GREMLIN Database
Adenylate_cycl - Adenylate cyclase, class-I
PFAM: PF01295 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 600 (571)
Sequences: 645 (434)
Seq/√Len: 18.1
META: 0.536

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
502_L507_P7.0371.00
498_D507_P6.1751.00
57_R84_E5.1861.00
47_E81_R5.0491.00
501_A507_P4.6811.00
504_D507_P3.9691.00
108_E122_R3.9311.00
502_L505_H3.8371.00
481_L485_L3.5101.00
78_M82_V3.4821.00
110_L144_D3.4781.00
502_L506_L3.0870.99
33_K37_K3.0160.99
52_Q60_Q2.9970.99
501_A505_H2.9880.99
111_S144_D2.9440.99
498_D502_L2.9260.99
494_P498_D2.9110.99
507_P511_L2.8780.99
498_D501_A2.8230.98
346_G351_S2.8060.98
417_C426_I2.7110.98
501_A506_L2.6820.98
22_W33_K2.6800.98
60_Q64_A2.6740.98
80_R132_E2.6400.97
82_V98_V2.5800.97
497_L507_P2.5790.97
501_A504_D2.5410.97
212_N216_S2.5290.97
492_Y498_D2.3820.95
417_C420_S2.3240.94
36_L98_V2.2910.94
367_V370_I2.2650.94
153_Q156_E2.2590.94
22_W26_K2.2360.93
561_F568_R2.2210.93
26_K33_K2.2110.93
452_Y460_Y2.2030.93
452_Y455_Q2.1990.93
52_Q57_R2.1830.92
32_Y215_I2.1320.91
66_E71_E2.1210.91
355_D359_Y2.0870.90
134_G156_E2.0830.90
206_G265_E2.0820.90
91_E164_E2.0560.90
26_K37_K2.0510.90
22_W37_K2.0370.89
15_E22_W2.0350.89
482_L541_L2.0250.89
524_R531_D2.0180.89
499_R507_P2.0060.89
493_S498_D1.9990.88
494_P497_L1.9920.88
451_R460_Y1.9780.88
212_N215_I1.9610.87
95_L303_L1.9440.87
27_G38_L1.9370.87
57_R81_R1.9300.87
530_A548_F1.9020.86
18_G185_I1.8810.85
390_D394_D1.8760.85
15_E26_K1.8640.85
158_R214_G1.8550.84
565_V568_R1.8230.83
500_Y507_P1.8150.83
355_D429_R1.8120.83
43_A82_V1.8010.82
497_L511_L1.7890.82
78_M360_G1.7830.82
460_Y464_Q1.7670.81
419_S423_A1.7580.81
392_L430_V1.7540.81
497_L500_Y1.7530.81
514_A539_G1.7390.80
8_L55_S1.7310.80
330_L434_F1.7250.80
436_D499_R1.7090.79
48_Y360_G1.6950.78
452_Y462_V1.6900.78
557_P562_L1.6850.78
110_L123_R1.6630.77
42_E195_R1.6620.77
12_P15_E1.6610.77
386_Y398_D1.6430.76
557_P561_F1.6420.76
508_A511_L1.6160.75
493_S497_L1.6100.75
270_C280_T1.5990.74
452_Y461_Y1.5980.74
15_E37_K1.5930.74
15_E33_K1.5830.73
150_K221_E1.5810.73
49_P175_F1.5540.72
204_K259_R1.5510.72
451_R464_Q1.5500.72
6_G15_E1.5490.72
7_G102_F1.5360.71
24_L39_L1.5160.70
452_Y456_V1.5140.70
17_F53_L1.5080.69
221_E280_T1.5070.69
228_Q286_P1.5000.69
208_V410_P1.5000.69
31_P37_K1.4960.69
503_E507_P1.4910.69
241_L270_C1.4830.68
346_G349_L1.4830.68
404_P442_L1.4770.68
322_P517_G1.4770.68
129_L319_L1.4740.68
220_S391_A1.4470.66
37_K75_Y1.4390.66
319_L350_T1.4380.66
150_K215_I1.4280.65
258_K300_L1.4260.65
558_L562_L1.4190.65
169_Y194_G1.4120.64
242_Y256_P1.4100.64
20_G212_N1.4080.64
451_R462_V1.4040.64
104_L216_S1.4030.64
264_I373_V1.4000.64
120_S123_R1.3980.63
224_L276_I1.3930.63
37_K44_Y1.3860.63
536_D540_S1.3830.63
135_W273_N1.3780.62
31_P44_Y1.3670.62
91_E339_T1.3620.61
453_L460_Y1.3600.61
198_Y215_I1.3480.61
186_S397_K1.3440.60
172_L369_S1.3440.60
23_Q212_N1.3400.60
562_L565_V1.3390.60
128_R534_V1.3300.59
154_V215_I1.3300.59
183_S190_L1.3260.59
40_L44_Y1.3250.59
346_G350_T1.3250.59
150_K212_N1.3220.59
201_F272_F1.3210.59
26_K31_P1.3210.59
360_G455_Q1.3110.58
100_R214_G1.3090.58
17_F419_S1.3080.58
302_D416_F1.3050.58
359_Y426_I1.3040.58
219_L381_V1.3040.58
189_D520_Q1.3030.58
358_S370_I1.3020.58
329_L367_V1.3000.58
126_L140_L1.2950.57
189_D369_S1.2910.57
87_L96_E1.2840.57
75_Y105_K1.2840.57
29_D122_R1.2800.56
67_L71_E1.2760.56
15_E31_P1.2730.56
33_K75_Y1.2710.56
511_L514_A1.2710.56
495_L498_D1.2680.56
162_V169_Y1.2580.55
203_R209_E1.2570.55
22_W25_Y1.2550.55
104_L242_Y1.2550.55
150_K218_D1.2540.55
59_K63_Y1.2490.55
381_V503_E1.2480.54
22_W31_P1.2460.54
123_R144_D1.2440.54
81_R359_Y1.2320.54
94_R101_C1.2300.53
227_V251_I1.2280.53
454_L515_R1.2270.53
356_A425_A1.2270.53
150_K154_V1.2230.53
4_D59_K1.2170.53
1_E544_Q1.2170.53
19_A22_W1.2160.53
226_L244_G1.2130.52
501_A510_I1.2130.52
96_E359_Y1.2090.52
121_W161_L1.2060.52
102_F106_V1.2030.52
50_N510_I1.2020.52
257_L515_R1.2010.52
334_V385_R1.1990.51
325_I374_T1.1940.51
228_Q486_S1.1930.51
351_S426_I1.1880.51
502_L508_A1.1870.51
456_V463_L1.1850.51
399_Y434_F1.1800.50
296_L430_V1.1770.50
257_L442_L1.1760.50
517_G520_Q1.1740.50
105_K380_E1.1730.50
267_L300_L1.1690.50
547_P554_L1.1650.49
101_C151_I1.1610.49
32_Y150_K1.1600.49
12_P38_L1.1570.49
94_R149_W1.1530.49
3_I11_I1.1480.48
83_E427_A1.1430.48
357_L423_A1.1390.48
131_K313_A1.1370.48
33_K44_Y1.1340.47
429_R561_F1.1330.47
507_P510_I1.1320.47
35_V175_F1.1320.47
193_L280_T1.1280.47
331_F334_V1.1280.47
117_R534_V1.1230.47
189_D259_R1.1180.46
452_Y464_Q1.1170.46
514_A520_Q1.1170.46
225_T242_Y1.1160.46
37_K40_L1.1150.46
526_N531_D1.1140.46
164_E360_G1.1130.46
134_G547_P1.1120.46
44_Y75_Y1.1100.46
186_S327_Q1.1100.46
82_V198_Y1.1080.46
480_A532_I1.1070.46
148_Q311_L1.1030.46
177_R198_Y1.1030.46
63_Y354_T1.1010.45
105_K207_K1.0980.45
113_P123_R1.0950.45
189_D210_L1.0930.45
146_R215_I1.0890.45
8_L535_L1.0850.44
497_L501_A1.0840.44
25_Y196_K1.0840.44
71_E80_R1.0740.44
337_D366_L1.0730.44
343_S348_H1.0700.44
434_F437_V1.0680.43
464_Q489_Q1.0680.43
225_T461_Y1.0660.43
55_S281_R1.0650.43
173_S177_R1.0630.43
337_D535_L1.0610.43
98_V357_L1.0610.43
7_G196_K1.0610.43
316_E319_L1.0590.43
138_R413_L1.0560.43
178_R257_L1.0430.42
535_L541_L1.0430.42
97_L351_S1.0410.42
76_V79_Y1.0400.42
48_Y276_I1.0380.42
514_A544_Q1.0320.41
397_K417_C1.0300.41
150_K219_L1.0300.41
149_W378_W1.0290.41
122_R275_L1.0270.41
121_W172_L1.0240.41
207_K239_W1.0230.41
44_Y105_K1.0220.41
328_L372_Q1.0140.40
242_Y457_G1.0140.40
42_E94_R1.0110.40
22_W75_Y1.0090.40
203_R451_R1.0070.40
105_K378_W1.0070.40
204_K384_L1.0050.40
209_E266_L1.0040.40
23_Q143_L1.0010.39
225_T246_L1.0000.39
5_F191_N0.9940.39
208_V268_A0.9930.39
39_L98_V0.9920.39
305_Q482_L0.9860.39
387_E415_V0.9860.39
57_R370_I0.9840.38
331_F416_F0.9830.38
208_V318_A0.9810.38
38_L367_V0.9810.38
48_Y175_F0.9800.38
145_S148_Q0.9770.38
558_L563_Q0.9750.38
12_P26_K0.9740.38
34_S63_Y0.9720.38
38_L55_S0.9710.38
9_A276_I0.9670.37
192_I291_L0.9660.37
154_V158_R0.9650.37
351_S429_R0.9640.37
492_Y497_L0.9640.37
23_Q213_P0.9640.37
530_A557_P0.9640.37
151_I210_L0.9620.37
376_N514_A0.9610.37
347_L376_N0.9610.37
272_F383_T0.9610.37
517_G522_F0.9600.37
166_T204_K0.9560.37
539_G542_F0.9560.37
437_V452_Y0.9560.37
21_L53_L0.9520.37
75_Y86_L0.9500.36
399_Y405_Q0.9500.36
191_N517_G0.9490.36
327_Q412_S0.9460.36
26_K75_Y0.9460.36
19_A23_Q0.9460.36
96_E139_Q0.9440.36
161_L172_L0.9430.36
121_W365_N0.9410.36
65_G176_A0.9410.36
485_L488_P0.9390.36
94_R105_K0.9380.36
18_G172_L0.9360.36
227_V246_L0.9340.36
202_E205_P0.9320.35
342_L346_G0.9320.35
41_L419_S0.9310.35
175_F202_E0.9300.35
429_R568_R0.9300.35
140_L147_S0.9290.35
105_K149_W0.9280.35
461_Y472_Y0.9270.35
17_F294_F0.9250.35
257_L477_N0.9220.35
5_F10_H0.9220.35
463_L470_V0.9210.35
25_Y264_I0.9210.35
205_P530_A0.9200.35
53_L201_F0.9160.35
228_Q237_A0.9150.34
27_G372_Q0.9150.34
485_L494_P0.9110.34
282_L286_P0.9100.34
351_S356_A0.9090.34
23_Q39_L0.9090.34
13_A46_S0.9090.34
8_L85_Y0.9080.34
196_K391_A0.9070.34
357_L427_A0.9050.34
15_E19_A0.9030.34
38_L165_L0.8990.34
342_L347_L0.8970.33
311_L379_N0.8960.33
12_P22_W0.8960.33
15_E44_Y0.8950.33
23_Q158_R0.8920.33
21_L189_D0.8920.33
82_V343_S0.8910.33
33_K40_L0.8880.33
129_L337_D0.8850.33
422_R430_V0.8840.33
55_S87_L0.8840.33
45_A74_P0.8820.33
247_N252_I0.8820.33
405_Q442_L0.8820.33
5_F262_S0.8810.33
464_Q469_G0.8800.33
207_K380_E0.8780.32
111_S257_L0.8770.32
18_G22_W0.8750.32
77_M519_I0.8730.32
450_S494_P0.8710.32
50_N114_P0.8710.32
281_R293_E0.8710.32
175_F533_Y0.8710.32
500_Y503_E0.8710.32
558_L561_F0.8680.32
555_L562_L0.8670.32
14_E41_L0.8660.32
137_E315_S0.8650.32
322_P433_L0.8650.32
481_L488_P0.8640.32
557_P560_R0.8620.32
485_L492_Y0.8600.31
207_K378_W0.8600.31
108_E120_S0.8590.31
406_D468_G0.8590.31
131_K473_Q0.8580.31
31_P75_Y0.8570.31
322_P356_A0.8560.31
13_A48_Y0.8550.31
32_Y214_G0.8530.31
361_G365_N0.8530.31
58_F74_P0.8530.31
530_A549_G0.8500.31
168_S380_E0.8500.31
31_P105_K0.8490.31
154_V221_E0.8470.31
11_I38_L0.8470.31
151_I219_L0.8460.31
226_L267_L0.8460.31
337_D376_N0.8440.31
148_Q174_Q0.8410.30
104_L143_L0.8410.30
48_Y124_E0.8380.30
24_L169_Y0.8370.30
21_L283_H0.8340.30
20_G391_A0.8340.30
392_L568_R0.8340.30
272_F307_F0.8330.30
151_I268_A0.8320.30
175_F461_Y0.8300.30
258_K335_G0.8290.30
205_P259_R0.8290.30
81_R189_D0.8260.30
17_F20_G0.8250.30
164_E167_H0.8250.30
203_R460_Y0.8240.30
489_Q500_Y0.8220.29
32_Y157_E0.8210.29
473_Q487_E0.8190.29
159_R209_E0.8190.29
453_L462_V0.8180.29
59_K62_V0.8170.29
453_L496_V0.8140.29
304_Q532_I0.8140.29
219_L226_L0.8140.29
366_L426_I0.8140.29
27_G198_Y0.8120.29
153_Q275_L0.8110.29
29_D433_L0.8080.29
565_V569_Q0.8080.29
130_V173_S0.8080.29
7_G65_G0.8080.29
422_R426_I0.8070.29
225_T245_S0.8060.29
96_E130_V0.8040.29
37_K42_E0.8030.29
226_L282_L0.8010.28
3_I204_K0.8000.28
359_Y366_L0.8000.28
489_Q494_P0.7990.28
28_I164_E0.7990.28
190_L271_H0.7980.28
10_H303_L0.7980.28
357_L422_R0.7970.28
22_W44_Y0.7970.28
102_F220_S0.7940.28
330_L453_L0.7930.28
507_P520_Q0.7900.28
303_L322_P0.7870.28
263_L399_Y0.7860.28
203_R481_L0.7860.28
242_Y431_E0.7850.28
146_R212_N0.7840.28
28_I35_V0.7800.27
291_L394_D0.7790.27
133_W193_L0.7790.27
202_E207_K0.7780.27
492_Y516_P0.7720.27
342_L348_H0.7700.27
227_V539_G0.7690.27
42_E269_W0.7690.27
235_G347_L0.7680.27
204_K418_F0.7680.27
225_T244_G0.7660.27
284_L335_G0.7650.27
59_K263_L0.7650.27
60_Q473_Q0.7640.27
90_G128_R0.7610.26
511_L516_P0.7610.26
75_Y195_R0.7610.26
120_S192_I0.7600.26
165_L269_W0.7580.26
116_N124_E0.7580.26
194_G203_R0.7580.26
531_D545_R0.7580.26
31_P42_E0.7580.26
55_S59_K0.7570.26
6_G26_K0.7560.26
37_K105_K0.7540.26
55_S58_F0.7540.26
154_V218_D0.7540.26
275_L437_V0.7540.26
103_Y122_R0.7540.26
499_R502_L0.7530.26
142_L153_Q0.7530.26
4_D28_I0.7510.26
75_Y207_K0.7510.26
103_Y135_W0.7500.26
278_S359_Y0.7500.26
506_L509_L0.7490.26
454_L491_S0.7490.26
85_Y101_C0.7480.26
134_G512_P0.7480.26
17_F177_R0.7470.26
60_Q282_L0.7450.26
559_Q563_Q0.7450.26
346_G429_R0.7430.26
98_V356_A0.7430.26
361_G366_L0.7420.26
363_R367_V0.7420.26
376_N391_A0.7400.25
201_F391_A0.7390.25
332_I399_Y0.7370.25
338_P419_S0.7370.25
3_I358_S0.7370.25
3_I7_G0.7340.25
21_L337_D0.7340.25
163_N381_V0.7300.25
195_R378_W0.7290.25
336_V434_F0.7280.25
78_M535_L0.7280.25
108_E123_R0.7280.25
554_L561_F0.7260.25
62_V124_E0.7250.25
23_Q154_V0.7240.25
6_G12_P0.7230.25
262_S385_R0.7230.25
461_Y465_F0.7230.25
520_Q523_Y0.7220.25
20_G41_L0.7210.25
26_K44_Y0.7210.25
521_V544_Q0.7210.25
282_L371_D0.7210.25
121_W144_D0.7200.25
106_V150_K0.7200.25
25_Y525_D0.7180.24
36_L77_M0.7160.24
219_L271_H0.7130.24
405_Q440_L0.7120.24
102_F193_L0.7110.24
25_Y350_T0.7110.24
270_C276_I0.7110.24
79_Y95_L0.7100.24
486_S533_Y0.7100.24
54_L429_R0.7090.24
398_D404_P0.7060.24
172_L337_D0.7020.24
30_S35_V0.7010.24
171_F243_N0.6990.24
16_F540_S0.6970.23
172_L185_I0.6970.23
87_L487_E0.6970.23
226_L272_F0.6950.23
47_E126_L0.6940.23
51_T82_V0.6930.23
7_G25_Y0.6930.23
439_R491_S0.6910.23
264_I482_L0.6910.23
156_E208_V0.6900.23
64_A281_R0.6900.23
236_Q304_Q0.6890.23
357_L429_R0.6880.23
213_P391_A0.6870.23
28_I347_L0.6870.23
193_L201_F0.6850.23
12_P37_K0.6830.23
40_L75_Y0.6820.23
454_L463_L0.6820.23
46_S50_N0.6810.23
67_L330_L0.6810.23
224_L327_Q0.6800.23
3_I111_S0.6800.23
2_W79_Y0.6800.23
3_I25_Y0.6800.23
158_R265_E0.6790.23
18_G169_Y0.6790.23
60_Q88_A0.6770.23
86_L105_K0.6770.23
117_R473_Q0.6770.23
146_R154_V0.6770.23
386_Y391_A0.6760.23
68_D377_S0.6760.23
315_S405_Q0.6740.22
519_I532_I0.6740.22
16_F91_E0.6730.22
211_I260_S0.6730.22
515_R532_I0.6730.22
136_D477_N0.6720.22
149_W207_K0.6720.22
144_D212_N0.6720.22
90_G369_S0.6710.22
4_D207_K0.6710.22
146_R534_V0.6700.22
27_G319_L0.6690.22
9_A47_E0.6690.22
17_F176_A0.6690.22
241_L545_R0.6680.22
294_F373_V0.6670.22
11_I28_I0.6660.22
464_Q468_G0.6650.22
134_G140_L0.6650.22
3_I122_R0.6650.22
212_N296_L0.6620.22
502_L511_L0.6600.22
201_F386_Y0.6600.22
363_R417_C0.6580.22
44_Y73_D0.6580.22
66_E224_L0.6580.22
86_L101_C0.6580.22
268_A272_F0.6580.22
20_G54_L0.6560.22
158_R194_G0.6550.22
75_Y149_W0.6530.22
12_P33_K0.6530.22
242_Y264_I0.6510.22
98_V343_S0.6500.21
532_I556_N0.6480.21
25_Y33_K0.6480.21
134_G218_D0.6480.21
195_R381_V0.6470.21
523_Y544_Q0.6450.21
91_E335_G0.6450.21
139_Q142_L0.6450.21
91_E186_S0.6450.21
489_Q493_S0.6440.21
260_S265_E0.6440.21
346_G539_G0.6430.21
328_L374_T0.6430.21
8_L401_N0.6420.21
567_D571_Y0.6410.21
149_W380_E0.6410.21
419_S422_R0.6400.21
307_F423_A0.6390.21
16_F538_R0.6380.21
226_L270_C0.6370.21
271_H286_P0.6370.21
43_A78_M0.6370.21
75_Y380_E0.6370.21
38_L272_F0.6360.21
127_E512_P0.6360.21
451_R455_Q0.6360.21
78_M553_S0.6350.21
461_Y464_Q0.6350.21
3_I35_V0.6340.21
237_A390_D0.6320.21
28_I31_P0.6300.21
567_D570_T0.6270.21
486_S489_Q0.6270.21
132_E313_A0.6270.21
338_P366_L0.6250.20
197_L378_W0.6240.20
523_Y555_L0.6240.20
25_Y44_Y0.6230.20
498_D504_D0.6230.20
57_R88_A0.6220.20
8_L548_F0.6220.20
352_E362_V0.6210.20
13_A122_R0.6210.20
395_C434_F0.6200.20
25_Y37_K0.6200.20
158_R244_G0.6190.20
31_P73_D0.6180.20
145_S150_K0.6180.20
265_E539_G0.6180.20
173_S204_K0.6170.20
263_L535_L0.6170.20
141_A486_S0.6150.20
10_H90_G0.6140.20
514_A521_V0.6140.20
224_L282_L0.6140.20
198_Y204_K0.6120.20
80_R317_E0.6100.20
338_P367_V0.6100.20
410_P441_F0.6090.20
65_G420_S0.6090.20
33_K105_K0.6080.20
186_S204_K0.6080.20
111_S367_V0.6070.20
195_R207_K0.6070.20
453_L464_Q0.6060.20
54_L331_F0.6060.20
507_P513_F0.6050.20
299_L379_N0.6050.20
55_S328_L0.6040.20
385_R521_V0.6040.20
211_I297_R0.6030.20
137_E435_N0.6030.20
349_L358_S0.6030.20
302_D418_F0.6020.20
495_L540_S0.6010.19
354_T406_D0.6010.19
182_S407_A0.6010.19
19_A26_K0.6010.19
463_L485_L0.5990.19
31_P40_L0.5960.19
45_A55_S0.5960.19
107_N214_G0.5960.19
346_G360_G0.5950.19
156_E301_D0.5940.19
85_Y220_S0.5940.19
432_E499_R0.5940.19
56_L331_F0.5930.19
135_W522_F0.5910.19
219_L323_A0.5910.19
85_Y94_R0.5900.19
35_V416_F0.5900.19
485_L541_L0.5900.19
55_S389_E0.5900.19
421_N495_L0.5890.19
354_T425_A0.5890.19
204_K335_G0.5890.19
150_K213_P0.5880.19
338_P425_A0.5880.19
485_L489_Q0.5880.19
134_G235_G0.5860.19
81_R218_D0.5850.19
327_Q479_V0.5850.19
216_S423_A0.5850.19
260_S513_F0.5850.19
257_L288_D0.5850.19
4_D239_W0.5850.19
201_F361_G0.5840.19
78_M416_F0.5840.19
15_E105_K0.5830.19
173_S348_H0.5830.19
223_T283_H0.5830.19
398_D406_D0.5820.19
6_G22_W0.5820.19
110_L127_E0.5810.19
61_A431_E0.5810.19
274_G550_D0.5800.19
54_L63_Y0.5790.19
219_L337_D0.5790.19
196_K441_F0.5790.19
79_Y83_E0.5790.19
297_R413_L0.5790.19
105_K195_R0.5770.19
481_L489_Q0.5770.19
21_L49_P0.5770.19
292_S543_H0.5770.19
78_M296_L0.5770.19
222_D275_L0.5760.19
257_L274_G0.5740.18
84_E370_I0.5740.18
213_P470_V0.5740.18
194_G204_K0.5740.18
49_P65_G0.5740.18
504_D526_N0.5740.18
116_N131_K0.5730.18
478_L482_L0.5720.18
101_C360_G0.5710.18
25_Y195_R0.5700.18
437_V441_F0.5670.18
265_E385_R0.5670.18
108_E125_L0.5670.18
102_F318_A0.5660.18
6_G31_P0.5660.18
95_L376_N0.5650.18
262_S539_G0.5650.18
122_R463_L0.5640.18
271_H308_P0.5630.18
15_E25_Y0.5630.18
20_G23_Q0.5630.18
514_A542_F0.5630.18
114_P127_E0.5620.18
104_L539_G0.5620.18
75_Y378_W0.5610.18
30_S42_E0.5610.18
163_N325_I0.5610.18
173_S533_Y0.5600.18
166_T169_Y0.5590.18
213_P219_L0.5580.18
158_R209_E0.5580.18
465_F470_V0.5570.18
35_V62_V0.5560.18
49_P333_N0.5560.18
376_N382_L0.5540.18
355_D564_S0.5540.18
122_R171_F0.5530.18
497_L510_I0.5520.18
534_V543_H0.5510.18
84_E404_P0.5500.18
335_G395_C0.5500.18
460_Y481_L0.5480.18
296_L377_S0.5480.18
88_A275_L0.5480.18
66_E138_R0.5470.17
78_M126_L0.5460.17
344_R494_P0.5460.17
256_P568_R0.5450.17
270_C353_R0.5450.17
369_S379_N0.5430.17
255_A456_V0.5420.17
5_F59_K0.5410.17
95_L269_W0.5410.17
67_L80_R0.5410.17
296_L520_Q0.5400.17
78_M98_V0.5400.17
414_Q431_E0.5400.17
104_L441_F0.5400.17
72_L125_L0.5390.17
41_L397_K0.5390.17
143_L393_L0.5390.17
125_L486_S0.5390.17
34_S107_N0.5390.17
308_P319_L0.5390.17
367_V448_R0.5390.17
398_D413_L0.5380.17
11_I63_Y0.5380.17
189_D383_T0.5360.17
94_R168_S0.5340.17
93_E163_N0.5340.17
80_R441_F0.5340.17
42_E75_Y0.5330.17
119_K127_E0.5320.17
102_F219_L0.5320.17
209_E351_S0.5310.17
188_R535_L0.5310.17
566_L571_Y0.5300.17
98_V334_V0.5290.17
149_W169_Y0.5290.17
26_K40_L0.5280.17
242_Y439_R0.5280.17
344_R352_E0.5270.17
47_E189_D0.5260.17
448_R454_L0.5260.17
4_D99_R0.5250.17
15_E18_G0.5240.17
295_E429_R0.5230.17
479_V527_G0.5220.17
88_A394_D0.5210.17
15_E75_Y0.5200.17
41_L51_T0.5200.17
404_P440_L0.5200.17
358_S363_R0.5190.17
10_H174_Q0.5190.17
7_G14_E0.5190.17
24_L189_D0.5190.17
258_K536_D0.5190.17
74_P241_L0.5190.17
477_N494_P0.5180.16
4_D263_L0.5180.16
198_Y212_N0.5170.16
2_W82_V0.5160.16
79_Y374_T0.5150.16
326_R391_A0.5140.16
30_S59_K0.5140.16
90_G130_V0.5120.16
348_H351_S0.5120.16
461_Y533_Y0.5110.16
21_L41_L0.5110.16
171_F175_F0.5110.16
28_I172_L0.5100.16
33_K42_E0.5100.16
405_Q417_C0.5090.16
267_L508_A0.5090.16
299_L331_F0.5080.16
100_R216_S0.5070.16
88_A327_Q0.5070.16
198_Y416_F0.5050.16
247_N417_C0.5040.16
275_L477_N0.5040.16
157_E485_L0.5030.16
57_R270_C0.5030.16
68_D71_E0.5030.16
62_V226_L0.5000.16
102_F509_L0.5000.16
3_I6_G0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f7fA 2 0.255 26.5 0.984 Contact Map
2h34A 1 0.1217 20.1 0.985 Contact Map
2p22A 1 0.14 17.4 0.986 Contact Map
3pnwC 1 0.0317 10.7 0.987 Contact Map
1rh5C 1 0.0217 10.6 0.987 Contact Map
4a4fA 1 0.0367 9.3 0.987 Contact Map
1xg0A 1 0.06 9.2 0.987 Contact Map
4qpmA 1 0.175 9 0.987 Contact Map
4xmmE 1 0.2517 8.2 0.988 Contact Map
2k6vA 1 0.23 7.5 0.988 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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