GREMLIN Database
DDE_Tnp_ISL3 - Transposase
PFAM: PF01610 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 240 (237)
Sequences: 26090 (15172)
Seq/√Len: 985.6
META: 0.945

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_K68_K3.2411.00
88_K92_E3.2321.00
60_M79_I2.9841.00
164_P205_D2.7471.00
163_S166_W2.5691.00
89_L192_T2.5461.00
154_E177_W2.4841.00
90_L189_L2.4251.00
172_D197_R2.3741.00
45_E73_H2.3041.00
41_E73_H2.2711.00
58_V70_V2.2631.00
179_R194_R2.2081.00
48_G51_R2.1681.00
34_G39_T2.1521.00
62_M81_F2.0801.00
97_V148_A1.9931.00
48_G52_R1.9861.00
100_R185_P1.9811.00
227_A230_F1.9541.00
81_F199_G1.9541.00
57_A208_I1.9481.00
3_I40_L1.9291.00
123_N156_R1.9131.00
41_E72_E1.9101.00
19_V213_V1.8461.00
168_R197_R1.8261.00
176_A180_R1.8251.00
41_E69_A1.8191.00
232_N235_N1.7731.00
55_I74_L1.7531.00
90_L155_L1.7441.00
146_A150_L1.7381.00
96_E99_R1.7191.00
101_E144_K1.6991.00
60_M70_V1.6791.00
37_K72_E1.6761.00
221_K224_K1.6651.00
36_S39_T1.6241.00
67_I81_F1.6031.00
175_I194_R1.5841.00
84_F88_K1.5771.00
233_F237_R1.5611.00
161_Y170_F1.5551.00
101_E104_E1.5401.00
218_N225_R1.5351.00
2_G21_L1.5311.00
83_R87_V1.5301.00
219_K228_Y1.5271.00
222_V228_Y1.5261.00
164_P168_R1.5201.00
117_R121_L1.5081.00
199_G202_N1.4921.00
49_E53_A1.4891.00
44_F70_V1.4771.00
123_N126_N1.4731.00
215_G218_N1.4731.00
69_A73_H1.4721.00
20_D25_T1.4671.00
2_G213_V1.4551.00
67_I71_R1.4521.00
6_I221_K1.4421.00
17_V220_I1.4381.00
78_V205_D1.4281.00
95_D99_R1.4141.00
158_L170_F1.4081.00
128_T131_Q1.4021.00
116_S120_L1.3961.00
161_Y166_W1.3861.00
122_K131_Q1.3841.00
68_K72_E1.3811.00
174_W178_A1.3631.00
222_V225_R1.3491.00
100_R144_K1.3301.00
97_V185_P1.3291.00
218_N228_Y1.3071.00
57_A206_H1.3071.00
59_A208_I1.2871.00
7_S11_G1.2841.00
51_R54_K1.2831.00
179_R191_R1.2731.00
59_A210_N1.2691.00
210_N213_V1.2441.00
41_E45_E1.2431.00
127_L135_L1.2421.00
19_V216_L1.2361.00
178_A186_F1.2321.00
184_P187_K1.2161.00
78_V202_N1.2011.00
165_A169_R1.1991.00
57_A80_V1.1991.00
18_V43_F1.1981.00
175_I179_R1.1971.00
67_I199_G1.1951.00
37_K41_E1.1711.00
175_I190_A1.1681.00
92_E96_E1.1681.00
87_V156_R1.1651.00
179_R187_K1.1501.00
52_R73_H1.1481.00
60_M67_I1.1481.00
197_R201_L1.1461.00
35_R63_S1.1441.00
168_R201_L1.1321.00
16_T20_D1.1281.00
151_L178_A1.1231.00
196_H199_G1.1221.00
95_D98_R1.1141.00
222_V226_R1.1121.00
176_A179_R1.1121.00
67_I79_I1.1071.00
215_G219_K1.1021.00
167_A204_F1.0961.00
125_E156_R1.0951.00
168_R172_D1.0931.00
44_F74_L1.0791.00
26_G212_F1.0721.00
33_E233_F1.0711.00
89_L92_E1.0661.00
99_R103_R1.0651.00
96_E100_R1.0631.00
71_R79_I1.0531.00
67_I196_H1.0521.00
31_V237_R1.0411.00
175_I197_R1.0331.00
218_N222_V1.0331.00
83_R203_Y1.0231.00
151_L186_F1.0231.00
157_Q160_D1.0201.00
90_L186_F1.0131.00
158_L200_I1.0121.00
52_R74_L1.0091.00
95_D121_L1.0091.00
64_P68_K1.0041.00
102_Q114_K1.0041.00
55_I77_A0.9941.00
122_K126_N0.9891.00
14_Y20_D0.9841.00
151_L177_W0.9791.00
94_L152_K0.9761.00
124_P153_E0.9741.00
93_A188_K0.9711.00
181_S187_K0.9671.00
224_K236_F0.9671.00
89_L189_L0.9621.00
203_Y209_T0.9511.00
191_R195_R0.9501.00
7_S12_H0.9461.00
166_W169_R0.9421.00
6_I15_L0.9371.00
101_E145_L0.9341.00
32_G42_A0.9251.00
32_G39_T0.9251.00
17_V20_D0.9121.00
1_I18_V0.9111.00
78_V206_H0.9071.00
7_S10_K0.8951.00
93_A189_L0.8951.00
38_E42_A0.8951.00
83_R160_D0.8911.00
153_E156_R0.8821.00
168_R198_D0.8811.00
225_R228_Y0.8771.00
234_E237_R0.8761.00
33_E237_R0.8731.00
39_T42_A0.8691.00
21_L25_T0.8691.00
71_R199_G0.8671.00
124_P132_R0.8601.00
118_W122_K0.8581.00
148_A186_F0.8541.00
21_L59_A0.8461.00
86_V159_W0.8461.00
215_G228_Y0.8401.00
20_D24_D0.8381.00
218_N221_K0.8371.00
62_M89_L0.8361.00
9_R13_R0.8311.00
182_R187_K0.8301.00
80_V202_N0.8281.00
30_W42_A0.8271.00
189_L192_T0.8251.00
87_V91_N0.8231.00
187_K190_A0.8221.00
127_L149_Y0.8201.00
80_V206_H0.8191.00
187_K191_R0.8191.00
202_N205_D0.8131.00
212_F216_L0.8101.00
96_E188_K0.8061.00
53_A76_N0.8011.00
60_M81_F0.7991.00
95_D117_R0.7891.00
96_E185_P0.7891.00
116_S138_L0.7891.00
203_Y207_R0.7851.00
64_P196_H0.7791.00
116_S134_R0.7741.00
106_R114_K0.7721.00
134_R137_E0.7691.00
132_R136_E0.7651.00
65_A68_K0.7611.00
30_W43_F0.7601.00
38_E41_E0.7601.00
194_R197_R0.7571.00
189_L193_L0.7561.00
139_L146_A0.7551.00
119_L134_R0.7541.00
8_L13_R0.7511.00
62_M86_V0.7511.00
6_I220_I0.7511.00
127_L131_Q0.7501.00
86_V200_I0.7501.00
164_P201_L0.7441.00
47_L51_R0.7431.00
154_E170_F0.7411.00
64_P67_I0.7381.00
120_L145_L0.7341.00
70_V79_I0.7341.00
83_R209_T0.7331.00
116_S119_L0.7331.00
8_L15_L0.7291.00
154_E157_Q0.7291.00
149_Y153_E0.7261.00
223_I226_R0.7231.00
100_R104_E0.7221.00
124_P149_Y0.7201.00
171_L175_I0.7181.00
80_V203_Y0.7091.00
131_Q134_R0.7081.00
179_R190_A0.7041.00
106_R110_R0.7041.00
221_K225_R0.7041.00
122_K128_T0.7001.00
151_L181_S0.6971.00
102_Q106_R0.6951.00
14_Y18_V0.6951.00
172_D176_A0.6931.00
30_W237_R0.6911.00
1_I58_V0.6901.00
20_D27_R0.6881.00
147_R150_L0.6861.00
91_N152_K0.6831.00
15_L233_F0.6821.00
184_P188_K0.6821.00
94_L120_L0.6791.00
18_V30_W0.6761.00
44_F73_H0.6741.00
235_N238_L0.6721.00
112_L141_L0.6651.00
37_K69_A0.6631.00
178_A190_A0.6611.00
3_I60_M0.6601.00
91_N121_L0.6591.00
177_W180_R0.6531.00
162_K166_W0.6531.00
137_E140_R0.6521.00
7_S14_Y0.6511.00
28_V31_V0.6511.00
192_T195_R0.6511.00
155_L174_W0.6491.00
166_W170_F0.6491.00
123_N152_K0.6461.00
147_R182_R0.6411.00
63_S68_K0.6391.00
42_A45_E0.6361.00
79_I199_G0.6341.00
231_R235_N0.6331.00
94_L148_A0.6321.00
2_G19_V0.6271.00
89_L188_K0.6271.00
170_F173_R0.6241.00
209_T212_F0.6221.00
143_P146_A0.6131.00
40_L69_A0.6131.00
171_L193_L0.6111.00
9_R12_H0.6041.00
62_M192_T0.6031.00
173_R177_W0.5971.00
108_E111_K0.5961.00
186_F189_L0.5961.00
93_A97_V0.5961.00
49_E52_R0.5951.00
14_Y17_V0.5921.00
17_V28_V0.5901.00
92_E95_D0.5871.00
92_E99_R0.5871.00
122_K127_L0.5871.00
105_L109_K0.5871.00
80_V208_I0.5801.00
158_L171_L0.5801.00
179_R182_R0.5791.00
100_R103_R0.5781.00
106_R109_K0.5741.00
167_A201_L0.5701.00
188_K191_R0.5701.00
123_N160_D0.5701.00
201_L204_F0.5701.00
143_P147_R0.5661.00
142_N146_A0.5661.00
173_R176_A0.5651.00
99_R117_R0.5631.00
18_V21_L0.5601.00
30_W39_T0.5581.00
188_K192_T0.5571.00
68_K71_R0.5571.00
12_H35_R0.5561.00
2_G59_A0.5551.00
127_L132_R0.5541.00
151_L174_W0.5521.00
135_L139_L0.5511.00
17_V21_L0.5491.00
93_A186_F0.5491.00
159_W204_F0.5471.00
44_F69_A0.5471.00
42_A46_R0.5461.00
110_R114_K0.5451.00
230_F235_N0.5441.00
7_S13_R0.5421.00
144_K183_L0.5411.00
40_L43_F0.5411.00
88_K91_N0.5381.00
141_L144_K0.5371.00
45_E52_R0.5371.00
144_K147_R0.5351.00
94_L186_F0.5351.00
83_R156_R0.5341.00
235_N239_R0.5331.00
230_F236_F0.5331.00
129_E132_R0.5321.00
193_L200_I0.5311.00
139_L149_Y0.5301.00
150_L154_E0.5271.00
140_R143_P0.5261.00
158_L167_A0.5241.00
57_A78_V0.5231.00
21_L24_D0.5211.00
15_L20_D0.5191.00
216_L219_K0.5181.00
35_R65_A0.5171.00
129_E133_E0.5171.00
58_V74_L0.5161.00
157_Q170_F0.5151.00
158_L161_Y0.5131.00
139_L150_L0.5111.00
59_A80_V0.5101.00
226_R239_R0.5081.00
109_K141_L0.5071.00
112_L137_E0.5061.00
159_W203_Y0.5061.00
15_L18_V0.5051.00
220_I236_F0.5051.00
219_K222_V0.5021.00
147_R181_S0.5021.00
1_I29_L0.5011.00
57_A202_N0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cf8A 2 0.5792 76 0.921 Contact Map
1ex4A 5 0.5792 68 0.926 Contact Map
4u7bA 2 0.6417 67.5 0.926 Contact Map
1cxqA 2 0.4833 61.1 0.929 Contact Map
4fw2A 2 0.4708 60.2 0.929 Contact Map
4fw1A 2 0.6333 48.6 0.934 Contact Map
1c6vA 4 0.575 48.5 0.934 Contact Map
3oymA 3 0.4958 34.7 0.94 Contact Map
2bw3A 3 0.9417 31.8 0.941 Contact Map
3hphA 3 0.5917 31.6 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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