GREMLIN Database
OrfB_IS605 - Probable transposase
PFAM: PF01385 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 120 (108)
Sequences: 49710 (28229)
Seq/√Len: 2716.3
META: 0.886

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_D94_K3.5221.00
97_T101_R3.4231.00
49_A87_Q3.1131.00
112_N115_G2.9981.00
82_E86_N2.6051.00
93_H96_S2.4901.00
31_L35_E2.1111.00
98_R102_E2.0721.00
63_K73_A1.9611.00
27_N39_K1.8801.00
31_L99_L1.8371.00
45_F87_Q1.7951.00
27_N30_T1.7891.00
56_L73_A1.7791.00
59_R63_K1.7131.00
60_L74_R1.6741.00
56_L80_L1.6701.00
52_K56_L1.6201.00
57_Q77_L1.6021.00
28_F91_F1.5791.00
91_F95_L1.5221.00
19_V103_Y1.5221.00
71_R74_R1.5161.00
95_L98_R1.5001.00
57_Q61_S1.4911.00
89_K93_H1.4561.00
30_T39_K1.3511.00
18_V107_V1.3421.00
74_R78_A1.3291.00
83_K87_Q1.3051.00
66_G70_R1.2861.00
81_H84_I1.2851.00
92_L96_S1.2691.00
46_L50_E1.2661.00
21_I31_L1.2641.00
21_I29_A1.2391.00
53_L81_H1.2281.00
56_L59_R1.2231.00
73_A77_L1.2211.00
57_Q81_H1.2151.00
42_N45_F1.1811.00
18_V105_V1.1631.00
19_V31_L1.1601.00
50_E54_K1.1411.00
114_K117_V1.1331.00
70_R74_R1.1321.00
17_K104_D1.1261.00
60_L73_A1.1201.00
29_A95_L1.1161.00
55_R59_R1.1031.00
12_L15_T1.0771.00
28_F92_L1.0311.00
97_T100_V1.0201.00
85_A89_K1.0121.00
27_N41_E1.0091.00
68_K71_R1.0051.00
47_R50_E0.9851.00
93_H97_T0.9811.00
54_K58_R0.9691.00
49_A80_L0.9681.00
56_L76_K0.9661.00
52_K80_L0.9611.00
60_L77_L0.9531.00
75_R79_R0.9511.00
77_L81_H0.9451.00
86_N89_K0.9421.00
60_L63_K0.9401.00
40_I95_L0.9361.00
64_K67_S0.9201.00
21_I108_V0.9201.00
58_R61_S0.9181.00
45_F49_A0.9061.00
40_I98_R0.8871.00
60_L70_R0.8741.00
94_K97_T0.8671.00
100_V104_D0.8561.00
54_K57_Q0.8431.00
81_H85_A0.8361.00
31_L40_I0.8351.00
113_V117_V0.8191.00
23_L113_V0.8151.00
59_R73_A0.8051.00
19_V32_S0.8011.00
14_P17_K0.7981.00
64_K74_R0.7941.00
15_T104_D0.7931.00
49_A53_L0.7921.00
84_I88_R0.7911.00
63_K67_S0.7811.00
102_E106_I0.7781.00
24_G30_T0.7581.00
35_E98_R0.7531.00
43_P91_F0.7451.00
76_K79_R0.7391.00
76_K80_L0.7331.00
17_K103_Y0.7331.00
86_N90_D0.7241.00
103_Y106_I0.7171.00
61_S65_K0.7151.00
57_Q60_L0.7091.00
53_L80_L0.7071.00
92_L95_L0.7051.00
46_L49_A0.6941.00
53_L57_Q0.6921.00
49_A84_I0.6911.00
49_A52_K0.6891.00
79_R82_E0.6791.00
50_E84_I0.6791.00
49_A83_K0.6791.00
24_G29_A0.6761.00
73_A76_K0.6741.00
107_V110_D0.6701.00
24_G27_N0.6591.00
94_K98_R0.6541.00
26_K30_T0.6521.00
93_H100_V0.6501.00
71_R75_R0.6491.00
20_G32_S0.6461.00
53_L84_I0.6411.00
16_G104_D0.6401.00
69_N72_K0.6361.00
13_P16_G0.6341.00
61_S64_K0.6331.00
45_F48_K0.6271.00
23_L29_A0.6251.00
21_I99_L0.6241.00
65_K69_N0.6101.00
85_A88_R0.6071.00
83_K86_N0.6041.00
19_V33_D0.6031.00
52_K55_R0.6031.00
10_E13_P0.5971.00
78_A82_E0.5951.00
82_E85_A0.5931.00
31_L39_K0.5841.00
31_L103_Y0.5811.00
29_A99_L0.5761.00
66_G69_N0.5701.00
56_L77_L0.5651.00
64_K70_R0.5631.00
67_S70_R0.5611.00
58_R62_R0.5611.00
15_T18_V0.5591.00
63_K70_R0.5531.00
65_K70_R0.5461.00
51_K55_R0.5461.00
74_R77_L0.5451.00
101_R105_V0.5441.00
55_R58_R0.5411.00
35_E102_E0.5391.00
65_K68_K0.5351.00
11_P14_P0.5341.00
87_Q90_D0.5311.00
13_P17_K0.5301.00
23_L108_V0.5271.00
29_A40_I0.5131.00
103_Y111_L0.5111.00
101_R104_D0.5061.00
40_I43_P0.5061.00
100_V106_I0.5051.00
100_V103_Y0.5011.00
88_R92_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nu0A 1 0.5417 36.8 0.864 Contact Map
1iv0A 1 0.525 34.6 0.866 Contact Map
1vhxA 2 0.55 28.9 0.871 Contact Map
4ogeA 1 0.5667 12.9 0.891 Contact Map
4ep4A 2 0.6083 10.5 0.895 Contact Map
4jneA 2 0.8833 8 0.9 Contact Map
1hjrA 2 0.625 7.4 0.902 Contact Map
4w8jA 2 0.9167 7.3 0.902 Contact Map
3bzcA 1 0.675 7.2 0.902 Contact Map
1sf9A 1 0.6583 6.6 0.904 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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