GREMLIN Database
Pep_M12B_propep - Reprolysin family propeptide
PFAM: PF01562 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 133 (123)
Sequences: 3186 (2095)
Seq/√Len: 188.9
META: 0.168

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_C99_C6.1951.00
47_H87_E4.5271.00
39_A44_F3.1041.00
96_L104_G2.9761.00
98_T102_L2.6881.00
51_N83_Q2.6651.00
38_T43_D2.2821.00
51_N54_L2.1351.00
47_H85_Y2.0531.00
89_D108_T2.0181.00
36_S43_D1.8131.00
39_A132_V1.8111.00
84_G94_V1.6771.00
22_K25_L1.6211.00
20_R24_S1.6201.00
81_Y97_S1.6131.00
107_Q112_E1.5811.00
40_F44_F1.5731.00
80_C97_S1.5731.00
122_S125_S1.5021.00
44_F108_T1.4991.00
111_E118_L1.4961.00
86_V106_I1.4771.00
116_E133_Y1.4651.00
21_R24_S1.4581.00
23_R27_S1.4211.00
71_V74_S1.4121.00
20_R23_R1.3841.00
48_L94_V1.3821.00
88_G92_S1.3761.00
6_V10_A1.3711.00
80_C101_G1.3591.00
24_S27_S1.3341.00
80_C130_H1.3321.00
40_F81_Y1.3251.00
80_C98_T1.3231.00
31_D52_K1.2691.00
34_S47_H1.2511.00
86_V108_T1.2491.00
6_V9_D1.2461.00
35_Y102_L1.2251.00
125_S129_E1.1981.00
95_A105_L1.1741.00
113_Y116_E1.1611.00
70_L73_D1.1601.00
8_V21_R1.1351.00
54_L80_C1.1121.00
7_R10_A1.1101.00
35_Y106_I1.1001.00
20_R25_L1.0821.00
94_V106_I1.0801.00
34_S87_E1.0741.00
56_A60_T1.0641.00
59_F63_T1.0601.00
42_K88_G1.0521.00
97_S130_H1.0501.00
99_C130_H1.0481.00
87_E98_T1.0421.00
26_S29_S1.0281.00
48_L84_G1.0041.00
98_T101_G1.0041.00
44_F113_Y0.9960.99
21_R25_L0.9950.99
44_F86_V0.9670.99
23_R26_S0.9630.99
50_P82_Y0.9620.99
111_E115_I0.9530.99
89_D92_S0.9520.99
67_D70_L0.9500.99
83_Q98_T0.9500.99
80_C117_P0.9330.99
61_V72_T0.9180.99
24_S29_S0.8990.99
21_R29_S0.8960.99
118_L131_V0.8950.99
22_K27_S0.8930.99
70_L75_P0.8690.99
49_E83_Q0.8660.99
80_C104_G0.8580.98
93_L114_F0.8560.98
121_S126_S0.8530.98
4_I10_A0.8450.98
102_L117_P0.8380.98
103_R110_N0.8370.98
101_G117_P0.8350.98
96_L99_C0.8340.98
53_D57_P0.8210.98
22_K26_S0.8160.98
89_D109_G0.8130.98
34_S45_V0.8060.98
82_Y97_S0.8050.98
45_V87_E0.8040.98
70_L74_S0.8030.98
82_Y92_S0.7970.97
59_F62_E0.7890.97
24_S28_P0.7890.97
26_S30_E0.7850.97
83_Q132_V0.7740.97
7_R35_Y0.7660.97
126_S129_E0.7650.97
55_L81_Y0.7650.97
120_S124_D0.7650.97
95_A99_C0.7640.97
75_P79_D0.7540.96
10_A24_S0.7540.96
83_Q95_A0.7530.96
52_K56_A0.7470.96
33_L98_T0.7430.96
122_S127_G0.7410.96
23_R29_S0.7410.96
22_K29_S0.7410.96
54_L99_C0.7410.96
83_Q93_L0.7390.96
35_Y48_L0.7350.96
68_G71_V0.7330.96
124_D127_G0.7280.96
103_R116_E0.7280.96
71_V76_F0.7070.95
36_S45_V0.7060.95
111_E114_F0.7030.95
127_G131_V0.7020.95
21_R27_S0.7020.95
95_A130_H0.6980.95
66_E70_L0.6960.94
23_R30_E0.6880.94
37_L44_F0.6850.94
99_C102_L0.6770.94
6_V43_D0.6760.94
80_C95_A0.6730.93
51_N81_Y0.6710.93
107_Q111_E0.6680.93
74_S77_V0.6620.93
50_P59_F0.6560.93
124_D128_F0.6550.93
46_L106_I0.6530.92
25_L28_P0.6480.92
99_C117_P0.6470.92
89_D106_I0.6410.92
27_S30_E0.6360.91
4_I7_R0.6360.91
4_I9_D0.6330.91
115_I132_V0.6270.91
66_E69_A0.6270.91
22_K28_P0.6260.91
97_S101_G0.6260.91
34_S109_G0.6240.91
21_R26_S0.6150.90
99_C104_G0.6120.90
59_F92_S0.6080.89
8_V19_L0.6010.89
75_P78_E0.5960.89
23_R48_L0.5960.89
60_T74_S0.5940.88
93_L107_Q0.5790.87
120_S125_S0.5730.87
63_T82_Y0.5710.86
68_G72_T0.5700.86
48_L56_A0.5680.86
91_G108_T0.5650.86
35_Y99_C0.5620.85
20_R26_S0.5620.85
86_V89_D0.5550.85
82_Y101_G0.5510.84
40_F53_D0.5500.84
43_D76_F0.5490.84
122_S128_F0.5450.84
32_Q42_K0.5400.83
55_L71_V0.5360.83
44_F65_S0.5340.83
55_L59_F0.5330.82
40_F46_L0.5310.82
76_F79_D0.5280.82
65_S69_A0.5270.82
8_V34_S0.5260.82
119_E129_E0.5240.81
59_F75_P0.5230.81
121_S129_E0.5220.81
82_Y106_I0.5190.81
54_L95_A0.5150.80
85_Y92_S0.5140.80
128_F131_V0.5080.79
39_A42_K0.5050.79
128_F132_V0.5050.79
54_L81_Y0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4on1A 1 0.7218 50.9 0.882 Contact Map
2kd0A 1 0.6391 6.7 0.923 Contact Map
4pyuA 1 0.5564 6.7 0.923 Contact Map
4hcnB 1 0.5564 6.6 0.923 Contact Map
3m63B 1 0.5414 5.9 0.925 Contact Map
3phxB 1 0.5714 5.4 0.926 Contact Map
3dbhI 1 0.6241 5.4 0.926 Contact Map
1wggA 1 0.7143 5.3 0.927 Contact Map
3pluA 1 0.5414 4.8 0.928 Contact Map
4dguA 4 0.4436 4.6 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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