PHO4 - PFAM28P - GREMLIN Contacts

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PHO4 - Phosphate transporter family

PFAM:	PF01384	Sequences: IGANDVANAMATSVGSKALTPRQAVIIAAIFEFAGALLAGGAVAETIRKGIIDPSLFDPELLVLGMLAALLAAALWLLLATYLGLPVSTTHSIVGAIVGAGIAAAGFSAVNWGKVGKIVASWVISPLLGGIIAALLFLLIKRLILRREDPLAAAKRWVPVLVFLVAFIISLVLLLKGIALGIGLVVALIGYLLLRPINRDASVEKLFRRLQILSAALVSFAHGANDVANAIGPLAAIVSIVQTGKAAVPLWVLLLGGLGIALGLATGGWRVIKTVGEKITKLTPSRGFAAELAAAITVLLASRLGLPVSTTHTLVGAVFGVGLARGISAVNWRVVRNIVLAWVITLPAAALLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	353 (353)
Sequences:	7681 (4338)
Seq/√Len:	230.9
META:	0.738

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
114_K	117_K	4.136	1.00
20_T	23_Q	3.809	1.00
301_A	308_V	3.483	1.00
31_F	216_A	3.274	1.00
42_A	305_G	3.160	1.00
65_G	100_A	3.101	1.00
102_I	107_F	2.989	1.00
147_R	153_A	2.955	1.00
98_V	115_V	2.807	1.00
26_I	30_I	2.789	1.00
262_L	266_T	2.782	1.00
27_I	216_A	2.562	1.00
200_D	203_V	2.533	1.00
217_L	295_A	2.500	1.00
191_Y	195_R	2.499	1.00
119_V	123_V	2.409	1.00
149_D	152_A	2.395	1.00
333_R	336_R	2.354	1.00
273_K	277_E	2.337	1.00
79_L	83_L	2.273	1.00
13_S	215_A	2.264	1.00
200_D	204_E	2.210	1.00
308_V	313_T	2.130	1.00
44_A	47_I	2.071	1.00
34_A	220_F	2.063	1.00
32_E	222_H	2.062	1.00
59_P	62_L	2.049	1.00
37_L	250_L	1.982	1.00
330_V	335_V	1.956	1.00
120_A	124_I	1.948	1.00
34_A	38_L	1.943	1.00
275_V	315_V	1.905	1.00
139_L	143_L	1.899	1.00
136_L	289_A	1.876	1.00
193_L	196_P	1.861	1.00
19_L	27_I	1.860	1.00
75_L	79_L	1.831	1.00
171_L	175_L	1.826	1.00
42_A	47_I	1.820	1.00
17_K	277_E	1.800	1.00
42_A	46_T	1.759	1.00
58_D	61_L	1.743	1.00
116_G	120_A	1.742	1.00
181_G	184_L	1.703	1.00
91_H	312_H	1.684	1.00
21_P	272_I	1.683	1.00
81_T	271_V	1.679	1.00
43_V	47_I	1.667	1.00
184_L	188_L	1.653	1.00
190_G	194_L	1.652	1.00
340_L	344_I	1.649	1.00
131_I	135_L	1.619	1.00
32_E	264_L	1.617	1.00
188_L	192_L	1.611	1.00
72_A	352_L	1.608	1.00
224_A	302_S	1.582	1.00
60_E	63_V	1.577	1.00
319_F	335_V	1.569	1.00
271_V	274_T	1.553	1.00
180_L	184_L	1.550	1.00
68_A	72_A	1.536	1.00
19_L	212_I	1.535	1.00
153_A	156_R	1.514	1.00
290_A	314_L	1.511	1.00
129_G	313_T	1.503	1.00
124_I	128_L	1.503	1.00
27_I	31_F	1.500	1.00
39_A	42_A	1.493	1.00
336_R	340_L	1.488	1.00
183_G	186_V	1.486	1.00
194_L	197_I	1.475	1.00
192_L	196_P	1.474	1.00
293_A	297_T	1.468	1.00
77_L	87_V	1.459	1.00
138_L	142_R	1.456	1.00
187_A	191_Y	1.453	1.00
98_V	110_V	1.451	1.00
135_L	139_L	1.441	1.00
63_V	241_V	1.436	1.00
166_A	186_V	1.436	1.00
154_A	159_P	1.429	1.00
181_G	185_V	1.421	1.00
188_L	191_Y	1.419	1.00
211_Q	291_E	1.413	1.00
138_L	141_K	1.411	1.00
121_S	125_S	1.402	1.00
48_R	52_I	1.393	1.00
300_L	304_L	1.390	1.00
52_I	101_G	1.386	1.00
231_I	252_V	1.381	1.00
292_L	295_A	1.377	1.00
333_R	337_N	1.367	1.00
113_G	117_K	1.350	1.00
105_A	109_A	1.347	1.00
166_A	170_S	1.342	1.00
326_G	329_A	1.326	1.00
111_N	114_K	1.325	1.00
152_A	156_R	1.325	1.00
183_G	187_A	1.320	1.00
151_L	155_K	1.320	1.00
217_L	296_I	1.319	1.00
300_L	303_R	1.309	1.00
238_V	252_V	1.308	1.00
3_A	81_T	1.304	1.00
39_A	220_F	1.300	1.00
4_N	81_T	1.293	1.00
302_S	305_G	1.289	1.00
253_L	257_G	1.284	1.00
14_V	24_A	1.281	1.00
138_L	324_A	1.280	1.00
155_K	158_V	1.261	1.00
185_V	189_I	1.257	1.00
294_A	314_L	1.255	1.00
261_A	264_L	1.253	1.00
275_V	318_V	1.252	1.00
25_V	265_A	1.252	1.00
45_E	48_R	1.241	1.00
179_A	187_A	1.234	1.00
168_I	171_L	1.231	1.00
190_G	196_P	1.230	1.00
19_L	23_Q	1.223	1.00
294_A	298_V	1.221	1.00
48_R	51_I	1.219	1.00
134_A	324_A	1.205	1.00
211_Q	287_G	1.188	1.00
156_R	160_V	1.187	1.00
76_W	92_S	1.184	1.00
4_N	80_A	1.182	1.00
69_A	93_I	1.174	1.00
193_L	197_I	1.174	1.00
1_I	89_T	1.170	1.00
331_N	334_V	1.170	1.00
199_R	202_S	1.170	1.00
152_A	155_K	1.169	1.00
221_A	298_V	1.169	1.00
128_L	300_L	1.166	1.00
76_W	87_V	1.160	1.00
45_E	49_K	1.157	1.00
296_I	300_L	1.156	1.00
94_V	118_I	1.156	1.00
29_A	261_A	1.147	1.00
124_I	127_L	1.146	1.00
141_K	325_R	1.145	1.00
115_V	346_L	1.138	1.00
43_V	46_T	1.137	1.00
139_L	161_L	1.135	1.00
348_A	352_L	1.134	1.00
155_K	159_P	1.130	1.00
215_A	291_E	1.129	1.00
163_F	187_A	1.124	1.00
64_L	68_A	1.123	1.00
5_D	8_N	1.122	1.00
141_K	146_R	1.121	1.00
158_V	162_V	1.119	1.00
210_L	288_F	1.116	1.00
33_F	261_A	1.115	1.00
344_I	348_A	1.115	1.00
134_A	138_L	1.111	1.00
82_Y	267_G	1.106	1.00
184_L	187_A	1.104	1.00
179_A	183_G	1.101	1.00
178_I	181_G	1.098	1.00
290_A	318_V	1.091	1.00
241_V	244_G	1.091	1.00
25_V	29_A	1.087	1.00
190_G	195_R	1.085	1.00
167_F	171_L	1.085	1.00
199_R	203_V	1.081	1.00
62_L	240_I	1.079	1.00
159_P	163_F	1.069	1.00
4_N	271_V	1.069	1.00
125_S	312_H	1.068	1.00
154_A	158_V	1.062	1.00
77_L	81_T	1.059	1.00
12_T	291_E	1.054	1.00
331_N	337_N	1.051	1.00
291_E	314_L	1.048	1.00
334_V	337_N	1.043	1.00
219_S	223_G	1.035	1.00
162_V	190_G	1.034	1.00
63_V	240_I	1.032	1.00
273_K	278_K	1.028	1.00
153_A	157_W	1.025	1.00
298_V	301_A	1.022	1.00
170_S	174_L	1.021	1.00
101_G	105_A	1.020	1.00
37_L	254_L	1.020	1.00
96_A	100_A	1.018	1.00
13_S	291_E	1.016	1.00
69_A	73_A	1.016	1.00
235_A	238_V	1.012	1.00
171_L	176_K	1.007	1.00
190_G	193_L	1.006	1.00
191_Y	194_L	1.003	1.00
168_I	175_L	1.001	1.00
180_L	188_L	0.999	1.00
81_T	85_L	0.998	1.00
218_V	294_A	0.996	1.00
224_A	299_L	0.995	1.00
266_T	269_W	0.994	1.00
157_W	161_L	0.985	1.00
154_A	157_W	0.981	1.00
77_L	89_T	0.980	1.00
49_K	53_D	0.979	1.00
208_R	284_P	0.977	1.00
4_N	77_L	0.976	1.00
84_G	278_K	0.971	1.00
148_E	151_L	0.969	1.00
130_G	316_G	0.968	1.00
59_P	63_V	0.967	1.00
167_F	170_S	0.966	1.00
173_L	177_G	0.965	1.00
203_V	206_L	0.963	1.00
36_A	257_G	0.961	1.00
42_A	45_E	0.961	1.00
22_R	26_I	0.956	1.00
72_A	349_A	0.956	1.00
162_V	166_A	0.952	1.00
11_A	275_V	0.949	1.00
231_I	256_G	0.948	1.00
187_A	190_G	0.948	1.00
178_I	184_L	0.939	1.00
39_A	47_I	0.935	1.00
69_A	353_S	0.933	1.00
179_A	182_I	0.932	1.00
113_G	116_G	0.930	1.00
349_A	353_S	0.916	1.00
200_D	206_L	0.915	1.00
150_P	153_A	0.913	1.00
151_L	154_A	0.912	1.00
329_A	332_W	0.909	1.00
18_A	25_V	0.908	1.00
156_R	159_P	0.907	1.00
214_S	291_E	0.903	0.99
269_W	273_K	0.899	0.99
84_G	270_R	0.895	0.99
53_D	56_L	0.893	0.99
350_A	353_S	0.891	0.99
137_F	286_R	0.890	0.99
157_W	160_V	0.888	0.99
277_E	281_K	0.887	0.99
145_L	200_D	0.886	0.99
198_N	202_S	0.884	0.99
69_A	97_I	0.877	0.99
128_L	306_L	0.875	0.99
248_V	253_L	0.874	0.99
201_A	206_L	0.874	0.99
283_T	286_R	0.872	0.99
54_P	111_N	0.869	0.99
167_F	176_K	0.866	0.99
170_S	182_I	0.866	0.99
23_Q	26_I	0.856	0.99
78_L	267_G	0.855	0.99
172_V	175_L	0.855	0.99
10_M	14_V	0.854	0.99
322_G	325_R	0.852	0.99
238_V	241_V	0.851	0.99
270_R	273_K	0.849	0.99
294_A	297_T	0.848	0.99
201_A	204_E	0.848	0.99
132_I	297_T	0.847	0.99
300_L	306_L	0.846	0.99
85_L	341_A	0.844	0.99
50_G	53_D	0.842	0.99
205_K	209_R	0.835	0.99
331_N	341_A	0.826	0.99
291_E	295_A	0.825	0.99
159_P	162_V	0.822	0.99
9_A	13_S	0.822	0.99
169_I	175_L	0.821	0.99
134_A	137_F	0.821	0.99
144_I	157_W	0.821	0.99
291_E	294_A	0.821	0.99
70_L	237_I	0.820	0.99
335_V	339_V	0.820	0.99
136_L	164_L	0.819	0.99
82_Y	270_R	0.817	0.99
142_R	146_R	0.817	0.99
298_V	302_S	0.817	0.99
40_G	47_I	0.813	0.99
167_F	179_A	0.808	0.99
287_G	291_E	0.808	0.99
189_I	192_L	0.806	0.99
124_I	306_L	0.805	0.99
322_G	330_V	0.802	0.99
198_N	201_A	0.799	0.99
192_L	197_I	0.792	0.99
98_V	102_I	0.791	0.99
143_L	157_W	0.790	0.99
27_I	212_I	0.790	0.99
163_F	167_F	0.790	0.99
181_G	188_L	0.783	0.99
185_V	188_L	0.780	0.98
33_F	37_L	0.779	0.98
150_P	154_A	0.778	0.98
183_G	192_L	0.777	0.98
190_G	197_I	0.776	0.98
338_I	347_P	0.773	0.98
185_V	192_L	0.773	0.98
168_I	172_V	0.771	0.98
77_L	84_G	0.770	0.98
4_N	87_V	0.767	0.98
239_S	243_T	0.764	0.98
148_E	152_A	0.762	0.98
80_A	89_T	0.762	0.98
112_W	116_G	0.760	0.98
81_T	87_V	0.759	0.98
171_L	174_L	0.756	0.98
105_A	108_S	0.755	0.98
48_R	246_A	0.752	0.98
206_L	210_L	0.751	0.98
313_T	317_A	0.746	0.98
18_A	208_R	0.745	0.98
70_L	233_P	0.743	0.98
187_A	193_L	0.742	0.98
133_A	321_V	0.742	0.98
293_A	299_L	0.742	0.98
182_I	185_V	0.741	0.98
298_V	308_V	0.737	0.98
127_L	131_I	0.736	0.98
325_R	329_A	0.735	0.98
80_A	271_V	0.735	0.98
160_V	164_L	0.733	0.98
160_V	163_F	0.732	0.98
41_G	253_L	0.726	0.98
181_G	189_I	0.725	0.98
39_A	44_A	0.724	0.98
250_L	254_L	0.721	0.98
274_T	338_I	0.720	0.97
9_A	218_V	0.719	0.97
140_I	289_A	0.716	0.97
154_A	162_V	0.716	0.97
41_G	44_A	0.714	0.97
31_F	34_A	0.714	0.97
267_G	270_R	0.712	0.97
154_A	160_V	0.711	0.97
339_V	343_V	0.711	0.97
275_V	314_L	0.711	0.97
130_G	323_L	0.711	0.97
184_L	190_G	0.709	0.97
33_F	257_G	0.706	0.97
87_V	271_V	0.706	0.97
100_A	353_S	0.704	0.97
183_G	196_P	0.703	0.97
234_L	238_V	0.701	0.97
221_A	299_L	0.700	0.97
170_S	175_L	0.700	0.97
41_G	47_I	0.700	0.97
172_V	176_K	0.698	0.97
79_L	352_L	0.698	0.97
74_A	78_L	0.697	0.97
169_I	174_L	0.695	0.97
81_T	270_R	0.695	0.97
169_I	172_V	0.692	0.97
13_S	19_L	0.688	0.97
101_G	109_A	0.687	0.97
189_I	195_R	0.686	0.97
310_T	313_T	0.685	0.97
77_L	80_A	0.682	0.97
129_G	133_A	0.682	0.97
284_P	287_G	0.681	0.96
218_V	282_L	0.677	0.96
66_M	97_I	0.672	0.96
268_G	271_V	0.672	0.96
44_A	48_R	0.669	0.96
31_F	219_S	0.665	0.96
207_F	288_F	0.663	0.96
1_I	11_A	0.662	0.96
282_L	290_A	0.661	0.96
75_L	352_L	0.659	0.96
112_W	115_V	0.659	0.96
36_A	40_G	0.657	0.96
35_G	257_G	0.657	0.96
33_F	258_L	0.656	0.96
199_R	204_E	0.655	0.96
101_G	280_T	0.655	0.96
178_I	182_I	0.655	0.96
2_G	5_D	0.655	0.96
174_L	177_G	0.655	0.96
184_L	192_L	0.654	0.96
153_A	158_V	0.654	0.96
204_E	283_T	0.653	0.96
293_A	317_A	0.652	0.96
28_A	31_F	0.652	0.96
32_E	261_A	0.651	0.95
178_I	189_I	0.649	0.95
227_V	260_I	0.648	0.95
183_G	191_Y	0.648	0.95
58_D	62_L	0.646	0.95
13_S	212_I	0.646	0.95
156_R	163_F	0.645	0.95
28_A	264_L	0.643	0.95
296_I	303_R	0.642	0.95
315_V	318_V	0.642	0.95
163_F	169_I	0.640	0.95
17_K	20_T	0.638	0.95
335_V	348_A	0.634	0.95
71_L	74_A	0.634	0.95
51_I	118_I	0.631	0.95
47_I	94_V	0.631	0.95
80_A	87_V	0.631	0.95
231_I	248_V	0.630	0.95
162_V	165_V	0.630	0.95
332_W	336_R	0.629	0.95
234_L	255_L	0.629	0.95
180_L	191_Y	0.628	0.95
255_L	258_L	0.626	0.94
56_L	105_A	0.626	0.94
178_I	183_G	0.625	0.94
10_M	218_V	0.624	0.94
9_A	32_E	0.624	0.94
209_R	213_L	0.623	0.94
169_I	173_L	0.621	0.94
272_I	275_V	0.620	0.94
149_D	153_A	0.620	0.94
6_V	28_A	0.619	0.94
279_I	319_F	0.616	0.94
53_D	57_F	0.615	0.94
299_L	349_A	0.615	0.94
8_N	222_H	0.613	0.94
332_W	335_V	0.611	0.94
205_K	208_R	0.609	0.94
191_Y	196_P	0.609	0.94
200_D	205_K	0.608	0.94
297_T	300_L	0.607	0.93
222_H	226_D	0.607	0.93
166_A	176_K	0.606	0.93
66_M	236_A	0.604	0.93
172_V	177_G	0.604	0.93
188_L	194_L	0.603	0.93
165_V	169_I	0.603	0.93
3_A	6_V	0.602	0.93
293_A	296_I	0.602	0.93
169_I	176_K	0.600	0.93
187_A	194_L	0.599	0.93
221_A	302_S	0.599	0.93
171_L	179_A	0.598	0.93
284_P	291_E	0.597	0.93
186_V	194_L	0.593	0.93
143_L	147_R	0.593	0.93
166_A	173_L	0.593	0.93
149_D	154_A	0.592	0.93
179_A	197_I	0.591	0.93
316_G	319_F	0.590	0.92
186_V	190_G	0.589	0.92
122_W	126_P	0.587	0.92
108_S	111_N	0.585	0.92
150_P	203_V	0.585	0.92
204_E	285_S	0.584	0.92
173_L	176_K	0.582	0.92
18_A	291_E	0.582	0.92
293_A	316_G	0.582	0.92
13_S	18_A	0.579	0.92
170_S	176_K	0.578	0.92
102_I	350_A	0.577	0.92
76_W	348_A	0.576	0.92
178_I	186_V	0.576	0.92
137_F	285_S	0.575	0.92
64_L	67_L	0.573	0.91
181_G	190_G	0.572	0.91
12_T	211_Q	0.571	0.91
180_L	183_G	0.570	0.91
286_R	325_R	0.566	0.91
163_F	171_L	0.565	0.91
183_G	195_R	0.565	0.91
17_K	23_Q	0.565	0.91
65_G	69_A	0.562	0.91
51_I	97_I	0.562	0.91
202_S	205_K	0.561	0.91
146_R	149_D	0.560	0.90
328_S	333_R	0.559	0.90
213_L	216_A	0.559	0.90
182_I	194_L	0.558	0.90
147_R	150_P	0.557	0.90
167_F	174_L	0.557	0.90
258_L	261_A	0.557	0.90
186_V	191_Y	0.556	0.90
129_G	317_A	0.555	0.90
218_V	314_L	0.555	0.90
45_E	50_G	0.554	0.90
69_A	96_A	0.551	0.90
158_V	161_L	0.551	0.90
36_A	227_V	0.551	0.90
184_L	191_Y	0.549	0.90
72_A	96_A	0.548	0.89
187_A	195_R	0.548	0.89
66_M	94_V	0.547	0.89
299_L	303_R	0.547	0.89
18_A	218_V	0.546	0.89
72_A	350_A	0.546	0.89
110_V	115_V	0.544	0.89
128_L	131_I	0.543	0.89
180_L	186_V	0.543	0.89
180_L	192_L	0.542	0.89
155_K	170_S	0.536	0.88
312_H	345_T	0.536	0.88
179_A	192_L	0.536	0.88
151_L	160_V	0.536	0.88
166_A	183_G	0.535	0.88
10_M	31_F	0.532	0.88
89_T	229_N	0.532	0.88
258_L	262_L	0.532	0.88
4_N	89_T	0.529	0.88
227_V	256_G	0.528	0.88
165_V	168_I	0.528	0.88
168_I	176_K	0.527	0.88
184_L	195_R	0.527	0.88
44_A	235_A	0.524	0.87
140_I	161_L	0.524	0.87
344_I	347_P	0.523	0.87
73_A	93_I	0.522	0.87
139_L	157_W	0.522	0.87
192_L	195_R	0.520	0.87
139_L	186_V	0.517	0.87
165_V	172_V	0.516	0.87
47_I	97_I	0.516	0.87
234_L	256_G	0.516	0.87
167_F	183_G	0.516	0.87
249_P	252_V	0.515	0.86
255_L	259_G	0.513	0.86
315_V	338_I	0.511	0.86
38_L	41_G	0.510	0.86
102_I	115_V	0.505	0.85
90_T	311_T	0.504	0.85
228_A	311_T	0.503	0.85
7_A	14_V	0.503	0.85
185_V	193_L	0.503	0.85
152_A	158_V	0.502	0.85
274_T	278_K	0.501	0.85
44_A	231_I	0.500	0.85

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4bwzA	2	0.7365	27.4	0.964	Contact Map
4czbA	2	0.762	16.5	0.968	Contact Map
3s90C	1	0.0538	5	0.975	Contact Map
3zojA	3	0.4079	4.7	0.975	Contact Map
1jb0I	1	0.1076	4.6	0.975	Contact Map
4nefA	4	0.4306	4.4	0.975	Contact Map
3qe7A	2	0.3966	4	0.976	Contact Map
4l6vi	1	0.1076	4	0.976	Contact Map
2kv5A	1	0.0935	3.9	0.976	Contact Map
4xk8I	1	0.0822	3.7	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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