GREMLIN Database
UPF0118 - Domain of unknown function DUF20
PFAM: PF01594 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 327 (322)
Sequences: 99878 (76545)
Seq/√Len: 4265.7
META: 0.841

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
210_G225_G5.2391.00
212_G265_V4.5061.00
296_A316_A3.0041.00
209_T228_A2.9051.00
210_G214_W2.8091.00
41_R45_R2.7011.00
206_G229_G2.6261.00
257_T261_I2.6221.00
12_L16_W2.6141.00
16_W19_R2.4651.00
33_Y188_D2.4191.00
270_Q274_G2.3071.00
48_P51_L2.2391.00
41_R44_R2.2331.00
199_L233_F2.2271.00
15_L18_L2.1831.00
85_N88_A2.1761.00
206_G225_G2.0701.00
36_N40_R2.0541.00
96_W100_L2.0451.00
169_L181_R2.0271.00
31_L154_L1.9801.00
320_K324_R1.9371.00
260_L264_I1.9241.00
227_L231_L1.8851.00
280_R284_R1.8551.00
13_A16_W1.8441.00
249_L253_T1.8141.00
117_S120_D1.8121.00
50_G54_L1.7751.00
210_G221_A1.7691.00
53_A57_L1.7621.00
65_V69_A1.6971.00
214_W221_A1.6771.00
250_A254_G1.6771.00
258_A261_I1.6731.00
121_A124_S1.6681.00
125_L128_S1.6511.00
92_R96_W1.6361.00
155_F159_L1.6181.00
213_L218_V1.6111.00
47_L55_L1.6031.00
88_A92_R1.6021.00
124_S127_G1.5961.00
197_G281_L1.5731.00
94_Q98_A1.5671.00
187_I318_V1.5581.00
50_G159_L1.5491.00
261_I264_I1.5461.00
172_L180_V1.5141.00
15_L19_R1.5091.00
98_A101_P1.4951.00
92_R95_E1.4851.00
113_Q116_D1.4851.00
24_P28_A1.4831.00
96_W99_D1.4791.00
91_D94_Q1.4781.00
301_G309_L1.4771.00
81_E85_N1.4701.00
206_G210_G1.4611.00
267_L271_Q1.4601.00
35_L158_L1.4511.00
211_I214_W1.4491.00
83_A87_P1.4471.00
208_L269_V1.4371.00
80_A84_E1.4341.00
224_L246_A1.4291.00
121_A126_L1.4241.00
100_L103_L1.4221.00
91_D95_E1.4211.00
120_D123_S1.4051.00
153_L291_L1.4031.00
103_L106_E1.4011.00
270_Q273_E1.4001.00
205_Q232_N1.3991.00
261_I265_V1.3951.00
150_V154_L1.3851.00
28_A154_L1.3811.00
186_E325_E1.3791.00
160_D289_H1.3731.00
88_A91_D1.3691.00
250_A253_T1.3621.00
225_G229_G1.3621.00
221_A225_G1.3581.00
160_D163_R1.3541.00
213_L228_A1.3521.00
300_G304_F1.3501.00
101_P104_L1.3491.00
74_L78_Q1.3491.00
32_A157_L1.3391.00
101_P105_P1.3301.00
257_T260_L1.3251.00
112_E115_L1.3251.00
254_G258_A1.3211.00
202_A232_N1.3171.00
137_L141_G1.3171.00
296_A300_G1.3061.00
119_S123_S1.3041.00
205_Q269_V1.3021.00
247_A263_L1.3011.00
104_L107_L1.2971.00
103_L107_L1.2941.00
292_V316_A1.2891.00
229_G233_F1.2861.00
81_E84_E1.2811.00
231_L242_G1.2761.00
241_I245_P1.2761.00
256_P260_L1.2721.00
95_E99_D1.2721.00
209_T213_L1.2651.00
14_L18_L1.2621.00
216_L261_I1.2511.00
251_L255_G1.2471.00
38_L56_V1.2401.00
263_L267_L1.2371.00
133_L136_L1.2321.00
201_V273_E1.2271.00
115_L118_L1.2231.00
110_D113_Q1.2181.00
133_L137_L1.2131.00
31_L150_V1.2071.00
256_P259_A1.2011.00
116_D119_S1.1981.00
165_R169_L1.1971.00
11_L14_L1.1931.00
232_N239_P1.1891.00
300_G316_A1.1881.00
36_N49_R1.1871.00
90_L94_Q1.1861.00
53_A155_F1.1721.00
262_V266_F1.1671.00
251_L259_A1.1591.00
12_L15_L1.1561.00
186_E324_R1.1511.00
25_L295_L1.1501.00
192_G196_R1.1471.00
63_L67_L1.1461.00
265_V269_V1.1411.00
99_D102_E1.1401.00
97_L101_P1.1401.00
111_L114_L1.1341.00
38_L41_R1.1311.00
190_T317_A1.1271.00
212_G216_L1.1231.00
39_V56_V1.1131.00
163_R167_R1.1101.00
13_A17_L1.1051.00
271_Q275_N1.1001.00
264_I268_V1.0951.00
117_S121_A1.0941.00
52_A56_V1.0931.00
277_L281_L1.0891.00
166_R170_R1.0881.00
120_D124_S1.0871.00
77_S81_E1.0861.00
247_A259_A1.0821.00
212_G269_V1.0801.00
153_L157_L1.0791.00
36_N161_G1.0701.00
110_D115_L1.0701.00
90_L93_L1.0621.00
116_D120_D1.0621.00
102_E105_P1.0601.00
111_L117_S1.0541.00
210_G222_L1.0441.00
255_G258_A1.0401.00
198_Q278_R1.0381.00
57_L154_L1.0361.00
280_R283_G1.0361.00
202_A233_F1.0311.00
99_D103_L1.0301.00
7_L11_L1.0281.00
207_V210_G1.0281.00
115_L121_A1.0271.00
182_R186_E1.0261.00
250_A255_G1.0241.00
78_Q81_E1.0181.00
66_L70_L1.0151.00
251_L254_G1.0151.00
122_L125_L1.0121.00
203_L229_G1.0091.00
211_I215_I1.0071.00
39_V53_A0.9991.00
182_R325_E0.9991.00
50_G155_F0.9981.00
126_L129_L0.9901.00
79_A83_A0.9881.00
61_L65_V0.9871.00
5_L9_L0.9791.00
174_R177_R0.9741.00
228_A242_G0.9711.00
247_A251_L0.9631.00
89_Y93_L0.9621.00
201_V232_N0.9571.00
232_N273_E0.9561.00
179_R182_R0.9551.00
104_L108_G0.9551.00
123_S127_G0.9551.00
125_L129_L0.9511.00
199_L203_L0.9501.00
14_L17_L0.9501.00
219_P253_T0.9411.00
118_L121_A0.9401.00
181_R185_R0.9331.00
97_L104_L0.9331.00
183_L322_L0.9321.00
98_A102_E0.9311.00
132_G136_L0.9291.00
216_L262_V0.9261.00
43_E49_R0.9261.00
259_A263_L0.9201.00
202_A206_G0.9201.00
50_G53_A0.9171.00
212_G261_I0.9161.00
142_G146_N0.9151.00
39_V49_R0.9121.00
114_L117_S0.9111.00
288_L316_A0.9101.00
201_V278_R0.9031.00
121_A125_L0.8981.00
95_E98_A0.8951.00
130_L133_L0.8941.00
156_F160_D0.8941.00
63_L66_L0.8921.00
40_R162_E0.8911.00
115_L119_S0.8891.00
47_L51_L0.8891.00
193_G196_R0.8881.00
278_R282_M0.8751.00
112_E116_D0.8751.00
198_Q202_A0.8741.00
100_L104_L0.8741.00
306_I309_L0.8731.00
193_G285_S0.8721.00
246_A250_A0.8701.00
161_G165_R0.8641.00
136_L140_L0.8591.00
39_V158_L0.8551.00
286_V313_V0.8551.00
11_L15_L0.8541.00
124_S128_S0.8521.00
53_A67_L0.8511.00
232_N278_R0.8511.00
173_P176_R0.8501.00
154_L158_L0.8461.00
292_V320_K0.8461.00
113_Q117_S0.8421.00
13_A19_R0.8411.00
205_Q209_T0.8401.00
187_I190_T0.8391.00
297_L309_L0.8381.00
28_A153_L0.8371.00
69_A73_P0.8361.00
243_A247_A0.8341.00
245_P248_L0.8281.00
78_Q82_L0.8281.00
274_G278_R0.8271.00
207_V211_I0.8261.00
242_G246_A0.8251.00
218_V250_A0.8241.00
32_A154_L0.8231.00
153_L295_L0.8201.00
85_N89_Y0.8181.00
173_P177_R0.8171.00
8_L12_L0.8161.00
169_L177_R0.8121.00
111_L115_L0.8121.00
205_Q239_P0.8101.00
76_V79_A0.8091.00
29_L157_L0.8071.00
198_Q233_F0.8061.00
220_Y223_L0.7991.00
12_L19_R0.7981.00
6_L10_L0.7941.00
167_R170_R0.7931.00
185_R189_R0.7931.00
89_Y92_R0.7921.00
96_W101_P0.7911.00
130_L134_L0.7891.00
28_A32_A0.7881.00
188_D192_G0.7851.00
45_R48_P0.7841.00
186_E321_V0.7841.00
97_L100_L0.7831.00
201_V277_L0.7821.00
163_R166_R0.7821.00
196_R200_L0.7811.00
213_L224_L0.7781.00
8_L11_L0.7751.00
43_E52_A0.7681.00
10_L14_L0.7651.00
176_R179_R0.7621.00
87_P91_D0.7611.00
307_L311_L0.7581.00
319_L323_L0.7571.00
183_L187_I0.7561.00
213_L262_V0.7561.00
78_Q83_A0.7551.00
143_F147_L0.7501.00
240_I244_I0.7471.00
180_V184_L0.7461.00
200_L204_I0.7461.00
178_E182_R0.7431.00
68_L72_V0.7421.00
165_R181_R0.7401.00
193_G197_G0.7371.00
93_L96_W0.7361.00
150_V153_L0.7361.00
32_A36_N0.7351.00
268_V271_Q0.7341.00
162_E166_R0.7281.00
42_L56_V0.7281.00
110_D114_L0.7271.00
216_L258_A0.7271.00
101_P108_G0.7271.00
204_I277_L0.7261.00
227_L245_P0.7251.00
295_L299_G0.7211.00
167_R171_L0.7181.00
80_A83_A0.7171.00
47_L52_A0.7171.00
25_L153_L0.7161.00
54_L58_L0.7161.00
216_L265_V0.7141.00
259_A266_F0.7101.00
105_P108_G0.7101.00
201_V282_M0.7081.00
10_L13_A0.7061.00
248_L252_L0.7051.00
52_A55_L0.7051.00
276_V280_R0.7051.00
94_Q100_L0.7051.00
40_R43_E0.7041.00
14_L19_R0.7031.00
203_L207_V0.7021.00
27_L150_V0.7011.00
84_E87_P0.7011.00
135_S138_G0.7001.00
166_R181_R0.6991.00
179_R325_E0.6961.00
51_L54_L0.6921.00
134_L137_L0.6861.00
264_I267_L0.6861.00
186_E190_T0.6851.00
147_L151_L0.6851.00
123_S126_L0.6841.00
75_L79_A0.6841.00
139_S142_G0.6821.00
300_G315_L0.6821.00
114_L118_L0.6791.00
288_L292_V0.6751.00
119_S122_L0.6741.00
76_V80_A0.6731.00
24_P33_Y0.6721.00
101_P107_L0.6691.00
13_A18_L0.6681.00
289_H320_K0.6671.00
98_A108_G0.6661.00
289_H292_V0.6661.00
9_L13_A0.6641.00
177_R180_V0.6631.00
39_V52_A0.6631.00
9_L16_W0.6631.00
126_L130_L0.6571.00
262_V265_V0.6551.00
316_A320_K0.6551.00
72_V76_V0.6551.00
247_A250_A0.6551.00
214_W217_G0.6551.00
250_A262_V0.6521.00
103_L108_G0.6491.00
205_Q273_E0.6461.00
232_N270_Q0.6461.00
179_R183_L0.6451.00
201_V205_Q0.6441.00
44_R47_L0.6431.00
129_L132_G0.6421.00
272_L277_L0.6421.00
73_P77_S0.6421.00
272_L276_V0.6411.00
239_P243_A0.6351.00
186_E189_R0.6341.00
172_L176_R0.6321.00
240_I243_A0.6311.00
24_P146_N0.6311.00
42_L45_R0.6301.00
258_A262_V0.6291.00
49_R53_A0.6271.00
82_L86_L0.6241.00
35_L154_L0.6231.00
12_L18_L0.6221.00
100_L108_G0.6201.00
246_A249_L0.6161.00
243_A266_F0.6131.00
66_L69_A0.6131.00
209_T269_V0.6111.00
149_L153_L0.6101.00
212_G215_I0.6091.00
189_R193_G0.6031.00
32_A158_L0.5991.00
194_Y198_Q0.5981.00
42_L47_L0.5971.00
70_L74_L0.5951.00
259_A262_V0.5951.00
114_L119_S0.5941.00
98_A104_L0.5931.00
198_Q201_V0.5921.00
202_A229_G0.5911.00
196_R285_S0.5901.00
202_A205_Q0.5891.00
101_P106_E0.5891.00
185_R188_D0.5861.00
127_G131_G0.5861.00
165_R185_R0.5851.00
146_N150_V0.5841.00
100_L107_L0.5831.00
177_R181_R0.5811.00
283_G293_V0.5811.00
273_E278_R0.5801.00
259_A265_V0.5791.00
282_M286_V0.5791.00
253_T256_P0.5761.00
7_L15_L0.5751.00
169_L172_L0.5741.00
293_V313_V0.5741.00
288_L293_V0.5731.00
121_A128_S0.5731.00
128_S132_G0.5711.00
265_V268_V0.5711.00
246_A262_V0.5711.00
97_L103_L0.5701.00
268_V272_L0.5701.00
59_L62_L0.5691.00
119_S125_L0.5681.00
121_A127_G0.5671.00
249_L254_G0.5661.00
266_F270_Q0.5631.00
97_L102_E0.5621.00
206_G209_T0.5611.00
89_Y96_W0.5591.00
299_G302_A0.5581.00
77_S80_A0.5541.00
29_L161_G0.5511.00
141_G145_L0.5501.00
208_L212_G0.5481.00
48_P52_A0.5481.00
283_G287_G0.5431.00
252_L255_G0.5421.00
117_S122_L0.5421.00
5_L16_W0.5411.00
102_E106_E0.5411.00
41_R46_G0.5401.00
85_N219_P0.5351.00
257_T264_I0.5321.00
75_L78_Q0.5321.00
184_L188_D0.5311.00
249_L252_L0.5291.00
90_L96_W0.5291.00
118_L124_S0.5281.00
204_I208_L0.5261.00
49_R162_E0.5221.00
239_P270_Q0.5221.00
239_P274_G0.5151.00
138_G141_G0.5151.00
6_L15_L0.5151.00
164_L167_R0.5141.00
166_R169_L0.5131.00
29_L32_A0.5121.00
9_L12_L0.5111.00
67_L71_L0.5111.00
277_L280_R0.5111.00
129_L133_L0.5101.00
132_G135_S0.5091.00
312_A316_A0.5091.00
48_P53_A0.5091.00
290_P294_L0.5091.00
4_L8_L0.5091.00
227_L242_G0.5071.00
65_V68_L0.5061.00
199_L202_A0.5061.00
213_L266_F0.5051.00
209_T212_G0.5041.00
42_L59_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rvyA 3 0.2202 11.7 0.95 Contact Map
4bgnA 3 0.2599 11.5 0.951 Contact Map
2ksdA 1 0.1651 9.4 0.952 Contact Map
2kv5A 1 0.1009 3.5 0.961 Contact Map
3bz1X 1 0.1131 2.7 0.963 Contact Map
1qp6A 2 0.107 2.7 0.963 Contact Map
3j2wE 1 0.1407 2.5 0.964 Contact Map
3bo0B 1 0.1988 2.3 0.965 Contact Map
4dx5A 3 0.4648 2.1 0.965 Contact Map
3w4tA 1 0.633 2.1 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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