GREMLIN Database
DUF21 - Domain of unknown function DUF21
PFAM: PF01595 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 184 (181)
Sequences: 72584 (45516)
Seq/√Len: 3383.2
META: 0.864

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
128_R132_R3.7851.00
139_W143_G3.2841.00
35_A46_L2.8571.00
44_R128_R2.8121.00
115_N118_R2.7641.00
47_R128_R2.4591.00
98_F144_S2.3181.00
122_L126_P2.3171.00
135_Y139_W2.2611.00
143_G147_L2.2291.00
30_R117_E2.1721.00
44_R125_P2.0951.00
46_L50_E2.0241.00
18_A112_A2.0191.00
12_L66_A2.0091.00
51_N54_R1.9841.00
126_P129_L1.9701.00
118_R122_L1.9531.00
34_L121_L1.9031.00
70_A96_I1.8941.00
16_F62_G1.8881.00
19_S123_V1.8751.00
39_D121_L1.8741.00
34_L39_D1.8531.00
32_E46_L1.8171.00
54_R135_Y1.8041.00
147_L151_L1.7911.00
47_R51_N1.7041.00
143_G146_N1.6671.00
33_Q37_E1.6661.00
35_A43_R1.6641.00
132_R135_Y1.6401.00
45_A120_A1.6401.00
54_R131_S1.6301.00
16_F130_L1.6121.00
13_S67_N1.6071.00
15_F126_P1.6001.00
44_R124_A1.5851.00
58_T131_S1.5541.00
45_A124_A1.5431.00
125_P129_L1.5061.00
48_L124_A1.4891.00
74_A96_I1.4621.00
147_L150_R1.4511.00
59_I127_L1.4431.00
15_F123_V1.4371.00
123_V126_P1.4351.00
122_L125_P1.4211.00
131_S135_Y1.4201.00
54_R139_W1.3631.00
40_R125_P1.3581.00
72_A75_E1.3491.00
41_G121_L1.3451.00
42_A121_L1.3451.00
164_E168_R1.3161.00
41_G125_P1.3101.00
78_L81_L1.3001.00
18_A119_I1.2791.00
142_N146_N1.2781.00
32_E35_A1.2631.00
44_R47_R1.2581.00
136_P140_L1.2501.00
86_T90_A1.2411.00
32_E36_E1.2381.00
72_A76_A1.2371.00
21_T24_V1.2251.00
128_R131_S1.1961.00
58_T130_L1.1891.00
54_R142_N1.1631.00
88_A92_A1.1511.00
30_R33_Q1.1351.00
53_D146_N1.1231.00
30_R34_L1.1221.00
43_R46_L1.1091.00
67_N100_I1.1031.00
80_R83_G1.0981.00
48_L55_L1.0961.00
106_L110_T1.0891.00
18_A123_V1.0651.00
9_L66_A1.0631.00
6_I70_A1.0611.00
58_T138_V1.0581.00
118_R121_L1.0541.00
140_L143_G1.0501.00
81_L84_P1.0491.00
68_I71_G1.0431.00
90_A94_L1.0411.00
52_P55_L1.0341.00
5_L73_L1.0321.00
76_A80_R1.0101.00
8_L12_L1.0091.00
149_L154_I1.0081.00
31_L45_A1.0031.00
39_D42_A1.0001.00
133_L136_P0.9991.00
31_L46_L0.9921.00
169_A173_E0.9831.00
3_L7_L0.9811.00
19_S127_L0.9771.00
10_L104_G0.9761.00
129_L132_R0.9711.00
9_L70_A0.9711.00
31_L49_L0.9641.00
174_G178_G0.9621.00
10_L99_L0.9621.00
34_L117_E0.9581.00
53_D142_N0.9541.00
87_L91_I0.9521.00
13_S63_N0.9451.00
75_E79_A0.9411.00
9_L69_L0.9391.00
20_E109_K0.9381.00
112_A119_I0.9301.00
87_L90_A0.9291.00
34_L37_E0.9291.00
43_R47_R0.9191.00
119_I123_V0.9151.00
78_L82_L0.9141.00
28_R50_E0.9121.00
89_V93_T0.9021.00
80_R84_P0.8811.00
26_L30_R0.8741.00
4_L8_L0.8731.00
55_L131_S0.8661.00
104_G108_P0.8621.00
40_R43_R0.8551.00
135_Y138_V0.8481.00
74_A78_L0.8471.00
125_P128_R0.8451.00
78_L92_A0.8441.00
73_L76_A0.8411.00
26_L117_E0.8381.00
26_L31_L0.8361.00
139_W142_N0.8301.00
136_P139_W0.8291.00
45_A49_L0.8281.00
111_L119_I0.8271.00
174_G179_V0.8261.00
140_L144_S0.8261.00
73_L77_L0.8251.00
41_G44_R0.8171.00
146_N150_R0.8161.00
170_L173_E0.8051.00
79_A83_G0.8041.00
14_A18_A0.7991.00
129_L133_L0.7951.00
26_L45_A0.7891.00
47_R50_E0.7861.00
53_D57_S0.7841.00
130_L134_L0.7831.00
175_E182_E0.7791.00
11_L14_A0.7761.00
173_E177_E0.7671.00
5_L9_L0.7651.00
74_A92_A0.7611.00
37_E42_A0.7611.00
82_L85_L0.7601.00
41_G124_A0.7591.00
132_R136_P0.7571.00
68_I72_A0.7561.00
41_G122_L0.7561.00
151_L155_K0.7541.00
26_L116_P0.7531.00
39_D43_R0.7501.00
26_L120_A0.7461.00
162_V167_L0.7451.00
18_A22_A0.7441.00
134_L138_V0.7431.00
51_N142_N0.7341.00
26_L49_L0.7321.00
22_A119_I0.7291.00
6_I74_A0.7291.00
162_V170_L0.7181.00
63_N67_N0.7151.00
149_L153_G0.7151.00
150_R155_K0.7011.00
62_G134_L0.7001.00
4_L7_L0.6971.00
77_L81_L0.6941.00
107_V148_L0.6931.00
78_L88_A0.6901.00
41_G45_A0.6891.00
7_L11_L0.6891.00
77_L80_R0.6871.00
168_R172_E0.6871.00
69_L93_T0.6861.00
22_A112_A0.6811.00
23_L45_A0.6721.00
61_L64_T0.6691.00
94_L98_F0.6681.00
138_V142_N0.6651.00
31_L42_A0.6621.00
27_R30_R0.6601.00
28_R46_L0.6581.00
49_L52_P0.6521.00
65_L69_L0.6501.00
38_G43_R0.6481.00
119_I122_L0.6441.00
83_G87_L0.6441.00
63_N66_A0.6431.00
88_A91_I0.6381.00
28_R49_L0.6321.00
76_A79_A0.6301.00
10_L14_A0.6281.00
15_F19_S0.6281.00
167_L180_I0.6261.00
68_I93_T0.6251.00
10_L70_A0.6221.00
174_G180_I0.6161.00
42_A46_L0.6131.00
5_L8_L0.6111.00
38_G42_A0.6111.00
59_I63_N0.6091.00
83_G88_A0.6061.00
92_A96_I0.6041.00
29_S33_Q0.6031.00
48_L52_P0.6011.00
28_R32_E0.5991.00
95_V98_F0.5991.00
74_A77_L0.5981.00
73_L78_L0.5981.00
58_T127_L0.5951.00
144_S147_L0.5951.00
153_G156_P0.5931.00
30_R116_P0.5931.00
81_L85_L0.5901.00
21_T112_A0.5891.00
161_A164_E0.5831.00
151_L154_I0.5761.00
161_A177_E0.5761.00
110_T114_R0.5751.00
13_S17_S0.5741.00
65_L97_T0.5691.00
68_I100_I0.5651.00
79_A84_P0.5641.00
62_G130_L0.5621.00
59_I106_L0.5581.00
35_A39_D0.5561.00
111_L115_N0.5531.00
34_L38_G0.5531.00
48_L131_S0.5491.00
115_N122_L0.5481.00
117_E121_L0.5471.00
110_T113_L0.5461.00
168_R171_V0.5421.00
110_T146_N0.5411.00
14_A104_G0.5411.00
31_L35_A0.5391.00
23_L55_L0.5381.00
67_N70_A0.5361.00
13_S100_I0.5331.00
23_L48_L0.5311.00
22_A116_P0.5281.00
35_A42_A0.5281.00
48_L128_R0.5231.00
44_R48_L0.5231.00
6_I77_L0.5211.00
82_L91_I0.5201.00
34_L42_A0.5181.00
57_S142_N0.5171.00
69_L73_L0.5161.00
16_F66_A0.5151.00
55_L59_I0.5141.00
63_N104_G0.5121.00
143_G150_R0.5111.00
6_I96_I0.5101.00
67_N105_E0.5051.00
45_A121_L0.5041.00
63_N100_I0.5011.00
171_V174_G0.5011.00
62_G66_A0.5001.00
121_L125_P0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4twkA 2 0.7663 34.2 0.892 Contact Map
4wfeA 2 0.7554 29.5 0.895 Contact Map
4h33A 3 0.4891 25.5 0.898 Contact Map
3pjsK 4 0.6685 25 0.899 Contact Map
3vouA 4 0.7337 23.9 0.9 Contact Map
3ukmA 2 0.7337 17.1 0.906 Contact Map
4bw5A 2 0.7772 15.5 0.908 Contact Map
3effK 4 0.7065 11.3 0.914 Contact Map
1rh5A 1 0.5 7.2 0.921 Contact Map
2kvcA 1 0.2772 7.1 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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