GREMLIN Database
Cyto_heme_lyase - Cytochrome c/c1 heme lyase
PFAM: PF01265 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 292 (241)
Sequences: 509 (393)
Seq/√Len: 25.3
META: 0.108

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_R208_E3.3231.00
59_C63_H3.0801.00
124_P145_E2.9661.00
26_P32_H2.7820.99
105_R110_I2.7220.99
253_R280_D2.7070.99
101_L105_R2.7010.99
201_R251_E2.6230.99
286_K290_K2.6050.99
125_Q129_N2.5090.99
253_R278_A2.4930.99
158_A273_L2.3880.98
101_L110_I2.3230.98
25_P31_M2.2910.98
36_R39_W2.2120.97
241_D249_G2.1460.97
169_H287_D2.1360.97
36_R40_L2.0840.96
280_D284_A2.0790.96
105_R112_R2.0700.96
26_P31_M2.0650.96
39_W42_Q2.0460.96
215_I218_W2.0180.95
185_C243_C2.0050.95
105_R111_P1.9470.94
153_F271_F1.9470.94
101_L112_R1.8980.93
147_M154_L1.8890.93
34_K37_S1.8750.93
212_K230_E1.8710.93
209_L231_P1.8600.93
90_S93_P1.8520.93
139_T212_K1.8340.92
97_Q125_Q1.8240.92
217_S231_P1.8210.92
158_A258_Y1.7960.91
127_F150_I1.7550.90
58_A61_V1.6850.89
147_M158_A1.6830.88
58_A63_H1.6300.87
127_F157_G1.6260.87
44_S47_P1.5990.86
62_P65_A1.5920.85
265_P289_M1.5900.85
28_G32_H1.5750.85
161_E164_K1.5740.85
117_G198_K1.5550.84
261_G272_Y1.5550.84
113_G200_V1.5330.83
281_S284_A1.5210.83
25_P32_H1.4890.81
43_A53_A1.4870.81
106_E112_R1.4820.81
97_Q129_N1.4770.81
198_K241_D1.4640.80
101_L111_P1.4410.79
35_T38_A1.4390.79
48_A51_A1.4320.79
93_P100_P1.4300.79
85_M258_Y1.4190.78
135_G161_E1.4090.78
205_R253_R1.4030.77
59_C62_P1.4000.77
108_S111_P1.3980.77
243_C249_G1.3940.77
105_R108_S1.3930.77
43_A46_P1.3920.77
47_P50_P1.3870.76
35_T39_W1.3750.76
153_F262_P1.3690.75
83_N125_Q1.3670.75
205_R280_D1.3660.75
107_E118_N1.3650.75
104_E107_E1.3530.75
127_F143_D1.3500.74
46_P50_P1.3440.74
83_N97_Q1.3310.73
80_N83_N1.3210.73
106_E109_S1.2970.71
128_Y270_V1.2900.71
25_P33_H1.2730.70
120_E154_L1.2560.69
143_D241_D1.2440.68
196_G243_C1.2430.68
149_P258_Y1.2330.67
262_P271_F1.2120.66
28_G31_M1.2110.66
148_V206_P1.2040.65
168_L275_V1.1940.65
204_G212_K1.1920.65
209_L217_S1.1890.64
47_P52_A1.1830.64
154_L262_P1.1820.64
109_S118_N1.1640.63
263_P269_P1.1520.62
150_I239_I1.1370.61
118_N162_I1.1350.61
206_P253_R1.1250.60
158_A271_F1.1230.60
187_C243_C1.1230.60
44_S48_A1.1200.60
109_S215_I1.1170.60
47_P51_A1.1130.59
249_G252_V1.1040.59
27_S33_H1.1040.59
90_S94_A1.1010.58
139_T287_D1.0970.58
131_M144_M1.0970.58
201_R239_I1.0960.58
46_P54_S1.0910.58
106_E141_E1.0890.58
212_K274_D1.0810.57
37_S40_L1.0700.56
131_M162_I1.0700.56
49_P53_A1.0480.55
154_L258_Y1.0460.54
279_L289_M1.0430.54
27_S32_H1.0330.54
58_A239_I1.0160.52
85_M97_Q1.0160.52
249_G281_S1.0140.52
218_W221_Y1.0090.52
208_E280_D1.0060.52
89_L126_Q1.0050.51
161_E214_R1.0010.51
106_E162_I1.0000.51
101_L108_S0.9970.51
37_S42_Q0.9930.51
132_L184_E0.9920.51
263_P267_G0.9920.51
154_L271_F0.9910.50
139_T147_M0.9910.50
124_P147_M0.9880.50
107_E112_R0.9850.50
127_F144_M0.9850.50
146_S284_A0.9840.50
208_E253_R0.9810.50
35_T53_A0.9740.49
46_P49_P0.9730.49
206_P278_A0.9720.49
153_F261_G0.9700.49
187_C275_V0.9680.49
211_P279_L0.9630.48
108_S112_R0.9630.48
91_Q97_Q0.9560.48
206_P280_D0.9510.48
205_R282_P0.9390.47
91_Q94_A0.9390.47
279_L286_K0.9370.47
51_A54_S0.9330.46
37_S43_A0.9320.46
209_L214_R0.9320.46
264_E267_G0.9290.46
126_Q269_P0.9290.46
45_A48_A0.9260.46
126_Q140_P0.9190.45
80_N125_Q0.9190.45
150_I157_G0.9160.45
187_C196_G0.9120.45
18_S21_S0.8980.44
205_R278_A0.8910.43
140_P144_M0.8880.43
201_R280_D0.8800.42
136_W260_S0.8790.42
144_M241_D0.8730.42
163_L230_E0.8680.42
218_W275_V0.8580.41
136_W164_K0.8580.41
107_E198_K0.8550.41
16_P19_A0.8550.41
56_P61_V0.8550.41
35_T40_L0.8470.40
38_A41_S0.8440.40
164_K214_R0.8440.40
52_A56_P0.8430.40
31_M34_K0.8420.40
210_S255_V0.8420.40
187_C249_G0.8380.39
128_Y154_L0.8290.39
126_Q143_D0.8260.39
221_Y263_P0.8230.38
215_I221_Y0.8210.38
18_S22_S0.8210.38
256_I273_L0.8200.38
200_V251_E0.8140.38
35_T255_V0.8020.37
49_P52_A0.8010.37
147_M153_F0.7990.37
127_F136_W0.7910.36
160_Q163_L0.7900.36
144_M147_M0.7840.36
109_S126_Q0.7760.35
40_L43_A0.7680.35
213_A235_R0.7680.35
68_P71_A0.7680.35
101_L109_S0.7650.34
258_Y262_P0.7640.34
124_P148_V0.7630.34
59_C65_A0.7590.34
165_W275_V0.7580.34
28_G33_H0.7570.34
144_M153_F0.7560.34
41_S45_A0.7550.34
27_S31_M0.7510.34
278_A284_A0.7490.33
131_M143_D0.7430.33
113_G197_P0.7400.33
126_Q154_L0.7400.33
146_S150_I0.7400.33
164_K197_P0.7380.33
126_Q203_Q0.7370.33
109_S115_S0.7350.33
279_L284_A0.7310.32
50_P53_A0.7300.32
105_R109_S0.7220.32
276_R288_R0.7190.32
198_K219_L0.7180.31
221_Y243_C0.7140.31
203_Q239_I0.7120.31
48_A54_S0.7120.31
34_K38_A0.7110.31
136_W150_I0.7100.31
79_L201_R0.7080.31
21_S25_P0.7050.31
109_S240_V0.7050.31
75_T88_S0.7040.31
16_P20_S0.7040.31
57_S62_P0.7030.31
97_Q206_P0.7020.30
117_G217_S0.7010.30
83_N91_Q0.7000.30
136_W209_L0.6980.30
23_A53_A0.6970.30
89_L93_P0.6940.30
39_W43_A0.6940.30
147_M161_E0.6920.30
147_M270_V0.6910.30
20_S23_A0.6870.30
91_Q96_D0.6860.29
80_N85_M0.6840.29
162_I278_A0.6810.29
153_F269_P0.6810.29
69_A73_S0.6790.29
116_E255_V0.6760.29
168_L187_C0.6760.29
125_Q206_P0.6760.29
170_A185_C0.6760.29
158_A221_Y0.6720.29
74_S77_S0.6690.28
85_M253_R0.6640.28
127_F243_C0.6630.28
144_M154_L0.6590.28
101_L106_E0.6590.28
136_W231_P0.6580.28
117_G158_A0.6560.28
153_F158_A0.6560.28
208_E278_A0.6540.28
135_G138_D0.6490.27
153_F221_Y0.6470.27
25_P28_G0.6450.27
135_G210_S0.6410.27
115_S118_N0.6390.27
72_A75_T0.6350.26
154_L260_S0.6350.26
145_E196_G0.6330.26
164_K167_A0.6320.26
83_N86_P0.6300.26
150_I262_P0.6300.26
66_S69_A0.6300.26
115_S275_V0.6300.26
54_S57_S0.6270.26
162_I196_G0.6270.26
154_L216_R0.6270.26
23_A68_P0.6240.26
80_N97_Q0.6220.26
161_E261_G0.6200.26
20_S24_S0.6200.26
132_L240_V0.6180.26
215_I262_P0.6180.26
81_P258_Y0.6110.25
47_P54_S0.6100.25
158_A161_E0.6100.25
207_K241_D0.6100.25
19_A23_A0.6090.25
212_K270_V0.6060.25
251_E285_V0.6050.25
203_Q210_S0.6030.25
19_A22_S0.6030.25
89_L167_A0.5980.24
58_A240_V0.5980.24
120_E153_F0.5980.24
70_S73_S0.5960.24
201_R253_R0.5960.24
282_P286_K0.5960.24
52_A57_S0.5960.24
48_A53_A0.5950.24
141_E209_L0.5920.24
38_A75_T0.5900.24
139_T270_V0.5890.24
49_P55_P0.5870.24
73_S76_L0.5800.23
149_P284_A0.5800.23
243_C252_V0.5790.23
107_E201_R0.5780.23
124_P196_G0.5780.23
90_S260_S0.5770.23
131_M216_R0.5760.23
65_A68_P0.5760.23
126_Q241_D0.5730.23
35_T41_S0.5700.23
129_N206_P0.5680.23
77_S210_S0.5670.23
16_P52_A0.5660.23
21_S24_S0.5640.23
127_F146_S0.5640.23
83_N129_N0.5630.23
187_C279_L0.5610.23
20_S34_K0.5610.23
137_D143_D0.5610.23
143_D146_S0.5600.22
120_E147_M0.5580.22
137_D264_E0.5580.22
284_A287_D0.5540.22
186_G289_M0.5530.22
21_S66_S0.5530.22
185_C197_P0.5520.22
148_V271_F0.5460.22
102_P110_I0.5450.22
139_T144_M0.5450.22
80_N126_Q0.5450.22
214_R221_Y0.5450.22
16_P21_S0.5440.22
165_W273_L0.5430.22
120_E144_M0.5400.21
91_Q184_E0.5390.21
127_F148_V0.5380.21
54_S100_P0.5340.21
200_V241_D0.5320.21
116_E184_E0.5310.21
250_K283_E0.5280.21
38_A43_A0.5270.21
125_Q253_R0.5260.21
48_A69_A0.5240.21
31_M258_Y0.5240.21
185_C264_E0.5220.21
239_I282_P0.5200.20
53_A64_D0.5190.20
32_H36_R0.5190.20
34_K42_Q0.5190.20
143_D210_S0.5140.20
55_P61_V0.5140.20
240_V267_G0.5130.20
124_P270_V0.5130.20
127_F216_R0.5120.20
204_G208_E0.5110.20
23_A52_A0.5100.20
35_T70_S0.5090.20
127_F153_F0.5080.20
216_R272_Y0.5070.20
49_P65_A0.5040.20
69_A95_P0.5040.20
149_P154_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tr7A 1 0.2945 24.4 0.974 Contact Map
3fciA 1 0.3219 11.8 0.978 Contact Map
3gwlA 2 0.3219 10 0.978 Contact Map
3uf7A 1 0.2979 8.8 0.979 Contact Map
3u5sA 2 0.2842 7.1 0.98 Contact Map
2hj3A 4 0.3048 6.6 0.98 Contact Map
3zoqA 1 0.3185 5.6 0.981 Contact Map
3wdfA 1 0.3048 5.3 0.981 Contact Map
3drxA 3 0.2945 5 0.981 Contact Map
1tw0A 2 0.4452 4.4 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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