GREMLIN Database
Acyl_transf_3 - Acyltransferase family
PFAM: PF01757 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 340 (320)
Sequences: 123579 (108952)
Seq/√Len: 6090.6
META: 0.764

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
288_F292_I3.8751.00
11_A51_L3.8331.00
5_D291_R3.1901.00
135_S139_E3.0331.00
16_V296_I3.0061.00
83_P86_L2.8661.00
78_A82_L2.8001.00
331_S335_A2.6731.00
71_R75_K2.5641.00
61_T205_A2.5041.00
70_L74_Y2.4761.00
70_L147_P2.3751.00
201_F205_A2.3131.00
45_G48_G2.2221.00
69_S72_R2.1381.00
74_Y147_P2.0571.00
75_K79_L2.0501.00
9_G290_G2.0331.00
61_T146_F2.0221.00
53_F138_V2.0051.00
58_F211_R2.0011.00
50_D200_E1.9921.00
188_F194_R1.9811.00
110_L113_L1.9711.00
190_L193_P1.9561.00
191_P194_R1.9091.00
288_F291_R1.8851.00
5_D287_V1.8631.00
267_A271_L1.8571.00
20_A304_L1.7991.00
209_L213_R1.7711.00
84_P88_V1.7651.00
18_F45_G1.7111.00
137_A141_Q1.7101.00
15_V49_V1.7001.00
201_F204_G1.6991.00
9_G289_L1.6811.00
114_L117_L1.6651.00
224_L228_A1.6141.00
189_L193_P1.6121.00
287_V291_R1.6091.00
113_L116_L1.5891.00
200_E204_G1.5871.00
156_R159_R1.5801.00
151_L155_R1.5641.00
278_S281_R1.5411.00
139_E143_Y1.5331.00
208_A212_R1.5131.00
72_R75_K1.5091.00
323_L327_A1.5031.00
187_F193_P1.4941.00
111_L114_L1.4891.00
228_A232_L1.4861.00
88_V299_W1.4841.00
327_A331_S1.4781.00
83_P87_L1.4771.00
188_F191_P1.4711.00
118_L121_F1.4681.00
199_L204_G1.4591.00
231_L235_I1.4471.00
130_L133_L1.4451.00
292_I295_S1.4441.00
18_F48_G1.4431.00
322_L325_L1.4391.00
170_L173_L1.4291.00
12_A296_I1.4181.00
109_L112_L1.4021.00
88_V92_L1.3991.00
266_A270_L1.3901.00
9_G293_S1.3891.00
211_R214_L1.3791.00
7_L51_L1.3791.00
119_G122_G1.3711.00
235_I239_L1.3641.00
6_G286_L1.3541.00
269_L273_A1.3521.00
276_L279_L1.3491.00
190_L194_R1.3481.00
157_R160_L1.3451.00
210_L214_L1.3361.00
4_L59_L1.3361.00
280_R283_L1.3351.00
107_L110_L1.3291.00
172_A175_L1.3241.00
72_R76_R1.3211.00
279_L283_L1.3111.00
288_F336_W1.3091.00
108_L111_L1.3081.00
154_R157_R1.3061.00
62_R65_R1.3021.00
54_V207_L1.3001.00
188_F192_F1.2991.00
90_L94_L1.2951.00
225_L229_L1.2911.00
205_A209_L1.2871.00
221_L225_L1.2831.00
323_L326_L1.2831.00
189_L192_F1.2821.00
309_A313_G1.2781.00
285_P289_L1.2781.00
9_G13_L1.2671.00
268_L272_A1.2661.00
169_A173_L1.2631.00
226_L230_A1.2611.00
112_L115_L1.2601.00
274_L277_P1.2541.00
171_L174_L1.2531.00
227_L231_L1.2391.00
229_L233_A1.2381.00
146_F201_F1.2311.00
299_W302_P1.2291.00
169_A172_A1.2291.00
174_L177_L1.2211.00
131_G301_W1.2201.00
94_L97_L1.2121.00
173_L176_L1.2001.00
206_L210_L1.1931.00
132_H301_W1.1861.00
85_Y88_V1.1851.00
77_R143_Y1.1851.00
101_G104_L1.1771.00
187_F190_L1.1741.00
324_L327_A1.1731.00
62_R66_G1.1731.00
61_T208_A1.1721.00
85_Y89_L1.1691.00
257_L260_L1.1681.00
83_P89_L1.1651.00
202_L205_A1.1651.00
208_A211_R1.1571.00
46_F50_D1.1531.00
285_P288_F1.1491.00
319_G323_L1.1431.00
112_L116_L1.1411.00
154_R158_R1.1401.00
186_A190_L1.1381.00
204_G208_A1.1371.00
275_A278_S1.1321.00
278_S282_L1.1311.00
83_P92_L1.1271.00
82_L86_L1.1241.00
199_L202_L1.1231.00
255_P258_A1.1191.00
329_V333_A1.1171.00
307_L310_L1.1141.00
263_A266_A1.1131.00
63_S66_G1.1031.00
233_A237_L1.1011.00
74_Y140_E1.1001.00
292_I336_W1.0961.00
133_L298_L1.0951.00
240_L243_G1.0951.00
259_L263_A1.0921.00
188_F193_P1.0921.00
209_L212_R1.0881.00
264_L267_A1.0821.00
292_I296_I1.0811.00
262_L265_G1.0731.00
189_L194_R1.0711.00
173_L177_L1.0691.00
326_L329_V1.0671.00
321_L325_L1.0651.00
260_L271_L1.0601.00
332_L336_W1.0581.00
14_L48_G1.0531.00
232_L236_L1.0511.00
267_A270_L1.0511.00
279_L282_L1.0471.00
94_L98_L1.0441.00
222_L226_L1.0411.00
83_P94_L1.0371.00
3_A6_G1.0351.00
277_P280_R1.0331.00
230_A234_L1.0311.00
325_L329_V1.0301.00
320_P323_L1.0271.00
160_L163_L1.0251.00
155_R158_R1.0241.00
236_L239_L1.0241.00
300_H304_L1.0241.00
62_R68_R1.0151.00
236_L240_L1.0101.00
152_L156_R1.0091.00
310_L313_G1.0071.00
187_F191_P1.0061.00
264_L268_L1.0031.00
14_L18_F1.0031.00
262_L273_A1.0011.00
167_L171_L1.0011.00
60_I146_F1.0001.00
18_F46_F1.0001.00
61_T209_L1.0001.00
171_L175_L1.0001.00
146_F205_A0.9931.00
200_E208_A0.9901.00
234_L238_L0.9901.00
258_A261_L0.9891.00
68_R72_R0.9881.00
260_L263_A0.9831.00
158_R162_L0.9801.00
170_L174_L0.9761.00
93_L96_A0.9741.00
110_L114_L0.9711.00
265_G273_A0.9691.00
151_L154_R0.9631.00
92_L96_A0.9611.00
11_A48_G0.9581.00
237_L240_L0.9581.00
253_L257_L0.9581.00
265_G268_L0.9531.00
258_A262_L0.9451.00
113_L117_L0.9431.00
156_R160_L0.9431.00
111_L115_L0.9431.00
223_L227_L0.9421.00
142_F201_F0.9421.00
174_L178_L0.9411.00
58_F208_A0.9381.00
153_L156_R0.9361.00
205_A208_A0.9291.00
265_G269_L0.9261.00
260_L264_L0.9251.00
295_S299_W0.9231.00
303_V307_L0.9221.00
259_L270_L0.9171.00
83_P91_L0.9171.00
225_L228_A0.9161.00
83_P88_V0.9151.00
168_L172_A0.9131.00
262_L270_L0.9101.00
238_L242_L0.9091.00
159_R162_L0.9071.00
237_L241_L0.9051.00
238_L241_L0.9031.00
284_R287_V0.8981.00
324_L328_L0.8961.00
78_A140_E0.8911.00
97_L101_G0.8911.00
277_P281_R0.8901.00
328_L331_S0.8901.00
284_R288_F0.8881.00
262_L266_A0.8861.00
303_V306_L0.8851.00
160_L164_L0.8821.00
65_R68_R0.8821.00
220_R224_L0.8811.00
96_A100_L0.8801.00
319_G322_L0.8771.00
12_A16_V0.8761.00
56_S139_E0.8721.00
83_P95_L0.8691.00
14_L47_L0.8671.00
4_L55_L0.8661.00
332_L335_A0.8661.00
254_Y257_L0.8661.00
82_L140_E0.8611.00
159_R163_L0.8531.00
217_R220_R0.8511.00
10_L14_L0.8471.00
256_G259_L0.8421.00
106_G109_L0.8411.00
9_G286_L0.8291.00
254_Y258_A0.8261.00
329_V332_L0.8221.00
175_L178_L0.8171.00
68_R76_R0.8161.00
12_A135_S0.8131.00
140_E144_L0.8121.00
138_V141_Q0.8091.00
106_G110_L0.8091.00
267_A275_A0.8051.00
152_L155_R0.8051.00
85_Y93_L0.8041.00
175_L179_L0.8031.00
75_K78_A0.8021.00
78_A81_I0.8001.00
73_F77_R0.7991.00
223_L226_L0.7931.00
269_L272_A0.7911.00
176_L180_L0.7881.00
118_L122_G0.7851.00
95_L99_L0.7851.00
5_D8_R0.7851.00
263_A267_A0.7841.00
9_G12_A0.7821.00
60_I143_Y0.7811.00
200_E205_A0.7791.00
307_L311_L0.7711.00
12_A52_F0.7681.00
256_G260_L0.7671.00
157_R161_L0.7661.00
132_H300_H0.7651.00
158_R161_L0.7651.00
255_P262_L0.7601.00
264_L275_A0.7581.00
139_E294_Y0.7551.00
68_R71_R0.7541.00
15_V48_G0.7531.00
185_T189_L0.7521.00
214_L217_R0.7501.00
185_T188_F0.7481.00
274_L278_S0.7451.00
158_R173_L0.7421.00
153_L157_R0.7411.00
259_L262_L0.7401.00
108_L112_L0.7401.00
235_I238_L0.7361.00
320_P324_L0.7341.00
109_L113_L0.7341.00
105_A108_L0.7331.00
161_L164_L0.7321.00
211_R215_R0.7311.00
6_G9_G0.7291.00
177_L180_L0.7271.00
210_L213_R0.7271.00
198_L201_F0.7261.00
53_F139_E0.7241.00
100_L103_S0.7231.00
321_L324_L0.7231.00
276_L280_R0.7231.00
102_L105_A0.7211.00
257_L261_L0.7151.00
270_L274_L0.7151.00
9_G292_I0.7091.00
261_L265_G0.7091.00
107_L111_L0.7071.00
266_A269_L0.7071.00
305_V309_A0.7061.00
268_L271_L0.7031.00
84_P87_L0.7021.00
213_R216_R0.7021.00
63_S68_R0.7001.00
161_L172_A0.6981.00
239_L242_L0.6971.00
88_V91_L0.6971.00
108_L113_L0.6961.00
266_A273_A0.6931.00
273_A276_L0.6921.00
88_V133_L0.6911.00
141_Q145_L0.6891.00
322_L326_L0.6891.00
304_L308_R0.6871.00
259_L273_A0.6861.00
254_Y259_L0.6821.00
186_A189_L0.6821.00
330_L333_A0.6811.00
252_S255_P0.6791.00
162_L173_L0.6771.00
64_R67_R0.6761.00
294_Y298_L0.6761.00
44_G48_G0.6741.00
234_L237_L0.6741.00
6_G287_V0.6731.00
308_R312_G0.6701.00
200_E203_L0.6701.00
164_L168_L0.6681.00
64_R68_R0.6661.00
172_A176_L0.6631.00
108_L115_L0.6611.00
214_L218_R0.6601.00
268_L276_L0.6591.00
177_L181_F0.6591.00
221_L224_L0.6511.00
136_L294_Y0.6471.00
155_R159_R0.6431.00
306_L309_A0.6431.00
263_A274_L0.6431.00
215_R218_R0.6411.00
103_S106_G0.6401.00
99_L102_L0.6381.00
186_A192_F0.6371.00
183_P186_A0.6371.00
84_P91_L0.6361.00
287_V290_G0.6361.00
239_L243_G0.6361.00
100_L104_L0.6351.00
133_L137_A0.6341.00
164_L167_L0.6331.00
212_R215_R0.6251.00
199_L203_L0.6241.00
257_L268_L0.6221.00
271_L275_A0.6211.00
13_L17_L0.6191.00
73_F143_Y0.6181.00
166_A170_L0.6181.00
84_P92_L0.6171.00
12_A15_V0.6151.00
120_Y123_P0.6141.00
273_A277_P0.6141.00
142_F147_P0.6131.00
302_P306_L0.6121.00
150_L154_R0.6111.00
93_L97_L0.6071.00
138_V142_F0.6041.00
261_L272_A0.6031.00
187_F194_R0.6021.00
262_L271_L0.6011.00
201_F209_L0.6011.00
256_G262_L0.5981.00
187_F192_F0.5961.00
166_A169_A0.5961.00
182_G185_T0.5951.00
60_I140_E0.5951.00
213_R217_R0.5931.00
198_L202_L0.5911.00
89_L93_L0.5901.00
207_L211_R0.5891.00
162_L165_L0.5891.00
270_L273_A0.5841.00
253_L256_G0.5841.00
264_L272_A0.5811.00
161_L165_L0.5791.00
167_L170_L0.5791.00
310_L314_L0.5781.00
263_A272_A0.5771.00
228_A231_L0.5751.00
129_P133_L0.5751.00
79_L82_L0.5751.00
255_P259_L0.5741.00
220_R223_L0.5731.00
124_G127_P0.5711.00
8_R55_L0.5701.00
110_L117_L0.5691.00
320_P331_S0.5691.00
252_S256_G0.5681.00
165_L169_A0.5661.00
296_I331_S0.5661.00
99_L103_S0.5641.00
86_L89_L0.5641.00
87_L90_L0.5631.00
144_L147_P0.5621.00
134_W138_V0.5621.00
54_V200_E0.5601.00
275_A279_L0.5541.00
123_P126_G0.5531.00
267_A274_L0.5531.00
179_L182_G0.5531.00
229_L236_L0.5521.00
207_L210_L0.5511.00
328_L332_L0.5511.00
47_L50_D0.5511.00
53_F142_F0.5501.00
233_A236_L0.5451.00
199_L205_A0.5421.00
110_L116_L0.5421.00
91_L95_L0.5411.00
163_L167_L0.5411.00
101_G105_A0.5411.00
202_L206_L0.5401.00
162_L166_A0.5391.00
261_L270_L0.5381.00
296_I335_A0.5381.00
56_S135_S0.5361.00
136_L298_L0.5321.00
259_L268_L0.5321.00
302_P305_V0.5311.00
66_G69_S0.5301.00
63_S67_R0.5301.00
212_R216_R0.5291.00
301_W305_V0.5271.00
85_Y92_L0.5261.00
254_Y262_L0.5241.00
309_A312_G0.5241.00
182_G186_A0.5221.00
29_G32_W0.5211.00
263_A271_L0.5181.00
215_R219_R0.5171.00
278_S283_L0.5161.00
81_I143_Y0.5161.00
226_L229_L0.5151.00
206_L209_L0.5151.00
110_L115_L0.5121.00
218_R221_L0.5121.00
163_L166_A0.5111.00
257_L262_L0.5111.00
266_A274_L0.5101.00
121_F124_G0.5081.00
104_L107_L0.5071.00
261_L264_L0.5021.00
251_P254_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2latA 1 0.0882 2.3 0.946 Contact Map
1rklA 1 0.0853 1.4 0.952 Contact Map
3j1rA 5 0.0676 1 0.956 Contact Map
4uc1A 3 0.3412 1 0.957 Contact Map
4hfiA 3 0.2706 0.9 0.958 Contact Map
4p02A 1 0.3088 0.8 0.959 Contact Map
3j1zP 8 0.3735 0.8 0.96 Contact Map
2k1eA 3 0.2706 0.8 0.96 Contact Map
3w5aC 1 0.0794 0.7 0.96 Contact Map
2lulA 1 0.1618 0.7 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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