GREMLIN Database
T2SSN - Type II secretion system (T2SS), protein N
PFAM: PF01203 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 211 (198)
Sequences: 4693 (3860)
Seq/√Len: 274.3
META: 0.851

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
123_W126_A5.9611.00
78_L81_L3.6161.00
83_A102_L3.4081.00
34_L46_A2.8731.00
114_C146_G2.5281.00
9_S16_S2.4281.00
82_R103_D2.2581.00
153_L168_G2.1651.00
105_D118_D2.1271.00
125_D128_V2.0841.00
203_D207_R2.0771.00
5_L17_A2.0081.00
157_T185_R2.0011.00
104_L107_L1.9611.00
194_N197_N1.9351.00
140_Y157_T1.8841.00
157_T160_G1.8481.00
166_G178_F1.8411.00
38_S41_T1.8341.00
120_R143_T1.8281.00
87_A123_W1.8201.00
16_S31_S1.8161.00
141_R158_L1.7821.00
33_R36_P1.7701.00
122_E141_R1.7381.00
145_S154_T1.7331.00
108_R116_A1.7211.00
104_L119_G1.7061.00
75_G108_R1.6891.00
16_S29_R1.6511.00
120_R141_R1.6341.00
166_G180_G1.5951.00
142_L153_L1.5821.00
165_S181_T1.5661.00
84_R99_Q1.5581.00
154_T167_T1.5551.00
47_D64_R1.5421.00
18_L21_T1.5341.00
84_R101_R1.5261.00
15_G32_W1.4981.00
150_A169_T1.4891.00
38_S45_A1.4661.00
157_T161_P1.4631.00
8_V17_A1.4531.00
87_A100_L1.4461.00
106_S116_A1.4431.00
38_S44_L1.4421.00
144_L153_L1.4371.00
7_G18_L1.4351.00
147_D152_T1.4331.00
101_R124_R1.4111.00
123_W128_V1.4031.00
30_L50_L1.3971.00
101_R122_E1.3921.00
163_Q183_R1.3881.00
3_V22_V1.3641.00
106_S118_D1.3551.00
201_R208_Y1.3471.00
155_L164_L1.3391.00
31_S49_E1.3281.00
79_S106_S1.3091.00
50_L61_G1.3001.00
142_L155_L1.3001.00
124_R139_S1.2761.00
171_S177_R1.2691.00
171_S175_R1.2661.00
20_L26_P1.2581.00
13_W46_A1.2381.00
35_S45_A1.2361.00
17_A32_W1.2091.00
38_S43_R1.2051.00
17_A20_L1.1901.00
119_G125_D1.1811.00
14_S33_R1.1781.00
70_R73_G1.1711.00
141_R156_S1.1661.00
35_S47_D1.1641.00
163_Q185_R1.1581.00
35_S38_S1.1521.00
36_P40_L1.1421.00
6_A19_G1.1371.00
28_G50_L1.1331.00
107_L117_A1.1311.00
97_G127_A1.1301.00
186_P189_P1.1241.00
181_T207_R1.1241.00
102_L121_L1.1171.00
123_W127_A1.1121.00
5_L8_V1.1091.00
4_R21_T1.1081.00
139_S159_G1.1081.00
200_G208_Y1.1061.00
39_L42_G1.0991.00
22_V25_S1.0941.00
154_T165_S1.0841.00
66_G77_T1.0761.00
86_P89_L1.0721.00
85_L89_L1.0701.00
81_L104_L1.0691.00
63_G66_G1.0671.00
142_L146_G1.0661.00
71_G74_G1.0621.00
117_A121_L1.0621.00
63_G81_L1.0591.00
110_E115_V1.0581.00
119_G123_W1.0551.00
66_G70_R1.0531.00
85_L100_L1.0411.00
87_A126_A1.0401.00
184_A188_A1.0381.00
145_S152_T1.0341.00
18_L22_V1.0171.00
19_G26_P1.0151.00
131_L134_L1.0131.00
32_W98_G1.0051.00
202_P206_G0.9971.00
103_D120_R0.9961.00
38_S42_G0.9921.00
161_P185_R0.9811.00
127_A136_P0.9761.00
77_T108_R0.9681.00
203_D206_G0.9641.00
45_A66_G0.9601.00
35_S46_A0.9501.00
202_P208_Y0.9481.00
143_T156_S0.9481.00
34_L44_L0.9421.00
95_Q130_R0.9401.00
140_Y161_P0.9381.00
139_S158_L0.9341.00
202_P207_R0.9261.00
42_G48_L0.9251.00
77_T106_S0.9241.00
170_L176_Y0.9211.00
146_G151_L0.9201.00
170_L174_G0.9181.00
37_L41_T0.9171.00
183_R207_R0.9141.00
98_G138_G0.9141.00
9_S18_L0.9021.00
88_A97_G0.8911.00
202_P205_D0.8831.00
162_L192_L0.8791.00
188_A191_A0.8751.00
109_L114_C0.8731.00
21_T24_G0.8711.00
140_Y158_L0.8701.00
190_A193_A0.8571.00
63_G78_L0.8571.00
195_L198_L0.8541.00
22_V26_P0.8411.00
35_S41_T0.8381.00
109_L112_G0.8341.00
76_L109_L0.8110.99
124_R141_R0.8100.99
41_T45_A0.8090.99
168_G178_F0.8080.99
46_A50_L0.8000.99
33_R37_L0.7940.99
152_T169_T0.7930.99
124_R158_L0.7920.99
192_L199_L0.7920.99
184_A200_G0.7840.99
181_T206_G0.7840.99
201_R204_G0.7770.99
197_N202_P0.7760.99
37_L45_A0.7680.99
37_L40_L0.7670.99
153_L157_T0.7590.99
185_R188_A0.7530.99
36_P39_L0.7490.99
181_T203_D0.7480.99
170_L175_R0.7460.99
204_G208_Y0.7450.99
78_L101_R0.7430.99
42_G45_A0.7400.99
10_G15_G0.7310.99
203_D208_Y0.7300.99
122_E139_S0.7290.99
130_R133_G0.7200.99
188_A193_A0.7200.99
152_T167_T0.7180.99
155_L180_G0.7170.99
93_P96_L0.7160.99
98_G123_W0.7150.99
80_D105_D0.7150.99
195_L199_L0.7130.98
155_L166_G0.7010.98
197_N208_Y0.6980.98
86_P98_G0.6900.98
129_S133_G0.6880.98
39_L43_R0.6860.98
96_L128_V0.6860.98
46_A49_E0.6850.98
132_S136_P0.6840.98
198_L205_D0.6820.98
104_L176_Y0.6820.98
190_A194_N0.6820.98
46_A65_L0.6800.98
108_R115_V0.6790.98
3_V20_L0.6740.98
129_S132_S0.6700.98
142_L166_G0.6700.98
104_L117_A0.6690.98
137_L162_L0.6680.98
78_L82_R0.6650.98
119_G144_L0.6640.98
46_A52_G0.6630.98
186_P193_A0.6620.98
140_Y160_G0.6530.97
194_N201_R0.6520.97
29_R51_G0.6510.97
182_A208_Y0.6490.97
157_T178_F0.6480.97
70_R76_L0.6470.97
201_R206_G0.6450.97
138_G166_G0.6450.97
28_G52_G0.6410.97
118_D143_T0.6400.97
70_R74_G0.6370.97
14_S36_P0.6320.97
19_G22_V0.6320.97
10_G13_W0.6290.97
64_R71_G0.6240.97
65_L70_R0.6240.97
110_E113_G0.6200.96
177_R180_G0.6200.96
19_G28_G0.6080.96
188_A192_L0.5970.96
21_T26_P0.5970.96
181_T205_D0.5940.95
136_P161_P0.5900.95
63_G73_G0.5830.95
153_L159_G0.5820.95
161_P187_G0.5820.95
99_Q125_D0.5820.95
37_L66_G0.5790.95
7_G29_R0.5790.95
64_R70_R0.5790.95
23_G26_P0.5780.95
161_P188_A0.5770.95
29_R50_L0.5760.95
133_G138_G0.5740.94
50_L53_P0.5680.94
146_G157_T0.5640.94
191_A195_L0.5640.94
6_A156_S0.5630.94
137_L194_N0.5630.94
45_A77_T0.5610.94
204_G207_R0.5590.94
189_P203_D0.5570.94
157_T164_L0.5570.94
65_L71_G0.5560.93
3_V93_P0.5550.93
46_A78_L0.5510.93
66_G79_S0.5480.93
118_D145_S0.5480.93
18_L24_G0.5470.93
16_S66_G0.5450.93
156_S165_S0.5450.93
27_L92_N0.5410.93
185_R189_P0.5400.92
114_C151_L0.5390.92
171_S176_Y0.5380.92
77_T81_L0.5380.92
14_S49_E0.5330.92
53_P100_L0.5320.92
193_A203_D0.5310.92
66_G71_G0.5290.92
134_L166_G0.5280.92
39_L48_L0.5270.92
80_D106_S0.5270.92
189_P198_L0.5260.92
114_C160_G0.5250.91
176_Y180_G0.5250.91
136_P139_S0.5230.91
162_L195_L0.5200.91
78_L107_L0.5170.91
99_Q127_A0.5170.91
103_D122_E0.5160.91
195_L200_G0.5150.91
5_L32_W0.5150.91
83_A103_D0.5120.90
12_V109_L0.5110.90
105_D149_G0.5100.90
182_A188_A0.5100.90
43_R66_G0.5100.90
184_A199_L0.5090.90
48_L63_G0.5080.90
178_F182_A0.5080.90
131_L164_L0.5060.90
173_D193_A0.5050.90
155_L178_F0.5050.90
100_L129_S0.5050.90
125_D139_S0.5010.89
5_L20_L0.5010.89
114_C157_T0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xmxA 1 0.782 10.3 0.934 Contact Map
4dzgA 1 0.436 7.5 0.938 Contact Map
3butA 2 0.455 5.2 0.942 Contact Map
3szeA 1 0.91 4 0.946 Contact Map
4c1wA 1 0.3223 3.7 0.946 Contact Map
2krhA 1 0.1706 3.7 0.946 Contact Map
2jvfA 1 0.3555 3.4 0.947 Contact Map
3zf7M 1 0.4408 3.3 0.948 Contact Map
5a1uH 1 0 2.9 0.95 Contact Map
4aw7A 1 0.3223 2.7 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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