ELO - PFAM28P - GREMLIN Contacts

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ELO - GNS1/SUR4 family

PFAM:	PF01151	Sequences: WLMSSPWPVLTIIALYLLFVFLGPKLMKNRKPFKLKGLLILYNLFLVLFSAYMFYETLPELLGWLTNHGFYSLICQDYSDDPGALRNGRLGFWYWLFYLSKFLELLDTVFFVLRKKQLSFLHVYHHATVLLLCWLGLKYVPGGGSWFIALLNSFVHVIMYSYYFLSALGIRKYPLWWKKYITTLQIVQFVIGLVHSYYALYYYFAGTGDCDGSNYPKGAAYLGLLYYLSYLVLFINFYIKTYLKKKKKKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	250 (238)
Sequences:	3201 (2302)
Seq/√Len:	149.2
META:	0.246

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
75_C	210_C	4.307	1.00
236_N	240_K	4.158	1.00
51_A	157_V	3.697	1.00
124_Y	229_S	3.448	1.00
54_F	154_F	3.412	1.00
155_V	184_L	3.282	1.00
40_I	164_F	3.174	1.00
105_L	130_L	2.862	1.00
44_L	164_F	2.854	1.00
47_V	161_S	2.758	1.00
186_I	235_I	2.747	1.00
27_M	115_K	2.726	1.00
111_F	118_L	2.715	1.00
120_F	124_Y	2.624	1.00
19_F	109_V	2.484	1.00
186_I	231_L	2.402	1.00
25_K	28_K	2.340	1.00
27_M	30_R	2.146	1.00
165_L	170_I	2.134	1.00
154_F	158_I	2.058	1.00
38_L	110_F	2.056	1.00
226_Y	230_Y	2.041	1.00
50_S	104_E	2.037	1.00
49_F	100_S	2.029	1.00
190_V	231_L	2.014	1.00
109_V	113_L	2.012	1.00
154_F	184_L	1.950	1.00
40_I	167_A	1.942	1.00
17_L	127_A	1.924	1.00
232_V	236_N	1.915	1.00
46_L	104_E	1.895	1.00
158_I	184_L	1.867	1.00
19_F	23_G	1.842	1.00
42_Y	46_L	1.788	1.00
39_L	110_F	1.782	1.00
40_I	168_L	1.776	1.00
183_T	238_Y	1.760	1.00
51_A	55_Y	1.751	1.00
23_G	112_V	1.741	1.00
178_K	241_T	1.710	1.00
231_L	235_I	1.693	1.00
45_F	103_L	1.662	1.00
105_L	109_V	1.630	1.00
39_L	114_R	1.618	1.00
95_W	99_L	1.610	1.00
53_M	153_S	1.604	1.00
128_T	230_Y	1.573	1.00
176_W	180_Y	1.553	1.00
27_M	33_F	1.520	1.00
58_L	150_L	1.451	1.00
94_Y	97_F	1.436	1.00
15_L	19_F	1.425	1.00
35_L	38_L	1.422	1.00
13_I	131_L	1.412	1.00
239_I	243_L	1.409	1.00
18_L	22_L	1.382	1.00
92_F	96_L	1.371	1.00
144_G	148_I	1.359	1.00
26_L	30_R	1.357	1.00
97_F	100_S	1.350	1.00
177_W	181_I	1.349	1.00
12_I	105_L	1.327	1.00
235_I	239_I	1.310	1.00
228_L	232_V	1.298	1.00
170_I	173_Y	1.289	1.00
106_L	110_F	1.265	1.00
99_L	103_L	1.264	1.00
142_G	145_S	1.255	1.00
102_F	106_L	1.244	1.00
24_P	28_K	1.239	1.00
56_E	93_W	1.233	1.00
159_M	182_T	1.219	1.00
88_G	91_G	1.218	1.00
13_I	127_A	1.218	1.00
98_Y	102_F	1.215	1.00
49_F	53_M	1.205	1.00
84_A	87_N	1.204	1.00
179_K	238_Y	1.191	1.00
23_G	27_M	1.184	1.00
152_N	156_H	1.182	1.00
192_G	227_Y	1.166	1.00
145_S	148_I	1.166	1.00
156_H	159_M	1.157	1.00
125_H	156_H	1.153	1.00
226_Y	229_S	1.153	1.00
42_Y	103_L	1.152	1.00
125_H	152_N	1.152	1.00
22_L	26_L	1.147	1.00
102_F	130_L	1.144	1.00
158_I	181_I	1.140	1.00
198_Y	202_Y	1.136	1.00
164_F	168_L	1.128	0.99
12_I	102_F	1.114	0.99
35_L	113_L	1.113	0.99
88_G	92_F	1.099	0.99
21_F	25_K	1.087	0.99
32_P	115_K	1.085	0.99
53_M	100_S	1.073	0.99
82_P	86_R	1.072	0.99
87_N	90_L	1.071	0.99
156_H	182_T	1.067	0.99
47_V	164_F	1.060	0.99
238_Y	243_L	1.058	0.99
79_S	84_A	1.054	0.99
91_G	137_L	1.053	0.99
13_I	130_L	1.050	0.99
98_Y	133_C	1.048	0.99
174_P	177_W	1.037	0.99
5_S	8_P	1.028	0.99
174_P	180_Y	1.023	0.99
70_F	73_L	1.021	0.99
47_V	104_E	1.019	0.99
89_R	93_W	1.017	0.99
227_Y	230_Y	1.005	0.99
26_L	33_F	1.004	0.99
79_S	82_P	1.003	0.99
82_P	87_N	0.995	0.99
33_F	113_L	0.994	0.99
169_G	172_K	0.980	0.99
41_L	45_F	0.976	0.99
156_H	185_Q	0.970	0.98
112_V	118_L	0.967	0.98
30_R	115_K	0.966	0.98
56_E	89_R	0.961	0.98
126_H	156_H	0.957	0.98
152_N	182_T	0.957	0.98
10_L	14_A	0.956	0.98
151_L	192_G	0.949	0.98
13_I	105_L	0.947	0.98
132_L	226_Y	0.943	0.98
27_M	32_P	0.941	0.98
52_Y	93_W	0.934	0.98
196_S	227_Y	0.932	0.98
30_R	33_F	0.927	0.98
54_F	157_V	0.924	0.98
36_K	40_I	0.919	0.98
169_G	173_Y	0.913	0.98
182_T	188_Q	0.911	0.98
111_F	116_K	0.909	0.98
218_G	222_L	0.901	0.97
147_F	191_I	0.898	0.97
225_L	229_S	0.893	0.97
237_F	242_Y	0.891	0.97
120_F	233_L	0.891	0.97
239_I	244_K	0.888	0.97
182_T	185_Q	0.885	0.97
152_N	188_Q	0.882	0.97
11_T	15_L	0.882	0.97
235_I	243_L	0.879	0.97
37_G	40_I	0.872	0.97
46_L	103_L	0.870	0.97
154_F	157_V	0.867	0.97
129_V	230_Y	0.859	0.97
111_F	117_Q	0.858	0.97
14_A	22_L	0.858	0.97
145_S	149_A	0.856	0.97
128_T	229_S	0.856	0.97
39_L	167_A	0.854	0.97
40_I	44_L	0.847	0.96
181_I	184_L	0.837	0.96
35_L	39_L	0.837	0.96
124_Y	226_Y	0.837	0.96
156_H	188_Q	0.836	0.96
7_W	11_T	0.836	0.96
82_P	85_L	0.835	0.96
27_M	34_K	0.830	0.96
178_K	189_F	0.824	0.96
49_F	96_L	0.823	0.96
132_L	223_G	0.823	0.96
223_G	226_Y	0.823	0.96
179_K	189_F	0.818	0.96
90_L	94_Y	0.815	0.95
119_S	163_Y	0.806	0.95
8_P	12_I	0.801	0.95
54_F	153_S	0.795	0.95
46_L	100_S	0.792	0.95
166_S	178_K	0.792	0.95
180_Y	183_T	0.791	0.95
119_S	123_V	0.789	0.95
144_G	147_F	0.779	0.94
177_W	180_Y	0.778	0.94
50_S	100_S	0.777	0.94
163_Y	182_T	0.773	0.94
152_N	159_M	0.772	0.94
238_Y	242_Y	0.770	0.94
44_L	161_S	0.768	0.94
6_P	10_L	0.767	0.94
29_N	115_K	0.766	0.94
161_S	165_L	0.765	0.94
193_L	224_L	0.761	0.94
156_H	234_F	0.758	0.93
128_T	226_Y	0.758	0.93
129_V	149_A	0.758	0.93
100_S	226_Y	0.753	0.93
20_V	24_P	0.752	0.93
57_T	150_L	0.750	0.93
152_N	160_Y	0.748	0.93
34_K	115_K	0.746	0.93
147_F	151_L	0.746	0.93
45_F	48_L	0.746	0.93
37_G	168_L	0.746	0.93
186_I	190_V	0.738	0.92
82_P	88_G	0.734	0.92
126_H	152_N	0.733	0.92
161_S	164_F	0.727	0.92
133_C	148_I	0.725	0.92
179_K	183_T	0.723	0.92
244_K	248_K	0.722	0.92
155_V	181_I	0.720	0.91
132_L	219_A	0.718	0.91
37_G	41_L	0.713	0.91
31_K	34_K	0.713	0.91
34_K	114_R	0.711	0.91
83_G	88_G	0.710	0.91
223_G	230_Y	0.705	0.91
128_T	222_L	0.705	0.91
9_V	13_I	0.701	0.90
129_V	226_Y	0.696	0.90
93_W	100_S	0.690	0.90
229_S	232_V	0.687	0.89
68_H	72_S	0.686	0.89
86_R	89_R	0.684	0.89
43_N	162_Y	0.684	0.89
96_L	99_L	0.681	0.89
240_K	244_K	0.680	0.89
185_Q	188_Q	0.678	0.89
151_L	191_I	0.672	0.88
69_G	72_S	0.669	0.88
129_V	227_Y	0.668	0.88
19_F	112_V	0.667	0.88
18_L	21_F	0.667	0.88
95_W	98_Y	0.666	0.88
191_I	202_Y	0.666	0.88
73_L	146_W	0.664	0.88
114_R	117_Q	0.663	0.88
221_Y	225_L	0.660	0.88
87_N	91_G	0.659	0.87
63_G	66_T	0.656	0.87
106_L	109_V	0.656	0.87
21_F	24_P	0.655	0.87
156_H	160_Y	0.654	0.87
33_F	115_K	0.654	0.87
46_L	50_S	0.653	0.87
22_L	25_K	0.651	0.87
42_Y	47_V	0.650	0.87
24_P	119_S	0.648	0.87
171_R	175_L	0.644	0.86
136_G	227_Y	0.643	0.86
34_K	38_L	0.642	0.86
31_K	115_K	0.642	0.86
128_T	132_L	0.637	0.86
133_C	149_A	0.635	0.85
165_L	168_L	0.632	0.85
189_F	230_Y	0.631	0.85
144_G	149_A	0.631	0.85
81_D	84_A	0.631	0.85
80_D	85_L	0.629	0.85
175_L	179_K	0.629	0.85
196_S	200_L	0.629	0.85
160_Y	182_T	0.628	0.85
57_T	148_I	0.628	0.85
171_R	174_P	0.626	0.85
91_G	94_Y	0.625	0.85
92_F	95_W	0.624	0.84
196_S	199_A	0.618	0.84
159_M	188_Q	0.617	0.84
173_Y	177_W	0.617	0.84
159_M	185_Q	0.617	0.84
166_S	177_W	0.617	0.84
135_L	219_A	0.616	0.84
125_H	188_Q	0.616	0.84
121_L	126_H	0.613	0.83
14_A	18_L	0.610	0.83
182_T	234_F	0.610	0.83
107_D	126_H	0.609	0.83
125_H	160_Y	0.609	0.83
121_L	159_M	0.609	0.83
148_I	192_G	0.609	0.83
70_F	74_I	0.609	0.83
120_F	229_S	0.608	0.83
169_G	174_P	0.608	0.83
98_Y	189_F	0.607	0.83
135_L	223_G	0.606	0.83
152_N	185_Q	0.605	0.83
147_F	192_G	0.604	0.83
121_L	234_F	0.601	0.82
164_F	167_A	0.601	0.82
197_Y	224_L	0.600	0.82
125_H	159_M	0.598	0.82
160_Y	185_Q	0.596	0.82
175_L	178_K	0.595	0.82
232_V	235_I	0.595	0.82
116_K	166_S	0.593	0.81
85_L	94_Y	0.591	0.81
39_L	42_Y	0.587	0.81
36_K	169_G	0.583	0.80
201_Y	205_A	0.582	0.80
112_V	115_K	0.582	0.80
57_T	149_A	0.579	0.80
32_P	116_K	0.578	0.80
65_L	73_L	0.578	0.80
81_D	85_L	0.577	0.80
223_G	227_Y	0.573	0.79
155_V	182_T	0.572	0.79
129_V	223_G	0.572	0.79
108_T	122_H	0.568	0.79
51_A	161_S	0.566	0.78
126_H	159_M	0.566	0.78
42_Y	178_K	0.563	0.78
197_Y	201_Y	0.562	0.78
100_S	133_C	0.561	0.78
205_A	208_G	0.560	0.78
13_I	17_L	0.559	0.77
46_L	192_G	0.559	0.77
122_H	163_Y	0.559	0.77
79_S	86_R	0.558	0.77
114_R	166_S	0.557	0.77
38_L	106_L	0.557	0.77
142_G	149_A	0.557	0.77
160_Y	188_Q	0.553	0.77
196_S	223_G	0.553	0.77
193_L	227_Y	0.552	0.77
146_W	150_L	0.549	0.76
236_N	239_I	0.546	0.76
189_F	227_Y	0.544	0.76
193_L	228_L	0.541	0.75
85_L	88_G	0.538	0.75
121_L	182_T	0.538	0.75
62_L	66_T	0.538	0.75
49_F	103_L	0.538	0.75
27_M	113_L	0.536	0.75
142_G	146_W	0.533	0.74
115_K	118_L	0.533	0.74
20_V	109_V	0.531	0.74
42_Y	189_F	0.531	0.74
35_L	114_R	0.531	0.74
136_G	148_I	0.529	0.74
87_N	94_Y	0.527	0.73
159_M	163_Y	0.526	0.73
229_S	233_L	0.524	0.73
51_A	54_F	0.523	0.73
50_S	53_M	0.523	0.73
50_S	107_D	0.520	0.72
87_N	92_F	0.520	0.72
12_I	19_F	0.519	0.72
237_F	241_T	0.515	0.72
122_H	128_T	0.513	0.71
86_R	90_L	0.513	0.71
152_N	234_F	0.512	0.71
121_L	125_H	0.508	0.71
132_L	230_Y	0.507	0.70
97_F	133_C	0.506	0.70
46_L	164_F	0.505	0.70
42_Y	123_V	0.504	0.70
224_L	228_L	0.501	0.70
44_L	104_E	0.501	0.70
71_Y	198_Y	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ks1B	1	0.16	9.4	0.959	Contact Map
2losA	1	0.232	6.1	0.962	Contact Map
2lomA	1	0.284	4.2	0.965	Contact Map
2rddB	1	0.116	3.4	0.967	Contact Map
2jwaA	2	0.156	2.6	0.969	Contact Map
3j9pD	4	0.744	2.3	0.97	Contact Map
4qndA	2	0.356	2.2	0.97	Contact Map
4hkcB	1	0.032	2.1	0.97	Contact Map
2lonA	1	0.304	2	0.97	Contact Map
2wwbC	1	0.128	2	0.97	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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