.5761.00
150_L165_L0.5751.00
87_L90_L0.5751.00
107_P162_L0.5731.00
142_E177_I0.5721.00
134_P137_L0.5701.00
175_F192_S0.5691.00
114_A118_I0.5671.00
35_R100_R0.5661.00
27_L111_L0.5651.00
38_D42_D0.5621.00
137_L140_A0.5571.00
78_F166_Y0.5561.00
59_Y63_Y0.5561.00
124_G127_Y0.5531.00
188_G191_L0.5511.00
171_G192_S0.5481.00
107_P111_L0.5471.00
139_E142_E0.5471.00
143_G170_Y0.5471.00
189_Q193_L0.5471.00
187_M190_L0.5451.00
110_P147_F0.5421.00
4_F7_G0.5411.00
99_L202_L0.5401.00
16_M115_I0.5311.00
162_L165_L0.5311.00
28_A32_A0.5291.00
99_L163_F0.5261.00
47_A51_G0.5251.00
69_F73_E0.5251.00
33_K36_G0.5221.00
126_L135_T0.5191.00
11_R123_N0.5161.00
17_Y21_F0.5151.00
12_W16_M0.5141.00
117_R139_E0.5111.00
50_L91_L0.5071.00
17_Y20_G0.5051.00
45_L48_V0.5051.00
89_A102_A0.5041.00
46_W91_L0.5031.00
9_A12_W0.5021.00
107_P154_R0.5011.00
167_L171_G0.5001.00
124_G132_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.3707 8.6 0.941 Contact Map
3b5dA 2 0.4829 5.6 0.946 Contact Map
3dh4A 3 0.878 4.7 0.947 Contact Map
4qncA 2 0.4 3.1 0.952 Contact Map
2xq2A 2 0.878 2.9 0.953 Contact Map
2qi9A 2 0.4244 1.8 0.957 Contact Map
4x5mA 2 0.4585 1.5 0.959 Contact Map
3ga2A 1 0.239 1.5 0.96 Contact Map
3m73A 3 0.9073 1.4 0.96 Contact Map
3tqgA 2 0.2927 1.3 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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