GREMLIN Database
MotA_ExbB - MotA/TolQ/ExbB proton channel family
PFAM: PF01618 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 123 (118)
Sequences: 45316 (22401)
Seq/√Len: 2062.1
META: 0.864

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
66_N88_E3.0521.00
35_V118_V2.9881.00
109_Y113_R2.5951.00
12_G27_L2.4011.00
11_A30_A2.0761.00
7_R34_E2.0471.00
10_A14_R2.0281.00
34_E37_R1.9681.00
69_Q87_A1.8951.00
49_G104_V1.8891.00
112_R116_R1.8501.00
19_D22_A1.8381.00
66_N70_A1.8191.00
30_A34_E1.7891.00
59_G92_T1.7821.00
42_L114_V1.7631.00
65_I94_A1.7221.00
52_A99_V1.6931.00
62_W88_E1.6901.00
66_N85_G1.6641.00
62_W94_A1.6611.00
113_R117_L1.6591.00
51_V105_I1.6431.00
38_L114_V1.6291.00
61_V93_T1.6161.00
107_Y111_S1.6001.00
69_Q73_A1.5471.00
99_V103_A1.4921.00
36_A119_A1.4501.00
20_P24_E1.4001.00
70_A81_V1.3961.00
18_R22_A1.3641.00
81_V84_P1.3561.00
34_E38_L1.3501.00
78_S81_V1.3451.00
29_R33_R1.3441.00
47_T108_N1.3261.00
70_A73_A1.3261.00
72_A87_A1.3071.00
24_E28_E1.2961.00
74_A81_V1.2671.00
58_L94_A1.2631.00
46_A107_Y1.2461.00
113_R116_R1.2431.00
44_F48_I1.2301.00
45_L106_A1.2211.00
7_R10_A1.2061.00
31_I35_V1.1811.00
22_A26_A1.1621.00
63_G85_G1.1531.00
30_A33_R1.1401.00
9_L13_L1.1371.00
114_V118_V1.1251.00
28_E32_A1.1111.00
35_V114_V1.0881.00
26_A30_A1.0791.00
25_R28_E1.0501.00
72_A84_P1.0441.00
58_L98_A1.0431.00
117_L120_E1.0321.00
73_A81_V1.0211.00
45_L103_A1.0201.00
111_S115_D1.0141.00
66_N69_Q1.0121.00
36_A116_R1.0081.00
35_V39_E1.0021.00
91_I95_A0.9921.00
47_T105_I0.9871.00
67_A85_G0.9841.00
38_L117_L0.9801.00
75_G78_S0.9771.00
32_A36_A0.9751.00
70_A74_A0.9681.00
50_S104_V0.9581.00
70_A85_G0.9491.00
108_N111_S0.9321.00
21_E25_R0.9241.00
73_A80_A0.9141.00
79_L84_P0.9061.00
106_A110_L0.8971.00
48_I103_A0.8961.00
42_L46_A0.8841.00
43_S112_R0.8811.00
97_L101_I0.8741.00
22_A25_R0.8691.00
23_I26_A0.8561.00
58_L97_L0.8551.00
58_L62_W0.8541.00
62_W66_N0.8471.00
11_A15_E0.8201.00
67_A70_A0.8201.00
39_E114_V0.8181.00
20_P25_R0.8121.00
50_S53_P0.8001.00
62_W65_I0.7991.00
52_A103_A0.7891.00
29_R36_A0.7881.00
92_T99_V0.7861.00
11_A14_R0.7861.00
31_I118_V0.7791.00
58_L101_I0.7781.00
118_V122_E0.7731.00
65_I91_I0.7731.00
43_S47_T0.7711.00
6_A10_A0.7691.00
67_A90_L0.7581.00
89_A93_T0.7491.00
71_I83_A0.7491.00
25_R29_R0.7481.00
13_L16_L0.7471.00
69_Q72_A0.7451.00
15_E26_A0.7361.00
61_V90_L0.7291.00
32_A35_V0.7261.00
23_I27_L0.7261.00
105_I109_Y0.7251.00
74_A77_A0.7191.00
19_D23_I0.7141.00
76_S80_A0.7101.00
51_V104_V0.7061.00
43_S46_A0.6971.00
42_L110_L0.6911.00
26_A29_R0.6881.00
54_F100_A0.6831.00
42_L111_S0.6801.00
118_V121_M0.6781.00
61_V94_A0.6671.00
55_L101_I0.6601.00
46_A50_S0.6541.00
8_V121_M0.6541.00
106_A109_Y0.6451.00
84_P88_E0.6421.00
29_R32_A0.6331.00
46_A108_N0.6301.00
12_G16_L0.6251.00
73_A77_A0.6201.00
31_I121_M0.6181.00
48_I52_A0.6161.00
112_R115_D0.6121.00
102_P106_A0.6111.00
21_E24_E0.6101.00
46_A111_S0.6091.00
73_A76_S0.6021.00
70_A79_L0.6001.00
94_A98_A0.5911.00
115_D118_V0.5891.00
95_A99_V0.5851.00
116_R120_E0.5791.00
15_E18_R0.5751.00
98_A102_P0.5731.00
119_A122_E0.5731.00
7_R37_R0.5661.00
33_R36_A0.5651.00
104_V108_N0.5611.00
12_G15_E0.5601.00
99_V102_P0.5551.00
39_E43_S0.5541.00
76_S79_L0.5501.00
27_L30_A0.5491.00
74_A78_S0.5491.00
37_R40_R0.5471.00
51_V101_I0.5471.00
40_R43_S0.5441.00
44_F47_T0.5381.00
67_A82_V0.5351.00
57_L86_I0.5341.00
42_L107_Y0.5331.00
6_A9_L0.5321.00
109_Y112_R0.5311.00
60_T94_A0.5281.00
57_L93_T0.5251.00
20_P23_I0.5201.00
88_E91_I0.5081.00
54_F64_I0.5041.00
68_F85_G0.5041.00
16_L19_D0.5021.00
49_G107_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kluA 1 0.3659 13.3 0.889 Contact Map
4tllB 2 0.6098 12.2 0.89 Contact Map
4tllA 1 0.4553 9.5 0.896 Contact Map
1ji6A 1 0.4878 9.1 0.897 Contact Map
4cbkA 3 0.4959 8.8 0.897 Contact Map
4ev6A 3 0.8293 8.5 0.898 Contact Map
4u2pA 4 0.6423 8.1 0.899 Contact Map
3eb7A 2 0.5203 7.8 0.899 Contact Map
4aurA 1 0.9106 7.4 0.9 Contact Map
4v1gA 3 0.6423 7.3 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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