Mucin - PFAM28P - GREMLIN Contacts

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Mucin - Mucin-like glycoprotein

PFAM:	PF01456	Sequences: MMTCRLLCALLVLALCCCPSVCVTASEEGQSNSQGTSGASGQSKTTTTTTTTQPPTTTTTTTTATTTTTTTTTTTTTTTTTTTTTTTTTEAPSTTTTTTEAPTTTTTRAPSRLREIDGSLSSSAWVCAPLLLAVSALAYTTVG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	143 (141)
Sequences:	645 (551)
Seq/√Len:	46.4
META:	0.009

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
24_T	27_E	3.299	1.00
6_L	10_L	2.474	1.00
57_T	61_T	2.432	1.00
23_V	27_E	2.284	1.00
3_T	6_L	2.253	1.00
90_E	93_S	2.238	1.00
89_T	93_S	2.135	1.00
65_T	68_T	2.123	1.00
64_A	67_T	2.078	1.00
58_T	62_T	1.997	0.99
112_R	116_I	1.972	0.99
69_T	72_T	1.864	0.99
78_T	81_T	1.829	0.99
4_C	7_L	1.787	0.99
53_Q	56_T	1.761	0.98
21_V	24_T	1.718	0.98
73_T	76_T	1.714	0.98
108_R	114_R	1.714	0.98
3_T	7_L	1.713	0.98
4_C	10_L	1.703	0.98
58_T	61_T	1.682	0.98
67_T	70_T	1.664	0.98
67_T	71_T	1.643	0.98
139_Y	142_V	1.640	0.97
23_V	26_S	1.635	0.97
64_A	68_T	1.602	0.97
52_T	55_P	1.600	0.97
68_T	71_T	1.561	0.97
63_T	66_T	1.560	0.97
66_T	69_T	1.515	0.96
41_G	44_K	1.487	0.95
52_T	58_T	1.451	0.95
3_T	10_L	1.451	0.95
75_T	78_T	1.437	0.95
104_T	131_L	1.373	0.93
45_T	51_T	1.364	0.93
96_T	99_T	1.356	0.93
67_T	72_T	1.355	0.93
50_T	56_T	1.342	0.92
48_T	51_T	1.329	0.92
76_T	79_T	1.303	0.91
105_T	131_L	1.301	0.91
35_G	38_G	1.293	0.91
51_T	57_T	1.291	0.91
71_T	75_T	1.288	0.91
38_G	41_G	1.285	0.91
47_T	55_P	1.280	0.90
15_L	18_C	1.277	0.90
34_Q	39_A	1.263	0.90
6_L	19_P	1.250	0.89
131_L	134_V	1.241	0.89
107_T	110_P	1.238	0.89
39_A	43_S	1.229	0.88
55_P	58_T	1.225	0.88
59_T	62_T	1.219	0.88
63_T	68_T	1.214	0.88
34_Q	43_S	1.185	0.87
10_L	19_P	1.181	0.86
55_P	61_T	1.173	0.86
36_T	40_S	1.170	0.86
45_T	48_T	1.144	0.85
41_G	45_T	1.139	0.84
73_T	77_T	1.120	0.83
7_L	10_L	1.109	0.83
71_T	76_T	1.108	0.83
55_P	60_T	1.101	0.82
54_P	62_T	1.093	0.82
52_T	57_T	1.090	0.82
31_S	57_T	1.075	0.81
72_T	76_T	1.046	0.79
30_Q	33_S	1.043	0.79
56_T	59_T	1.035	0.78
47_T	50_T	1.031	0.78
4_C	19_P	1.028	0.78
51_T	62_T	1.012	0.76
18_C	21_V	1.009	0.76
34_Q	40_S	1.004	0.76
31_S	35_G	1.004	0.76
54_P	58_T	1.003	0.76
32_N	40_S	1.002	0.76
1_M	7_L	0.996	0.75
37_S	44_K	0.993	0.75
51_T	58_T	0.990	0.75
83_T	86_T	0.969	0.73
76_T	80_T	0.965	0.73
30_Q	38_G	0.961	0.73
48_T	52_T	0.957	0.72
20_S	24_T	0.943	0.71
46_T	49_T	0.940	0.71
53_Q	57_T	0.931	0.70
47_T	51_T	0.930	0.70
28_E	49_T	0.922	0.69
40_S	44_K	0.922	0.69
36_T	39_A	0.915	0.69
34_Q	42_Q	0.911	0.69
30_Q	34_Q	0.910	0.68
51_T	55_P	0.908	0.68
29_G	36_T	0.906	0.68
26_S	141_T	0.901	0.68
49_T	56_T	0.899	0.67
40_S	46_T	0.893	0.67
6_L	12_V	0.893	0.67
51_T	60_T	0.888	0.67
40_S	45_T	0.885	0.66
33_S	43_S	0.882	0.66
37_S	56_T	0.866	0.65
54_P	57_T	0.855	0.64
63_T	69_T	0.850	0.63
73_T	78_T	0.850	0.63
45_T	50_T	0.843	0.62
68_T	72_T	0.839	0.62
38_G	46_T	0.830	0.61
34_Q	46_T	0.829	0.61
50_T	53_Q	0.827	0.61
33_S	37_S	0.819	0.60
86_T	89_T	0.818	0.60
101_A	139_Y	0.816	0.60
1_M	6_L	0.814	0.60
75_T	79_T	0.812	0.60
48_T	56_T	0.809	0.59
43_S	54_P	0.801	0.58
32_N	52_T	0.791	0.58
46_T	54_P	0.789	0.57
44_K	53_Q	0.788	0.57
7_L	12_V	0.781	0.57
99_T	120_L	0.772	0.56
44_K	47_T	0.771	0.56
77_T	80_T	0.768	0.55
37_S	55_P	0.766	0.55
114_R	127_C	0.765	0.55
103_T	131_L	0.763	0.55
46_T	50_T	0.753	0.54
49_T	57_T	0.747	0.53
79_T	82_T	0.743	0.53
34_Q	37_S	0.740	0.53
42_Q	45_T	0.736	0.52
64_A	71_T	0.734	0.52
32_N	36_T	0.732	0.52
49_T	53_Q	0.726	0.51
51_T	59_T	0.724	0.51
51_T	61_T	0.724	0.51
35_G	39_A	0.723	0.51
8_C	18_C	0.722	0.51
39_A	45_T	0.718	0.50
64_A	69_T	0.711	0.50
48_T	54_P	0.711	0.50
33_S	36_T	0.710	0.50
30_Q	36_T	0.700	0.49
51_T	56_T	0.698	0.48
54_P	61_T	0.688	0.47
85_T	88_T	0.681	0.47
118_G	122_S	0.680	0.47
30_Q	37_S	0.678	0.46
39_A	55_P	0.677	0.46
63_T	77_T	0.676	0.46
87_T	92_P	0.676	0.46
21_V	25_A	0.675	0.46
16_C	19_P	0.673	0.46
4_C	13_L	0.672	0.46
37_S	40_S	0.665	0.45
28_E	43_S	0.662	0.45
30_Q	47_T	0.656	0.44
57_T	60_T	0.650	0.44
36_T	41_G	0.649	0.44
47_T	52_T	0.646	0.43
44_K	57_T	0.642	0.43
52_T	141_T	0.640	0.43
51_T	54_P	0.639	0.43
45_T	60_T	0.638	0.43
32_N	35_G	0.637	0.42
50_T	60_T	0.637	0.42
75_T	81_T	0.630	0.42
33_S	50_T	0.618	0.41
59_T	142_V	0.617	0.41
47_T	59_T	0.616	0.40
102_P	139_Y	0.612	0.40
48_T	53_Q	0.609	0.40
37_S	50_T	0.600	0.39
2_M	108_R	0.596	0.39
30_Q	39_A	0.584	0.37
47_T	53_Q	0.583	0.37
41_G	59_T	0.581	0.37
48_T	57_T	0.578	0.37
55_P	59_T	0.577	0.37
45_T	54_P	0.575	0.37
71_T	74_T	0.575	0.37
32_N	49_T	0.575	0.37
50_T	59_T	0.574	0.36
88_T	91_A	0.572	0.36
52_T	60_T	0.571	0.36
5_R	10_L	0.568	0.36
38_G	42_Q	0.565	0.36
66_T	70_T	0.560	0.35
46_T	52_T	0.558	0.35
83_T	88_T	0.552	0.34
88_T	93_S	0.547	0.34
1_M	4_C	0.546	0.34
4_C	12_V	0.536	0.33
35_G	40_S	0.534	0.33
41_G	53_Q	0.532	0.33
115_E	126_V	0.531	0.33
42_Q	47_T	0.528	0.32
120_L	127_C	0.525	0.32
6_L	9_A	0.523	0.32
53_Q	60_T	0.521	0.32
36_T	47_T	0.517	0.31
23_V	58_T	0.515	0.31
34_Q	38_G	0.513	0.31
39_A	44_K	0.507	0.31
28_E	50_T	0.507	0.31
21_V	140_T	0.505	0.30
35_G	53_Q	0.500	0.30

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3m0cC	1	0.2238	7.9	0.952	Contact Map
2mtsA	1	0.1469	2.7	0.961	Contact Map
3qu6A	1	0.2517	2.2	0.963	Contact Map
2irfG	1	0.2657	2.1	0.964	Contact Map
2m6xA	6	0.1469	2	0.964	Contact Map
1kmoA	1	0	1.6	0.966	Contact Map
2dq0A	2	0.2727	1.4	0.967	Contact Map
2rmsB	1	0.1538	1.3	0.967	Contact Map
2vdaB	1	0.1608	1.1	0.969	Contact Map
1iw4A	1	0.2168	0.9	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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