FTSW_RODA_SPOVE - PFAM28P - GREMLIN Contacts

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FTSW_RODA_SPOVE - Cell cycle protein

PFAM:	PF01098	Sequences: QWLLLAVVLLLALIGLVMVYSASSALALRLGGDPFYFLKRQLIWLALGLVAMLVVSRIDYRFLRRLAPPLYLLSLLLLVLVLVPFGVEVNGARRWIDLGGFSFQPSEFAKLALILFLAAYLSRKRRRLRPFLRGLLPPLLLVGLPVLLILLQPDLGTALVLFAIGLAMLFVAGVRLRYLLGLLLALAGVAALVLLILLKPYQRERILTFLDPWADPLGAGYQIIQSLIAIGSGGLFGKGLGNGTQKLGFLPEAHTDFIFAVIGEELGFIGALLVLLLFLLLIWRGLRIALRARDRFGRLLAAGITALIAFQAFINIGVVLGLLPVTGIPLPFISYGGSSLLATLIALGILLNISRRRR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	358 (351)
Sequences:	64074 (43048)
Seq/√Len:	2297.7
META:	0.838

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
285_G	305_T	4.554	1.00
167_A	306_A	3.644	1.00
285_G	350_L	3.131	1.00
263_G	271_A	3.117	1.00
97_D	100_G	3.105	1.00
230_I	263_G	2.962	1.00
171_V	302_A	2.908	1.00
282_I	309_A	2.856	1.00
211_D	214_A	2.710	1.00
55_V	345_I	2.689	1.00
60_Y	297_G	2.552	1.00
74_S	112_A	2.543	1.00
88_E	93_R	2.461	1.00
48_G	344_L	2.423	1.00
262_I	274_V	2.406	1.00
259_F	271_A	2.390	1.00
213_W	224_I	2.347	1.00
301_A	350_L	2.280	1.00
70_L	112_A	2.249	1.00
90_N	252_E	2.249	1.00
33_D	39_K	2.237	1.00
146_V	158_A	2.166	1.00
215_D	218_G	2.151	1.00
318_V	325_V	2.136	1.00
74_S	109_A	2.078	1.00
44_W	337_G	2.062	1.00
52_M	351_L	2.046	1.00
97_D	102_S	2.034	1.00
192_L	195_L	2.025	1.00
64_R	296_F	2.017	1.00
107_E	110_K	1.983	1.00
119_A	123_R	1.973	1.00
191_A	194_L	1.951	1.00
66_L	69_P	1.929	1.00
287_R	291_R	1.916	1.00
252_E	255_T	1.910	1.00
142_V	165_G	1.891	1.00
312_A	316_I	1.852	1.00
18_M	262_I	1.835	1.00
332_F	343_T	1.827	1.00
106_S	157_T	1.802	1.00
80_L	96_I	1.779	1.00
238_K	244_T	1.770	1.00
308_I	343_T	1.745	1.00
304_I	346_A	1.735	1.00
285_G	301_A	1.713	1.00
197_L	200_P	1.701	1.00
332_F	347_L	1.672	1.00
114_I	303_G	1.669	1.00
294_D	297_G	1.666	1.00
131_F	134_G	1.663	1.00
87_V	97_D	1.656	1.00
204_E	219_A	1.652	1.00
223_I	325_V	1.634	1.00
168_M	303_G	1.632	1.00
216_P	224_I	1.631	1.00
203_R	207_L	1.603	1.00
36_Y	40_R	1.600	1.00
175_R	178_Y	1.597	1.00
147_L	151_L	1.594	1.00
272_L	276_L	1.583	1.00
304_I	350_L	1.581	1.00
149_I	161_L	1.579	1.00
352_N	356_R	1.573	1.00
109_A	145_P	1.547	1.00
163_A	310_F	1.531	1.00
329_P	339_S	1.530	1.00
282_I	305_T	1.523	1.00
80_L	85_F	1.519	1.00
295_R	298_R	1.517	1.00
240_L	266_L	1.516	1.00
257_F	325_V	1.505	1.00
40_R	44_W	1.502	1.00
259_F	316_I	1.501	1.00
51_A	345_I	1.468	1.00
72_L	76_L	1.467	1.00
232_S	238_K	1.463	1.00
236_F	269_I	1.457	1.00
199_K	202_Q	1.455	1.00
288_I	301_A	1.448	1.00
7_V	280_L	1.443	1.00
307_L	346_A	1.443	1.00
220_G	224_I	1.435	1.00
18_M	266_L	1.429	1.00
243_G	261_V	1.427	1.00
12_A	45_L	1.424	1.00
223_I	321_G	1.418	1.00
302_A	306_A	1.415	1.00
317_G	323_L	1.408	1.00
64_R	119_A	1.389	1.00
278_F	312_A	1.368	1.00
156_G	326_T	1.367	1.00
191_A	195_L	1.365	1.00
62_F	65_R	1.347	1.00
114_I	164_I	1.346	1.00
226_S	319_V	1.346	1.00
200_P	203_R	1.345	1.00
243_G	265_E	1.339	1.00
215_D	219_A	1.331	1.00
52_M	55_V	1.320	1.00
117_L	165_G	1.316	1.00
45_L	340_L	1.310	1.00
62_F	66_L	1.290	1.00
154_D	157_T	1.286	1.00
292_A	353_I	1.275	1.00
69_P	73_L	1.269	1.00
281_L	347_L	1.268	1.00
168_M	299_L	1.267	1.00
301_A	353_I	1.260	1.00
208_T	220_G	1.259	1.00
262_I	333_I	1.252	1.00
297_G	353_I	1.252	1.00
275_L	316_I	1.250	1.00
116_F	141_L	1.249	1.00
306_A	310_F	1.244	1.00
289_A	305_T	1.229	1.00
167_A	310_F	1.228	1.00
64_R	122_S	1.228	1.00
68_P	72_L	1.226	1.00
120_Y	138_P	1.225	1.00
164_I	307_L	1.225	1.00
230_I	320_L	1.218	1.00
286_L	305_T	1.218	1.00
178_Y	181_G	1.217	1.00
204_E	207_L	1.215	1.00
121_L	168_M	1.210	1.00
41_Q	44_W	1.208	1.00
75_L	145_P	1.208	1.00
225_Q	245_Q	1.205	1.00
227_L	321_G	1.203	1.00
176_L	180_L	1.197	1.00
262_I	266_L	1.195	1.00
46_A	50_V	1.191	1.00
66_L	70_L	1.187	1.00
276_L	280_L	1.185	1.00
81_V	96_I	1.178	1.00
286_L	306_A	1.169	1.00
42_L	46_A	1.168	1.00
289_A	301_A	1.162	1.00
315_N	319_V	1.161	1.00
39_K	43_I	1.157	1.00
67_A	119_A	1.156	1.00
78_L	109_A	1.147	1.00
71_Y	145_P	1.147	1.00
115_L	300_L	1.134	1.00
36_Y	39_K	1.119	1.00
160_V	328_I	1.118	1.00
296_F	300_L	1.114	1.00
60_Y	294_D	1.106	1.00
138_P	165_G	1.102	1.00
200_P	204_E	1.101	1.00
180_L	184_L	1.097	1.00
81_V	105_P	1.095	1.00
8_V	347_L	1.093	1.00
146_V	162_F	1.091	1.00
318_V	326_T	1.084	1.00
283_W	287_R	1.082	1.00
208_T	219_A	1.082	1.00
17_V	240_L	1.080	1.00
59_D	62_F	1.076	1.00
35_F	39_K	1.074	1.00
16_L	38_L	1.071	1.00
60_Y	352_N	1.068	1.00
113_L	161_L	1.068	1.00
89_V	102_S	1.067	1.00
178_Y	182_L	1.066	1.00
288_I	354_S	1.064	1.00
76_L	80_L	1.061	1.00
52_M	347_L	1.061	1.00
134_G	137_P	1.060	1.00
282_I	312_A	1.058	1.00
121_L	169_L	1.055	1.00
131_F	137_P	1.055	1.00
111_L	346_A	1.051	1.00
289_A	302_A	1.050	1.00
108_F	342_A	1.050	1.00
77_L	81_V	1.048	1.00
339_S	343_T	1.048	1.00
53_L	57_R	1.045	1.00
7_V	281_L	1.044	1.00
300_L	353_I	1.042	1.00
75_L	144_L	1.040	1.00
279_L	283_W	1.025	1.00
225_Q	228_I	1.016	1.00
87_V	102_S	1.008	1.00
352_N	355_R	1.007	1.00
343_T	346_A	1.006	1.00
311_Q	339_S	1.004	1.00
275_L	312_A	1.000	1.00
228_I	245_Q	0.993	1.00
14_I	274_V	0.992	1.00
150_L	158_A	0.990	1.00
235_L	268_F	0.988	1.00
39_K	42_L	0.986	1.00
68_P	116_F	0.984	1.00
52_M	348_G	0.984	1.00
142_V	146_V	0.978	1.00
12_A	344_L	0.975	1.00
52_M	56_S	0.974	1.00
258_I	333_I	0.969	1.00
69_P	72_L	0.967	1.00
121_L	172_A	0.965	1.00
222_Q	257_F	0.965	1.00
274_V	333_I	0.963	1.00
188_G	191_A	0.961	1.00
255_T	335_Y	0.959	1.00
114_I	307_L	0.958	1.00
82_L	151_L	0.958	1.00
194_L	198_L	0.958	1.00
86_G	93_R	0.956	1.00
111_L	349_I	0.956	1.00
10_L	13_L	0.955	1.00
193_V	197_L	0.952	1.00
196_I	200_P	0.952	1.00
111_L	342_A	0.951	1.00
37_F	254_H	0.947	1.00
316_I	330_L	0.935	1.00
271_A	275_L	0.932	1.00
103_F	108_F	0.928	1.00
9_L	12_A	0.925	1.00
351_L	354_S	0.919	1.00
51_A	341_L	0.915	1.00
128_L	132_L	0.914	1.00
16_L	41_Q	0.914	1.00
63_L	67_A	0.910	1.00
170_F	176_L	0.909	1.00
94_R	156_G	0.904	1.00
188_G	192_L	0.891	1.00
266_L	270_G	0.883	1.00
71_Y	75_L	0.881	1.00
159_L	163_A	0.879	1.00
111_L	345_I	0.878	1.00
37_F	335_Y	0.877	1.00
228_I	231_G	0.877	1.00
343_T	347_L	0.871	1.00
128_L	131_F	0.870	1.00
56_S	348_G	0.866	1.00
16_L	42_L	0.864	1.00
278_F	330_L	0.863	1.00
208_T	212_P	0.863	1.00
97_D	101_F	0.863	1.00
213_W	227_L	0.862	1.00
114_I	168_M	0.860	1.00
40_R	43_I	0.858	1.00
177_R	181_G	0.857	1.00
209_F	212_P	0.856	1.00
197_L	203_R	0.855	1.00
50_V	54_V	0.854	1.00
14_I	277_L	0.847	1.00
164_I	168_M	0.844	1.00
314_I	323_L	0.844	1.00
198_L	202_Q	0.842	1.00
55_V	63_L	0.842	1.00
281_L	308_I	0.839	1.00
47_L	341_L	0.836	1.00
68_P	119_A	0.834	1.00
38_L	42_L	0.833	1.00
186_L	194_L	0.833	1.00
317_G	322_L	0.833	1.00
284_R	287_R	0.832	1.00
61_R	65_R	0.832	1.00
257_F	319_V	0.827	1.00
6_A	10_L	0.825	1.00
301_A	305_T	0.825	1.00
250_L	260_A	0.823	1.00
155_L	159_L	0.822	1.00
308_I	312_A	0.821	1.00
113_L	142_V	0.820	1.00
8_V	12_A	0.818	1.00
118_A	122_S	0.817	1.00
71_Y	116_F	0.815	1.00
209_F	213_W	0.813	1.00
316_I	320_L	0.813	1.00
73_L	77_L	0.812	1.00
79_V	82_L	0.812	1.00
221_Y	225_Q	0.809	1.00
224_I	228_I	0.809	1.00
280_L	284_R	0.808	1.00
14_I	262_I	0.805	1.00
253_A	261_V	0.804	1.00
67_A	112_A	0.804	1.00
35_F	38_L	0.802	1.00
268_F	272_L	0.802	1.00
208_T	214_A	0.801	1.00
204_E	214_A	0.800	1.00
221_Y	251_P	0.794	1.00
226_S	257_F	0.792	1.00
163_A	167_A	0.789	1.00
56_S	352_N	0.788	1.00
162_F	166_L	0.788	1.00
133_R	137_P	0.787	1.00
43_I	46_A	0.786	1.00
54_V	57_R	0.784	1.00
128_L	134_G	0.784	1.00
117_L	138_P	0.784	1.00
114_I	300_L	0.782	1.00
309_A	313_F	0.782	1.00
196_I	202_Q	0.776	1.00
130_P	134_G	0.776	1.00
172_A	299_L	0.776	1.00
18_M	258_I	0.775	1.00
115_L	349_I	0.774	1.00
295_R	299_L	0.773	1.00
212_P	224_I	0.773	1.00
125_R	128_L	0.770	1.00
143_G	147_L	0.769	1.00
224_I	227_L	0.768	1.00
311_Q	329_P	0.760	1.00
60_Y	353_I	0.759	1.00
94_R	326_T	0.759	1.00
117_L	142_V	0.758	1.00
204_E	208_T	0.757	1.00
127_R	133_R	0.752	1.00
20_Y	24_S	0.746	1.00
80_L	83_V	0.745	1.00
132_L	138_P	0.745	1.00
14_I	18_M	0.745	1.00
20_Y	38_L	0.744	1.00
49_L	53_L	0.743	1.00
109_A	161_L	0.734	1.00
190_A	194_L	0.733	1.00
87_V	93_R	0.731	1.00
125_R	129_R	0.727	1.00
67_A	115_L	0.727	1.00
273_L	276_L	0.727	1.00
192_L	196_I	0.726	1.00
63_L	349_I	0.726	1.00
47_L	51_A	0.725	1.00
348_G	352_N	0.724	1.00
135_L	139_L	0.724	1.00
56_S	355_R	0.723	1.00
109_A	112_A	0.721	1.00
167_A	302_A	0.720	1.00
115_L	296_F	0.718	1.00
342_A	346_A	0.717	1.00
305_T	350_L	0.716	1.00
7_V	11_L	0.715	1.00
292_A	297_G	0.715	1.00
246_K	265_E	0.713	1.00
140_L	144_L	0.712	1.00
136_L	140_L	0.711	1.00
198_L	201_Y	0.711	1.00
193_V	196_I	0.708	1.00
330_L	333_I	0.705	1.00
205_R	209_F	0.704	1.00
155_L	202_Q	0.700	1.00
113_L	145_P	0.699	1.00
21_S	265_E	0.698	1.00
174_V	178_Y	0.698	1.00
308_I	347_L	0.697	1.00
82_L	93_R	0.697	1.00
137_P	140_L	0.695	1.00
27_A	31_G	0.695	1.00
26_L	29_R	0.693	1.00
129_R	132_L	0.693	1.00
164_I	167_A	0.692	1.00
54_V	58_I	0.688	1.00
342_A	345_I	0.686	1.00
48_G	340_L	0.686	1.00
189_V	194_L	0.685	1.00
134_G	138_P	0.684	1.00
129_R	133_R	0.684	1.00
318_V	323_L	0.684	1.00
118_A	168_M	0.684	1.00
58_I	63_L	0.680	1.00
132_L	136_L	0.678	1.00
171_V	306_A	0.678	1.00
132_L	178_Y	0.677	1.00
119_A	296_F	0.675	1.00
261_V	265_E	0.671	1.00
243_G	264_E	0.670	1.00
292_A	301_A	0.669	1.00
79_V	83_V	0.668	1.00
177_R	180_L	0.667	1.00
226_S	260_A	0.664	1.00
281_L	285_G	0.664	1.00
223_I	226_S	0.664	1.00
26_L	30_L	0.663	1.00
250_L	253_A	0.660	1.00
77_L	103_F	0.658	1.00
300_L	304_I	0.658	1.00
124_K	127_R	0.658	1.00
19_V	23_S	0.657	1.00
127_R	130_P	0.655	1.00
144_L	147_L	0.653	1.00
239_G	265_E	0.651	1.00
207_L	214_A	0.650	1.00
126_R	129_R	0.649	1.00
169_L	174_V	0.645	1.00
254_H	335_Y	0.641	1.00
87_V	90_N	0.639	1.00
284_R	354_S	0.637	1.00
90_N	93_R	0.637	1.00
27_A	37_F	0.635	1.00
187_A	191_A	0.632	1.00
114_I	304_I	0.632	1.00
108_F	112_A	0.632	1.00
125_R	295_R	0.631	1.00
297_G	300_L	0.629	1.00
350_L	353_I	0.629	1.00
305_T	309_A	0.627	1.00
313_F	322_L	0.626	1.00
20_Y	35_F	0.625	1.00
49_L	52_M	0.625	1.00
287_R	290_L	0.624	1.00
94_R	106_S	0.623	1.00
44_W	47_L	0.623	1.00
56_S	351_L	0.622	1.00
41_Q	45_L	0.616	1.00
89_V	93_R	0.616	1.00
190_A	193_V	0.615	1.00
47_L	50_V	0.614	1.00
148_L	152_Q	0.610	1.00
207_L	211_D	0.610	1.00
300_L	349_I	0.608	1.00
304_I	307_L	0.605	1.00
207_L	210_L	0.605	1.00
195_L	200_P	0.605	1.00
194_L	197_L	0.604	1.00
118_A	300_L	0.603	1.00
307_L	311_Q	0.601	1.00
10_L	277_L	0.601	1.00
52_M	344_L	0.600	1.00
120_Y	141_L	0.600	1.00
194_L	200_P	0.599	1.00
304_I	353_I	0.599	1.00
351_L	355_R	0.598	1.00
121_L	138_P	0.598	1.00
212_P	215_D	0.597	1.00
349_I	353_I	0.595	1.00
44_W	48_G	0.594	1.00
122_S	295_R	0.593	1.00
8_V	344_L	0.590	1.00
235_L	269_I	0.588	1.00
228_I	249_F	0.588	1.00
51_A	55_V	0.588	1.00
103_F	342_A	0.584	1.00
64_R	68_P	0.583	1.00
31_G	37_F	0.582	1.00
110_K	307_L	0.581	1.00
156_G	318_V	0.581	1.00
65_R	69_P	0.580	1.00
238_K	264_E	0.580	1.00
74_S	77_L	0.580	1.00
186_L	190_A	0.579	1.00
142_V	162_F	0.578	1.00
161_L	165_G	0.577	1.00
344_L	348_G	0.576	1.00
196_I	199_K	0.575	1.00
223_I	227_L	0.575	1.00
61_R	64_R	0.574	1.00
314_I	328_I	0.571	1.00
314_I	318_V	0.571	1.00
212_P	220_G	0.570	1.00
13_L	17_V	0.568	1.00
53_L	56_S	0.568	1.00
166_L	183_L	0.566	1.00
28_L	34_P	0.566	1.00
94_R	153_P	0.566	1.00
19_V	22_A	0.565	1.00
307_L	343_T	0.564	1.00
226_S	230_I	0.564	1.00
28_L	31_G	0.564	1.00
149_I	157_T	0.562	1.00
81_V	93_R	0.561	1.00
16_L	45_L	0.560	1.00
195_L	199_K	0.560	1.00
129_R	134_G	0.560	1.00
223_I	257_F	0.558	1.00
7_V	277_L	0.553	1.00
124_K	137_P	0.553	1.00
81_V	152_Q	0.553	1.00
59_D	356_R	0.552	1.00
158_A	162_F	0.551	1.00
338_S	342_A	0.550	1.00
74_S	108_F	0.549	1.00
197_L	201_Y	0.549	1.00
31_G	36_Y	0.548	1.00
189_V	192_L	0.546	1.00
117_L	168_M	0.544	1.00
332_F	344_L	0.544	1.00
70_L	73_L	0.544	1.00
27_A	30_L	0.543	1.00
180_L	183_L	0.542	1.00
165_G	169_L	0.541	1.00
273_L	277_L	0.538	1.00
284_R	288_I	0.538	1.00
136_L	139_L	0.538	1.00
73_L	76_L	0.535	1.00
313_F	317_G	0.535	1.00
215_D	220_G	0.535	1.00
109_A	113_L	0.535	1.00
82_L	85_F	0.535	1.00
7_V	13_L	0.534	1.00
9_L	13_L	0.533	1.00
55_V	348_G	0.533	1.00
298_R	301_A	0.533	1.00
153_P	202_Q	0.533	1.00
148_L	153_P	0.532	1.00
121_L	299_L	0.531	1.00
20_Y	23_S	0.531	1.00
288_I	292_A	0.530	1.00
260_A	319_V	0.530	1.00
212_P	216_P	0.529	1.00
79_V	148_L	0.527	1.00
259_F	275_L	0.524	1.00
70_L	74_S	0.524	1.00
22_A	261_V	0.519	1.00
258_I	262_I	0.519	1.00
110_K	311_Q	0.518	1.00
286_L	290_L	0.517	1.00
276_L	279_L	0.516	1.00
89_V	97_D	0.516	1.00
23_S	27_A	0.515	1.00
33_D	36_Y	0.515	1.00
92_A	153_P	0.513	1.00
89_V	92_A	0.512	1.00
190_A	195_L	0.508	1.00
24_S	28_L	0.508	1.00
229_A	264_E	0.507	1.00
229_A	250_L	0.507	1.00
243_G	246_K	0.506	1.00
118_A	296_F	0.506	1.00
288_I	291_R	0.504	1.00
196_I	203_R	0.503	1.00
292_A	295_R	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4qncA	2	0.2123	4.2	0.971	Contact Map
2micA	2	0.1145	2.8	0.974	Contact Map
4x5mA	2	0.243	2.4	0.975	Contact Map
3wu2Z	1	0.1341	2.1	0.975	Contact Map
3rqwA	4	0.2318	2.1	0.975	Contact Map
3rceA	1	0.7402	2	0.976	Contact Map
2gfpA	2	0.8687	1.8	0.976	Contact Map
2xq2A	2	0.2207	1.6	0.977	Contact Map
2k9jB	1	0.1201	1.6	0.977	Contact Map
2l9uA	2	0.0894	1.5	0.977	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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