GREMLIN Database
Cytochrom_C_asm - Cytochrome C assembly protein
PFAM: PF01578 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 214 (207)
Sequences: 41109 (22715)
Seq/√Len: 1578.8
META: 0.883

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_F172_A5.3651.00
137_T168_W5.1521.00
79_L139_G4.2721.00
86_F171_Y4.2001.00
170_V195_G3.1261.00
153_G156_G3.0431.00
170_V198_L2.8381.00
89_A129_L2.5461.00
129_L174_L2.4291.00
90_F196_F2.4081.00
86_F132_G2.4031.00
87_A196_F2.1901.00
123_R127_R2.1171.00
132_G171_Y2.0761.00
171_Y195_G2.0091.00
10_L14_L1.8751.00
174_L192_A1.8051.00
34_L38_L1.7551.00
85_A132_G1.7341.00
36_A40_P1.7201.00
81_L135_F1.6861.00
183_W187_W1.6771.00
117_P120_T1.6731.00
122_D178_R1.6711.00
37_V40_P1.6661.00
47_G50_L1.6041.00
126_R130_L1.5941.00
85_A131_V1.5861.00
133_F137_T1.5771.00
182_G185_G1.5761.00
181_R184_R1.5491.00
45_L49_A1.5451.00
36_A39_L1.5451.00
126_R178_R1.5231.00
46_L50_L1.5161.00
35_G38_L1.5101.00
133_F168_W1.5031.00
174_L191_L1.4881.00
38_L42_A1.4871.00
129_L192_A1.4651.00
25_F28_R1.4621.00
13_W17_L1.4561.00
52_L55_P1.4561.00
32_R35_G1.4541.00
165_L169_L1.4391.00
27_R30_P1.4391.00
100_E186_R1.4161.00
47_G51_F1.4151.00
18_L85_A1.3981.00
92_F124_L1.3841.00
140_I168_W1.3691.00
156_G161_E1.3661.00
96_Y189_A1.3531.00
34_L37_V1.3341.00
173_A177_S1.3191.00
33_L40_P1.3061.00
174_L188_A1.2991.00
9_L13_W1.2921.00
80_Y84_A1.2921.00
130_L175_L1.2811.00
55_P58_P1.2691.00
85_A128_W1.2661.00
42_A46_L1.2631.00
78_L138_L1.2551.00
24_R27_R1.2481.00
92_F125_A1.2361.00
40_P43_L1.2181.00
33_L37_V1.2171.00
46_L49_A1.2141.00
48_F51_F1.2111.00
101_R105_R1.2001.00
70_P73_A1.1881.00
120_T123_R1.1631.00
114_R117_P1.1601.00
90_F193_I1.1571.00
35_G42_A1.1501.00
110_G113_R1.1421.00
44_L48_F1.1411.00
57_P60_G1.1391.00
122_D185_G1.1311.00
41_L44_L1.1221.00
16_A20_L1.1211.00
196_F200_L1.1201.00
208_S212_G1.1171.00
186_R190_L1.1161.00
90_F94_I1.1161.00
35_G39_L1.1151.00
38_L41_L1.1061.00
93_A192_A1.1041.00
204_F208_S1.1011.00
137_T141_I1.0911.00
89_A192_A1.0911.00
82_G164_S1.0731.00
177_S188_A1.0721.00
45_L48_F1.0671.00
40_P46_L1.0661.00
130_L134_P1.0631.00
93_A125_A1.0511.00
180_E184_R1.0381.00
29_L32_R1.0371.00
167_P199_V1.0291.00
92_F121_L1.0261.00
32_R36_A1.0021.00
183_W186_R0.9971.00
12_A16_A0.9891.00
24_R28_R0.9861.00
40_P44_L0.9841.00
119_E123_R0.9821.00
13_W19_G0.9751.00
184_R187_W0.9681.00
78_L142_L0.9571.00
97_L193_I0.9521.00
187_W190_L0.9401.00
133_F175_L0.9361.00
157_W161_E0.9351.00
121_L125_A0.9331.00
52_L56_L0.9251.00
205_G208_S0.9221.00
80_Y83_Y0.9181.00
89_A128_W0.9111.00
125_A174_L0.9071.00
62_G65_P0.9061.00
202_G205_G0.9011.00
7_S203_Y0.9001.00
39_L43_L0.8991.00
53_L58_P0.8891.00
33_L36_A0.8861.00
36_A41_L0.8841.00
21_L25_F0.8841.00
125_A192_A0.8771.00
14_L84_A0.8771.00
42_A49_A0.8731.00
94_I193_I0.8681.00
147_A151_W0.8671.00
99_Q102_R0.8671.00
37_V41_L0.8601.00
26_Y29_L0.8601.00
174_L178_R0.8601.00
37_V42_A0.8571.00
206_V210_L0.8571.00
203_Y207_R0.8551.00
43_L47_G0.8541.00
201_L210_L0.8521.00
53_L56_L0.8491.00
30_P33_L0.8451.00
61_A64_N0.8441.00
193_I197_A0.8391.00
138_L142_L0.8391.00
14_L18_L0.8381.00
148_E154_Y0.8321.00
71_W145_I0.8311.00
185_G189_A0.8291.00
19_G23_E0.8251.00
31_L35_G0.8241.00
160_K207_R0.8211.00
96_Y118_L0.8161.00
108_L112_L0.8131.00
188_A192_A0.8051.00
42_A45_L0.8031.00
82_G136_L0.7961.00
136_L139_G0.7941.00
169_L173_A0.7931.00
92_F128_W0.7931.00
184_R188_A0.7921.00
131_V135_F0.7891.00
177_S183_W0.7801.00
39_L46_L0.7761.00
147_A155_W0.7761.00
34_L42_A0.7711.00
190_L194_L0.7691.00
46_L51_F0.7671.00
33_L38_L0.7601.00
83_Y160_K0.7561.00
35_G43_L0.7551.00
167_P202_G0.7541.00
149_L153_G0.7521.00
147_A150_G0.7521.00
116_P120_T0.7511.00
73_A77_P0.7511.00
54_L57_P0.7511.00
34_L41_L0.7491.00
13_W16_A0.7481.00
115_L118_L0.7471.00
30_P34_L0.7461.00
44_L47_G0.7461.00
13_W20_L0.7441.00
102_R107_R0.7431.00
53_L57_P0.7411.00
39_L42_A0.7391.00
14_L81_L0.7391.00
122_D189_A0.7371.00
31_L38_L0.7351.00
64_N67_L0.7331.00
83_Y136_L0.7321.00
129_L171_Y0.7291.00
109_G113_R0.7281.00
183_W188_A0.7251.00
171_Y192_A0.7221.00
148_E151_W0.7201.00
187_W191_L0.7161.00
148_E153_G0.7151.00
108_L113_R0.7121.00
163_W166_I0.7111.00
205_G209_L0.7041.00
102_R109_G0.7011.00
157_W162_N0.7001.00
23_E26_Y0.6981.00
182_G187_W0.6951.00
30_P40_P0.6921.00
176_H180_E0.6911.00
122_D125_A0.6901.00
182_G188_A0.6891.00
28_R31_L0.6871.00
86_F136_L0.6831.00
140_I164_S0.6821.00
95_A121_L0.6801.00
34_L39_L0.6791.00
176_H179_L0.6791.00
40_P47_G0.6711.00
7_S11_W0.6691.00
56_L59_D0.6691.00
17_L21_L0.6681.00
41_L47_G0.6661.00
74_I77_P0.6661.00
105_R108_L0.6611.00
109_G112_L0.6581.00
70_P74_I0.6561.00
86_F195_G0.6541.00
93_A97_L0.6531.00
40_P45_L0.6501.00
31_L36_A0.6481.00
36_A49_A0.6471.00
38_L43_L0.6461.00
151_W156_G0.6461.00
65_P68_Q0.6441.00
9_L12_A0.6431.00
54_L58_P0.6431.00
195_G199_V0.6401.00
122_D126_R0.6331.00
186_R189_A0.6321.00
182_G186_R0.6321.00
116_P119_E0.6291.00
149_L152_G0.6271.00
152_G155_W0.6231.00
52_L57_P0.6211.00
7_S80_Y0.6181.00
31_L34_L0.6161.00
140_I165_L0.6151.00
144_A147_A0.6141.00
27_R32_R0.6141.00
112_L116_P0.6101.00
34_L40_P0.6081.00
185_G188_A0.6071.00
118_L121_L0.6051.00
20_L23_E0.6041.00
90_F93_A0.6011.00
16_A19_G0.6001.00
69_S72_L0.6001.00
111_L115_L0.5971.00
78_L135_F0.5961.00
180_E183_W0.5951.00
79_L140_I0.5941.00
144_A148_E0.5911.00
44_L51_F0.5871.00
88_V128_W0.5851.00
58_P61_A0.5851.00
97_L189_A0.5851.00
44_L49_A0.5811.00
72_L76_V0.5801.00
160_K164_S0.5791.00
106_K109_G0.5751.00
129_L178_R0.5751.00
34_L46_L0.5731.00
136_L167_P0.5731.00
15_L87_A0.5721.00
133_F171_Y0.5711.00
30_P35_G0.5701.00
111_L114_R0.5701.00
102_R112_L0.5671.00
154_Y157_W0.5651.00
36_A46_L0.5611.00
190_L193_I0.5611.00
113_R116_P0.5601.00
33_L39_L0.5601.00
7_S10_L0.5591.00
139_G164_S0.5541.00
202_G207_R0.5531.00
189_A192_A0.5521.00
20_L24_R0.5451.00
42_A48_F0.5441.00
189_A193_I0.5411.00
14_L17_L0.5401.00
154_Y161_E0.5381.00
40_P51_F0.5351.00
11_W80_Y0.5341.00
26_Y30_P0.5321.00
198_L202_G0.5321.00
35_G40_P0.5321.00
36_A43_L0.5311.00
96_Y122_D0.5301.00
35_G41_L0.5241.00
172_A176_H0.5231.00
4_L8_L0.5151.00
30_P36_A0.5141.00
151_W155_W0.5081.00
176_H181_R0.5061.00
32_R42_A0.5051.00
116_P121_L0.5021.00
38_L45_L0.5011.00
29_L33_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zcdA 1 0.4159 5.6 0.945 Contact Map
3ayfA 2 0.9206 4.2 0.948 Contact Map
2m20A 2 0.2804 3.1 0.951 Contact Map
4o6yA 2 0.743 2.8 0.952 Contact Map
3giaA 1 0.4252 2.3 0.954 Contact Map
2l2tA 2 0.2056 2.1 0.955 Contact Map
1q16C 2 0.6402 1.8 0.957 Contact Map
1mhsA 2 0.6075 1.7 0.957 Contact Map
3rkoL 1 0.8785 1.6 0.958 Contact Map
4px7A 1 0.4065 1.6 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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