GREMLIN Database
MARVEL - Membrane-associating domain
PFAM: PF01284 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 144 (131)
Sequences: 3861 (2432)
Seq/√Len: 212.5
META: 0.068

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_A96_A3.1431.00
47_F51_L3.0681.00
13_Q141_S2.8161.00
94_F132_F2.5991.00
139_A143_V2.5921.00
87_A139_A2.5871.00
125_I129_A2.4111.00
95_I99_A2.3591.00
91_L95_I2.2911.00
94_F131_G2.2461.00
24_V127_A2.2411.00
126_A130_F2.1731.00
46_V50_V2.1571.00
10_R83_D2.1401.00
98_A132_F2.0621.00
110_S113_C1.9911.00
21_F25_A1.9201.00
21_F53_F1.9041.00
87_A142_A1.8791.00
22_G26_S1.8141.00
128_V132_F1.7841.00
16_F130_F1.7521.00
52_S90_W1.6051.00
18_I22_G1.5601.00
51_L86_A1.5331.00
17_A90_W1.5151.00
135_F139_A1.5131.00
45_F131_G1.4951.00
8_I12_L1.4631.00
121_C125_I1.4451.00
41_A96_A1.4281.00
26_S123_S1.4141.00
55_L82_F1.3951.00
43_G47_F1.3811.00
58_L62_L1.3791.00
45_F93_A1.3741.00
84_A142_A1.3651.00
91_L135_F1.3611.00
48_V89_L1.3601.00
98_A128_V1.3331.00
47_F89_L1.3291.00
25_A46_V1.3151.00
83_D141_S1.2741.00
56_T138_Y1.2731.00
129_A133_L1.2711.00
38_S43_G1.2041.00
133_L137_L1.1671.00
84_A88_L1.1641.00
44_F48_V1.1501.00
106_C121_C1.1451.00
111_N114_S1.1331.00
24_V27_S1.1271.00
80_L84_A1.1191.00
11_I15_V1.1111.00
44_F93_A1.1051.00
52_S86_A1.1031.00
82_F86_A1.0891.00
20_V130_F1.0871.00
79_D83_D1.0761.00
81_I85_L1.0561.00
87_A135_F1.0561.00
20_V49_A1.0541.00
94_F98_A1.0521.00
90_W134_A1.0281.00
36_G39_P1.0251.00
134_A137_L1.0181.00
95_I132_F1.0171.00
14_L57_L1.0031.00
43_G46_V1.0011.00
17_A134_A0.9951.00
77_L81_I0.9891.00
10_R141_S0.9761.00
20_V90_W0.9681.00
113_C116_G0.9631.00
114_S117_S0.9491.00
116_G119_S0.9320.99
125_I138_Y0.9260.99
56_T59_L0.9190.99
99_A103_D0.9120.99
134_A138_Y0.9010.99
44_F89_L0.8980.99
12_L137_L0.8870.99
136_L140_A0.8840.99
25_A50_V0.8800.99
20_V134_A0.8740.99
111_N115_G0.8710.99
46_V49_A0.8680.99
19_I22_G0.8660.99
112_S115_G0.8640.99
22_G28_G0.8500.99
48_V51_L0.8480.99
112_S116_G0.8450.99
20_V45_F0.8440.99
137_L141_S0.8410.99
90_W94_F0.8400.99
101_L128_V0.8260.99
7_G10_R0.8240.99
28_G46_V0.8220.99
17_A49_A0.8210.99
13_Q137_L0.8190.99
23_L26_S0.8180.99
16_F134_A0.8160.99
23_L126_A0.8110.98
24_V97_L0.8050.98
40_S96_A0.8010.98
40_S43_G0.7780.98
113_C117_S0.7780.98
62_L65_F0.7760.98
128_V133_L0.7670.98
16_F133_L0.7610.98
119_S123_S0.7570.98
99_A102_S0.7560.98
122_G125_I0.7550.98
18_I53_F0.7530.98
16_F27_S0.7530.98
21_F46_V0.7530.98
19_I130_F0.7500.97
115_G118_G0.7450.97
49_A90_W0.7320.97
13_Q138_Y0.7160.97
57_L61_V0.6970.96
119_S122_G0.6950.96
127_A131_G0.6930.96
14_L53_F0.6930.96
63_Y79_D0.6900.96
48_V93_A0.6880.96
8_I11_I0.6880.96
17_A138_Y0.6720.95
20_V131_G0.6680.95
21_F24_V0.6680.95
69_Y72_R0.6590.95
56_T60_L0.6590.95
27_S123_S0.6550.94
12_L15_V0.6520.94
52_S138_Y0.6510.94
122_G126_A0.6500.94
55_L86_A0.6490.94
16_F137_L0.6470.94
50_V54_L0.6420.94
52_S56_T0.6400.94
125_I128_V0.6380.94
62_L75_W0.6380.94
128_V138_Y0.6310.93
58_L63_Y0.6260.93
45_F49_A0.6200.93
84_A137_L0.6170.93
110_S114_S0.6140.92
91_L96_A0.6120.92
17_A21_F0.6110.92
77_L93_A0.6100.92
39_P93_A0.6070.92
133_L136_L0.6060.92
61_V64_L0.6050.92
42_L97_L0.6040.92
42_L45_F0.5930.91
84_A117_S0.5920.91
23_L27_S0.5850.90
38_S100_A0.5810.90
113_C118_G0.5760.90
89_L92_A0.5730.90
54_L58_L0.5700.89
51_L55_L0.5690.89
12_L16_F0.5660.89
96_A99_A0.5660.89
75_W78_V0.5640.89
58_L66_G0.5580.88
77_L80_L0.5550.88
23_L127_A0.5540.88
8_I14_L0.5530.88
17_A20_V0.5510.88
71_L77_L0.5490.87
65_F68_S0.5480.87
92_A95_I0.5480.87
70_L75_W0.5470.87
5_P12_L0.5450.87
140_A143_V0.5390.87
114_S118_G0.5380.86
7_G11_I0.5330.86
11_I14_L0.5310.86
138_Y141_S0.5300.86
14_L18_I0.5290.86
94_F101_L0.5260.85
76_P79_D0.5260.85
21_F50_V0.5230.85
14_L17_A0.5200.85
44_F92_A0.5160.84
121_C128_V0.5160.84
101_L124_A0.5140.84
80_L89_L0.5090.83
13_Q17_A0.5090.83
57_L60_L0.5070.83
71_L75_W0.5050.83
59_L63_Y0.5030.83
22_G25_A0.5020.82
76_P80_L0.5000.82
49_A131_G0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p79A 1 0.7153 5.8 0.896 Contact Map
3x29A 1 0.4583 3.8 0.904 Contact Map
2ks1B 1 0.3056 2.2 0.915 Contact Map
4k5yA 1 0.6667 2 0.917 Contact Map
4o6yA 2 0.9444 1.8 0.919 Contact Map
2k1aA 1 0.2917 1.7 0.921 Contact Map
2kihA 3 0.1736 1.4 0.924 Contact Map
4qinA 2 0.9306 1.2 0.928 Contact Map
2ljbA 3 0.1736 1.1 0.929 Contact Map
2jwaA 2 0.3056 1.1 0.929 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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