GREMLIN Database
PHO4 - Phosphate transporter family
PFAM: PF01384 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 353 (353)
Sequences: 7681 (4338)
Seq/√Len: 230.9
META: 0.738

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_K117_K4.1361.00
20_T23_Q3.8091.00
301_A308_V3.4831.00
31_F216_A3.2741.00
42_A305_G3.1601.00
65_G100_A3.1011.00
102_I107_F2.9891.00
147_R153_A2.9551.00
98_V115_V2.8071.00
26_I30_I2.7891.00
262_L266_T2.7821.00
27_I216_A2.5621.00
200_D203_V2.5331.00
217_L295_A2.5001.00
191_Y195_R2.4991.00
119_V123_V2.4091.00
149_D152_A2.3951.00
333_R336_R2.3541.00
273_K277_E2.3371.00
79_L83_L2.2731.00
13_S215_A2.2641.00
200_D204_E2.2101.00
308_V313_T2.1301.00
44_A47_I2.0711.00
34_A220_F2.0631.00
32_E222_H2.0621.00
59_P62_L2.0491.00
37_L250_L1.9821.00
330_V335_V1.9561.00
120_A124_I1.9481.00
34_A38_L1.9431.00
275_V315_V1.9051.00
139_L143_L1.8991.00
136_L289_A1.8761.00
193_L196_P1.8611.00
19_L27_I1.8601.00
75_L79_L1.8311.00
171_L175_L1.8261.00
42_A47_I1.8201.00
17_K277_E1.8001.00
42_A46_T1.7591.00
58_D61_L1.7431.00
116_G120_A1.7421.00
181_G184_L1.7031.00
91_H312_H1.6841.00
21_P272_I1.6831.00
81_T271_V1.6791.00
43_V47_I1.6671.00
184_L188_L1.6531.00
190_G194_L1.6521.00
340_L344_I1.6491.00
131_I135_L1.6191.00
32_E264_L1.6171.00
188_L192_L1.6111.00
72_A352_L1.6081.00
224_A302_S1.5821.00
60_E63_V1.5771.00
319_F335_V1.5691.00
271_V274_T1.5531.00
180_L184_L1.5501.00
68_A72_A1.5361.00
19_L212_I1.5351.00
153_A156_R1.5141.00
290_A314_L1.5111.00
129_G313_T1.5031.00
124_I128_L1.5031.00
27_I31_F1.5001.00
39_A42_A1.4931.00
336_R340_L1.4881.00
183_G186_V1.4861.00
194_L197_I1.4751.00
192_L196_P1.4741.00
293_A297_T1.4681.00
77_L87_V1.4591.00
138_L142_R1.4561.00
187_A191_Y1.4531.00
98_V110_V1.4511.00
135_L139_L1.4411.00
63_V241_V1.4361.00
166_A186_V1.4361.00
154_A159_P1.4291.00
181_G185_V1.4211.00
188_L191_Y1.4191.00
211_Q291_E1.4131.00
138_L141_K1.4111.00
121_S125_S1.4021.00
48_R52_I1.3931.00
300_L304_L1.3901.00
52_I101_G1.3861.00
231_I252_V1.3811.00
292_L295_A1.3771.00
333_R337_N1.3671.00
113_G117_K1.3501.00
105_A109_A1.3471.00
166_A170_S1.3421.00
326_G329_A1.3261.00
111_N114_K1.3251.00
152_A156_R1.3251.00
183_G187_A1.3201.00
151_L155_K1.3201.00
217_L296_I1.3191.00
300_L303_R1.3091.00
238_V252_V1.3081.00
3_A81_T1.3041.00
39_A220_F1.3001.00
4_N81_T1.2931.00
302_S305_G1.2891.00
253_L257_G1.2841.00
14_V24_A1.2811.00
138_L324_A1.2801.00
155_K158_V1.2611.00
185_V189_I1.2571.00
294_A314_L1.2551.00
261_A264_L1.2531.00
275_V318_V1.2521.00
25_V265_A1.2521.00
45_E48_R1.2411.00
179_A187_A1.2341.00
168_I171_L1.2311.00
190_G196_P1.2301.00
19_L23_Q1.2231.00
294_A298_V1.2211.00
48_R51_I1.2191.00
134_A324_A1.2051.00
211_Q287_G1.1881.00
156_R160_V1.1871.00
76_W92_S1.1841.00
4_N80_A1.1821.00
69_A93_I1.1741.00
193_L197_I1.1741.00
1_I89_T1.1701.00
331_N334_V1.1701.00
199_R202_S1.1701.00
152_A155_K1.1691.00
221_A298_V1.1691.00
128_L300_L1.1661.00
76_W87_V1.1601.00
45_E49_K1.1571.00
296_I300_L1.1561.00
94_V118_I1.1561.00
29_A261_A1.1471.00
124_I127_L1.1461.00
141_K325_R1.1451.00
115_V346_L1.1381.00
43_V46_T1.1371.00
139_L161_L1.1351.00
348_A352_L1.1341.00
155_K159_P1.1301.00
215_A291_E1.1291.00
163_F187_A1.1241.00
64_L68_A1.1231.00
5_D8_N1.1221.00
141_K146_R1.1211.00
158_V162_V1.1191.00
210_L288_F1.1161.00
33_F261_A1.1151.00
344_I348_A1.1151.00
134_A138_L1.1111.00
82_Y267_G1.1061.00
184_L187_A1.1041.00
179_A183_G1.1011.00
178_I181_G1.0981.00
290_A318_V1.0911.00
241_V244_G1.0911.00
25_V29_A1.0871.00
190_G195_R1.0851.00
167_F171_L1.0851.00
199_R203_V1.0811.00
62_L240_I1.0791.00
159_P163_F1.0691.00
4_N271_V1.0691.00
125_S312_H1.0681.00
154_A158_V1.0621.00
77_L81_T1.0591.00
12_T291_E1.0541.00
331_N337_N1.0511.00
291_E314_L1.0481.00
334_V337_N1.0431.00
219_S223_G1.0351.00
162_V190_G1.0341.00
63_V240_I1.0321.00
273_K278_K1.0281.00
153_A157_W1.0251.00
298_V301_A1.0221.00
170_S174_L1.0211.00
101_G105_A1.0201.00
37_L254_L1.0201.00
96_A100_A1.0181.00
13_S291_E1.0161.00
69_A73_A1.0161.00
235_A238_V1.0121.00
171_L176_K1.0071.00
190_G193_L1.0061.00
191_Y194_L1.0031.00
168_I175_L1.0011.00
180_L188_L0.9991.00
81_T85_L0.9981.00
218_V294_A0.9961.00
224_A299_L0.9951.00
266_T269_W0.9941.00
157_W161_L0.9851.00
154_A157_W0.9811.00
77_L89_T0.9801.00
49_K53_D0.9791.00
208_R284_P0.9771.00
4_N77_L0.9761.00
84_G278_K0.9711.00
148_E151_L0.9691.00
130_G316_G0.9681.00
59_P63_V0.9671.00
167_F170_S0.9661.00
173_L177_G0.9651.00
203_V206_L0.9631.00
36_A257_G0.9611.00
42_A45_E0.9611.00
22_R26_I0.9561.00
72_A349_A0.9561.00
162_V166_A0.9521.00
11_A275_V0.9491.00
231_I256_G0.9481.00
187_A190_G0.9481.00
178_I184_L0.9391.00
39_A47_I0.9351.00
69_A353_S0.9331.00
179_A182_I0.9321.00
113_G116_G0.9301.00
349_A353_S0.9161.00
200_D206_L0.9151.00
150_P153_A0.9131.00
151_L154_A0.9121.00
329_A332_W0.9091.00
18_A25_V0.9081.00
156_R159_P0.9071.00
214_S291_E0.9030.99
269_W273_K0.8990.99
84_G270_R0.8950.99
53_D56_L0.8930.99
350_A353_S0.8910.99
137_F286_R0.8900.99
157_W160_V0.8880.99
277_E281_K0.8870.99
145_L200_D0.8860.99
198_N202_S0.8840.99
69_A97_I0.8770.99
128_L306_L0.8750.99
248_V253_L0.8740.99
201_A206_L0.8740.99
283_T286_R0.8720.99
54_P111_N0.8690.99
167_F176_K0.8660.99
170_S182_I0.8660.99
23_Q26_I0.8560.99
78_L267_G0.8550.99
172_V175_L0.8550.99
10_M14_V0.8540.99
322_G325_R0.8520.99
238_V241_V0.8510.99
270_R273_K0.8490.99
294_A297_T0.8480.99
201_A204_E0.8480.99
132_I297_T0.8470.99
300_L306_L0.8460.99
85_L341_A0.8440.99
50_G53_D0.8420.99
205_K209_R0.8350.99
331_N341_A0.8260.99
291_E295_A0.8250.99
159_P162_V0.8220.99
9_A13_S0.8220.99
169_I175_L0.8210.99
134_A137_F0.8210.99
144_I157_W0.8210.99
291_E294_A0.8210.99
70_L237_I0.8200.99
335_V339_V0.8200.99
136_L164_L0.8190.99
82_Y270_R0.8170.99
142_R146_R0.8170.99
298_V302_S0.8170.99
40_G47_I0.8130.99
167_F179_A0.8080.99
287_G291_E0.8080.99
189_I192_L0.8060.99
124_I306_L0.8050.99
322_G330_V0.8020.99
198_N201_A0.7990.99
192_L197_I0.7920.99
98_V102_I0.7910.99
143_L157_W0.7900.99
27_I212_I0.7900.99
163_F167_F0.7900.99
181_G188_L0.7830.99
185_V188_L0.7800.98
33_F37_L0.7790.98
150_P154_A0.7780.98
183_G192_L0.7770.98
190_G197_I0.7760.98
338_I347_P0.7730.98
185_V192_L0.7730.98
168_I172_V0.7710.98
77_L84_G0.7700.98
4_N87_V0.7670.98
239_S243_T0.7640.98
148_E152_A0.7620.98
80_A89_T0.7620.98
112_W116_G0.7600.98
81_T87_V0.7590.98
171_L174_L0.7560.98
105_A108_S0.7550.98
48_R246_A0.7520.98
206_L210_L0.7510.98
313_T317_A0.7460.98
18_A208_R0.7450.98
70_L233_P0.7430.98
187_A193_L0.7420.98
133_A321_V0.7420.98
293_A299_L0.7420.98
182_I185_V0.7410.98
298_V308_V0.7370.98
127_L131_I0.7360.98
325_R329_A0.7350.98
80_A271_V0.7350.98
160_V164_L0.7330.98
160_V163_F0.7320.98
41_G253_L0.7260.98
181_G189_I0.7250.98
39_A44_A0.7240.98
250_L254_L0.7210.98
274_T338_I0.7200.97
9_A218_V0.7190.97
140_I289_A0.7160.97
154_A162_V0.7160.97
41_G44_A0.7140.97
31_F34_A0.7140.97
267_G270_R0.7120.97
154_A160_V0.7110.97
339_V343_V0.7110.97
275_V314_L0.7110.97
130_G323_L0.7110.97
184_L190_G0.7090.97
33_F257_G0.7060.97
87_V271_V0.7060.97
100_A353_S0.7040.97
183_G196_P0.7030.97
234_L238_V0.7010.97
221_A299_L0.7000.97
170_S175_L0.7000.97
41_G47_I0.7000.97
172_V176_K0.6980.97
79_L352_L0.6980.97
74_A78_L0.6970.97
169_I174_L0.6950.97
81_T270_R0.6950.97
169_I172_V0.6920.97
13_S19_L0.6880.97
101_G109_A0.6870.97
189_I195_R0.6860.97
310_T313_T0.6850.97
77_L80_A0.6820.97
129_G133_A0.6820.97
284_P287_G0.6810.96
218_V282_L0.6770.96
66_M97_I0.6720.96
268_G271_V0.6720.96
44_A48_R0.6690.96
31_F219_S0.6650.96
207_F288_F0.6630.96
1_I11_A0.6620.96
282_L290_A0.6610.96
75_L352_L0.6590.96
112_W115_V0.6590.96
36_A40_G0.6570.96
35_G257_G0.6570.96
33_F258_L0.6560.96
199_R204_E0.6550.96
101_G280_T0.6550.96
178_I182_I0.6550.96
2_G5_D0.6550.96
174_L177_G0.6550.96
184_L192_L0.6540.96
153_A158_V0.6540.96
204_E283_T0.6530.96
293_A317_A0.6520.96
28_A31_F0.6520.96
32_E261_A0.6510.95
178_I189_I0.6490.95
227_V260_I0.6480.95
183_G191_Y0.6480.95
58_D62_L0.6460.95
13_S212_I0.6460.95
156_R163_F0.6450.95
28_A264_L0.6430.95
296_I303_R0.6420.95
315_V318_V0.6420.95
163_F169_I0.6400.95
17_K20_T0.6380.95
335_V348_A0.6340.95
71_L74_A0.6340.95
51_I118_I0.6310.95
47_I94_V0.6310.95
80_A87_V0.6310.95
231_I248_V0.6300.95
162_V165_V0.6300.95
332_W336_R0.6290.95
234_L255_L0.6290.95
180_L191_Y0.6280.95
255_L258_L0.6260.94
56_L105_A0.6260.94
178_I183_G0.6250.94
10_M218_V0.6240.94
9_A32_E0.6240.94
209_R213_L0.6230.94
169_I173_L0.6210.94
272_I275_V0.6200.94
149_D153_A0.6200.94
6_V28_A0.6190.94
279_I319_F0.6160.94
53_D57_F0.6150.94
299_L349_A0.6150.94
8_N222_H0.6130.94
332_W335_V0.6110.94
205_K208_R0.6090.94
191_Y196_P0.6090.94
200_D205_K0.6080.94
297_T300_L0.6070.93
222_H226_D0.6070.93
166_A176_K0.6060.93
66_M236_A0.6040.93
172_V177_G0.6040.93
188_L194_L0.6030.93
165_V169_I0.6030.93
3_A6_V0.6020.93
293_A296_I0.6020.93
169_I176_K0.6000.93
187_A194_L0.5990.93
221_A302_S0.5990.93
171_L179_A0.5980.93
284_P291_E0.5970.93
186_V194_L0.5930.93
143_L147_R0.5930.93
166_A173_L0.5930.93
149_D154_A0.5920.93
179_A197_I0.5910.93
316_G319_F0.5900.92
186_V190_G0.5890.92
122_W126_P0.5870.92
108_S111_N0.5850.92
150_P203_V0.5850.92
204_E285_S0.5840.92
173_L176_K0.5820.92
18_A291_E0.5820.92
293_A316_G0.5820.92
13_S18_A0.5790.92
170_S176_K0.5780.92
102_I350_A0.5770.92
76_W348_A0.5760.92
178_I186_V0.5760.92
137_F285_S0.5750.92
64_L67_L0.5730.91
181_G190_G0.5720.91
12_T211_Q0.5710.91
180_L183_G0.5700.91
286_R325_R0.5660.91
163_F171_L0.5650.91
183_G195_R0.5650.91
17_K23_Q0.5650.91
65_G69_A0.5620.91
51_I97_I0.5620.91
202_S205_K0.5610.91
146_R149_D0.5600.90
328_S333_R0.5590.90
213_L216_A0.5590.90
182_I194_L0.5580.90
147_R150_P0.5570.90
167_F174_L0.5570.90
258_L261_A0.5570.90
186_V191_Y0.5560.90
129_G317_A0.5550.90
218_V314_L0.5550.90
45_E50_G0.5540.90
69_A96_A0.5510.90
158_V161_L0.5510.90
36_A227_V0.5510.90
184_L191_Y0.5490.90
72_A96_A0.5480.89
187_A195_R0.5480.89
66_M94_V0.5470.89
299_L303_R0.5470.89
18_A218_V0.5460.89
72_A350_A0.5460.89
110_V115_V0.5440.89
128_L131_I0.5430.89
180_L186_V0.5430.89
180_L192_L0.5420.89
155_K170_S0.5360.88
312_H345_T0.5360.88
179_A192_L0.5360.88
151_L160_V0.5360.88
166_A183_G0.5350.88
10_M31_F0.5320.88
89_T229_N0.5320.88
258_L262_L0.5320.88
4_N89_T0.5290.88
227_V256_G0.5280.88
165_V168_I0.5280.88
168_I176_K0.5270.88
184_L195_R0.5270.88
44_A235_A0.5240.87
140_I161_L0.5240.87
344_I347_P0.5230.87
73_A93_I0.5220.87
139_L157_W0.5220.87
192_L195_R0.5200.87
139_L186_V0.5170.87
165_V172_V0.5160.87
47_I97_I0.5160.87
234_L256_G0.5160.87
167_F183_G0.5160.87
249_P252_V0.5150.86
255_L259_G0.5130.86
315_V338_I0.5110.86
38_L41_G0.5100.86
102_I115_V0.5050.85
90_T311_T0.5040.85
228_A311_T0.5030.85
7_A14_V0.5030.85
185_V193_L0.5030.85
152_A158_V0.5020.85
274_T278_K0.5010.85
44_A231_I0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwzA 2 0.7365 27.4 0.964 Contact Map
4czbA 2 0.762 16.5 0.968 Contact Map
3s90C 1 0.0538 5 0.975 Contact Map
3zojA 3 0.4079 4.7 0.975 Contact Map
1jb0I 1 0.1076 4.6 0.975 Contact Map
4nefA 4 0.4306 4.4 0.975 Contact Map
3qe7A 2 0.3966 4 0.976 Contact Map
4l6vi 1 0.1076 4 0.976 Contact Map
2kv5A 1 0.0935 3.9 0.976 Contact Map
4xk8I 1 0.0822 3.7 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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