Acyl_transf_3 - PFAM28P - GREMLIN Contacts

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Acyl_transf_3 - Acyltransferase family

PFAM:	PF01757	Sequences: RPALDGLRGLAALLVVLFHAGLALLPGGGLGWLLFALLSSVLSGGFLGVDLFFVLSGFLITRSRRGRRSLRRFYKRRALRILPPYLLVLLLLLLLALLLLGLSLAGLLLLLLLLLLLLGYFGPGGGPSPLGHLWSLAVEEQFYLLFPLLLLLLRRRRRRLLLLLLALLALLALLLLLLLLFGPPTAFFLLPFPRVLALLEFLLGALLALLRRRLRRRRRRLLLLLLLALALLALILLLLLLLGLGGGLLAPSLYPGLALLLLALGAALLLLAALALPSLRRLLRPLVFLGRISYSIYLWHWPVLVLLRALLGGLGLPLGPLLLLLLALVLSLALAWLLYR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	340 (320)
Sequences:	123579 (108952)
Seq/√Len:	6090.6
META:	0.764

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
288_F	292_I	3.875	1.00
11_A	51_L	3.833	1.00
5_D	291_R	3.190	1.00
135_S	139_E	3.033	1.00
16_V	296_I	3.006	1.00
83_P	86_L	2.866	1.00
78_A	82_L	2.800	1.00
331_S	335_A	2.673	1.00
71_R	75_K	2.564	1.00
61_T	205_A	2.504	1.00
70_L	74_Y	2.476	1.00
70_L	147_P	2.375	1.00
201_F	205_A	2.313	1.00
45_G	48_G	2.222	1.00
69_S	72_R	2.138	1.00
74_Y	147_P	2.057	1.00
75_K	79_L	2.050	1.00
9_G	290_G	2.033	1.00
61_T	146_F	2.022	1.00
53_F	138_V	2.005	1.00
58_F	211_R	2.001	1.00
50_D	200_E	1.992	1.00
188_F	194_R	1.981	1.00
110_L	113_L	1.971	1.00
190_L	193_P	1.956	1.00
191_P	194_R	1.909	1.00
288_F	291_R	1.885	1.00
5_D	287_V	1.863	1.00
267_A	271_L	1.857	1.00
20_A	304_L	1.799	1.00
209_L	213_R	1.771	1.00
84_P	88_V	1.765	1.00
18_F	45_G	1.711	1.00
137_A	141_Q	1.710	1.00
15_V	49_V	1.700	1.00
201_F	204_G	1.699	1.00
9_G	289_L	1.681	1.00
114_L	117_L	1.665	1.00
224_L	228_A	1.614	1.00
189_L	193_P	1.612	1.00
287_V	291_R	1.609	1.00
113_L	116_L	1.589	1.00
200_E	204_G	1.587	1.00
156_R	159_R	1.580	1.00
151_L	155_R	1.564	1.00
278_S	281_R	1.541	1.00
139_E	143_Y	1.533	1.00
208_A	212_R	1.513	1.00
72_R	75_K	1.509	1.00
323_L	327_A	1.503	1.00
187_F	193_P	1.494	1.00
111_L	114_L	1.489	1.00
228_A	232_L	1.486	1.00
88_V	299_W	1.484	1.00
327_A	331_S	1.478	1.00
83_P	87_L	1.477	1.00
188_F	191_P	1.471	1.00
118_L	121_F	1.468	1.00
199_L	204_G	1.459	1.00
231_L	235_I	1.447	1.00
130_L	133_L	1.445	1.00
292_I	295_S	1.444	1.00
18_F	48_G	1.443	1.00
322_L	325_L	1.439	1.00
170_L	173_L	1.429	1.00
12_A	296_I	1.418	1.00
109_L	112_L	1.402	1.00
88_V	92_L	1.399	1.00
266_A	270_L	1.390	1.00
9_G	293_S	1.389	1.00
211_R	214_L	1.379	1.00
7_L	51_L	1.379	1.00
119_G	122_G	1.371	1.00
235_I	239_L	1.364	1.00
6_G	286_L	1.354	1.00
269_L	273_A	1.352	1.00
276_L	279_L	1.349	1.00
190_L	194_R	1.348	1.00
157_R	160_L	1.345	1.00
210_L	214_L	1.336	1.00
4_L	59_L	1.336	1.00
280_R	283_L	1.335	1.00
107_L	110_L	1.329	1.00
172_A	175_L	1.324	1.00
72_R	76_R	1.321	1.00
279_L	283_L	1.311	1.00
288_F	336_W	1.309	1.00
108_L	111_L	1.308	1.00
154_R	157_R	1.306	1.00
62_R	65_R	1.302	1.00
54_V	207_L	1.300	1.00
188_F	192_F	1.299	1.00
90_L	94_L	1.295	1.00
225_L	229_L	1.291	1.00
205_A	209_L	1.287	1.00
221_L	225_L	1.283	1.00
323_L	326_L	1.283	1.00
189_L	192_F	1.282	1.00
309_A	313_G	1.278	1.00
285_P	289_L	1.278	1.00
9_G	13_L	1.267	1.00
268_L	272_A	1.266	1.00
169_A	173_L	1.263	1.00
226_L	230_A	1.261	1.00
112_L	115_L	1.260	1.00
274_L	277_P	1.254	1.00
171_L	174_L	1.253	1.00
227_L	231_L	1.239	1.00
229_L	233_A	1.238	1.00
146_F	201_F	1.231	1.00
299_W	302_P	1.229	1.00
169_A	172_A	1.229	1.00
174_L	177_L	1.221	1.00
131_G	301_W	1.220	1.00
94_L	97_L	1.212	1.00
173_L	176_L	1.200	1.00
206_L	210_L	1.193	1.00
132_H	301_W	1.186	1.00
85_Y	88_V	1.185	1.00
77_R	143_Y	1.185	1.00
101_G	104_L	1.177	1.00
187_F	190_L	1.174	1.00
324_L	327_A	1.173	1.00
62_R	66_G	1.173	1.00
61_T	208_A	1.172	1.00
85_Y	89_L	1.169	1.00
257_L	260_L	1.168	1.00
83_P	89_L	1.165	1.00
202_L	205_A	1.165	1.00
208_A	211_R	1.157	1.00
46_F	50_D	1.153	1.00
285_P	288_F	1.149	1.00
319_G	323_L	1.143	1.00
112_L	116_L	1.141	1.00
154_R	158_R	1.140	1.00
186_A	190_L	1.138	1.00
204_G	208_A	1.137	1.00
275_A	278_S	1.132	1.00
278_S	282_L	1.131	1.00
83_P	92_L	1.127	1.00
82_L	86_L	1.124	1.00
199_L	202_L	1.123	1.00
255_P	258_A	1.119	1.00
329_V	333_A	1.117	1.00
307_L	310_L	1.114	1.00
263_A	266_A	1.113	1.00
63_S	66_G	1.103	1.00
233_A	237_L	1.101	1.00
74_Y	140_E	1.100	1.00
292_I	336_W	1.096	1.00
133_L	298_L	1.095	1.00
240_L	243_G	1.095	1.00
259_L	263_A	1.092	1.00
188_F	193_P	1.092	1.00
209_L	212_R	1.088	1.00
264_L	267_A	1.082	1.00
292_I	296_I	1.081	1.00
262_L	265_G	1.073	1.00
189_L	194_R	1.071	1.00
173_L	177_L	1.069	1.00
326_L	329_V	1.067	1.00
321_L	325_L	1.065	1.00
260_L	271_L	1.060	1.00
332_L	336_W	1.058	1.00
14_L	48_G	1.053	1.00
232_L	236_L	1.051	1.00
267_A	270_L	1.051	1.00
279_L	282_L	1.047	1.00
94_L	98_L	1.044	1.00
222_L	226_L	1.041	1.00
83_P	94_L	1.037	1.00
3_A	6_G	1.035	1.00
277_P	280_R	1.033	1.00
230_A	234_L	1.031	1.00
325_L	329_V	1.030	1.00
320_P	323_L	1.027	1.00
160_L	163_L	1.025	1.00
155_R	158_R	1.024	1.00
236_L	239_L	1.024	1.00
300_H	304_L	1.024	1.00
62_R	68_R	1.015	1.00
236_L	240_L	1.010	1.00
152_L	156_R	1.009	1.00
310_L	313_G	1.007	1.00
187_F	191_P	1.006	1.00
264_L	268_L	1.003	1.00
14_L	18_F	1.003	1.00
262_L	273_A	1.001	1.00
167_L	171_L	1.001	1.00
60_I	146_F	1.000	1.00
18_F	46_F	1.000	1.00
61_T	209_L	1.000	1.00
171_L	175_L	1.000	1.00
146_F	205_A	0.993	1.00
200_E	208_A	0.990	1.00
234_L	238_L	0.990	1.00
258_A	261_L	0.989	1.00
68_R	72_R	0.988	1.00
260_L	263_A	0.983	1.00
158_R	162_L	0.980	1.00
170_L	174_L	0.976	1.00
93_L	96_A	0.974	1.00
110_L	114_L	0.971	1.00
265_G	273_A	0.969	1.00
151_L	154_R	0.963	1.00
92_L	96_A	0.961	1.00
11_A	48_G	0.958	1.00
237_L	240_L	0.958	1.00
253_L	257_L	0.958	1.00
265_G	268_L	0.953	1.00
258_A	262_L	0.945	1.00
113_L	117_L	0.943	1.00
156_R	160_L	0.943	1.00
111_L	115_L	0.943	1.00
223_L	227_L	0.942	1.00
142_F	201_F	0.942	1.00
174_L	178_L	0.941	1.00
58_F	208_A	0.938	1.00
153_L	156_R	0.936	1.00
205_A	208_A	0.929	1.00
265_G	269_L	0.926	1.00
260_L	264_L	0.925	1.00
295_S	299_W	0.923	1.00
303_V	307_L	0.922	1.00
259_L	270_L	0.917	1.00
83_P	91_L	0.917	1.00
225_L	228_A	0.916	1.00
83_P	88_V	0.915	1.00
168_L	172_A	0.913	1.00
262_L	270_L	0.910	1.00
238_L	242_L	0.909	1.00
159_R	162_L	0.907	1.00
237_L	241_L	0.905	1.00
238_L	241_L	0.903	1.00
284_R	287_V	0.898	1.00
324_L	328_L	0.896	1.00
78_A	140_E	0.891	1.00
97_L	101_G	0.891	1.00
277_P	281_R	0.890	1.00
328_L	331_S	0.890	1.00
284_R	288_F	0.888	1.00
262_L	266_A	0.886	1.00
303_V	306_L	0.885	1.00
160_L	164_L	0.882	1.00
65_R	68_R	0.882	1.00
220_R	224_L	0.881	1.00
96_A	100_L	0.880	1.00
319_G	322_L	0.877	1.00
12_A	16_V	0.876	1.00
56_S	139_E	0.872	1.00
83_P	95_L	0.869	1.00
14_L	47_L	0.867	1.00
4_L	55_L	0.866	1.00
332_L	335_A	0.866	1.00
254_Y	257_L	0.866	1.00
82_L	140_E	0.861	1.00
159_R	163_L	0.853	1.00
217_R	220_R	0.851	1.00
10_L	14_L	0.847	1.00
256_G	259_L	0.842	1.00
106_G	109_L	0.841	1.00
9_G	286_L	0.829	1.00
254_Y	258_A	0.826	1.00
329_V	332_L	0.822	1.00
175_L	178_L	0.817	1.00
68_R	76_R	0.816	1.00
12_A	135_S	0.813	1.00
140_E	144_L	0.812	1.00
138_V	141_Q	0.809	1.00
106_G	110_L	0.809	1.00
267_A	275_A	0.805	1.00
152_L	155_R	0.805	1.00
85_Y	93_L	0.804	1.00
175_L	179_L	0.803	1.00
75_K	78_A	0.802	1.00
78_A	81_I	0.800	1.00
73_F	77_R	0.799	1.00
223_L	226_L	0.793	1.00
269_L	272_A	0.791	1.00
176_L	180_L	0.788	1.00
118_L	122_G	0.785	1.00
95_L	99_L	0.785	1.00
5_D	8_R	0.785	1.00
263_A	267_A	0.784	1.00
9_G	12_A	0.782	1.00
60_I	143_Y	0.781	1.00
200_E	205_A	0.779	1.00
307_L	311_L	0.771	1.00
12_A	52_F	0.768	1.00
256_G	260_L	0.767	1.00
157_R	161_L	0.766	1.00
132_H	300_H	0.765	1.00
158_R	161_L	0.765	1.00
255_P	262_L	0.760	1.00
264_L	275_A	0.758	1.00
139_E	294_Y	0.755	1.00
68_R	71_R	0.754	1.00
15_V	48_G	0.753	1.00
185_T	189_L	0.752	1.00
214_L	217_R	0.750	1.00
185_T	188_F	0.748	1.00
274_L	278_S	0.745	1.00
158_R	173_L	0.742	1.00
153_L	157_R	0.741	1.00
259_L	262_L	0.740	1.00
108_L	112_L	0.740	1.00
235_I	238_L	0.736	1.00
320_P	324_L	0.734	1.00
109_L	113_L	0.734	1.00
105_A	108_L	0.733	1.00
161_L	164_L	0.732	1.00
211_R	215_R	0.731	1.00
6_G	9_G	0.729	1.00
177_L	180_L	0.727	1.00
210_L	213_R	0.727	1.00
198_L	201_F	0.726	1.00
53_F	139_E	0.724	1.00
100_L	103_S	0.723	1.00
321_L	324_L	0.723	1.00
276_L	280_R	0.723	1.00
102_L	105_A	0.721	1.00
257_L	261_L	0.715	1.00
270_L	274_L	0.715	1.00
9_G	292_I	0.709	1.00
261_L	265_G	0.709	1.00
107_L	111_L	0.707	1.00
266_A	269_L	0.707	1.00
305_V	309_A	0.706	1.00
268_L	271_L	0.703	1.00
84_P	87_L	0.702	1.00
213_R	216_R	0.702	1.00
63_S	68_R	0.700	1.00
161_L	172_A	0.698	1.00
239_L	242_L	0.697	1.00
88_V	91_L	0.697	1.00
108_L	113_L	0.696	1.00
266_A	273_A	0.693	1.00
273_A	276_L	0.692	1.00
88_V	133_L	0.691	1.00
141_Q	145_L	0.689	1.00
322_L	326_L	0.689	1.00
304_L	308_R	0.687	1.00
259_L	273_A	0.686	1.00
254_Y	259_L	0.682	1.00
186_A	189_L	0.682	1.00
330_L	333_A	0.681	1.00
252_S	255_P	0.679	1.00
162_L	173_L	0.677	1.00
64_R	67_R	0.676	1.00
294_Y	298_L	0.676	1.00
44_G	48_G	0.674	1.00
234_L	237_L	0.674	1.00
6_G	287_V	0.673	1.00
308_R	312_G	0.670	1.00
200_E	203_L	0.670	1.00
164_L	168_L	0.668	1.00
64_R	68_R	0.666	1.00
172_A	176_L	0.663	1.00
108_L	115_L	0.661	1.00
214_L	218_R	0.660	1.00
268_L	276_L	0.659	1.00
177_L	181_F	0.659	1.00
221_L	224_L	0.651	1.00
136_L	294_Y	0.647	1.00
155_R	159_R	0.643	1.00
306_L	309_A	0.643	1.00
263_A	274_L	0.643	1.00
215_R	218_R	0.641	1.00
103_S	106_G	0.640	1.00
99_L	102_L	0.638	1.00
186_A	192_F	0.637	1.00
183_P	186_A	0.637	1.00
84_P	91_L	0.636	1.00
287_V	290_G	0.636	1.00
239_L	243_G	0.636	1.00
100_L	104_L	0.635	1.00
133_L	137_A	0.634	1.00
164_L	167_L	0.633	1.00
212_R	215_R	0.625	1.00
199_L	203_L	0.624	1.00
257_L	268_L	0.622	1.00
271_L	275_A	0.621	1.00
13_L	17_L	0.619	1.00
73_F	143_Y	0.618	1.00
166_A	170_L	0.618	1.00
84_P	92_L	0.617	1.00
12_A	15_V	0.615	1.00
120_Y	123_P	0.614	1.00
273_A	277_P	0.614	1.00
142_F	147_P	0.613	1.00
302_P	306_L	0.612	1.00
150_L	154_R	0.611	1.00
93_L	97_L	0.607	1.00
138_V	142_F	0.604	1.00
261_L	272_A	0.603	1.00
187_F	194_R	0.602	1.00
262_L	271_L	0.601	1.00
201_F	209_L	0.601	1.00
256_G	262_L	0.598	1.00
187_F	192_F	0.596	1.00
166_A	169_A	0.596	1.00
182_G	185_T	0.595	1.00
60_I	140_E	0.595	1.00
213_R	217_R	0.593	1.00
198_L	202_L	0.591	1.00
89_L	93_L	0.590	1.00
207_L	211_R	0.589	1.00
162_L	165_L	0.589	1.00
270_L	273_A	0.584	1.00
253_L	256_G	0.584	1.00
264_L	272_A	0.581	1.00
161_L	165_L	0.579	1.00
167_L	170_L	0.579	1.00
310_L	314_L	0.578	1.00
263_A	272_A	0.577	1.00
228_A	231_L	0.575	1.00
129_P	133_L	0.575	1.00
79_L	82_L	0.575	1.00
255_P	259_L	0.574	1.00
220_R	223_L	0.573	1.00
124_G	127_P	0.571	1.00
8_R	55_L	0.570	1.00
110_L	117_L	0.569	1.00
320_P	331_S	0.569	1.00
252_S	256_G	0.568	1.00
165_L	169_A	0.566	1.00
296_I	331_S	0.566	1.00
99_L	103_S	0.564	1.00
86_L	89_L	0.564	1.00
87_L	90_L	0.563	1.00
144_L	147_P	0.562	1.00
134_W	138_V	0.562	1.00
54_V	200_E	0.560	1.00
275_A	279_L	0.554	1.00
123_P	126_G	0.553	1.00
267_A	274_L	0.553	1.00
179_L	182_G	0.553	1.00
229_L	236_L	0.552	1.00
207_L	210_L	0.551	1.00
328_L	332_L	0.551	1.00
47_L	50_D	0.551	1.00
53_F	142_F	0.550	1.00
233_A	236_L	0.545	1.00
199_L	205_A	0.542	1.00
110_L	116_L	0.542	1.00
91_L	95_L	0.541	1.00
163_L	167_L	0.541	1.00
101_G	105_A	0.541	1.00
202_L	206_L	0.540	1.00
162_L	166_A	0.539	1.00
261_L	270_L	0.538	1.00
296_I	335_A	0.538	1.00
56_S	135_S	0.536	1.00
136_L	298_L	0.532	1.00
259_L	268_L	0.532	1.00
302_P	305_V	0.531	1.00
66_G	69_S	0.530	1.00
63_S	67_R	0.530	1.00
212_R	216_R	0.529	1.00
301_W	305_V	0.527	1.00
85_Y	92_L	0.526	1.00
254_Y	262_L	0.524	1.00
309_A	312_G	0.524	1.00
182_G	186_A	0.522	1.00
29_G	32_W	0.521	1.00
263_A	271_L	0.518	1.00
215_R	219_R	0.517	1.00
278_S	283_L	0.516	1.00
81_I	143_Y	0.516	1.00
226_L	229_L	0.515	1.00
206_L	209_L	0.515	1.00
110_L	115_L	0.512	1.00
218_R	221_L	0.512	1.00
163_L	166_A	0.511	1.00
257_L	262_L	0.511	1.00
266_A	274_L	0.510	1.00
121_F	124_G	0.508	1.00
104_L	107_L	0.507	1.00
261_L	264_L	0.502	1.00
251_P	254_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2latA	1	0.0882	2.3	0.946	Contact Map
1rklA	1	0.0853	1.4	0.952	Contact Map
3j1rA	5	0.0676	1	0.956	Contact Map
4uc1A	3	0.3412	1	0.957	Contact Map
4hfiA	3	0.2706	0.9	0.958	Contact Map
4p02A	1	0.3088	0.8	0.959	Contact Map
3j1zP	8	0.3735	0.8	0.96	Contact Map
2k1eA	3	0.2706	0.8	0.96	Contact Map
3w5aC	1	0.0794	0.7	0.96	Contact Map
2lulA	1	0.1618	0.7	0.961	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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