GREMLIN Database
Intron_maturas2 - Type II intron maturase
PFAM: PF01348 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 140 (110)
Sequences: 1661 (806)
Seq/√Len: 76.8
META: 0.43

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_D90_H4.5401.00
23_C77_I3.6941.00
83_A99_L3.6631.00
92_S98_F3.0821.00
80_L95_V2.8131.00
18_A23_C2.8101.00
34_S88_R2.7151.00
86_L90_H2.6861.00
22_F78_L2.5591.00
43_D86_L2.2211.00
36_P88_R2.0751.00
32_P80_L1.7881.00
50_F81_S1.7071.00
15_G19_K1.6381.00
56_N59_H1.6361.00
107_S110_L1.6351.00
9_P61_Y1.5080.99
82_C86_L1.5050.99
84_K94_T1.4780.99
51_N54_C1.4730.99
99_L103_G1.4720.99
32_P76_Y1.4700.99
11_I15_G1.4530.99
90_H102_L1.4400.99
35_K38_W1.4380.99
22_F53_I1.4330.99
113_E116_T1.4220.99
38_W49_R1.4050.99
14_I30_G1.3920.99
114_F119_E1.3490.98
112_E118_E1.2920.98
17_L23_C1.2910.98
58_S67_K1.2650.97
110_L113_E1.2350.97
114_F117_E1.2180.97
76_Y80_L1.2160.97
14_I57_L1.2140.97
98_F102_L1.1400.95
118_E121_V1.1320.95
112_E117_E1.1140.95
75_K79_R1.1070.95
116_T120_Q1.1020.94
39_A88_R1.1010.94
92_S97_K1.0970.94
86_L102_L1.0950.94
95_V98_F1.0900.94
92_S95_V1.0740.94
49_R53_I1.0730.94
112_E116_T1.0520.93
16_S66_N1.0230.92
107_S114_F1.0210.92
110_L114_F1.0190.92
17_L78_L1.0070.91
16_S56_N1.0040.91
112_E115_F1.0030.91
55_R59_H0.9970.91
22_F38_W0.9910.91
9_P60_Y0.9630.89
11_I56_N0.9570.89
23_C75_K0.9510.89
116_T119_E0.9370.88
68_K71_Y0.9170.87
50_F78_L0.9090.86
53_I78_L0.9030.86
48_D52_R0.8990.86
51_N55_R0.8870.85
74_I78_L0.8850.85
52_R55_R0.8810.85
24_N76_Y0.8670.84
6_T64_S0.8640.83
96_R100_K0.8580.83
9_P70_L0.8490.82
34_S84_K0.8230.80
50_F82_C0.8230.80
46_I82_C0.8180.80
109_F114_F0.8050.79
45_D48_D0.8050.79
77_I94_T0.8030.79
41_L54_C0.8020.79
54_C75_K0.7970.78
19_K56_N0.7870.77
30_G73_R0.7820.77
110_L115_F0.7720.76
117_E120_Q0.7710.76
6_T63_G0.7700.76
8_V58_S0.7660.75
46_I89_K0.7650.75
22_F49_R0.7640.75
20_A47_I0.7610.75
12_P15_G0.7560.74
67_K70_L0.7550.74
17_L74_I0.7520.74
36_P85_T0.7500.74
14_I23_C0.7440.73
115_F121_V0.7440.73
79_R83_A0.7430.73
73_R77_I0.7410.73
43_D46_I0.7320.72
80_L99_L0.7300.72
54_C58_S0.7190.71
44_S48_D0.7150.70
30_G77_I0.6920.68
116_T121_V0.6850.67
114_F121_V0.6820.67
57_L63_G0.6760.66
107_S112_E0.6750.66
18_A25_V0.6730.66
113_E117_E0.6690.65
113_E119_E0.6660.65
117_E121_V0.6630.64
40_D69_S0.6630.64
49_R77_I0.6610.64
80_L84_K0.6490.63
23_C30_G0.6470.62
84_K95_V0.6440.62
14_I73_R0.6400.62
84_K90_H0.6320.61
21_K48_D0.6290.60
109_F118_E0.6260.60
8_V66_N0.6230.60
46_I85_T0.6200.59
68_K100_K0.6150.59
23_C73_R0.6130.58
55_R97_K0.6050.57
109_F117_E0.6040.57
112_E119_E0.6020.57
11_I14_I0.6010.57
80_L85_T0.5970.56
112_E121_V0.5970.56
92_S103_G0.5920.56
40_D45_D0.5890.55
40_D86_L0.5880.55
68_K95_V0.5850.55
62_S67_K0.5800.54
71_Y79_R0.5770.54
109_F112_E0.5770.54
33_I36_P0.5770.54
42_S45_D0.5750.54
45_D54_C0.5730.53
67_K71_Y0.5700.53
6_T65_S0.5700.53
108_E119_E0.5690.53
13_L75_K0.5650.52
57_L70_L0.5650.52
84_K87_A0.5630.52
10_I69_S0.5610.52
54_C74_I0.5560.51
12_P16_S0.5520.51
43_D85_T0.5510.51
115_F120_Q0.5490.50
11_I19_K0.5420.49
21_K97_K0.5410.49
109_F113_E0.5410.49
91_K115_F0.5310.48
112_E120_Q0.5300.48
8_V13_L0.5160.46
114_F118_E0.5150.46
89_K102_L0.5140.46
6_T71_Y0.5120.46
24_N33_I0.5100.45
46_I102_L0.5070.45
83_A95_V0.5050.45
40_D50_F0.5020.44
10_I73_R0.5020.44
47_I73_R0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w50A 1 0.2286 5.7 0.94 Contact Map
2k4bA 1 0.2786 4.4 0.943 Contact Map
3kk7A 1 0.5571 3.9 0.945 Contact Map
2dulA 2 0.35 3.8 0.945 Contact Map
2x5qA 2 0.4714 3.5 0.946 Contact Map
1gkuB 1 0.5357 3.2 0.947 Contact Map
1rcuA 3 0.3357 3 0.948 Contact Map
3quaA 2 0.3357 2.6 0.95 Contact Map
3kylA 1 0.8357 2.5 0.95 Contact Map
1hsjA 2 0.4143 2.1 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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