GREMLIN Database
DDE_Tnp_Tn3 - Tn3 transposase DDE domain
PFAM: PF01526 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 390 (389)
Sequences: 4000 (2414)
Seq/√Len: 122.4
META: 0.836

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_A80_R4.2391.00
194_R288_R3.8611.00
70_R73_T3.7791.00
41_G342_V3.7761.00
101_S306_G3.6581.00
7_D13_T3.6491.00
7_D30_R3.6421.00
285_F299_I3.4721.00
175_T179_G3.3991.00
83_N167_D3.2541.00
102_S173_H2.9101.00
205_Q282_K2.7471.00
84_A348_L2.7091.00
231_D235_E2.7051.00
236_H239_D2.6941.00
162_L247_L2.6931.00
240_M274_L2.6291.00
196_A295_L2.5851.00
316_I346_I2.5721.00
289_Y299_I2.5431.00
189_H281_I2.5151.00
3_L345_A2.4711.00
81_I345_A2.4651.00
100_A173_H2.4441.00
358_L373_L2.4291.00
172_E298_R2.3991.00
2_L384_I2.3871.00
78_N344_N2.3041.00
187_L244_A2.2761.00
152_R178_H2.2491.00
355_Q359_E2.2271.00
240_M277_L2.2191.00
106_K124_G2.2031.00
198_R300_Q2.1451.00
350_N383_H2.1151.00
276_E279_R2.1061.00
7_D10_T2.0861.00
99_T174_Y2.0811.00
210_P230_W2.0711.00
189_H277_L2.0701.00
9_W352_L2.0511.00
243_L257_I2.0381.00
134_H160_G2.0241.00
311_A381_W1.9941.00
15_A76_A1.9921.00
295_L299_I1.9771.00
285_F289_Y1.9531.00
177_T200_R1.9311.00
14_D80_R1.9061.00
201_D204_D1.9001.00
240_M244_A1.8771.00
129_V146_V1.8741.00
174_Y302_G1.8551.00
288_R292_D1.8401.00
46_L61_L1.8391.00
90_L351_T1.8361.00
190_L244_A1.8261.00
154_A184_V1.8251.00
159_D255_S1.8031.00
316_I343_A1.7891.00
182_E208_Y1.7861.00
97_G137_D1.7381.00
207_L283_T1.7331.00
85_Q140_I1.7281.00
202_L286_L1.7151.00
180_Q282_K1.6951.00
228_I276_E1.6821.00
142_F170_P1.6681.00
145_Q156_Y1.6591.00
309_R313_A1.6571.00
308_A311_A1.6481.00
346_I384_I1.6451.00
11_G14_D1.6211.00
36_A69_I1.6091.00
190_L240_M1.6031.00
243_L274_L1.5861.00
360_Q364_E1.5861.00
235_E269_P1.5801.00
134_H142_F1.5491.00
6_V9_W1.5361.00
6_V10_T1.5321.00
143_Y160_G1.5301.00
186_A281_I1.5291.00
157_V175_T1.5191.00
13_T34_L1.4661.00
182_E279_R1.4651.00
209_R216_Y1.4601.00
77_A341_L1.4531.00
182_E282_K1.4521.00
315_A386_L1.4451.00
275_R279_R1.4351.00
354_L380_G1.4221.00
109_V116_A1.4121.00
362_R370_D1.4111.00
105_Q314_R1.3981.00
232_L276_E1.3931.00
236_H270_L1.3841.00
210_P280_I1.3781.00
102_S132_Y1.3741.00
131_A336_A1.3731.00
369_T372_D1.3631.00
47_K58_Y1.3561.00
230_W234_E1.3471.00
157_V173_H1.3441.00
82_V140_I1.3331.00
373_L376_L1.3321.00
129_V324_I1.3301.00
243_L270_L1.3271.00
285_F295_L1.3231.00
219_L223_L1.3171.00
58_Y62_S1.3121.00
132_Y160_G1.3121.00
102_S179_G1.2941.00
318_F390_Y1.2771.00
371_E374_A1.2701.00
177_T201_D1.2691.00
349_W353_Y1.2641.00
229_N272_K1.2531.00
88_L351_T1.2430.99
10_T13_T1.2380.99
84_A87_R1.2320.99
228_I279_R1.2200.99
12_F37_L1.2190.99
293_E297_R1.2150.99
144_S336_A1.2150.99
316_I342_V1.2110.99
209_R220_D1.2100.99
231_D234_E1.2080.99
215_D220_D1.2070.99
63_W67_W1.1930.99
43_N317_F1.1880.99
7_D11_G1.1860.99
148_S151_E1.1860.99
2_L346_I1.1850.99
212_K227_T1.1850.99
218_H221_P1.1770.99
88_L355_Q1.1750.99
180_Q199_I1.1720.99
236_H269_P1.1710.99
233_I276_E1.1690.99
232_L272_K1.1560.99
159_D163_R1.1500.99
151_E156_Y1.1480.99
182_E205_Q1.1450.99
115_L332_Q1.1410.99
229_N276_E1.1380.99
99_T302_G1.1360.99
102_S175_T1.1350.99
122_Y128_G1.1340.99
229_N232_L1.1340.99
326_D335_R1.1300.99
208_Y228_I1.1250.99
372_D376_L1.1230.99
40_Y65_N1.1170.99
207_L286_L1.1140.99
123_F127_R1.1130.99
220_D223_L1.1110.99
131_A146_V1.1100.99
141_P344_N1.1090.99
81_I348_L1.1080.99
32_R64_V1.1060.99
366_E369_T1.0960.99
162_L254_A1.0750.98
228_I233_I1.0720.98
102_S157_V1.0690.98
245_A249_L1.0630.98
211_D216_Y1.0570.98
297_R300_Q1.0560.98
284_I288_R1.0550.98
133_T141_P1.0470.98
152_R180_Q1.0420.98
123_F128_G1.0400.98
320_N325_R1.0370.98
7_D12_F1.0360.98
239_D270_L1.0340.98
92_K138_Q1.0340.98
152_R155_A1.0330.98
16_F77_A1.0300.98
156_Y255_S1.0300.98
158_L188_C1.0210.98
229_N235_E1.0190.98
358_L362_R1.0160.98
314_R321_R1.0150.98
130_T153_E1.0140.98
85_Q91_A1.0130.98
85_Q344_N1.0100.98
161_L193_F1.0100.98
2_L345_A1.0100.98
85_Q88_L1.0060.98
79_A83_N0.9990.98
359_E363_A0.9960.97
25_K29_D0.9950.97
253_T256_T0.9950.97
236_H273_A0.9930.97
7_D14_D0.9850.97
205_Q286_L0.9840.97
31_R56_L0.9830.97
346_I386_L0.9830.97
4_L8_A0.9810.97
172_E196_A0.9740.97
159_D253_T0.9710.97
356_R359_E0.9710.97
211_D215_D0.9680.97
139_Y379_L0.9680.97
187_L258_L0.9620.97
9_W348_L0.9590.97
175_T303_L0.9570.97
209_R215_D0.9570.97
183_V271_Y0.9540.97
74_L338_C0.9520.97
98_T171_D0.9510.97
83_N166_T0.9500.97
369_T376_L0.9450.97
104_G130_T0.9450.97
76_A80_R0.9410.96
83_N164_N0.9370.96
42_T342_V0.9360.96
317_F335_R0.9360.96
159_D254_A0.9340.96
78_N340_R0.9340.96
219_L222_L0.9330.96
96_D137_D0.9320.96
44_L48_R0.9240.96
37_L342_V0.9200.96
223_L226_G0.9190.96
328_T331_E0.9160.96
32_R60_Q0.9140.96
209_R213_G0.9120.96
198_R303_L0.9110.96
277_L281_I0.9090.96
152_R181_S0.9080.96
57_S60_Q0.9070.96
156_Y161_L0.9050.96
95_G137_D0.9030.95
140_I168_L0.9010.95
180_Q205_Q0.9010.95
324_I332_Q0.8990.95
183_V258_L0.8980.95
18_H67_W0.8960.95
117_E150_T0.8960.95
219_L224_T0.8950.95
210_P214_A0.8940.95
145_Q163_R0.8940.95
319_G387_Y0.8900.95
247_L254_A0.8900.95
2_L8_A0.8800.95
131_A324_I0.8790.95
232_L269_P0.8780.95
107_F314_R0.8780.95
147_I151_E0.8760.95
33_L37_L0.8750.95
211_D214_A0.8690.94
315_A381_W0.8660.94
142_F160_G0.8650.94
99_T172_E0.8630.94
186_A240_M0.8590.94
177_T180_Q0.8580.94
43_N46_L0.8540.94
134_H143_Y0.8540.94
6_V12_F0.8520.94
59_D62_S0.8510.94
164_N168_L0.8500.94
130_T149_C0.8480.94
147_I156_Y0.8430.94
381_W386_L0.8420.93
100_A142_F0.8400.93
80_R87_R0.8380.93
16_F74_L0.8380.93
264_Y268_N0.8360.93
81_I341_L0.8350.93
308_A381_W0.8340.93
361_L365_G0.8320.93
158_L162_L0.8310.93
29_D68_Y0.8280.93
94_W250_G0.8280.93
90_L93_I0.8250.93
220_D224_T0.8200.93
367_E371_E0.8190.93
130_T178_H0.8170.92
82_V168_L0.8160.92
163_R253_T0.8150.92
249_L254_A0.8110.92
158_L187_L0.8100.92
369_T373_L0.8090.92
3_L34_L0.8080.92
269_P272_K0.8050.92
159_D164_N0.8040.92
154_A181_S0.8040.92
342_V345_A0.8020.92
71_E333_E0.8000.92
221_P224_T0.7910.91
196_A299_I0.7880.91
73_T148_S0.7840.91
106_K314_R0.7820.91
261_L268_N0.7780.90
132_Y157_V0.7760.90
370_D376_L0.7760.90
329_R333_E0.7740.90
312_L381_W0.7730.90
336_A339_L0.7710.90
324_I336_A0.7700.90
6_V348_L0.7700.90
340_R343_A0.7700.90
158_L193_F0.7690.90
140_I162_L0.7670.90
113_N327_R0.7660.90
336_A340_R0.7630.90
368_V373_L0.7610.89
274_L296_R0.7590.89
106_K130_T0.7580.89
256_T259_R0.7560.89
233_I273_A0.7550.89
26_D29_D0.7500.89
90_L358_L0.7500.89
82_V166_T0.7500.89
352_L356_R0.7480.89
362_R365_G0.7480.89
281_I284_I0.7450.88
21_G24_A0.7430.88
240_M273_A0.7390.88
60_Q64_V0.7390.88
16_F68_Y0.7380.88
363_A369_T0.7380.88
1_D5_E0.7360.88
174_Y285_F0.7350.88
81_I85_Q0.7350.88
132_Y147_I0.7320.88
232_L236_H0.7310.88
351_T355_Q0.7300.87
253_T264_Y0.7290.87
280_I284_I0.7270.87
119_H122_Y0.7250.87
359_E362_R0.7210.87
21_G25_K0.7210.87
154_A160_G0.7200.87
161_L173_H0.7190.87
153_E178_H0.7190.87
129_V147_I0.7190.87
346_I350_N0.7180.87
61_L69_I0.7170.87
182_E275_R0.7170.87
117_E149_C0.7160.86
318_F322_G0.7150.86
376_L385_N0.7130.86
39_A49_M0.7120.86
174_Y303_L0.7110.86
139_Y305_K0.7110.86
191_L248_K0.7100.86
134_H157_V0.7080.86
87_R167_D0.7060.86
6_V352_L0.7050.86
371_E375_H0.7040.86
179_G303_L0.7020.85
4_L7_D0.7020.85
101_S302_G0.7000.85
194_R295_L0.6980.85
124_G274_L0.6970.85
107_F313_A0.6960.85
230_W280_I0.6960.85
35_A61_L0.6940.85
361_L364_E0.6930.85
318_F387_Y0.6930.85
208_Y226_G0.6930.85
6_V345_A0.6900.84
369_T375_H0.6890.84
303_L306_G0.6860.84
174_Y196_A0.6830.84
36_A61_L0.6780.83
213_G227_T0.6750.83
50_A57_S0.6740.83
281_I285_F0.6720.83
263_S267_Q0.6720.83
245_A248_K0.6720.83
216_Y223_L0.6700.83
65_N69_I0.6690.83
4_L34_L0.6680.82
230_W233_I0.6670.82
370_D374_A0.6660.82
308_A312_L0.6650.82
162_L193_F0.6640.82
175_T195_F0.6570.81
106_K152_R0.6560.81
286_L290_L0.6560.81
115_L148_S0.6550.81
151_E154_A0.6550.81
259_R265_S0.6550.81
92_K95_G0.6520.81
42_T318_F0.6520.81
242_R246_S0.6510.81
4_L31_R0.6510.81
115_L329_R0.6490.81
282_K324_I0.6470.80
44_L387_Y0.6470.80
132_Y179_G0.6470.80
80_R83_N0.6470.80
106_K153_E0.6460.80
5_E9_W0.6450.80
237_W241_L0.6420.80
36_A64_V0.6420.80
136_S140_I0.6410.80
264_Y274_L0.6400.80
190_L248_K0.6400.80
353_Y356_R0.6390.80
40_Y338_C0.6390.80
283_T286_L0.6380.79
120_P125_K0.6370.79
252_V256_T0.6360.79
360_Q369_T0.6340.79
306_G310_H0.6330.79
206_R226_G0.6330.79
238_D324_I0.6330.79
35_A56_L0.6320.79
262_G266_R0.6300.79
2_L6_V0.6300.79
300_Q304_N0.6300.79
49_M52_A0.6300.79
22_R39_A0.6290.78
106_K149_C0.6280.78
312_L384_I0.6250.78
36_A65_N0.6230.78
367_E376_L0.6200.78
129_V193_F0.6180.77
15_A19_L0.6170.77
12_F77_A0.6170.77
56_L60_Q0.6170.77
86_A92_K0.6170.77
134_H145_Q0.6160.77
187_L247_L0.6150.77
214_A217_P0.6150.77
88_L348_L0.6130.77
369_T374_A0.6120.77
105_Q133_T0.6120.77
161_L170_P0.6110.76
212_K216_Y0.6110.76
191_L244_A0.6110.76
106_K120_P0.6110.76
362_R373_L0.6090.76
184_V258_L0.6090.76
228_I280_I0.6080.76
157_V161_L0.6080.76
314_R317_F0.6070.76
150_T181_S0.6060.76
108_E126_G0.6060.76
19_L70_R0.6050.76
46_L58_Y0.6050.76
258_L271_Y0.6040.76
53_S56_L0.6030.76
131_A144_S0.6010.75
13_T33_L0.6000.75
37_L338_C0.5970.75
83_N86_A0.5970.75
259_R387_Y0.5960.75
322_G339_L0.5960.75
23_E27_R0.5950.75
357_A360_Q0.5940.74
317_F339_L0.5940.74
284_I287_L0.5930.74
351_T378_P0.5900.74
260_R271_Y0.5890.74
155_A184_V0.5890.74
16_F341_L0.5880.74
195_F282_K0.5880.74
89_P355_Q0.5850.73
380_G386_L0.5840.73
246_S322_G0.5840.73
102_S254_A0.5840.73
60_Q63_W0.5830.73
109_V128_G0.5830.73
329_R332_Q0.5830.73
76_A79_A0.5820.73
3_L342_V0.5810.73
364_E368_V0.5800.73
85_Q351_T0.5800.73
82_V344_N0.5790.73
14_D23_E0.5780.72
94_W378_P0.5770.72
267_Q275_R0.5770.72
186_A274_L0.5770.72
210_P282_K0.5760.72
17_T24_A0.5750.72
361_L366_E0.5750.72
154_A254_A0.5730.72
111_V327_R0.5720.72
212_K215_D0.5710.72
216_Y220_D0.5700.71
264_Y267_Q0.5680.71
334_I337_S0.5680.71
199_I205_Q0.5670.71
124_G150_T0.5630.70
277_L280_I0.5620.70
208_Y279_R0.5610.70
79_A214_A0.5610.70
136_S168_L0.5600.70
151_E259_R0.5600.70
211_D217_P0.5600.70
357_A368_V0.5590.70
138_Q168_L0.5590.70
333_E337_S0.5590.70
213_G220_D0.5580.70
348_L352_L0.5560.70
107_F203_K0.5560.70
313_A317_F0.5560.70
265_S271_Y0.5550.69
365_G368_V0.5550.69
176_D307_E0.5530.69
383_H390_Y0.5520.69
259_R356_R0.5520.69
45_G48_R0.5500.69
32_R56_L0.5500.69
37_L74_L0.5490.69
307_E310_H0.5490.69
74_L341_L0.5480.68
50_A58_Y0.5480.68
238_D245_A0.5480.68
266_R332_Q0.5470.68
1_D29_D0.5450.68
343_A347_I0.5440.68
317_F322_G0.5440.68
144_S164_N0.5440.68
232_L235_E0.5430.68
28_D31_R0.5420.68
29_D33_L0.5400.67
387_Y390_Y0.5400.67
199_I305_K0.5380.67
183_V274_L0.5370.67
309_R343_A0.5370.67
343_A348_L0.5370.67
196_A285_F0.5370.67
326_D332_Q0.5360.67
81_I211_D0.5360.67
11_G30_R0.5340.66
384_I390_Y0.5330.66
368_V372_D0.5330.66
191_L285_F0.5330.66
178_H269_P0.5310.66
100_A136_S0.5300.66
151_E155_A0.5300.66
298_R302_G0.5300.66
86_A138_Q0.5290.66
309_R347_I0.5280.66
99_T298_R0.5280.66
368_V375_H0.5270.65
365_G376_L0.5270.65
149_C153_E0.5250.65
358_L376_L0.5250.65
183_V262_G0.5250.65
356_R360_Q0.5230.65
263_S280_I0.5230.65
112_Q327_R0.5230.65
42_T319_G0.5200.64
177_T199_I0.5200.64
195_F210_P0.5190.64
361_L368_V0.5180.64
317_F324_I0.5170.64
185_F285_F0.5160.64
380_G383_H0.5160.64
141_P347_I0.5160.64
122_Y149_C0.5150.64
16_F33_L0.5140.64
378_P384_I0.5130.63
316_I321_R0.5130.63
218_H222_L0.5130.63
178_H201_D0.5130.63
209_R214_A0.5110.63
158_L247_L0.5110.63
127_R274_L0.5100.63
177_T303_L0.5100.63
90_L312_L0.5090.63
86_A140_I0.5080.63
362_R367_E0.5070.63
113_N127_R0.5070.63
234_E238_D0.5070.63
143_Y164_N0.5060.62
29_D64_V0.5060.62
56_L254_A0.5060.62
18_H22_R0.5050.62
90_L332_Q0.5050.62
83_N256_T0.5040.62
364_E373_L0.5030.62
202_L290_L0.5020.62
89_P359_E0.5020.62
175_T180_Q0.5000.61
260_R265_S0.5000.61
75_R78_N0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1elkA 1 0.3667 72.8 0.968 Contact Map
3ldzA 1 0.3205 28.7 0.976 Contact Map
3rruA 1 0.3385 27.1 0.976 Contact Map
3g2sA 1 0.3615 25.1 0.976 Contact Map
1mhqA 1 0.3615 18.8 0.978 Contact Map
3ga2A 1 0.5359 11.6 0.98 Contact Map
1x5bA 1 0.3897 11.3 0.98 Contact Map
1dvpA 2 0.3949 11 0.98 Contact Map
4cr2J 1 0.2205 10.3 0.98 Contact Map
1juqA 3 0.3718 9.7 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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