GREMLIN Database
Vmethyltransf - Viral methyltransferase
PFAM: PF01660 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 340 (326)
Sequences: 506 (419)
Seq/√Len: 23.2
META: 0.265

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_A155_A4.5281.00
138_L161_A4.4381.00
56_D59_G4.1211.00
227_Y243_I3.9691.00
34_K37_E3.7011.00
132_A159_L3.5741.00
5_L9_Q3.5031.00
234_S239_H3.3931.00
150_L227_Y3.3211.00
193_F196_D3.1941.00
121_E145_D3.1331.00
161_A241_F2.7330.99
161_A243_I2.6450.99
6_S9_Q2.5990.99
37_E40_L2.5780.99
193_F237_A2.5750.99
275_V296_L2.5300.99
30_H88_R2.5200.98
143_P213_W2.5160.98
296_L325_A2.3510.98
126_K154_G2.3460.98
229_V243_I2.3230.97
75_H123_C2.2930.97
88_R203_Y2.2800.97
136_D238_H2.2450.97
333_K336_Q2.2250.97
120_F149_A2.2120.96
166_P169_L2.1390.96
11_E15_K2.1240.95
101_S104_K2.1010.95
55_V153_H2.0750.95
146_L219_I2.0710.95
53_T222_P2.0660.95
37_E59_G2.0270.94
176_S185_W1.9800.93
34_K136_D1.9720.93
37_E79_P1.9170.92
311_R314_W1.8910.92
116_C123_C1.8880.92
123_C127_A1.8840.92
34_K38_N1.8550.91
98_S103_L1.8540.91
331_M335_R1.8490.91
134_A137_S1.8440.91
77_C123_C1.8440.91
146_L213_W1.8170.90
191_F195_P1.8020.90
190_K204_T1.7980.90
139_Y205_H1.7890.89
37_E61_K1.7630.89
56_D64_H1.7490.88
84_R132_A1.7320.88
134_A159_L1.6850.86
136_D168_E1.6850.86
37_E56_D1.6770.86
13_L167_P1.6770.86
56_D139_Y1.6630.85
119_T122_D1.6620.85
44_L240_L1.6600.85
33_A196_D1.6530.85
41_Y135_H1.6350.84
18_I35_A1.6340.84
140_D205_H1.6330.84
172_G207_L1.6070.83
316_I324_L1.6010.83
166_P176_S1.5990.83
55_V132_A1.5820.82
229_V241_F1.5710.82
160_Y240_L1.5600.81
79_P227_Y1.5260.80
30_H203_Y1.5160.79
200_G217_S1.5140.79
332_A336_Q1.5130.79
58_G140_D1.4850.78
58_G139_Y1.4820.78
56_D79_P1.4680.77
213_W227_Y1.4320.75
29_S201_E1.4310.75
44_L133_F1.4290.75
163_L193_F1.4170.75
223_G274_R1.4160.75
160_Y242_S1.4080.74
151_E221_L1.3920.73
111_E114_P1.3910.73
243_I293_L1.3800.73
140_D210_L1.3700.72
136_D139_Y1.3680.72
317_D320_L1.3660.72
81_L119_T1.3610.72
218_K247_D1.3510.71
269_K292_L1.3470.71
34_K61_K1.3400.70
310_V318_P1.3350.70
107_D110_K1.3340.70
126_K189_G1.3190.69
309_T325_A1.3160.69
136_D195_P1.3030.68
82_D140_D1.2830.67
316_I321_L1.2740.66
166_P237_A1.2640.66
12_L15_K1.2630.66
251_P327_A1.2530.65
33_A205_H1.2300.64
61_K309_T1.2280.63
106_K110_K1.2260.63
136_D182_Y1.2260.63
198_S201_E1.2190.63
312_S316_I1.2150.63
7_P187_R1.2110.62
135_H205_H1.2110.62
323_D326_V1.2040.62
151_E223_G1.2040.62
59_G76_C1.2020.62
39_L304_V1.1980.61
192_I202_S1.1960.61
322_P326_V1.1860.61
161_A314_W1.1820.60
5_L274_R1.1760.60
196_D199_L1.1700.60
138_L168_E1.1640.59
82_D298_S1.1590.59
5_L292_L1.1420.58
58_G75_H1.1400.58
204_T256_K1.1260.57
36_L238_H1.1190.56
119_T210_L1.1150.56
320_L327_A1.1110.56
13_L32_V1.1010.55
84_R241_F1.0930.54
33_A193_F1.0820.54
59_G64_H1.0730.53
100_L104_K1.0650.52
294_S335_R1.0590.52
123_C140_D1.0580.52
9_Q13_L1.0500.51
309_T333_K1.0360.50
44_L57_I1.0330.50
273_P292_L1.0330.50
219_I229_V1.0310.50
165_F179_P1.0210.49
139_Y210_L1.0190.49
108_R114_P1.0190.49
29_S45_P1.0180.49
148_D152_R1.0120.49
229_V236_G1.0100.49
312_S326_V1.0090.48
279_A292_L1.0080.48
77_C116_C1.0060.48
3_Y86_A1.0060.48
218_K228_S1.0030.48
323_D327_A0.9960.48
227_Y307_G0.9870.47
137_S205_H0.9860.47
59_G134_A0.9830.47
332_A335_R0.9830.47
77_C140_D0.9760.46
58_G77_C0.9730.46
163_L216_T0.9720.46
208_S319_D0.9710.46
162_T310_V0.9700.46
313_G321_L0.9680.46
133_F223_G0.9660.45
315_D328_I0.9650.45
101_S111_E0.9620.45
36_L136_D0.9570.45
173_D184_F0.9540.45
140_D230_E0.9500.44
317_D324_L0.9450.44
121_E144_E0.9430.44
164_V314_W0.9420.44
327_A332_A0.9420.44
26_T75_H0.9270.43
57_I123_C0.9260.43
194_Y197_G0.9230.43
194_Y258_S0.9130.42
136_D239_H0.9050.41
98_S190_K0.9040.41
84_R230_E0.9000.41
169_L207_L0.8990.41
230_E246_G0.8960.41
200_G273_P0.8910.40
221_L224_G0.8890.40
79_P210_L0.8880.40
11_E269_K0.8870.40
8_E12_L0.8860.40
95_S99_Y0.8830.40
317_D326_V0.8800.40
165_F213_W0.8730.39
75_H79_P0.8710.39
124_D127_A0.8710.39
29_S162_T0.8700.39
161_A227_Y0.8700.39
178_N299_L0.8700.39
150_L156_L0.8700.39
7_P25_A0.8700.39
79_P150_L0.8650.39
58_G61_K0.8630.38
54_F283_P0.8610.38
123_C152_R0.8580.38
97_R102_R0.8570.38
165_F210_L0.8570.38
15_K187_R0.8560.38
118_N124_D0.8560.38
103_L106_K0.8530.38
292_L325_A0.8500.38
97_R101_S0.8490.38
132_A191_F0.8440.37
251_P318_P0.8430.37
102_R105_D0.8410.37
184_F214_L0.8400.37
87_A91_N0.8310.36
308_K313_G0.8300.36
320_L325_A0.8260.36
5_L160_Y0.8250.36
254_P260_G0.8220.36
58_G123_C0.8210.36
321_L325_A0.8200.36
58_G79_P0.8200.36
284_V287_T0.8190.36
303_V306_N0.8180.36
37_E58_G0.8140.35
138_L314_W0.8130.35
9_Q14_S0.8130.35
224_G294_S0.8110.35
147_A219_I0.8060.35
33_A181_L0.8050.35
170_L267_V0.8040.35
255_D258_S0.8040.35
158_T242_S0.8030.35
179_P318_P0.8020.35
320_L328_I0.8020.35
95_S105_D0.8000.34
37_E135_H0.8000.34
103_L113_D0.7950.34
35_A48_L0.7940.34
243_I259_F0.7930.34
71_N167_P0.7890.34
77_C81_L0.7870.34
109_S114_P0.7870.34
219_I227_Y0.7860.34
109_S113_D0.7820.33
196_D205_H0.7790.33
142_S213_W0.7770.33
310_V316_I0.7760.33
195_P198_S0.7720.33
6_S122_D0.7700.33
310_V336_Q0.7680.32
111_E179_P0.7680.32
97_R105_D0.7670.32
102_R106_K0.7670.32
8_E163_L0.7660.32
309_T322_P0.7660.32
139_Y278_Y0.7630.32
293_L297_R0.7630.32
187_R247_D0.7620.32
105_D111_E0.7600.32
114_P118_N0.7590.32
297_R301_K0.7590.32
34_K40_L0.7580.32
308_K323_D0.7550.32
310_V314_W0.7530.31
155_A159_L0.7530.31
7_P14_S0.7490.31
302_R305_I0.7470.31
110_K113_D0.7460.31
115_F327_A0.7450.31
155_A158_T0.7420.31
44_L162_T0.7420.31
116_C140_D0.7410.31
325_A328_I0.7410.31
62_L162_T0.7390.31
141_I149_A0.7360.30
311_R320_L0.7350.30
163_L245_R0.7320.30
169_L185_W0.7320.30
32_V233_E0.7320.30
134_A213_W0.7310.30
260_G304_V0.7280.30
198_S236_G0.7280.30
4_A12_L0.7280.30
34_K301_K0.7260.30
301_K307_G0.7240.30
292_L296_L0.7240.30
16_L236_G0.7200.30
239_H306_N0.7180.29
251_P321_L0.7120.29
185_W202_S0.7110.29
59_G79_P0.7080.29
233_E267_V0.7070.29
295_Y299_L0.7050.29
57_I77_C0.7040.29
48_L250_T0.7040.29
6_S14_S0.7040.29
165_F172_G0.7040.29
79_P119_T0.7010.28
56_D135_H0.6980.28
188_G266_L0.6950.28
293_L321_L0.6950.28
313_G320_L0.6940.28
299_L302_R0.6940.28
171_F289_Y0.6930.28
33_A139_Y0.6930.28
308_K328_I0.6910.28
96_L175_E0.6910.28
59_G139_Y0.6900.28
81_L180_E0.6890.28
150_L245_R0.6870.28
142_S158_T0.6870.28
98_S111_E0.6860.28
26_T261_P0.6850.28
34_K58_G0.6850.28
290_E297_R0.6850.28
161_A287_T0.6840.27
262_F276_L0.6830.27
79_P137_S0.6830.27
27_P147_A0.6810.27
136_D164_V0.6790.27
322_P335_R0.6790.27
99_Y105_D0.6780.27
171_F215_T0.6760.27
324_L328_I0.6760.27
315_D326_V0.6750.27
214_L328_I0.6740.27
85_D88_R0.6720.27
289_Y293_L0.6720.27
231_L239_H0.6710.27
316_I326_V0.6700.27
42_E223_G0.6670.27
161_A271_F0.6660.26
310_V313_G0.6640.26
249_L267_V0.6580.26
166_P314_W0.6550.26
195_P295_Y0.6530.26
85_D164_V0.6520.26
201_E305_I0.6520.26
134_A138_L0.6490.26
145_D169_L0.6460.25
256_K259_F0.6440.25
132_A169_L0.6430.25
77_C142_S0.6420.25
174_K183_T0.6390.25
211_L268_P0.6390.25
10_K29_S0.6390.25
314_W326_V0.6370.25
100_L109_S0.6350.25
136_D140_D0.6350.25
96_L102_R0.6340.25
121_E125_V0.6330.25
56_D77_C0.6320.25
149_A205_H0.6310.25
212_S227_Y0.6310.25
31_P166_P0.6300.25
136_D166_P0.6300.25
63_R141_I0.6300.25
61_K136_D0.6280.24
97_R130_P0.6280.24
78_N89_Y0.6260.24
15_K192_I0.6230.24
16_L20_F0.6230.24
102_R109_S0.6220.24
231_L241_F0.6210.24
95_S100_L0.6190.24
115_F322_P0.6180.24
4_A147_A0.6150.24
5_L154_G0.6140.24
132_A140_D0.6140.24
99_Y104_K0.6130.24
67_R84_R0.6130.24
278_Y281_C0.6080.23
145_D163_L0.6070.23
162_T238_H0.6070.23
138_L159_L0.6070.23
323_D328_I0.6060.23
322_P325_A0.6050.23
320_L323_D0.6030.23
75_H142_S0.6030.23
61_K162_T0.6030.23
75_H140_D0.6020.23
109_S112_L0.6020.23
71_N297_R0.6010.23
59_G90_T0.6010.23
319_D324_L0.6000.23
116_C121_E0.6000.23
40_L162_T0.5990.23
309_T312_S0.5960.23
104_K179_P0.5960.23
173_D215_T0.5940.23
96_L100_L0.5930.23
310_V321_L0.5930.23
240_L250_T0.5920.23
79_P140_D0.5910.23
177_L181_L0.5900.23
108_R111_E0.5890.23
29_S43_V0.5890.23
178_N226_V0.5890.23
26_T63_R0.5880.22
114_P189_G0.5870.22
120_F134_A0.5870.22
51_D145_D0.5870.22
93_A115_F0.5860.22
135_H139_Y0.5850.22
164_V238_H0.5850.22
167_P274_R0.5840.22
113_D159_L0.5830.22
306_N315_D0.5830.22
139_Y203_Y0.5820.22
121_E274_R0.5800.22
18_I181_L0.5800.22
191_F205_H0.5780.22
15_K185_W0.5770.22
98_S106_K0.5720.22
312_S318_P0.5710.22
27_P84_R0.5680.22
311_R328_I0.5670.21
56_D140_D0.5660.21
251_P317_D0.5650.21
58_G137_S0.5650.21
51_D138_L0.5640.21
146_L324_L0.5640.21
5_L10_K0.5620.21
99_Y267_V0.5620.21
64_H75_H0.5620.21
145_D177_L0.5610.21
18_I22_P0.5600.21
155_A187_R0.5580.21
206_P224_G0.5580.21
322_P328_I0.5570.21
185_W197_G0.5560.21
316_I320_L0.5560.21
5_L147_A0.5560.21
14_S186_I0.5560.21
313_G324_L0.5550.21
87_A207_L0.5480.21
22_P139_Y0.5470.21
33_A56_D0.5460.20
143_P215_T0.5440.20
127_A244_T0.5440.20
49_P298_S0.5440.20
93_A97_R0.5430.20
149_A152_R0.5420.20
79_P306_N0.5410.20
4_A15_K0.5410.20
287_T291_K0.5390.20
3_Y10_K0.5370.20
103_L111_E0.5370.20
3_Y209_N0.5350.20
124_D319_D0.5330.20
134_A219_I0.5330.20
193_F200_G0.5330.20
141_I197_G0.5320.20
144_E267_V0.5310.20
239_H322_P0.5310.20
40_L56_D0.5290.20
9_Q12_L0.5290.20
301_K316_I0.5260.20
87_A242_S0.5250.20
310_V323_D0.5250.20
36_L227_Y0.5250.20
216_T244_T0.5230.19
155_A220_V0.5230.19
311_R319_D0.5230.19
31_P307_G0.5230.19
123_C272_V0.5230.19
194_Y263_E0.5210.19
212_S215_T0.5190.19
172_G222_P0.5190.19
105_D109_S0.5190.19
140_D206_P0.5180.19
95_S103_L0.5150.19
34_K259_F0.5140.19
57_I302_R0.5140.19
31_P149_A0.5130.19
9_Q217_S0.5130.19
190_K255_D0.5120.19
84_R136_D0.5120.19
26_T131_Y0.5100.19
162_T324_L0.5090.19
6_S223_G0.5090.19
302_R307_G0.5070.19
119_T222_P0.5070.19
102_R190_K0.5050.19
189_G284_V0.5040.19
311_R321_L0.5030.19
139_Y302_R0.5030.19
37_E238_H0.5020.19
97_R159_L0.5020.19
3_Y286_K0.5020.19
178_N189_G0.5000.18
107_D111_E0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hnrA 1 0.5382 18.5 0.96 Contact Map
2gsvA 3 0.2 11.7 0.963 Contact Map
1x93A 2 0.1176 8.6 0.966 Contact Map
2zkoA 2 0.0735 7.7 0.966 Contact Map
2lf0A 1 0.1441 7.4 0.967 Contact Map
3p9cA 2 0.6088 6.9 0.967 Contact Map
1zg3A 2 0.6206 6.8 0.967 Contact Map
2knjA 1 0.0882 5.6 0.968 Contact Map
3reoA 2 0.6294 5.3 0.969 Contact Map
3mczA 2 0.6412 5.2 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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