GREMLIN Database
Grp1_Fun34_YaaH - GPR1/FUN34/yaaH family
PFAM: PF01184 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 207 (178)
Sequences: 8000 (4561)
Seq/√Len: 341.9
META: 0.788

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_A185_A3.2091.00
129_L150_T3.0281.00
144_L181_L2.9931.00
159_G168_T2.9471.00
132_F147_L2.7281.00
130_Y187_A2.6961.00
67_G83_T2.6051.00
160_D168_T2.5921.00
155_L174_E2.4991.00
127_F131_M2.4111.00
125_G154_F2.2721.00
166_G170_I2.2431.00
125_G157_A2.0981.00
118_G161_F2.0921.00
57_F90_L2.0891.00
122_L157_A2.0581.00
26_A186_A2.0351.00
85_Y128_T2.0261.00
130_Y186_A2.0221.00
91_S120_Y2.0101.00
37_L42_L2.0001.00
132_F143_Q1.9831.00
148_L181_L1.9541.00
40_A173_Y1.8461.00
62_A87_A1.8441.00
58_Y84_S1.8331.00
69_W79_A1.8191.00
65_I68_M1.7851.00
34_L54_M1.7641.00
148_L177_I1.7371.00
136_L143_Q1.7281.00
36_S175_G1.7191.00
68_M83_T1.7071.00
70_E75_N1.6171.00
151_I174_E1.5941.00
122_L161_F1.5931.00
144_L177_I1.5771.00
132_F150_T1.5371.00
37_L119_L1.5251.00
70_E78_G1.5241.00
30_L123_A1.5201.00
155_L167_L1.4981.00
140_R143_Q1.4461.00
155_L170_I1.4411.00
129_L154_F1.4311.00
154_F158_I1.4031.00
134_A191_L1.4011.00
150_T154_F1.3761.00
151_I155_L1.3391.00
93_A97_L1.3301.00
165_A169_K1.3271.00
158_I167_L1.3121.00
71_F79_A1.3101.00
33_F183_W1.3071.00
24_G66_A1.2721.00
99_K102_I1.2641.00
64_L87_A1.2511.00
145_V181_L1.2491.00
30_L183_W1.2461.00
152_T175_G1.2451.00
129_L133_I1.2311.00
114_G160_D1.2271.00
57_F94_L1.2091.00
132_F136_L1.2031.00
17_I71_F1.1861.00
148_L178_T1.1731.00
157_A161_F1.1721.00
101_G104_A1.1711.00
81_A146_F1.1691.00
144_L148_L1.1531.00
118_G122_L1.1441.00
132_F135_T1.1431.00
19_N73_K1.1351.00
185_A189_G1.1301.00
187_A191_L1.1281.00
103_A106_Y1.1221.00
84_S124_W1.1101.00
164_S167_L1.1071.00
84_S127_F1.0751.00
18_A76_T1.0641.00
99_K103_A1.0421.00
102_I106_Y1.0421.00
145_V185_A1.0331.00
131_M190_V1.0301.00
156_L171_G1.0231.00
33_F123_A1.0221.00
143_Q147_L1.0121.00
81_A131_M1.0091.00
129_L132_F0.9981.00
169_K173_Y0.9981.00
125_G150_T0.9951.00
17_I73_K0.9871.00
64_L83_T0.9821.00
33_F179_A0.9791.00
158_I162_T0.9721.00
54_M91_S0.9631.00
40_A176_I0.9591.00
135_T143_Q0.9571.00
64_L90_L0.9481.00
36_S152_T0.9451.00
92_L117_L0.9401.00
22_P189_G0.9341.00
170_I174_E0.9301.00
79_A83_T0.9271.00
75_N78_G0.9221.00
95_L117_L0.9111.00
128_T149_L0.9001.00
142_L185_A0.9001.00
138_T142_L0.8981.00
147_L150_T0.8971.00
23_L83_T0.8941.00
149_L178_T0.8891.00
128_T150_T0.8881.00
135_T138_T0.8791.00
139_N142_L0.8611.00
173_Y177_I0.8591.00
36_S39_N0.8561.00
101_G106_Y0.8481.00
99_K104_A0.8331.00
159_G171_G0.8321.00
98_P102_I0.8231.00
50_V116_A0.8181.00
83_T87_A0.8171.00
177_I181_L0.8171.00
117_L160_D0.8161.00
166_G169_K0.8151.00
52_L96_L0.8141.00
147_L151_I0.8141.00
148_L174_E0.8141.00
16_K74_G0.8121.00
39_N156_L0.8101.00
40_A172_G0.8071.00
29_A179_A0.8001.00
65_I69_W0.7961.00
17_I69_W0.7961.00
26_A187_A0.7961.00
29_A182_A0.7951.00
29_A33_F0.7841.00
119_L161_F0.7841.00
61_L90_L0.7801.00
170_I173_Y0.7741.00
126_I180_L0.7741.00
27_G62_A0.7721.00
37_L43_F0.7671.00
135_T146_F0.7641.00
26_A183_W0.7621.00
32_T63_Q0.7611.00
121_L159_G0.7571.00
60_G90_L0.7521.00
141_A188_A0.7481.00
17_I72_K0.7441.00
174_E177_I0.7431.00
29_A183_W0.7410.99
54_M120_Y0.7390.99
62_A83_T0.7370.99
31_T59_G0.7360.99
165_A168_T0.7320.99
35_L121_L0.7290.99
15_D73_K0.7290.99
19_N189_G0.7280.99
15_D72_K0.7260.99
122_L154_F0.7230.99
38_H48_P0.7230.99
98_P101_G0.7180.99
125_G129_L0.7140.99
16_K73_K0.7140.99
38_H47_S0.7130.99
43_F47_S0.7090.99
21_A70_E0.7090.99
61_L65_I0.7080.99
152_T174_E0.7040.99
92_L96_L0.6990.99
98_P104_A0.6980.99
159_G167_L0.6960.99
67_G86_G0.6940.99
52_L93_A0.6920.99
41_G169_K0.6870.99
38_H43_F0.6840.99
37_L176_I0.6840.99
152_T178_T0.6830.99
188_A192_N0.6820.99
64_L86_G0.6800.99
138_T194_T0.6800.99
119_L122_L0.6800.99
176_I180_L0.6780.99
80_T131_M0.6780.99
101_G105_A0.6670.99
120_Y124_W0.6670.99
162_T165_A0.6630.99
53_G94_L0.6630.99
85_Y153_F0.6610.99
179_A183_W0.6520.99
21_A82_F0.6450.99
116_A119_L0.6430.99
60_G86_G0.6430.99
76_T193_E0.6400.99
100_F104_A0.6400.99
141_A181_L0.6390.99
33_F180_L0.6390.99
122_L126_I0.6380.98
94_L98_P0.6340.98
28_F85_Y0.6300.98
110_P113_A0.6300.98
22_P76_T0.6300.98
114_G163_G0.6290.98
142_L145_V0.6280.98
56_L93_A0.6250.98
18_A79_A0.6200.98
99_K106_Y0.6190.98
100_F103_A0.6180.98
114_G117_L0.6140.98
34_L123_A0.6060.98
36_S55_A0.6040.98
42_L173_Y0.6020.98
134_A187_A0.5970.98
113_A117_L0.5960.98
100_F106_Y0.5950.98
180_L183_W0.5940.98
43_F46_G0.5930.98
178_T181_L0.5830.97
141_A145_V0.5790.97
99_K105_A0.5770.97
167_L170_I0.5770.97
57_F61_L0.5760.97
86_G90_L0.5710.97
98_P106_Y0.5660.97
98_P103_A0.5660.97
55_A93_A0.5650.97
112_D115_T0.5630.97
97_L102_I0.5610.97
93_A98_P0.5590.97
53_G95_L0.5570.96
184_Y188_A0.5560.96
174_E178_T0.5550.96
30_L127_F0.5540.96
34_L51_V0.5540.96
139_N143_Q0.5530.96
57_F93_A0.5470.96
17_I74_G0.5460.96
56_L97_L0.5450.96
91_S95_L0.5440.96
43_F116_A0.5420.96
88_F153_F0.5410.96
121_L171_G0.5410.96
160_D163_G0.5400.96
23_L71_F0.5380.96
134_A194_T0.5340.96
37_L40_A0.5300.95
118_G157_A0.5290.95
84_S87_A0.5290.95
139_N185_A0.5290.95
44_G115_T0.5260.95
140_R144_L0.5250.95
81_A145_V0.5230.95
150_T157_A0.5210.95
111_A115_T0.5200.95
42_L176_I0.5200.95
45_L48_P0.5190.95
138_T189_G0.5170.95
40_A169_K0.5170.95
55_A59_G0.5110.94
123_A179_A0.5100.94
25_L81_A0.5090.94
115_T118_G0.5030.94
155_L171_G0.5010.94
128_T153_F0.5000.94
19_N76_T0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ux4A 3 0.7729 51.7 0.917 Contact Map
4ogqG 1 0.1787 4.4 0.951 Contact Map
1q90G 1 0.1449 2.8 0.955 Contact Map
4cbkA 3 0.1739 1.6 0.961 Contact Map
1wu0A 1 0.1787 1.3 0.963 Contact Map
4f4sA 3 0.1787 1.3 0.963 Contact Map
4wfeA 2 0.2271 1 0.966 Contact Map
4lxjA 1 0.2754 1 0.966 Contact Map
4bu0A 1 0.285 1 0.966 Contact Map
3wu2Y 1 0.1353 0.9 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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