GREMLIN Database
FTSW_RODA_SPOVE - Cell cycle protein
PFAM: PF01098 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 358 (351)
Sequences: 64074 (43048)
Seq/√Len: 2297.7
META: 0.838

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
285_G305_T4.5541.00
167_A306_A3.6441.00
285_G350_L3.1311.00
263_G271_A3.1171.00
97_D100_G3.1051.00
230_I263_G2.9621.00
171_V302_A2.9081.00
282_I309_A2.8561.00
211_D214_A2.7101.00
55_V345_I2.6891.00
60_Y297_G2.5521.00
74_S112_A2.5431.00
88_E93_R2.4611.00
48_G344_L2.4231.00
262_I274_V2.4061.00
259_F271_A2.3901.00
213_W224_I2.3471.00
301_A350_L2.2801.00
70_L112_A2.2491.00
90_N252_E2.2491.00
33_D39_K2.2371.00
146_V158_A2.1661.00
215_D218_G2.1511.00
318_V325_V2.1361.00
74_S109_A2.0781.00
44_W337_G2.0621.00
52_M351_L2.0461.00
97_D102_S2.0341.00
192_L195_L2.0251.00
64_R296_F2.0171.00
107_E110_K1.9831.00
119_A123_R1.9731.00
191_A194_L1.9511.00
66_L69_P1.9291.00
287_R291_R1.9161.00
252_E255_T1.9101.00
142_V165_G1.8911.00
312_A316_I1.8521.00
18_M262_I1.8351.00
332_F343_T1.8271.00
106_S157_T1.8021.00
80_L96_I1.7791.00
238_K244_T1.7701.00
308_I343_T1.7451.00
304_I346_A1.7351.00
285_G301_A1.7131.00
197_L200_P1.7011.00
332_F347_L1.6721.00
114_I303_G1.6691.00
294_D297_G1.6661.00
131_F134_G1.6631.00
87_V97_D1.6561.00
204_E219_A1.6521.00
223_I325_V1.6341.00
168_M303_G1.6321.00
216_P224_I1.6311.00
203_R207_L1.6031.00
36_Y40_R1.6001.00
175_R178_Y1.5971.00
147_L151_L1.5941.00
272_L276_L1.5831.00
304_I350_L1.5811.00
149_I161_L1.5791.00
352_N356_R1.5731.00
109_A145_P1.5471.00
163_A310_F1.5311.00
329_P339_S1.5301.00
282_I305_T1.5231.00
80_L85_F1.5191.00
295_R298_R1.5171.00
240_L266_L1.5161.00
257_F325_V1.5051.00
40_R44_W1.5021.00
259_F316_I1.5011.00
51_A345_I1.4681.00
72_L76_L1.4671.00
232_S238_K1.4631.00
236_F269_I1.4571.00
199_K202_Q1.4551.00
288_I301_A1.4481.00
7_V280_L1.4431.00
307_L346_A1.4431.00
220_G224_I1.4351.00
18_M266_L1.4291.00
243_G261_V1.4271.00
12_A45_L1.4241.00
223_I321_G1.4181.00
302_A306_A1.4151.00
317_G323_L1.4081.00
64_R119_A1.3891.00
278_F312_A1.3681.00
156_G326_T1.3671.00
191_A195_L1.3651.00
62_F65_R1.3471.00
114_I164_I1.3461.00
226_S319_V1.3461.00
200_P203_R1.3451.00
243_G265_E1.3391.00
215_D219_A1.3311.00
52_M55_V1.3201.00
117_L165_G1.3161.00
45_L340_L1.3101.00
62_F66_L1.2901.00
154_D157_T1.2861.00
292_A353_I1.2751.00
69_P73_L1.2691.00
281_L347_L1.2681.00
168_M299_L1.2671.00
301_A353_I1.2601.00
208_T220_G1.2591.00
262_I333_I1.2521.00
297_G353_I1.2521.00
275_L316_I1.2501.00
116_F141_L1.2491.00
306_A310_F1.2441.00
289_A305_T1.2291.00
167_A310_F1.2281.00
64_R122_S1.2281.00
68_P72_L1.2261.00
120_Y138_P1.2251.00
164_I307_L1.2251.00
230_I320_L1.2181.00
286_L305_T1.2181.00
178_Y181_G1.2171.00
204_E207_L1.2151.00
121_L168_M1.2101.00
41_Q44_W1.2081.00
75_L145_P1.2081.00
225_Q245_Q1.2051.00
227_L321_G1.2031.00
176_L180_L1.1971.00
262_I266_L1.1951.00
46_A50_V1.1911.00
66_L70_L1.1871.00
276_L280_L1.1851.00
81_V96_I1.1781.00
286_L306_A1.1691.00
42_L46_A1.1681.00
289_A301_A1.1621.00
315_N319_V1.1611.00
39_K43_I1.1571.00
67_A119_A1.1561.00
78_L109_A1.1471.00
71_Y145_P1.1471.00
115_L300_L1.1341.00
36_Y39_K1.1191.00
160_V328_I1.1181.00
296_F300_L1.1141.00
60_Y294_D1.1061.00
138_P165_G1.1021.00
200_P204_E1.1011.00
180_L184_L1.0971.00
81_V105_P1.0951.00
8_V347_L1.0931.00
146_V162_F1.0911.00
318_V326_T1.0841.00
283_W287_R1.0821.00
208_T219_A1.0821.00
17_V240_L1.0801.00
59_D62_F1.0761.00
35_F39_K1.0741.00
16_L38_L1.0711.00
60_Y352_N1.0681.00
113_L161_L1.0681.00
89_V102_S1.0671.00
178_Y182_L1.0661.00
288_I354_S1.0641.00
76_L80_L1.0611.00
52_M347_L1.0611.00
134_G137_P1.0601.00
282_I312_A1.0581.00
121_L169_L1.0551.00
131_F137_P1.0551.00
111_L346_A1.0511.00
289_A302_A1.0501.00
108_F342_A1.0501.00
77_L81_V1.0481.00
339_S343_T1.0481.00
53_L57_R1.0451.00
7_V281_L1.0441.00
300_L353_I1.0421.00
75_L144_L1.0401.00
279_L283_W1.0251.00
225_Q228_I1.0161.00
87_V102_S1.0081.00
352_N355_R1.0071.00
343_T346_A1.0061.00
311_Q339_S1.0041.00
275_L312_A1.0001.00
228_I245_Q0.9931.00
14_I274_V0.9921.00
150_L158_A0.9901.00
235_L268_F0.9881.00
39_K42_L0.9861.00
68_P116_F0.9841.00
52_M348_G0.9841.00
142_V146_V0.9781.00
12_A344_L0.9751.00
52_M56_S0.9741.00
258_I333_I0.9691.00
69_P72_L0.9671.00
121_L172_A0.9651.00
222_Q257_F0.9651.00
274_V333_I0.9631.00
188_G191_A0.9611.00
255_T335_Y0.9591.00
114_I307_L0.9581.00
82_L151_L0.9581.00
194_L198_L0.9581.00
86_G93_R0.9561.00
111_L349_I0.9561.00
10_L13_L0.9551.00
193_V197_L0.9521.00
196_I200_P0.9521.00
111_L342_A0.9511.00
37_F254_H0.9471.00
316_I330_L0.9351.00
271_A275_L0.9321.00
103_F108_F0.9281.00
9_L12_A0.9251.00
351_L354_S0.9191.00
51_A341_L0.9151.00
128_L132_L0.9141.00
16_L41_Q0.9141.00
63_L67_A0.9101.00
170_F176_L0.9091.00
94_R156_G0.9041.00
188_G192_L0.8911.00
266_L270_G0.8831.00
71_Y75_L0.8811.00
159_L163_A0.8791.00
111_L345_I0.8781.00
37_F335_Y0.8771.00
228_I231_G0.8771.00
343_T347_L0.8711.00
128_L131_F0.8701.00
56_S348_G0.8661.00
16_L42_L0.8641.00
278_F330_L0.8631.00
208_T212_P0.8631.00
97_D101_F0.8631.00
213_W227_L0.8621.00
114_I168_M0.8601.00
40_R43_I0.8581.00
177_R181_G0.8571.00
209_F212_P0.8561.00
197_L203_R0.8551.00
50_V54_V0.8541.00
14_I277_L0.8471.00
164_I168_M0.8441.00
314_I323_L0.8441.00
198_L202_Q0.8421.00
55_V63_L0.8421.00
281_L308_I0.8391.00
47_L341_L0.8361.00
68_P119_A0.8341.00
38_L42_L0.8331.00
186_L194_L0.8331.00
317_G322_L0.8331.00
284_R287_R0.8321.00
61_R65_R0.8321.00
257_F319_V0.8271.00
6_A10_L0.8251.00
301_A305_T0.8251.00
250_L260_A0.8231.00
155_L159_L0.8221.00
308_I312_A0.8211.00
113_L142_V0.8201.00
8_V12_A0.8181.00
118_A122_S0.8171.00
71_Y116_F0.8151.00
209_F213_W0.8131.00
316_I320_L0.8131.00
73_L77_L0.8121.00
79_V82_L0.8121.00
221_Y225_Q0.8091.00
224_I228_I0.8091.00
280_L284_R0.8081.00
14_I262_I0.8051.00
253_A261_V0.8041.00
67_A112_A0.8041.00
35_F38_L0.8021.00
268_F272_L0.8021.00
208_T214_A0.8011.00
204_E214_A0.8001.00
221_Y251_P0.7941.00
226_S257_F0.7921.00
163_A167_A0.7891.00
56_S352_N0.7881.00
162_F166_L0.7881.00
133_R137_P0.7871.00
43_I46_A0.7861.00
54_V57_R0.7841.00
128_L134_G0.7841.00
117_L138_P0.7841.00
114_I300_L0.7821.00
309_A313_F0.7821.00
196_I202_Q0.7761.00
130_P134_G0.7761.00
172_A299_L0.7761.00
18_M258_I0.7751.00
115_L349_I0.7741.00
295_R299_L0.7731.00
212_P224_I0.7731.00
125_R128_L0.7701.00
143_G147_L0.7691.00
224_I227_L0.7681.00
311_Q329_P0.7601.00
60_Y353_I0.7591.00
94_R326_T0.7591.00
117_L142_V0.7581.00
204_E208_T0.7571.00
127_R133_R0.7521.00
20_Y24_S0.7461.00
80_L83_V0.7451.00
132_L138_P0.7451.00
14_I18_M0.7451.00
20_Y38_L0.7441.00
49_L53_L0.7431.00
109_A161_L0.7341.00
190_A194_L0.7331.00
87_V93_R0.7311.00
125_R129_R0.7271.00
67_A115_L0.7271.00
273_L276_L0.7271.00
192_L196_I0.7261.00
63_L349_I0.7261.00
47_L51_A0.7251.00
348_G352_N0.7241.00
135_L139_L0.7241.00
56_S355_R0.7231.00
109_A112_A0.7211.00
167_A302_A0.7201.00
115_L296_F0.7181.00
342_A346_A0.7171.00
305_T350_L0.7161.00
7_V11_L0.7151.00
292_A297_G0.7151.00
246_K265_E0.7131.00
140_L144_L0.7121.00
136_L140_L0.7111.00
198_L201_Y0.7111.00
193_V196_I0.7081.00
330_L333_I0.7051.00
205_R209_F0.7041.00
155_L202_Q0.7001.00
113_L145_P0.6991.00
21_S265_E0.6981.00
174_V178_Y0.6981.00
308_I347_L0.6971.00
82_L93_R0.6971.00
137_P140_L0.6951.00
27_A31_G0.6951.00
26_L29_R0.6931.00
129_R132_L0.6931.00
164_I167_A0.6921.00
54_V58_I0.6881.00
342_A345_I0.6861.00
48_G340_L0.6861.00
189_V194_L0.6851.00
134_G138_P0.6841.00
129_R133_R0.6841.00
318_V323_L0.6841.00
118_A168_M0.6841.00
58_I63_L0.6801.00
132_L136_L0.6781.00
171_V306_A0.6781.00
132_L178_Y0.6771.00
119_A296_F0.6751.00
261_V265_E0.6711.00
243_G264_E0.6701.00
292_A301_A0.6691.00
79_V83_V0.6681.00
177_R180_L0.6671.00
226_S260_A0.6641.00
281_L285_G0.6641.00
223_I226_S0.6641.00
26_L30_L0.6631.00
250_L253_A0.6601.00
77_L103_F0.6581.00
300_L304_I0.6581.00
124_K127_R0.6581.00
19_V23_S0.6571.00
127_R130_P0.6551.00
144_L147_L0.6531.00
239_G265_E0.6511.00
207_L214_A0.6501.00
126_R129_R0.6491.00
169_L174_V0.6451.00
254_H335_Y0.6411.00
87_V90_N0.6391.00
284_R354_S0.6371.00
90_N93_R0.6371.00
27_A37_F0.6351.00
187_A191_A0.6321.00
114_I304_I0.6321.00
108_F112_A0.6321.00
125_R295_R0.6311.00
297_G300_L0.6291.00
350_L353_I0.6291.00
305_T309_A0.6271.00
313_F322_L0.6261.00
20_Y35_F0.6251.00
49_L52_M0.6251.00
287_R290_L0.6241.00
94_R106_S0.6231.00
44_W47_L0.6231.00
56_S351_L0.6221.00
41_Q45_L0.6161.00
89_V93_R0.6161.00
190_A193_V0.6151.00
47_L50_V0.6141.00
148_L152_Q0.6101.00
207_L211_D0.6101.00
300_L349_I0.6081.00
304_I307_L0.6051.00
207_L210_L0.6051.00
195_L200_P0.6051.00
194_L197_L0.6041.00
118_A300_L0.6031.00
307_L311_Q0.6011.00
10_L277_L0.6011.00
52_M344_L0.6001.00
120_Y141_L0.6001.00
194_L200_P0.5991.00
304_I353_I0.5991.00
351_L355_R0.5981.00
121_L138_P0.5981.00
212_P215_D0.5971.00
349_I353_I0.5951.00
44_W48_G0.5941.00
122_S295_R0.5931.00
8_V344_L0.5901.00
235_L269_I0.5881.00
228_I249_F0.5881.00
51_A55_V0.5881.00
103_F342_A0.5841.00
64_R68_P0.5831.00
31_G37_F0.5821.00
110_K307_L0.5811.00
156_G318_V0.5811.00
65_R69_P0.5801.00
238_K264_E0.5801.00
74_S77_L0.5801.00
186_L190_A0.5791.00
142_V162_F0.5781.00
161_L165_G0.5771.00
344_L348_G0.5761.00
196_I199_K0.5751.00
223_I227_L0.5751.00
61_R64_R0.5741.00
314_I328_I0.5711.00
314_I318_V0.5711.00
212_P220_G0.5701.00
13_L17_V0.5681.00
53_L56_S0.5681.00
166_L183_L0.5661.00
28_L34_P0.5661.00
94_R153_P0.5661.00
19_V22_A0.5651.00
307_L343_T0.5641.00
226_S230_I0.5641.00
28_L31_G0.5641.00
149_I157_T0.5621.00
81_V93_R0.5611.00
16_L45_L0.5601.00
195_L199_K0.5601.00
129_R134_G0.5601.00
223_I257_F0.5581.00
7_V277_L0.5531.00
124_K137_P0.5531.00
81_V152_Q0.5531.00
59_D356_R0.5521.00
158_A162_F0.5511.00
338_S342_A0.5501.00
74_S108_F0.5491.00
197_L201_Y0.5491.00
31_G36_Y0.5481.00
189_V192_L0.5461.00
117_L168_M0.5441.00
332_F344_L0.5441.00
70_L73_L0.5441.00
27_A30_L0.5431.00
180_L183_L0.5421.00
165_G169_L0.5411.00
273_L277_L0.5381.00
284_R288_I0.5381.00
136_L139_L0.5381.00
73_L76_L0.5351.00
313_F317_G0.5351.00
215_D220_G0.5351.00
109_A113_L0.5351.00
82_L85_F0.5351.00
7_V13_L0.5341.00
9_L13_L0.5331.00
55_V348_G0.5331.00
298_R301_A0.5331.00
153_P202_Q0.5331.00
148_L153_P0.5321.00
121_L299_L0.5311.00
20_Y23_S0.5311.00
288_I292_A0.5301.00
260_A319_V0.5301.00
212_P216_P0.5291.00
79_V148_L0.5271.00
259_F275_L0.5241.00
70_L74_S0.5241.00
22_A261_V0.5191.00
258_I262_I0.5191.00
110_K311_Q0.5181.00
286_L290_L0.5171.00
276_L279_L0.5161.00
89_V97_D0.5161.00
23_S27_A0.5151.00
33_D36_Y0.5151.00
92_A153_P0.5131.00
89_V92_A0.5121.00
190_A195_L0.5081.00
24_S28_L0.5081.00
229_A264_E0.5071.00
229_A250_L0.5071.00
243_G246_K0.5061.00
118_A296_F0.5061.00
288_I291_R0.5041.00
196_I203_R0.5031.00
292_A295_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qncA 2 0.2123 4.2 0.971 Contact Map
2micA 2 0.1145 2.8 0.974 Contact Map
4x5mA 2 0.243 2.4 0.975 Contact Map
3wu2Z 1 0.1341 2.1 0.975 Contact Map
3rqwA 4 0.2318 2.1 0.975 Contact Map
3rceA 1 0.7402 2 0.976 Contact Map
2gfpA 2 0.8687 1.8 0.976 Contact Map
2xq2A 2 0.2207 1.6 0.977 Contact Map
2k9jB 1 0.1201 1.6 0.977 Contact Map
2l9uA 2 0.0894 1.5 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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