GREMLIN Database
zf-DHHC - DHHC palmitoyltransferase
PFAM: PF01529 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 134 (128)
Sequences: 8194 (6224)
Seq/√Len: 550.1
META: 0.372

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_C35_H3.8481.00
21_H28_C3.6571.00
30_L45_K3.4811.00
52_L118_L3.3331.00
25_C42_C3.1211.00
35_H42_C2.7451.00
11_C21_H2.7181.00
31_K48_Y2.5771.00
22_C25_C2.3541.00
48_Y117_H2.3311.00
29_V44_G2.3061.00
18_R129_E2.2231.00
16_P19_S2.1171.00
11_C28_C2.0671.00
20_H128_I2.0631.00
116_F120_L1.9901.00
39_V43_V1.8701.00
22_C42_C1.8571.00
31_K45_K1.8331.00
70_L74_I1.8221.00
32_F128_I1.8111.00
56_L114_L1.7941.00
116_F130_Y1.6231.00
119_Y123_R1.6051.00
53_L57_Y1.6031.00
49_R53_L1.5551.00
59_T114_L1.5551.00
115_G119_Y1.5531.00
67_I71_Y1.4941.00
36_C51_F1.4911.00
117_H127_T1.4851.00
59_T111_G1.4271.00
128_I132_K1.4081.00
20_H32_F1.4071.00
44_G47_N1.3391.00
63_L107_L1.3311.00
117_H120_L1.2791.00
55_L114_L1.2661.00
109_F113_L1.2301.00
64_Y68_L1.2301.00
33_D36_C1.2231.00
7_Y12_N1.2061.00
33_D51_F1.1821.00
8_C11_C1.1811.00
22_C35_H1.1721.00
52_L114_L1.1631.00
15_K20_H1.1511.00
56_L118_L1.1431.00
18_R31_K1.1401.00
66_L104_L1.1031.00
113_L117_H1.1011.00
7_Y14_Y1.0871.00
66_L107_L1.0621.00
118_L122_L1.0601.00
85_L89_S1.0491.00
10_T128_I1.0461.00
125_Q130_Y1.0351.00
119_Y122_L1.0331.00
15_K128_I1.0331.00
110_L113_L1.0001.00
61_L65_V0.9971.00
74_I78_S0.9911.00
52_L121_I0.9541.00
21_H25_C0.9351.00
63_L111_G0.9071.00
62_C106_F0.9061.00
59_T107_L0.9021.00
20_H23_S0.8821.00
70_L100_L0.8791.00
114_L118_L0.8771.00
18_R124_N0.8721.00
62_C107_L0.8681.00
54_F58_L0.8551.00
34_H51_F0.8541.00
6_R15_K0.8501.00
16_P30_L0.8491.00
5_L17_P0.8461.00
21_H26_N0.8461.00
82_L86_L0.8361.00
39_V54_F0.8351.00
106_F109_F0.8341.00
105_L109_F0.8301.00
116_F119_Y0.8291.00
85_L88_L0.8261.00
55_L110_L0.8221.00
49_R57_Y0.8211.00
120_L130_Y0.8111.00
50_Y53_L0.8111.00
52_L56_L0.8081.00
106_F110_L0.8051.00
89_S92_G0.7961.00
84_S89_S0.7951.00
82_L85_L0.7841.00
58_L62_C0.7831.00
32_F42_C0.7761.00
116_F127_T0.7751.00
81_S84_S0.7721.00
120_L127_T0.7691.00
31_K124_N0.7571.00
30_L46_R0.7531.00
75_R79_D0.7481.00
62_C103_S0.7451.00
76_L79_D0.7351.00
74_I77_I0.7331.00
85_L90_L0.7331.00
88_L91_L0.7331.00
8_C21_H0.7221.00
81_S90_L0.7191.00
126_T129_E0.7161.00
8_C28_C0.7151.00
65_V103_S0.7111.00
111_G115_G0.7111.00
84_S88_L0.7001.00
25_C28_C0.6991.00
7_Y13_I0.6951.00
28_C35_H0.6951.00
50_Y57_Y0.6911.00
10_T13_I0.6881.00
80_S84_S0.6871.00
37_P41_N0.6861.00
84_S87_L0.6851.00
10_T15_K0.6831.00
65_V68_L0.6811.00
11_C25_C0.6811.00
83_S87_L0.6791.00
84_S90_L0.6781.00
58_L110_L0.6751.00
55_L59_T0.6681.00
18_R126_T0.6671.00
51_F113_L0.6641.00
59_T110_L0.6541.00
77_I80_S0.6541.00
10_T20_H0.6531.00
119_Y130_Y0.6491.00
19_S30_L0.6461.00
82_L87_L0.6441.00
14_Y17_P0.6391.00
15_K23_S0.6321.00
8_C42_C0.6311.00
117_H121_I0.6261.00
10_T23_S0.6251.00
61_L64_Y0.6191.00
78_S82_L0.6181.00
78_S84_S0.6141.00
32_F41_N0.6121.00
30_L57_Y0.6111.00
72_Y75_R0.6101.00
6_R14_Y0.6071.00
81_S86_L0.6001.00
81_S85_L0.5971.00
64_Y67_I0.5971.00
88_L92_G0.5841.00
15_K37_P0.5841.00
87_L90_L0.5831.00
79_D87_L0.5810.99
15_K32_F0.5780.99
100_L104_L0.5750.99
71_Y75_R0.5740.99
107_L111_G0.5700.99
60_L64_Y0.5690.99
87_L91_L0.5690.99
83_S86_L0.5660.99
72_Y76_L0.5640.99
86_L90_L0.5560.99
36_C113_L0.5550.99
45_K48_Y0.5520.99
75_R84_S0.5510.99
96_L100_L0.5500.99
128_I131_L0.5470.99
63_L67_I0.5430.99
99_L102_L0.5410.99
99_L103_S0.5390.99
94_P98_L0.5330.99
81_S87_L0.5320.99
89_S93_S0.5310.99
115_G118_L0.5290.99
106_F116_F0.5290.99
83_S88_L0.5280.99
108_L112_G0.5240.99
21_H35_H0.5220.99
69_S100_L0.5190.99
31_K126_T0.5170.99
80_S83_S0.5140.99
101_V105_L0.5140.99
97_I101_V0.5130.99
56_L60_L0.5100.99
87_L92_G0.5100.99
90_L93_S0.5080.99
62_C66_L0.5040.99
83_S89_S0.5030.99
78_S92_G0.5010.99
85_L92_G0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vrwB 1 0.2612 21.1 0.901 Contact Map
2dktA 1 0.4328 20.5 0.902 Contact Map
1wflA 1 0.3657 20.1 0.902 Contact Map
3j21i 1 0.3657 15.2 0.907 Contact Map
3j21g 1 0.2836 14.2 0.909 Contact Map
3ky9A 1 0.2687 13 0.91 Contact Map
1wg2A 1 0.3657 11.6 0.912 Contact Map
1wfhA 1 0.3657 10.1 0.915 Contact Map
3mpxA 1 0 9.9 0.915 Contact Map
1wfpA 1 0.3657 9.3 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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