GREMLIN Database
Bac_export_1 - Bacterial export proteins, family 1
PFAM: PF01311 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 230 (224)
Sequences: 18326 (13498)
Seq/√Len: 901.9
META: 0.822

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
138_D141_E4.7111.00
9_A60_L4.3761.00
181_N204_K3.8311.00
92_M208_G3.7741.00
81_V119_A3.4601.00
134_R138_D3.4591.00
153_E157_R3.0481.00
53_L57_A2.9611.00
42_L137_A2.8451.00
127_G130_H2.6031.00
13_A64_L2.5191.00
147_L150_D2.5181.00
116_N120_L2.4101.00
164_V168_Q2.3861.00
12_G35_A2.3331.00
9_A64_L2.3101.00
180_V207_V2.2941.00
157_R161_Q2.1191.00
176_A211_L2.1171.00
83_L166_A1.9861.00
28_A31_R1.9781.00
7_V140_F1.9401.00
184_L200_G1.9191.00
8_F39_A1.9181.00
154_L157_R1.8991.00
11_I136_L1.8871.00
101_D104_S1.8851.00
9_A13_A1.8411.00
12_G16_M1.8341.00
96_F100_F1.8301.00
115_L212_L1.7201.00
123_F128_G1.6901.00
111_L212_L1.6741.00
6_L59_L1.6561.00
131_L134_R1.6371.00
82_Q116_N1.6311.00
8_F35_A1.6261.00
17_L68_L1.6231.00
206_L210_L1.5871.00
54_L57_A1.5821.00
59_L62_K1.5811.00
88_I173_V1.5721.00
79_A82_Q1.5651.00
75_R79_A1.5511.00
126_L224_E1.5081.00
83_L162_M1.5071.00
156_V159_G1.5041.00
161_Q164_V1.4981.00
52_S55_A1.4821.00
123_F132_L1.4751.00
49_A52_S1.4741.00
159_G162_M1.4061.00
221_G224_E1.3951.00
43_P46_A1.3651.00
161_Q165_L1.3631.00
176_A180_V1.3531.00
137_A141_E1.3481.00
13_A17_L1.3361.00
14_L136_L1.3281.00
96_F99_V1.3101.00
53_L56_L1.3031.00
58_L62_K1.2861.00
157_R160_G1.2851.00
158_L161_Q1.2581.00
124_L129_H1.2581.00
215_S218_L1.2551.00
130_H134_R1.2531.00
72_F76_L1.2461.00
202_P205_I1.2451.00
173_V211_L1.2391.00
89_D111_L1.2361.00
160_G164_V1.2321.00
63_E146_G1.2141.00
20_V124_L1.2081.00
63_E140_F1.2001.00
46_A50_P1.1991.00
29_R33_G1.1921.00
15_F38_L1.1821.00
13_A71_G1.1811.00
44_A47_L1.1801.00
78_F123_F1.1771.00
138_D142_L1.1741.00
66_I143_L1.1621.00
152_A156_V1.1571.00
198_F201_F1.1541.00
215_S219_L1.1431.00
62_K146_G1.1401.00
13_A68_L1.1371.00
122_L126_L1.1031.00
48_P52_S1.1021.00
26_V30_V1.1011.00
218_L221_G1.1011.00
11_I42_L1.1011.00
33_G37_A1.0981.00
17_L75_R1.0931.00
154_L158_L1.0931.00
7_V39_A1.0911.00
122_L220_L1.0911.00
211_L215_S1.0751.00
8_F36_L1.0711.00
36_L40_L1.0621.00
171_A175_A1.0571.00
11_I35_A1.0521.00
117_L121_L1.0331.00
47_L51_P1.0261.00
35_A39_A1.0251.00
7_V42_L1.0211.00
15_F35_A1.0201.00
88_I115_L1.0201.00
165_L226_L1.0191.00
11_I38_L1.0131.00
115_L219_L1.0121.00
138_D168_Q1.0121.00
80_A84_A1.0111.00
90_L95_S1.0101.00
217_P220_L1.0011.00
92_M111_L0.9861.00
4_F8_F0.9821.00
70_L139_S0.9801.00
17_L71_G0.9771.00
76_L159_G0.9621.00
27_P30_V0.9591.00
45_P48_P0.9581.00
75_R82_Q0.9511.00
170_A174_L0.9481.00
81_V223_F0.9461.00
87_L91_Q0.9451.00
188_A196_V0.9431.00
69_A73_A0.9351.00
14_L70_L0.9271.00
69_A151_L0.9271.00
43_P47_L0.9261.00
120_L124_L0.9241.00
4_F39_A0.9171.00
118_L220_L0.9101.00
90_L99_V0.9011.00
195_N198_F0.8991.00
14_L17_L0.8911.00
123_F126_L0.8841.00
9_A12_G0.8821.00
13_A16_M0.8801.00
51_P55_A0.8801.00
80_A165_L0.8761.00
15_F34_L0.8701.00
153_E156_V0.8691.00
213_A217_P0.8681.00
11_I140_F0.8671.00
191_A194_L0.8651.00
198_F202_P0.8651.00
61_L65_L0.8641.00
86_Q90_L0.8601.00
130_H133_L0.8541.00
47_L50_P0.8501.00
98_S107_Q0.8391.00
140_F145_P0.8391.00
128_G131_L0.8351.00
79_A162_M0.8331.00
38_L133_L0.8281.00
64_L68_L0.8271.00
117_L120_L0.8261.00
85_G115_L0.8231.00
84_A170_A0.8221.00
89_D109_P0.8221.00
121_L125_A0.8201.00
94_L205_I0.8191.00
100_F104_S0.8171.00
59_L146_G0.8141.00
29_R32_L0.8121.00
217_P221_G0.8121.00
156_V160_G0.8081.00
141_E144_P0.8041.00
37_A41_L0.7981.00
84_A88_I0.7951.00
59_L145_P0.7911.00
131_L135_A0.7901.00
223_F227_F0.7771.00
221_G225_R0.7731.00
161_Q168_Q0.7711.00
34_L38_L0.7701.00
119_A223_F0.7681.00
65_L68_L0.7631.00
58_L61_L0.7611.00
28_A32_L0.7561.00
55_A59_L0.7521.00
89_D94_L0.7491.00
134_R141_E0.7441.00
8_F12_G0.7441.00
135_A169_L0.7361.00
197_F201_F0.7311.00
187_L196_V0.7311.00
13_A35_A0.7301.00
7_V11_I0.7291.00
5_L60_L0.7221.00
14_L132_L0.7201.00
82_Q113_Q0.7191.00
184_L203_L0.7181.00
61_L64_L0.7181.00
83_L86_Q0.7161.00
97_A110_V0.7151.00
78_F119_A0.7111.00
36_L39_A0.7111.00
14_L18_A0.7071.00
214_L217_P0.7071.00
74_A135_A0.7051.00
126_L129_H0.6991.00
86_Q98_S0.6971.00
92_M177_L0.6971.00
2_A56_L0.6901.00
18_A74_A0.6901.00
32_L35_A0.6851.00
46_A51_P0.6841.00
50_P53_L0.6831.00
78_F116_N0.6821.00
220_L224_E0.6801.00
212_L215_S0.6791.00
85_G89_D0.6771.00
21_F133_L0.6731.00
173_V177_L0.6731.00
12_G32_L0.6711.00
32_L36_L0.6691.00
131_L138_D0.6691.00
91_Q174_L0.6671.00
73_A77_V0.6611.00
94_L97_A0.6601.00
70_L74_A0.6561.00
86_Q95_S0.6531.00
47_L52_S0.6501.00
84_A166_A0.6491.00
15_F31_R0.6461.00
188_A198_F0.6461.00
101_D108_S0.6451.00
88_I170_A0.6441.00
4_F36_L0.6431.00
54_L58_L0.6341.00
87_L174_L0.6341.00
46_A49_A0.6321.00
13_A18_A0.6281.00
91_Q178_L0.6241.00
209_L213_A0.6231.00
212_L216_L0.6221.00
129_H133_L0.6211.00
18_A132_L0.6201.00
188_A197_F0.6181.00
89_D204_K0.6181.00
76_L162_M0.6161.00
99_V102_P0.6161.00
91_Q181_N0.6151.00
73_A158_L0.6141.00
184_L196_V0.6131.00
167_L174_L0.6081.00
62_K66_I0.6081.00
224_E227_F0.6071.00
160_G163_F0.6051.00
171_A200_G0.6041.00
171_A174_L0.6041.00
214_L218_L0.6041.00
187_L190_A0.6031.00
67_G71_G0.6011.00
158_L162_M0.5991.00
151_L154_L0.5951.00
5_L56_L0.5951.00
89_D181_N0.5941.00
118_L216_L0.5931.00
11_I39_A0.5881.00
142_L165_L0.5851.00
184_L204_K0.5831.00
166_A170_A0.5811.00
18_A21_F0.5811.00
55_A58_L0.5791.00
122_L224_E0.5761.00
6_L60_L0.5751.00
134_R137_A0.5751.00
89_D112_G0.5721.00
77_V80_A0.5721.00
43_P48_P0.5721.00
150_D153_E0.5701.00
168_Q222_V0.5691.00
222_V225_R0.5691.00
137_A140_F0.5671.00
135_A165_L0.5671.00
201_F205_I0.5651.00
188_A195_N0.5631.00
86_Q109_P0.5621.00
74_A132_L0.5621.00
202_P206_L0.5611.00
43_P49_A0.5601.00
195_N201_F0.5581.00
194_L198_F0.5581.00
97_A100_F0.5581.00
98_S102_P0.5541.00
50_P54_L0.5491.00
96_F201_F0.5421.00
210_L213_A0.5421.00
50_P55_A0.5411.00
85_G110_V0.5411.00
201_F206_L0.5391.00
155_L159_G0.5391.00
191_A198_F0.5391.00
162_M165_L0.5341.00
122_L125_A0.5341.00
180_V184_L0.5331.00
207_V210_L0.5331.00
190_A200_G0.5321.00
76_L79_A0.5321.00
83_L87_L0.5321.00
218_L222_V0.5311.00
48_P51_P0.5311.00
43_P51_P0.5311.00
159_G163_F0.5271.00
24_R105_G0.5261.00
38_L136_L0.5241.00
195_N200_G0.5231.00
86_Q89_D0.5221.00
23_S185_G0.5211.00
219_L222_V0.5201.00
125_A128_G0.5191.00
131_L168_Q0.5181.00
173_V215_S0.5171.00
89_D92_M0.5171.00
22_G26_V0.5161.00
151_L155_L0.5141.00
34_L37_A0.5141.00
73_A154_L0.5121.00
101_D105_G0.5111.00
69_A72_F0.5111.00
63_E145_P0.5111.00
113_Q117_L0.5101.00
65_L69_A0.5101.00
133_L137_A0.5081.00
33_G41_L0.5081.00
92_M205_I0.5071.00
173_V212_L0.5071.00
114_F118_L0.5031.00
205_I208_G0.5021.00
210_L214_L0.5001.00
82_Q101_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zy9A 2 0.5478 1.6 0.961 Contact Map
4rp9A 2 0.2913 1.6 0.961 Contact Map
2m0sA 1 0.1217 1.1 0.964 Contact Map
2kncA 1 0.1913 0.9 0.966 Contact Map
4p6vE 1 0.4043 0.6 0.97 Contact Map
4p6vD 1 0.3478 0.5 0.972 Contact Map
4httA 1 0.5261 0.5 0.973 Contact Map
3ci9A 5 0.0783 0.4 0.974 Contact Map
2kzqA 1 0.1565 0.4 0.974 Contact Map
4ogqG 1 0.1609 0.4 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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