GREMLIN Database
Mucin - Mucin-like glycoprotein
PFAM: PF01456 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 143 (141)
Sequences: 645 (551)
Seq/√Len: 46.4
META: 0.009

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_T27_E3.2991.00
6_L10_L2.4741.00
57_T61_T2.4321.00
23_V27_E2.2841.00
3_T6_L2.2531.00
90_E93_S2.2381.00
89_T93_S2.1351.00
65_T68_T2.1231.00
64_A67_T2.0781.00
58_T62_T1.9970.99
112_R116_I1.9720.99
69_T72_T1.8640.99
78_T81_T1.8290.99
4_C7_L1.7870.99
53_Q56_T1.7610.98
21_V24_T1.7180.98
73_T76_T1.7140.98
108_R114_R1.7140.98
3_T7_L1.7130.98
4_C10_L1.7030.98
58_T61_T1.6820.98
67_T70_T1.6640.98
67_T71_T1.6430.98
139_Y142_V1.6400.97
23_V26_S1.6350.97
64_A68_T1.6020.97
52_T55_P1.6000.97
68_T71_T1.5610.97
63_T66_T1.5600.97
66_T69_T1.5150.96
41_G44_K1.4870.95
52_T58_T1.4510.95
3_T10_L1.4510.95
75_T78_T1.4370.95
104_T131_L1.3730.93
45_T51_T1.3640.93
96_T99_T1.3560.93
67_T72_T1.3550.93
50_T56_T1.3420.92
48_T51_T1.3290.92
76_T79_T1.3030.91
105_T131_L1.3010.91
35_G38_G1.2930.91
51_T57_T1.2910.91
71_T75_T1.2880.91
38_G41_G1.2850.91
47_T55_P1.2800.90
15_L18_C1.2770.90
34_Q39_A1.2630.90
6_L19_P1.2500.89
131_L134_V1.2410.89
107_T110_P1.2380.89
39_A43_S1.2290.88
55_P58_T1.2250.88
59_T62_T1.2190.88
63_T68_T1.2140.88
34_Q43_S1.1850.87
10_L19_P1.1810.86
55_P61_T1.1730.86
36_T40_S1.1700.86
45_T48_T1.1440.85
41_G45_T1.1390.84
73_T77_T1.1200.83
7_L10_L1.1090.83
71_T76_T1.1080.83
55_P60_T1.1010.82
54_P62_T1.0930.82
52_T57_T1.0900.82
31_S57_T1.0750.81
72_T76_T1.0460.79
30_Q33_S1.0430.79
56_T59_T1.0350.78
47_T50_T1.0310.78
4_C19_P1.0280.78
51_T62_T1.0120.76
18_C21_V1.0090.76
34_Q40_S1.0040.76
31_S35_G1.0040.76
54_P58_T1.0030.76
32_N40_S1.0020.76
1_M7_L0.9960.75
37_S44_K0.9930.75
51_T58_T0.9900.75
83_T86_T0.9690.73
76_T80_T0.9650.73
30_Q38_G0.9610.73
48_T52_T0.9570.72
20_S24_T0.9430.71
46_T49_T0.9400.71
53_Q57_T0.9310.70
47_T51_T0.9300.70
28_E49_T0.9220.69
40_S44_K0.9220.69
36_T39_A0.9150.69
34_Q42_Q0.9110.69
30_Q34_Q0.9100.68
51_T55_P0.9080.68
29_G36_T0.9060.68
26_S141_T0.9010.68
49_T56_T0.8990.67
40_S46_T0.8930.67
6_L12_V0.8930.67
51_T60_T0.8880.67
40_S45_T0.8850.66
33_S43_S0.8820.66
37_S56_T0.8660.65
54_P57_T0.8550.64
63_T69_T0.8500.63
73_T78_T0.8500.63
45_T50_T0.8430.62
68_T72_T0.8390.62
38_G46_T0.8300.61
34_Q46_T0.8290.61
50_T53_Q0.8270.61
33_S37_S0.8190.60
86_T89_T0.8180.60
101_A139_Y0.8160.60
1_M6_L0.8140.60
75_T79_T0.8120.60
48_T56_T0.8090.59
43_S54_P0.8010.58
32_N52_T0.7910.58
46_T54_P0.7890.57
44_K53_Q0.7880.57
7_L12_V0.7810.57
99_T120_L0.7720.56
44_K47_T0.7710.56
77_T80_T0.7680.55
37_S55_P0.7660.55
114_R127_C0.7650.55
103_T131_L0.7630.55
46_T50_T0.7530.54
49_T57_T0.7470.53
79_T82_T0.7430.53
34_Q37_S0.7400.53
42_Q45_T0.7360.52
64_A71_T0.7340.52
32_N36_T0.7320.52
49_T53_Q0.7260.51
51_T59_T0.7240.51
51_T61_T0.7240.51
35_G39_A0.7230.51
8_C18_C0.7220.51
39_A45_T0.7180.50
64_A69_T0.7110.50
48_T54_P0.7110.50
33_S36_T0.7100.50
30_Q36_T0.7000.49
51_T56_T0.6980.48
54_P61_T0.6880.47
85_T88_T0.6810.47
118_G122_S0.6800.47
30_Q37_S0.6780.46
39_A55_P0.6770.46
63_T77_T0.6760.46
87_T92_P0.6760.46
21_V25_A0.6750.46
16_C19_P0.6730.46
4_C13_L0.6720.46
37_S40_S0.6650.45
28_E43_S0.6620.45
30_Q47_T0.6560.44
57_T60_T0.6500.44
36_T41_G0.6490.44
47_T52_T0.6460.43
44_K57_T0.6420.43
52_T141_T0.6400.43
51_T54_P0.6390.43
45_T60_T0.6380.43
32_N35_G0.6370.42
50_T60_T0.6370.42
75_T81_T0.6300.42
33_S50_T0.6180.41
59_T142_V0.6170.41
47_T59_T0.6160.40
102_P139_Y0.6120.40
48_T53_Q0.6090.40
37_S50_T0.6000.39
2_M108_R0.5960.39
30_Q39_A0.5840.37
47_T53_Q0.5830.37
41_G59_T0.5810.37
48_T57_T0.5780.37
55_P59_T0.5770.37
45_T54_P0.5750.37
71_T74_T0.5750.37
32_N49_T0.5750.37
50_T59_T0.5740.36
88_T91_A0.5720.36
52_T60_T0.5710.36
5_R10_L0.5680.36
38_G42_Q0.5650.36
66_T70_T0.5600.35
46_T52_T0.5580.35
83_T88_T0.5520.34
88_T93_S0.5470.34
1_M4_C0.5460.34
4_C12_V0.5360.33
35_G40_S0.5340.33
41_G53_Q0.5320.33
115_E126_V0.5310.33
42_Q47_T0.5280.32
120_L127_C0.5250.32
6_L9_A0.5230.32
53_Q60_T0.5210.32
36_T47_T0.5170.31
23_V58_T0.5150.31
34_Q38_G0.5130.31
39_A44_K0.5070.31
28_E50_T0.5070.31
21_V140_T0.5050.30
35_G53_Q0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m0cC 1 0.2238 7.9 0.952 Contact Map
2mtsA 1 0.1469 2.7 0.961 Contact Map
3qu6A 1 0.2517 2.2 0.963 Contact Map
2irfG 1 0.2657 2.1 0.964 Contact Map
2m6xA 6 0.1469 2 0.964 Contact Map
1kmoA 1 0 1.6 0.966 Contact Map
2dq0A 2 0.2727 1.4 0.967 Contact Map
2rmsB 1 0.1538 1.3 0.967 Contact Map
2vdaB 1 0.1608 1.1 0.969 Contact Map
1iw4A 1 0.2168 0.9 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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