GREMLIN Database
ELO - GNS1/SUR4 family
PFAM: PF01151 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 250 (238)
Sequences: 3201 (2302)
Seq/√Len: 149.2
META: 0.246

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_C210_C4.3071.00
236_N240_K4.1581.00
51_A157_V3.6971.00
124_Y229_S3.4481.00
54_F154_F3.4121.00
155_V184_L3.2821.00
40_I164_F3.1741.00
105_L130_L2.8621.00
44_L164_F2.8541.00
47_V161_S2.7581.00
186_I235_I2.7471.00
27_M115_K2.7261.00
111_F118_L2.7151.00
120_F124_Y2.6241.00
19_F109_V2.4841.00
186_I231_L2.4021.00
25_K28_K2.3401.00
27_M30_R2.1461.00
165_L170_I2.1341.00
154_F158_I2.0581.00
38_L110_F2.0561.00
226_Y230_Y2.0411.00
50_S104_E2.0371.00
49_F100_S2.0291.00
190_V231_L2.0141.00
109_V113_L2.0121.00
154_F184_L1.9501.00
40_I167_A1.9421.00
17_L127_A1.9241.00
232_V236_N1.9151.00
46_L104_E1.8951.00
158_I184_L1.8671.00
19_F23_G1.8421.00
42_Y46_L1.7881.00
39_L110_F1.7821.00
40_I168_L1.7761.00
183_T238_Y1.7601.00
51_A55_Y1.7511.00
23_G112_V1.7411.00
178_K241_T1.7101.00
231_L235_I1.6931.00
45_F103_L1.6621.00
105_L109_V1.6301.00
39_L114_R1.6181.00
95_W99_L1.6101.00
53_M153_S1.6041.00
128_T230_Y1.5731.00
176_W180_Y1.5531.00
27_M33_F1.5201.00
58_L150_L1.4511.00
94_Y97_F1.4361.00
15_L19_F1.4251.00
35_L38_L1.4221.00
13_I131_L1.4121.00
239_I243_L1.4091.00
18_L22_L1.3821.00
92_F96_L1.3711.00
144_G148_I1.3591.00
26_L30_R1.3571.00
97_F100_S1.3501.00
177_W181_I1.3491.00
12_I105_L1.3271.00
235_I239_I1.3101.00
228_L232_V1.2981.00
170_I173_Y1.2891.00
106_L110_F1.2651.00
99_L103_L1.2641.00
142_G145_S1.2551.00
102_F106_L1.2441.00
24_P28_K1.2391.00
56_E93_W1.2331.00
159_M182_T1.2191.00
88_G91_G1.2181.00
13_I127_A1.2181.00
98_Y102_F1.2151.00
49_F53_M1.2051.00
84_A87_N1.2041.00
179_K238_Y1.1911.00
23_G27_M1.1841.00
152_N156_H1.1821.00
192_G227_Y1.1661.00
145_S148_I1.1661.00
156_H159_M1.1571.00
125_H156_H1.1531.00
226_Y229_S1.1531.00
42_Y103_L1.1521.00
125_H152_N1.1521.00
22_L26_L1.1471.00
102_F130_L1.1441.00
158_I181_I1.1401.00
198_Y202_Y1.1361.00
164_F168_L1.1280.99
12_I102_F1.1140.99
35_L113_L1.1130.99
88_G92_F1.0990.99
21_F25_K1.0870.99
32_P115_K1.0850.99
53_M100_S1.0730.99
82_P86_R1.0720.99
87_N90_L1.0710.99
156_H182_T1.0670.99
47_V164_F1.0600.99
238_Y243_L1.0580.99
79_S84_A1.0540.99
91_G137_L1.0530.99
13_I130_L1.0500.99
98_Y133_C1.0480.99
174_P177_W1.0370.99
5_S8_P1.0280.99
174_P180_Y1.0230.99
70_F73_L1.0210.99
47_V104_E1.0190.99
89_R93_W1.0170.99
227_Y230_Y1.0050.99
26_L33_F1.0040.99
79_S82_P1.0030.99
82_P87_N0.9950.99
33_F113_L0.9940.99
169_G172_K0.9800.99
41_L45_F0.9760.99
156_H185_Q0.9700.98
112_V118_L0.9670.98
30_R115_K0.9660.98
56_E89_R0.9610.98
126_H156_H0.9570.98
152_N182_T0.9570.98
10_L14_A0.9560.98
151_L192_G0.9490.98
13_I105_L0.9470.98
132_L226_Y0.9430.98
27_M32_P0.9410.98
52_Y93_W0.9340.98
196_S227_Y0.9320.98
30_R33_F0.9270.98
54_F157_V0.9240.98
36_K40_I0.9190.98
169_G173_Y0.9130.98
182_T188_Q0.9110.98
111_F116_K0.9090.98
218_G222_L0.9010.97
147_F191_I0.8980.97
225_L229_S0.8930.97
237_F242_Y0.8910.97
120_F233_L0.8910.97
239_I244_K0.8880.97
182_T185_Q0.8850.97
152_N188_Q0.8820.97
11_T15_L0.8820.97
235_I243_L0.8790.97
37_G40_I0.8720.97
46_L103_L0.8700.97
154_F157_V0.8670.97
129_V230_Y0.8590.97
111_F117_Q0.8580.97
14_A22_L0.8580.97
145_S149_A0.8560.97
128_T229_S0.8560.97
39_L167_A0.8540.97
40_I44_L0.8470.96
181_I184_L0.8370.96
35_L39_L0.8370.96
124_Y226_Y0.8370.96
156_H188_Q0.8360.96
7_W11_T0.8360.96
82_P85_L0.8350.96
27_M34_K0.8300.96
178_K189_F0.8240.96
49_F96_L0.8230.96
132_L223_G0.8230.96
223_G226_Y0.8230.96
179_K189_F0.8180.96
90_L94_Y0.8150.95
119_S163_Y0.8060.95
8_P12_I0.8010.95
54_F153_S0.7950.95
46_L100_S0.7920.95
166_S178_K0.7920.95
180_Y183_T0.7910.95
119_S123_V0.7890.95
144_G147_F0.7790.94
177_W180_Y0.7780.94
50_S100_S0.7770.94
163_Y182_T0.7730.94
152_N159_M0.7720.94
238_Y242_Y0.7700.94
44_L161_S0.7680.94
6_P10_L0.7670.94
29_N115_K0.7660.94
161_S165_L0.7650.94
193_L224_L0.7610.94
156_H234_F0.7580.93
128_T226_Y0.7580.93
129_V149_A0.7580.93
100_S226_Y0.7530.93
20_V24_P0.7520.93
57_T150_L0.7500.93
152_N160_Y0.7480.93
34_K115_K0.7460.93
147_F151_L0.7460.93
45_F48_L0.7460.93
37_G168_L0.7460.93
186_I190_V0.7380.92
82_P88_G0.7340.92
126_H152_N0.7330.92
161_S164_F0.7270.92
133_C148_I0.7250.92
179_K183_T0.7230.92
244_K248_K0.7220.92
155_V181_I0.7200.91
132_L219_A0.7180.91
37_G41_L0.7130.91
31_K34_K0.7130.91
34_K114_R0.7110.91
83_G88_G0.7100.91
223_G230_Y0.7050.91
128_T222_L0.7050.91
9_V13_I0.7010.90
129_V226_Y0.6960.90
93_W100_S0.6900.90
229_S232_V0.6870.89
68_H72_S0.6860.89
86_R89_R0.6840.89
43_N162_Y0.6840.89
96_L99_L0.6810.89
240_K244_K0.6800.89
185_Q188_Q0.6780.89
151_L191_I0.6720.88
69_G72_S0.6690.88
129_V227_Y0.6680.88
19_F112_V0.6670.88
18_L21_F0.6670.88
95_W98_Y0.6660.88
191_I202_Y0.6660.88
73_L146_W0.6640.88
114_R117_Q0.6630.88
221_Y225_L0.6600.88
87_N91_G0.6590.87
63_G66_T0.6560.87
106_L109_V0.6560.87
21_F24_P0.6550.87
156_H160_Y0.6540.87
33_F115_K0.6540.87
46_L50_S0.6530.87
22_L25_K0.6510.87
42_Y47_V0.6500.87
24_P119_S0.6480.87
171_R175_L0.6440.86
136_G227_Y0.6430.86
34_K38_L0.6420.86
31_K115_K0.6420.86
128_T132_L0.6370.86
133_C149_A0.6350.85
165_L168_L0.6320.85
189_F230_Y0.6310.85
144_G149_A0.6310.85
81_D84_A0.6310.85
80_D85_L0.6290.85
175_L179_K0.6290.85
196_S200_L0.6290.85
160_Y182_T0.6280.85
57_T148_I0.6280.85
171_R174_P0.6260.85
91_G94_Y0.6250.85
92_F95_W0.6240.84
196_S199_A0.6180.84
159_M188_Q0.6170.84
173_Y177_W0.6170.84
159_M185_Q0.6170.84
166_S177_W0.6170.84
135_L219_A0.6160.84
125_H188_Q0.6160.84
121_L126_H0.6130.83
14_A18_L0.6100.83
182_T234_F0.6100.83
107_D126_H0.6090.83
125_H160_Y0.6090.83
121_L159_M0.6090.83
148_I192_G0.6090.83
70_F74_I0.6090.83
120_F229_S0.6080.83
169_G174_P0.6080.83
98_Y189_F0.6070.83
135_L223_G0.6060.83
152_N185_Q0.6050.83
147_F192_G0.6040.83
121_L234_F0.6010.82
164_F167_A0.6010.82
197_Y224_L0.6000.82
125_H159_M0.5980.82
160_Y185_Q0.5960.82
175_L178_K0.5950.82
232_V235_I0.5950.82
116_K166_S0.5930.81
85_L94_Y0.5910.81
39_L42_Y0.5870.81
36_K169_G0.5830.80
201_Y205_A0.5820.80
112_V115_K0.5820.80
57_T149_A0.5790.80
32_P116_K0.5780.80
65_L73_L0.5780.80
81_D85_L0.5770.80
223_G227_Y0.5730.79
155_V182_T0.5720.79
129_V223_G0.5720.79
108_T122_H0.5680.79
51_A161_S0.5660.78
126_H159_M0.5660.78
42_Y178_K0.5630.78
197_Y201_Y0.5620.78
100_S133_C0.5610.78
205_A208_G0.5600.78
13_I17_L0.5590.77
46_L192_G0.5590.77
122_H163_Y0.5590.77
79_S86_R0.5580.77
114_R166_S0.5570.77
38_L106_L0.5570.77
142_G149_A0.5570.77
160_Y188_Q0.5530.77
196_S223_G0.5530.77
193_L227_Y0.5520.77
146_W150_L0.5490.76
236_N239_I0.5460.76
189_F227_Y0.5440.76
193_L228_L0.5410.75
85_L88_G0.5380.75
121_L182_T0.5380.75
62_L66_T0.5380.75
49_F103_L0.5380.75
27_M113_L0.5360.75
142_G146_W0.5330.74
115_K118_L0.5330.74
20_V109_V0.5310.74
42_Y189_F0.5310.74
35_L114_R0.5310.74
136_G148_I0.5290.74
87_N94_Y0.5270.73
159_M163_Y0.5260.73
229_S233_L0.5240.73
51_A54_F0.5230.73
50_S53_M0.5230.73
50_S107_D0.5200.72
87_N92_F0.5200.72
12_I19_F0.5190.72
237_F241_T0.5150.72
122_H128_T0.5130.71
86_R90_L0.5130.71
152_N234_F0.5120.71
121_L125_H0.5080.71
132_L230_Y0.5070.70
97_F133_C0.5060.70
46_L164_F0.5050.70
42_Y123_V0.5040.70
224_L228_L0.5010.70
44_L104_E0.5010.70
71_Y198_Y0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ks1B 1 0.16 9.4 0.959 Contact Map
2losA 1 0.232 6.1 0.962 Contact Map
2lomA 1 0.284 4.2 0.965 Contact Map
2rddB 1 0.116 3.4 0.967 Contact Map
2jwaA 2 0.156 2.6 0.969 Contact Map
3j9pD 4 0.744 2.3 0.97 Contact Map
4qndA 2 0.356 2.2 0.97 Contact Map
4hkcB 1 0.032 2.1 0.97 Contact Map
2lonA 1 0.304 2 0.97 Contact Map
2wwbC 1 0.128 2 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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