GREMLIN Database
EB - EB module
PFAM: PF01683 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (49)
Sequences: 3090 (2691)
Seq/√Len: 384.4
META: 0.182

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_L47_A3.4291.00
17_K20_E3.1911.00
42_P45_Y3.0211.00
16_V20_E2.8511.00
24_S27_Q2.1591.00
35_V40_Q2.0071.00
4_G15_K1.9191.00
33_V42_P1.6691.00
13_V27_Q1.5321.00
31_G42_P1.4591.00
18_L32_S1.4581.00
47_A50_G1.4521.00
21_S38_V1.3671.00
28_C39_C1.3661.00
17_K50_G1.3331.00
30_G33_V1.2231.00
48_V51_K1.2101.00
7_C41_C1.2061.00
8_V13_V1.1861.00
36_N40_Q1.1171.00
16_V27_Q1.0781.00
35_V43_P1.0781.00
6_V9_N1.0751.00
23_S27_Q1.0611.00
29_T32_S1.0391.00
19_G47_A0.9981.00
15_K30_G0.9701.00
15_K29_T0.8991.00
26_E31_G0.8141.00
23_S26_E0.7991.00
5_Y14_P0.7871.00
5_Y41_C0.7811.00
19_G34_C0.7501.00
24_S37_G0.7491.00
49_N52_C0.7421.00
43_P47_A0.7391.00
23_S44_G0.7381.00
18_L29_T0.7221.00
14_P20_E0.7191.00
37_G40_Q0.7171.00
6_V13_V0.7161.00
25_D42_P0.7151.00
47_A51_K0.6930.99
31_G45_Y0.6930.99
30_G47_A0.6840.99
21_S26_E0.6800.99
24_S51_K0.6770.99
21_S37_G0.6530.99
5_Y8_V0.6470.99
46_V50_G0.6410.99
16_V29_T0.6390.99
5_Y23_S0.6340.99
40_Q47_A0.6340.99
10_G15_K0.6180.99
17_K29_T0.6160.99
41_C52_C0.6140.99
12_C22_C0.6090.99
7_C29_T0.6050.99
22_C52_C0.6040.99
20_E50_G0.5990.98
8_V38_V0.5970.98
19_G40_Q0.5810.98
23_S51_K0.5670.98
6_V26_E0.5620.98
19_G38_V0.5590.98
11_K42_P0.5590.98
22_C41_C0.5550.97
22_C28_C0.5430.97
48_V52_C0.5350.97
14_P23_S0.5260.97
13_V37_G0.5210.96
6_V15_K0.5150.96
9_N49_N0.5020.96
15_K27_Q0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z1yA 2 0.7885 67 0.614 Contact Map
4um9B 2 0.1538 63.4 0.623 Contact Map
3fbyA 3 0.7115 62.5 0.625 Contact Map
4nehB 1 0.9038 62 0.627 Contact Map
1yo8A 1 0.9231 60.9 0.629 Contact Map
2wg3C 1 0.2885 58.5 0.634 Contact Map
4bspA 1 0.7692 58.4 0.634 Contact Map
2mgpA 1 0.9615 57.2 0.636 Contact Map
4ufrB 1 1 57.2 0.636 Contact Map
4xlwB 2 0.8846 55.3 0.641 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0041 seconds.