Adenylate_cycl - PFAM28P - GREMLIN Contacts

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Adenylate_cycl - Adenylate cyclase, class-I

PFAM:	PF01295	Sequences: EWIDFGGLAHIPAEEFFGAGLWQLYKGIDSPYKSVLKLLLLEAYASEYPNTQLLSLRFKQAVYAGELDLDELDPYVMMYRRVEEYLLARGEPERLELVRRCFYLKVNEKLSRPPRNRSKSWRRELLERLVKEWGWDERQLALLDSRSQWKIRQVLEERRALVNELTHSYRFLSQFARRHNASSSISPRDLNILGRKLYAAFERKPGKVELINPGISPDLSEDTLTLVQVPEGRAGQAGWYLYNGSLNAQEIIGHAPLKRSRSLIELLAWCHFNGLIDSSTRLHLHPGDSDLSEFELRQLLDDLQQFFPLPLPAVSEEALLRPAEIRQLLLFINVGVDPTAHLSRQGLHLTSERTDALSYGGVRENLVLSIDQVTLNSWNEVLTLRYEGEDALLDCLKDYLNKLPQDAAPPPSLQVFCFSSNRAQAIAQRVEELFNDVIRLFLSGRQPRNSRYLLQVGQQYYVLQFERGGVSYQKLENLVALLEHLSEPQLSYSPLVLDRYALEDHLPALILPFARPGCIQVFYRDNGDGADIYVLDERGSLFHQRQPFGDEESLLNPLQRFLQSVLDRQTYESSFINFNLPQFYQIVRNDGELQVVPFRS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	600 (571)
Sequences:	645 (434)
Seq/√Len:	18.1
META:	0.536

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
502_L	507_P	7.037	1.00
498_D	507_P	6.175	1.00
57_R	84_E	5.186	1.00
47_E	81_R	5.049	1.00
501_A	507_P	4.681	1.00
504_D	507_P	3.969	1.00
108_E	122_R	3.931	1.00
502_L	505_H	3.837	1.00
481_L	485_L	3.510	1.00
78_M	82_V	3.482	1.00
110_L	144_D	3.478	1.00
502_L	506_L	3.087	0.99
33_K	37_K	3.016	0.99
52_Q	60_Q	2.997	0.99
501_A	505_H	2.988	0.99
111_S	144_D	2.944	0.99
498_D	502_L	2.926	0.99
494_P	498_D	2.911	0.99
507_P	511_L	2.878	0.99
498_D	501_A	2.823	0.98
346_G	351_S	2.806	0.98
417_C	426_I	2.711	0.98
501_A	506_L	2.682	0.98
22_W	33_K	2.680	0.98
60_Q	64_A	2.674	0.98
80_R	132_E	2.640	0.97
82_V	98_V	2.580	0.97
497_L	507_P	2.579	0.97
501_A	504_D	2.541	0.97
212_N	216_S	2.529	0.97
492_Y	498_D	2.382	0.95
417_C	420_S	2.324	0.94
36_L	98_V	2.291	0.94
367_V	370_I	2.265	0.94
153_Q	156_E	2.259	0.94
22_W	26_K	2.236	0.93
561_F	568_R	2.221	0.93
26_K	33_K	2.211	0.93
452_Y	460_Y	2.203	0.93
452_Y	455_Q	2.199	0.93
52_Q	57_R	2.183	0.92
32_Y	215_I	2.132	0.91
66_E	71_E	2.121	0.91
355_D	359_Y	2.087	0.90
134_G	156_E	2.083	0.90
206_G	265_E	2.082	0.90
91_E	164_E	2.056	0.90
26_K	37_K	2.051	0.90
22_W	37_K	2.037	0.89
15_E	22_W	2.035	0.89
482_L	541_L	2.025	0.89
524_R	531_D	2.018	0.89
499_R	507_P	2.006	0.89
493_S	498_D	1.999	0.88
494_P	497_L	1.992	0.88
451_R	460_Y	1.978	0.88
212_N	215_I	1.961	0.87
95_L	303_L	1.944	0.87
27_G	38_L	1.937	0.87
57_R	81_R	1.930	0.87
530_A	548_F	1.902	0.86
18_G	185_I	1.881	0.85
390_D	394_D	1.876	0.85
15_E	26_K	1.864	0.85
158_R	214_G	1.855	0.84
565_V	568_R	1.823	0.83
500_Y	507_P	1.815	0.83
355_D	429_R	1.812	0.83
43_A	82_V	1.801	0.82
497_L	511_L	1.789	0.82
78_M	360_G	1.783	0.82
460_Y	464_Q	1.767	0.81
419_S	423_A	1.758	0.81
392_L	430_V	1.754	0.81
497_L	500_Y	1.753	0.81
514_A	539_G	1.739	0.80
8_L	55_S	1.731	0.80
330_L	434_F	1.725	0.80
436_D	499_R	1.709	0.79
48_Y	360_G	1.695	0.78
452_Y	462_V	1.690	0.78
557_P	562_L	1.685	0.78
110_L	123_R	1.663	0.77
42_E	195_R	1.662	0.77
12_P	15_E	1.661	0.77
386_Y	398_D	1.643	0.76
557_P	561_F	1.642	0.76
508_A	511_L	1.616	0.75
493_S	497_L	1.610	0.75
270_C	280_T	1.599	0.74
452_Y	461_Y	1.598	0.74
15_E	37_K	1.593	0.74
15_E	33_K	1.583	0.73
150_K	221_E	1.581	0.73
49_P	175_F	1.554	0.72
204_K	259_R	1.551	0.72
451_R	464_Q	1.550	0.72
6_G	15_E	1.549	0.72
7_G	102_F	1.536	0.71
24_L	39_L	1.516	0.70
452_Y	456_V	1.514	0.70
17_F	53_L	1.508	0.69
221_E	280_T	1.507	0.69
228_Q	286_P	1.500	0.69
208_V	410_P	1.500	0.69
31_P	37_K	1.496	0.69
503_E	507_P	1.491	0.69
241_L	270_C	1.483	0.68
346_G	349_L	1.483	0.68
404_P	442_L	1.477	0.68
322_P	517_G	1.477	0.68
129_L	319_L	1.474	0.68
220_S	391_A	1.447	0.66
37_K	75_Y	1.439	0.66
319_L	350_T	1.438	0.66
150_K	215_I	1.428	0.65
258_K	300_L	1.426	0.65
558_L	562_L	1.419	0.65
169_Y	194_G	1.412	0.64
242_Y	256_P	1.410	0.64
20_G	212_N	1.408	0.64
451_R	462_V	1.404	0.64
104_L	216_S	1.403	0.64
264_I	373_V	1.400	0.64
120_S	123_R	1.398	0.63
224_L	276_I	1.393	0.63
37_K	44_Y	1.386	0.63
536_D	540_S	1.383	0.63
135_W	273_N	1.378	0.62
31_P	44_Y	1.367	0.62
91_E	339_T	1.362	0.61
453_L	460_Y	1.360	0.61
198_Y	215_I	1.348	0.61
186_S	397_K	1.344	0.60
172_L	369_S	1.344	0.60
23_Q	212_N	1.340	0.60
562_L	565_V	1.339	0.60
128_R	534_V	1.330	0.59
154_V	215_I	1.330	0.59
183_S	190_L	1.326	0.59
40_L	44_Y	1.325	0.59
346_G	350_T	1.325	0.59
150_K	212_N	1.322	0.59
201_F	272_F	1.321	0.59
26_K	31_P	1.321	0.59
360_G	455_Q	1.311	0.58
100_R	214_G	1.309	0.58
17_F	419_S	1.308	0.58
302_D	416_F	1.305	0.58
359_Y	426_I	1.304	0.58
219_L	381_V	1.304	0.58
189_D	520_Q	1.303	0.58
358_S	370_I	1.302	0.58
329_L	367_V	1.300	0.58
126_L	140_L	1.295	0.57
189_D	369_S	1.291	0.57
87_L	96_E	1.284	0.57
75_Y	105_K	1.284	0.57
29_D	122_R	1.280	0.56
67_L	71_E	1.276	0.56
15_E	31_P	1.273	0.56
33_K	75_Y	1.271	0.56
511_L	514_A	1.271	0.56
495_L	498_D	1.268	0.56
162_V	169_Y	1.258	0.55
203_R	209_E	1.257	0.55
22_W	25_Y	1.255	0.55
104_L	242_Y	1.255	0.55
150_K	218_D	1.254	0.55
59_K	63_Y	1.249	0.55
381_V	503_E	1.248	0.54
22_W	31_P	1.246	0.54
123_R	144_D	1.244	0.54
81_R	359_Y	1.232	0.54
94_R	101_C	1.230	0.53
227_V	251_I	1.228	0.53
454_L	515_R	1.227	0.53
356_A	425_A	1.227	0.53
150_K	154_V	1.223	0.53
4_D	59_K	1.217	0.53
1_E	544_Q	1.217	0.53
19_A	22_W	1.216	0.53
226_L	244_G	1.213	0.52
501_A	510_I	1.213	0.52
96_E	359_Y	1.209	0.52
121_W	161_L	1.206	0.52
102_F	106_V	1.203	0.52
50_N	510_I	1.202	0.52
257_L	515_R	1.201	0.52
334_V	385_R	1.199	0.51
325_I	374_T	1.194	0.51
228_Q	486_S	1.193	0.51
351_S	426_I	1.188	0.51
502_L	508_A	1.187	0.51
456_V	463_L	1.185	0.51
399_Y	434_F	1.180	0.50
296_L	430_V	1.177	0.50
257_L	442_L	1.176	0.50
517_G	520_Q	1.174	0.50
105_K	380_E	1.173	0.50
267_L	300_L	1.169	0.50
547_P	554_L	1.165	0.49
101_C	151_I	1.161	0.49
32_Y	150_K	1.160	0.49
12_P	38_L	1.157	0.49
94_R	149_W	1.153	0.49
3_I	11_I	1.148	0.48
83_E	427_A	1.143	0.48
357_L	423_A	1.139	0.48
131_K	313_A	1.137	0.48
33_K	44_Y	1.134	0.47
429_R	561_F	1.133	0.47
507_P	510_I	1.132	0.47
35_V	175_F	1.132	0.47
193_L	280_T	1.128	0.47
331_F	334_V	1.128	0.47
117_R	534_V	1.123	0.47
189_D	259_R	1.118	0.46
452_Y	464_Q	1.117	0.46
514_A	520_Q	1.117	0.46
225_T	242_Y	1.116	0.46
37_K	40_L	1.115	0.46
526_N	531_D	1.114	0.46
164_E	360_G	1.113	0.46
134_G	547_P	1.112	0.46
44_Y	75_Y	1.110	0.46
186_S	327_Q	1.110	0.46
82_V	198_Y	1.108	0.46
480_A	532_I	1.107	0.46
148_Q	311_L	1.103	0.46
177_R	198_Y	1.103	0.46
63_Y	354_T	1.101	0.45
105_K	207_K	1.098	0.45
113_P	123_R	1.095	0.45
189_D	210_L	1.093	0.45
146_R	215_I	1.089	0.45
8_L	535_L	1.085	0.44
497_L	501_A	1.084	0.44
25_Y	196_K	1.084	0.44
71_E	80_R	1.074	0.44
337_D	366_L	1.073	0.44
343_S	348_H	1.070	0.44
434_F	437_V	1.068	0.43
464_Q	489_Q	1.068	0.43
225_T	461_Y	1.066	0.43
55_S	281_R	1.065	0.43
173_S	177_R	1.063	0.43
337_D	535_L	1.061	0.43
98_V	357_L	1.061	0.43
7_G	196_K	1.061	0.43
316_E	319_L	1.059	0.43
138_R	413_L	1.056	0.43
178_R	257_L	1.043	0.42
535_L	541_L	1.043	0.42
97_L	351_S	1.041	0.42
76_V	79_Y	1.040	0.42
48_Y	276_I	1.038	0.42
514_A	544_Q	1.032	0.41
397_K	417_C	1.030	0.41
150_K	219_L	1.030	0.41
149_W	378_W	1.029	0.41
122_R	275_L	1.027	0.41
121_W	172_L	1.024	0.41
207_K	239_W	1.023	0.41
44_Y	105_K	1.022	0.41
328_L	372_Q	1.014	0.40
242_Y	457_G	1.014	0.40
42_E	94_R	1.011	0.40
22_W	75_Y	1.009	0.40
203_R	451_R	1.007	0.40
105_K	378_W	1.007	0.40
204_K	384_L	1.005	0.40
209_E	266_L	1.004	0.40
23_Q	143_L	1.001	0.39
225_T	246_L	1.000	0.39
5_F	191_N	0.994	0.39
208_V	268_A	0.993	0.39
39_L	98_V	0.992	0.39
305_Q	482_L	0.986	0.39
387_E	415_V	0.986	0.39
57_R	370_I	0.984	0.38
331_F	416_F	0.983	0.38
208_V	318_A	0.981	0.38
38_L	367_V	0.981	0.38
48_Y	175_F	0.980	0.38
145_S	148_Q	0.977	0.38
558_L	563_Q	0.975	0.38
12_P	26_K	0.974	0.38
34_S	63_Y	0.972	0.38
38_L	55_S	0.971	0.38
9_A	276_I	0.967	0.37
192_I	291_L	0.966	0.37
154_V	158_R	0.965	0.37
351_S	429_R	0.964	0.37
492_Y	497_L	0.964	0.37
23_Q	213_P	0.964	0.37
530_A	557_P	0.964	0.37
151_I	210_L	0.962	0.37
376_N	514_A	0.961	0.37
347_L	376_N	0.961	0.37
272_F	383_T	0.961	0.37
517_G	522_F	0.960	0.37
166_T	204_K	0.956	0.37
539_G	542_F	0.956	0.37
437_V	452_Y	0.956	0.37
21_L	53_L	0.952	0.37
75_Y	86_L	0.950	0.36
399_Y	405_Q	0.950	0.36
191_N	517_G	0.949	0.36
327_Q	412_S	0.946	0.36
26_K	75_Y	0.946	0.36
19_A	23_Q	0.946	0.36
96_E	139_Q	0.944	0.36
161_L	172_L	0.943	0.36
121_W	365_N	0.941	0.36
65_G	176_A	0.941	0.36
485_L	488_P	0.939	0.36
94_R	105_K	0.938	0.36
18_G	172_L	0.936	0.36
227_V	246_L	0.934	0.36
202_E	205_P	0.932	0.35
342_L	346_G	0.932	0.35
41_L	419_S	0.931	0.35
175_F	202_E	0.930	0.35
429_R	568_R	0.930	0.35
140_L	147_S	0.929	0.35
105_K	149_W	0.928	0.35
461_Y	472_Y	0.927	0.35
17_F	294_F	0.925	0.35
257_L	477_N	0.922	0.35
5_F	10_H	0.922	0.35
463_L	470_V	0.921	0.35
25_Y	264_I	0.921	0.35
205_P	530_A	0.920	0.35
53_L	201_F	0.916	0.35
228_Q	237_A	0.915	0.34
27_G	372_Q	0.915	0.34
485_L	494_P	0.911	0.34
282_L	286_P	0.910	0.34
351_S	356_A	0.909	0.34
23_Q	39_L	0.909	0.34
13_A	46_S	0.909	0.34
8_L	85_Y	0.908	0.34
196_K	391_A	0.907	0.34
357_L	427_A	0.905	0.34
15_E	19_A	0.903	0.34
38_L	165_L	0.899	0.34
342_L	347_L	0.897	0.33
311_L	379_N	0.896	0.33
12_P	22_W	0.896	0.33
15_E	44_Y	0.895	0.33
23_Q	158_R	0.892	0.33
21_L	189_D	0.892	0.33
82_V	343_S	0.891	0.33
33_K	40_L	0.888	0.33
129_L	337_D	0.885	0.33
422_R	430_V	0.884	0.33
55_S	87_L	0.884	0.33
45_A	74_P	0.882	0.33
247_N	252_I	0.882	0.33
405_Q	442_L	0.882	0.33
5_F	262_S	0.881	0.33
464_Q	469_G	0.880	0.33
207_K	380_E	0.878	0.32
111_S	257_L	0.877	0.32
18_G	22_W	0.875	0.32
77_M	519_I	0.873	0.32
450_S	494_P	0.871	0.32
50_N	114_P	0.871	0.32
281_R	293_E	0.871	0.32
175_F	533_Y	0.871	0.32
500_Y	503_E	0.871	0.32
558_L	561_F	0.868	0.32
555_L	562_L	0.867	0.32
14_E	41_L	0.866	0.32
137_E	315_S	0.865	0.32
322_P	433_L	0.865	0.32
481_L	488_P	0.864	0.32
557_P	560_R	0.862	0.32
485_L	492_Y	0.860	0.31
207_K	378_W	0.860	0.31
108_E	120_S	0.859	0.31
406_D	468_G	0.859	0.31
131_K	473_Q	0.858	0.31
31_P	75_Y	0.857	0.31
322_P	356_A	0.856	0.31
13_A	48_Y	0.855	0.31
32_Y	214_G	0.853	0.31
361_G	365_N	0.853	0.31
58_F	74_P	0.853	0.31
530_A	549_G	0.850	0.31
168_S	380_E	0.850	0.31
31_P	105_K	0.849	0.31
154_V	221_E	0.847	0.31
11_I	38_L	0.847	0.31
151_I	219_L	0.846	0.31
226_L	267_L	0.846	0.31
337_D	376_N	0.844	0.31
148_Q	174_Q	0.841	0.30
104_L	143_L	0.841	0.30
48_Y	124_E	0.838	0.30
24_L	169_Y	0.837	0.30
21_L	283_H	0.834	0.30
20_G	391_A	0.834	0.30
392_L	568_R	0.834	0.30
272_F	307_F	0.833	0.30
151_I	268_A	0.832	0.30
175_F	461_Y	0.830	0.30
258_K	335_G	0.829	0.30
205_P	259_R	0.829	0.30
81_R	189_D	0.826	0.30
17_F	20_G	0.825	0.30
164_E	167_H	0.825	0.30
203_R	460_Y	0.824	0.30
489_Q	500_Y	0.822	0.29
32_Y	157_E	0.821	0.29
473_Q	487_E	0.819	0.29
159_R	209_E	0.819	0.29
453_L	462_V	0.818	0.29
59_K	62_V	0.817	0.29
453_L	496_V	0.814	0.29
304_Q	532_I	0.814	0.29
219_L	226_L	0.814	0.29
366_L	426_I	0.814	0.29
27_G	198_Y	0.812	0.29
153_Q	275_L	0.811	0.29
29_D	433_L	0.808	0.29
565_V	569_Q	0.808	0.29
130_V	173_S	0.808	0.29
7_G	65_G	0.808	0.29
422_R	426_I	0.807	0.29
225_T	245_S	0.806	0.29
96_E	130_V	0.804	0.29
37_K	42_E	0.803	0.29
226_L	282_L	0.801	0.28
3_I	204_K	0.800	0.28
359_Y	366_L	0.800	0.28
489_Q	494_P	0.799	0.28
28_I	164_E	0.799	0.28
190_L	271_H	0.798	0.28
10_H	303_L	0.798	0.28
357_L	422_R	0.797	0.28
22_W	44_Y	0.797	0.28
102_F	220_S	0.794	0.28
330_L	453_L	0.793	0.28
507_P	520_Q	0.790	0.28
303_L	322_P	0.787	0.28
263_L	399_Y	0.786	0.28
203_R	481_L	0.786	0.28
242_Y	431_E	0.785	0.28
146_R	212_N	0.784	0.28
28_I	35_V	0.780	0.27
291_L	394_D	0.779	0.27
133_W	193_L	0.779	0.27
202_E	207_K	0.778	0.27
492_Y	516_P	0.772	0.27
342_L	348_H	0.770	0.27
227_V	539_G	0.769	0.27
42_E	269_W	0.769	0.27
235_G	347_L	0.768	0.27
204_K	418_F	0.768	0.27
225_T	244_G	0.766	0.27
284_L	335_G	0.765	0.27
59_K	263_L	0.765	0.27
60_Q	473_Q	0.764	0.27
90_G	128_R	0.761	0.26
511_L	516_P	0.761	0.26
75_Y	195_R	0.761	0.26
120_S	192_I	0.760	0.26
165_L	269_W	0.758	0.26
116_N	124_E	0.758	0.26
194_G	203_R	0.758	0.26
531_D	545_R	0.758	0.26
31_P	42_E	0.758	0.26
55_S	59_K	0.757	0.26
6_G	26_K	0.756	0.26
37_K	105_K	0.754	0.26
55_S	58_F	0.754	0.26
154_V	218_D	0.754	0.26
275_L	437_V	0.754	0.26
103_Y	122_R	0.754	0.26
499_R	502_L	0.753	0.26
142_L	153_Q	0.753	0.26
4_D	28_I	0.751	0.26
75_Y	207_K	0.751	0.26
103_Y	135_W	0.750	0.26
278_S	359_Y	0.750	0.26
506_L	509_L	0.749	0.26
454_L	491_S	0.749	0.26
85_Y	101_C	0.748	0.26
134_G	512_P	0.748	0.26
17_F	177_R	0.747	0.26
60_Q	282_L	0.745	0.26
559_Q	563_Q	0.745	0.26
346_G	429_R	0.743	0.26
98_V	356_A	0.743	0.26
361_G	366_L	0.742	0.26
363_R	367_V	0.742	0.26
376_N	391_A	0.740	0.25
201_F	391_A	0.739	0.25
332_I	399_Y	0.737	0.25
338_P	419_S	0.737	0.25
3_I	358_S	0.737	0.25
3_I	7_G	0.734	0.25
21_L	337_D	0.734	0.25
163_N	381_V	0.730	0.25
195_R	378_W	0.729	0.25
336_V	434_F	0.728	0.25
78_M	535_L	0.728	0.25
108_E	123_R	0.728	0.25
554_L	561_F	0.726	0.25
62_V	124_E	0.725	0.25
23_Q	154_V	0.724	0.25
6_G	12_P	0.723	0.25
262_S	385_R	0.723	0.25
461_Y	465_F	0.723	0.25
520_Q	523_Y	0.722	0.25
20_G	41_L	0.721	0.25
26_K	44_Y	0.721	0.25
521_V	544_Q	0.721	0.25
282_L	371_D	0.721	0.25
121_W	144_D	0.720	0.25
106_V	150_K	0.720	0.25
25_Y	525_D	0.718	0.24
36_L	77_M	0.716	0.24
219_L	271_H	0.713	0.24
405_Q	440_L	0.712	0.24
102_F	193_L	0.711	0.24
25_Y	350_T	0.711	0.24
270_C	276_I	0.711	0.24
79_Y	95_L	0.710	0.24
486_S	533_Y	0.710	0.24
54_L	429_R	0.709	0.24
398_D	404_P	0.706	0.24
172_L	337_D	0.702	0.24
30_S	35_V	0.701	0.24
171_F	243_N	0.699	0.24
16_F	540_S	0.697	0.23
172_L	185_I	0.697	0.23
87_L	487_E	0.697	0.23
226_L	272_F	0.695	0.23
47_E	126_L	0.694	0.23
51_T	82_V	0.693	0.23
7_G	25_Y	0.693	0.23
439_R	491_S	0.691	0.23
264_I	482_L	0.691	0.23
156_E	208_V	0.690	0.23
64_A	281_R	0.690	0.23
236_Q	304_Q	0.689	0.23
357_L	429_R	0.688	0.23
213_P	391_A	0.687	0.23
28_I	347_L	0.687	0.23
193_L	201_F	0.685	0.23
12_P	37_K	0.683	0.23
40_L	75_Y	0.682	0.23
454_L	463_L	0.682	0.23
46_S	50_N	0.681	0.23
67_L	330_L	0.681	0.23
224_L	327_Q	0.680	0.23
3_I	111_S	0.680	0.23
2_W	79_Y	0.680	0.23
3_I	25_Y	0.680	0.23
158_R	265_E	0.679	0.23
18_G	169_Y	0.679	0.23
60_Q	88_A	0.677	0.23
86_L	105_K	0.677	0.23
117_R	473_Q	0.677	0.23
146_R	154_V	0.677	0.23
386_Y	391_A	0.676	0.23
68_D	377_S	0.676	0.23
315_S	405_Q	0.674	0.22
519_I	532_I	0.674	0.22
16_F	91_E	0.673	0.22
211_I	260_S	0.673	0.22
515_R	532_I	0.673	0.22
136_D	477_N	0.672	0.22
149_W	207_K	0.672	0.22
144_D	212_N	0.672	0.22
90_G	369_S	0.671	0.22
4_D	207_K	0.671	0.22
146_R	534_V	0.670	0.22
27_G	319_L	0.669	0.22
9_A	47_E	0.669	0.22
17_F	176_A	0.669	0.22
241_L	545_R	0.668	0.22
294_F	373_V	0.667	0.22
11_I	28_I	0.666	0.22
464_Q	468_G	0.665	0.22
134_G	140_L	0.665	0.22
3_I	122_R	0.665	0.22
212_N	296_L	0.662	0.22
502_L	511_L	0.660	0.22
201_F	386_Y	0.660	0.22
363_R	417_C	0.658	0.22
44_Y	73_D	0.658	0.22
66_E	224_L	0.658	0.22
86_L	101_C	0.658	0.22
268_A	272_F	0.658	0.22
20_G	54_L	0.656	0.22
158_R	194_G	0.655	0.22
75_Y	149_W	0.653	0.22
12_P	33_K	0.653	0.22
242_Y	264_I	0.651	0.22
98_V	343_S	0.650	0.21
532_I	556_N	0.648	0.21
25_Y	33_K	0.648	0.21
134_G	218_D	0.648	0.21
195_R	381_V	0.647	0.21
523_Y	544_Q	0.645	0.21
91_E	335_G	0.645	0.21
139_Q	142_L	0.645	0.21
91_E	186_S	0.645	0.21
489_Q	493_S	0.644	0.21
260_S	265_E	0.644	0.21
346_G	539_G	0.643	0.21
328_L	374_T	0.643	0.21
8_L	401_N	0.642	0.21
567_D	571_Y	0.641	0.21
149_W	380_E	0.641	0.21
419_S	422_R	0.640	0.21
307_F	423_A	0.639	0.21
16_F	538_R	0.638	0.21
226_L	270_C	0.637	0.21
271_H	286_P	0.637	0.21
43_A	78_M	0.637	0.21
75_Y	380_E	0.637	0.21
38_L	272_F	0.636	0.21
127_E	512_P	0.636	0.21
451_R	455_Q	0.636	0.21
78_M	553_S	0.635	0.21
461_Y	464_Q	0.635	0.21
3_I	35_V	0.634	0.21
237_A	390_D	0.632	0.21
28_I	31_P	0.630	0.21
567_D	570_T	0.627	0.21
486_S	489_Q	0.627	0.21
132_E	313_A	0.627	0.21
338_P	366_L	0.625	0.20
197_L	378_W	0.624	0.20
523_Y	555_L	0.624	0.20
25_Y	44_Y	0.623	0.20
498_D	504_D	0.623	0.20
57_R	88_A	0.622	0.20
8_L	548_F	0.622	0.20
352_E	362_V	0.621	0.20
13_A	122_R	0.621	0.20
395_C	434_F	0.620	0.20
25_Y	37_K	0.620	0.20
158_R	244_G	0.619	0.20
31_P	73_D	0.618	0.20
145_S	150_K	0.618	0.20
265_E	539_G	0.618	0.20
173_S	204_K	0.617	0.20
263_L	535_L	0.617	0.20
141_A	486_S	0.615	0.20
10_H	90_G	0.614	0.20
514_A	521_V	0.614	0.20
224_L	282_L	0.614	0.20
198_Y	204_K	0.612	0.20
80_R	317_E	0.610	0.20
338_P	367_V	0.610	0.20
410_P	441_F	0.609	0.20
65_G	420_S	0.609	0.20
33_K	105_K	0.608	0.20
186_S	204_K	0.608	0.20
111_S	367_V	0.607	0.20
195_R	207_K	0.607	0.20
453_L	464_Q	0.606	0.20
54_L	331_F	0.606	0.20
507_P	513_F	0.605	0.20
299_L	379_N	0.605	0.20
55_S	328_L	0.604	0.20
385_R	521_V	0.604	0.20
211_I	297_R	0.603	0.20
137_E	435_N	0.603	0.20
349_L	358_S	0.603	0.20
302_D	418_F	0.602	0.20
495_L	540_S	0.601	0.19
354_T	406_D	0.601	0.19
182_S	407_A	0.601	0.19
19_A	26_K	0.601	0.19
463_L	485_L	0.599	0.19
31_P	40_L	0.596	0.19
45_A	55_S	0.596	0.19
107_N	214_G	0.596	0.19
346_G	360_G	0.595	0.19
156_E	301_D	0.594	0.19
85_Y	220_S	0.594	0.19
432_E	499_R	0.594	0.19
56_L	331_F	0.593	0.19
135_W	522_F	0.591	0.19
219_L	323_A	0.591	0.19
85_Y	94_R	0.590	0.19
35_V	416_F	0.590	0.19
485_L	541_L	0.590	0.19
55_S	389_E	0.590	0.19
421_N	495_L	0.589	0.19
354_T	425_A	0.589	0.19
204_K	335_G	0.589	0.19
150_K	213_P	0.588	0.19
338_P	425_A	0.588	0.19
485_L	489_Q	0.588	0.19
134_G	235_G	0.586	0.19
81_R	218_D	0.585	0.19
327_Q	479_V	0.585	0.19
216_S	423_A	0.585	0.19
260_S	513_F	0.585	0.19
257_L	288_D	0.585	0.19
4_D	239_W	0.585	0.19
201_F	361_G	0.584	0.19
78_M	416_F	0.584	0.19
15_E	105_K	0.583	0.19
173_S	348_H	0.583	0.19
223_T	283_H	0.583	0.19
398_D	406_D	0.582	0.19
6_G	22_W	0.582	0.19
110_L	127_E	0.581	0.19
61_A	431_E	0.581	0.19
274_G	550_D	0.580	0.19
54_L	63_Y	0.579	0.19
219_L	337_D	0.579	0.19
196_K	441_F	0.579	0.19
79_Y	83_E	0.579	0.19
297_R	413_L	0.579	0.19
105_K	195_R	0.577	0.19
481_L	489_Q	0.577	0.19
21_L	49_P	0.577	0.19
292_S	543_H	0.577	0.19
78_M	296_L	0.577	0.19
222_D	275_L	0.576	0.19
257_L	274_G	0.574	0.18
84_E	370_I	0.574	0.18
213_P	470_V	0.574	0.18
194_G	204_K	0.574	0.18
49_P	65_G	0.574	0.18
504_D	526_N	0.574	0.18
116_N	131_K	0.573	0.18
478_L	482_L	0.572	0.18
101_C	360_G	0.571	0.18
25_Y	195_R	0.570	0.18
437_V	441_F	0.567	0.18
265_E	385_R	0.567	0.18
108_E	125_L	0.567	0.18
102_F	318_A	0.566	0.18
6_G	31_P	0.566	0.18
95_L	376_N	0.565	0.18
262_S	539_G	0.565	0.18
122_R	463_L	0.564	0.18
271_H	308_P	0.563	0.18
15_E	25_Y	0.563	0.18
20_G	23_Q	0.563	0.18
514_A	542_F	0.563	0.18
114_P	127_E	0.562	0.18
104_L	539_G	0.562	0.18
75_Y	378_W	0.561	0.18
30_S	42_E	0.561	0.18
163_N	325_I	0.561	0.18
173_S	533_Y	0.560	0.18
166_T	169_Y	0.559	0.18
213_P	219_L	0.558	0.18
158_R	209_E	0.558	0.18
465_F	470_V	0.557	0.18
35_V	62_V	0.556	0.18
49_P	333_N	0.556	0.18
376_N	382_L	0.554	0.18
355_D	564_S	0.554	0.18
122_R	171_F	0.553	0.18
497_L	510_I	0.552	0.18
534_V	543_H	0.551	0.18
84_E	404_P	0.550	0.18
335_G	395_C	0.550	0.18
460_Y	481_L	0.548	0.18
296_L	377_S	0.548	0.18
88_A	275_L	0.548	0.18
66_E	138_R	0.547	0.17
78_M	126_L	0.546	0.17
344_R	494_P	0.546	0.17
256_P	568_R	0.545	0.17
270_C	353_R	0.545	0.17
369_S	379_N	0.543	0.17
255_A	456_V	0.542	0.17
5_F	59_K	0.541	0.17
95_L	269_W	0.541	0.17
67_L	80_R	0.541	0.17
296_L	520_Q	0.540	0.17
78_M	98_V	0.540	0.17
414_Q	431_E	0.540	0.17
104_L	441_F	0.540	0.17
72_L	125_L	0.539	0.17
41_L	397_K	0.539	0.17
143_L	393_L	0.539	0.17
125_L	486_S	0.539	0.17
34_S	107_N	0.539	0.17
308_P	319_L	0.539	0.17
367_V	448_R	0.539	0.17
398_D	413_L	0.538	0.17
11_I	63_Y	0.538	0.17
189_D	383_T	0.536	0.17
94_R	168_S	0.534	0.17
93_E	163_N	0.534	0.17
80_R	441_F	0.534	0.17
42_E	75_Y	0.533	0.17
119_K	127_E	0.532	0.17
102_F	219_L	0.532	0.17
209_E	351_S	0.531	0.17
188_R	535_L	0.531	0.17
566_L	571_Y	0.530	0.17
98_V	334_V	0.529	0.17
149_W	169_Y	0.529	0.17
26_K	40_L	0.528	0.17
242_Y	439_R	0.528	0.17
344_R	352_E	0.527	0.17
47_E	189_D	0.526	0.17
448_R	454_L	0.526	0.17
4_D	99_R	0.525	0.17
15_E	18_G	0.524	0.17
295_E	429_R	0.523	0.17
479_V	527_G	0.522	0.17
88_A	394_D	0.521	0.17
15_E	75_Y	0.520	0.17
41_L	51_T	0.520	0.17
404_P	440_L	0.520	0.17
358_S	363_R	0.519	0.17
10_H	174_Q	0.519	0.17
7_G	14_E	0.519	0.17
24_L	189_D	0.519	0.17
258_K	536_D	0.519	0.17
74_P	241_L	0.519	0.17
477_N	494_P	0.518	0.16
4_D	263_L	0.518	0.16
198_Y	212_N	0.517	0.16
2_W	82_V	0.516	0.16
79_Y	374_T	0.515	0.16
326_R	391_A	0.514	0.16
30_S	59_K	0.514	0.16
90_G	130_V	0.512	0.16
348_H	351_S	0.512	0.16
461_Y	533_Y	0.511	0.16
21_L	41_L	0.511	0.16
171_F	175_F	0.511	0.16
28_I	172_L	0.510	0.16
33_K	42_E	0.510	0.16
405_Q	417_C	0.509	0.16
267_L	508_A	0.509	0.16
299_L	331_F	0.508	0.16
100_R	216_S	0.507	0.16
88_A	327_Q	0.507	0.16
198_Y	416_F	0.505	0.16
247_N	417_C	0.504	0.16
275_L	477_N	0.504	0.16
157_E	485_L	0.503	0.16
57_R	270_C	0.503	0.16
68_D	71_E	0.503	0.16
62_V	226_L	0.500	0.16
102_F	509_L	0.500	0.16
3_I	6_G	0.500	0.16

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3f7fA	2	0.255	26.5	0.984	Contact Map
2h34A	1	0.1217	20.1	0.985	Contact Map
2p22A	1	0.14	17.4	0.986	Contact Map
3pnwC	1	0.0317	10.7	0.987	Contact Map
1rh5C	1	0.0217	10.6	0.987	Contact Map
4a4fA	1	0.0367	9.3	0.987	Contact Map
1xg0A	1	0.06	9.2	0.987	Contact Map
4qpmA	1	0.175	9	0.987	Contact Map
4xmmE	1	0.2517	8.2	0.988	Contact Map
2k6vA	1	0.23	7.5	0.988	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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