GREMLIN Database
ABC2_membrane - ABC-2 type transporter
PFAM: PF01061 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 210 (204)
Sequences: 99551 (65267)
Seq/√Len: 4569.6
META: 0.709

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_L204_A4.9011.00
8_R12_K3.8891.00
140_L201_A3.7201.00
7_V106_L3.5361.00
92_S95_A3.3001.00
187_G191_W3.1991.00
188_W191_W3.0001.00
4_W8_R2.8611.00
191_W194_Y2.8481.00
190_Q194_Y2.7961.00
187_G190_Q2.6291.00
140_L144_F2.2951.00
54_G58_G2.2181.00
131_L134_L2.1651.00
136_L208_A2.0061.00
191_W195_L1.8811.00
47_S50_V1.8351.00
72_S148_G1.8211.00
140_L205_L1.8051.00
10_E100_K1.7861.00
45_S48_G1.7101.00
182_I193_A1.7091.00
54_G62_F1.6911.00
49_G52_Y1.6801.00
113_L134_L1.6731.00
4_W7_V1.6591.00
193_A199_T1.6521.00
182_I194_Y1.6481.00
15_Y18_P1.6311.00
46_S49_G1.6091.00
25_S29_P1.6071.00
5_A8_R1.5821.00
66_S70_S1.5821.00
132_L135_L1.5691.00
203_E207_A1.5401.00
7_V102_L1.5291.00
29_P33_L1.5161.00
178_V202_V1.5041.00
132_L208_A1.4951.00
118_V122_L1.4931.00
12_K15_Y1.4921.00
135_L139_L1.4811.00
58_G62_F1.4791.00
46_S50_V1.4741.00
199_T203_E1.4631.00
131_L135_L1.4591.00
67_S71_I1.4511.00
157_S160_D1.4071.00
194_Y199_T1.3881.00
194_Y200_Y1.3711.00
108_A111_Q1.3691.00
58_G61_L1.3611.00
45_S50_V1.3571.00
85_L88_T1.3521.00
75_S79_R1.3391.00
53_P57_A1.3181.00
57_A61_L1.3091.00
181_P184_S1.3081.00
167_F171_P1.3031.00
53_P58_G1.2951.00
45_S49_G1.2891.00
87_V90_L1.2851.00
48_G51_N1.2801.00
94_P98_L1.2531.00
166_N170_L1.2501.00
186_P190_Q1.2371.00
196_N199_T1.2331.00
74_V78_E1.2311.00
156_V160_D1.2151.00
185_L193_A1.2031.00
55_L59_L1.1981.00
107_I111_Q1.1931.00
200_Y204_A1.1841.00
54_G57_A1.1831.00
76_E81_T1.1811.00
118_V121_L1.1751.00
114_L117_L1.1731.00
172_L198_L1.1721.00
7_V99_G1.1671.00
133_L205_L1.1661.00
28_Q32_F1.1431.00
18_P21_G1.1241.00
111_Q115_V1.1191.00
59_L63_T1.1171.00
48_G52_Y1.1151.00
202_V206_R1.0811.00
76_E80_G1.0711.00
190_Q193_A1.0701.00
57_A60_V1.0681.00
85_L89_P1.0681.00
172_L196_N1.0601.00
76_E100_K1.0581.00
124_G127_I1.0571.00
117_L121_L1.0511.00
182_I199_T1.0501.00
185_L189_L1.0431.00
126_P129_S1.0361.00
11_L15_Y1.0281.00
133_L208_A1.0211.00
182_I190_Q1.0181.00
62_F65_F1.0161.00
173_F179_F1.0131.00
6_L99_G1.0041.00
119_A123_F1.0011.00
14_R18_P0.9911.00
73_L76_E0.9901.00
188_W192_I0.9871.00
74_V77_R0.9861.00
143_A146_G0.9791.00
47_S51_N0.9741.00
177_G199_T0.9721.00
107_I110_L0.9691.00
9_R13_R0.9661.00
34_L38_F0.9651.00
55_L58_G0.9651.00
75_S78_E0.9631.00
80_G84_R0.9621.00
182_I203_E0.9601.00
203_E206_R0.9591.00
177_G182_I0.9551.00
10_E13_R0.9541.00
109_L113_L0.9481.00
32_F36_F0.9461.00
144_F148_G0.9341.00
136_L140_L0.9291.00
69_T165_V0.9151.00
84_R87_V0.9121.00
201_A204_A0.9071.00
129_S132_L0.9021.00
110_L114_L0.9001.00
78_E158_F0.8961.00
134_L138_L0.8931.00
24_W28_Q0.8841.00
106_L110_L0.8691.00
168_V171_P0.8661.00
171_P175_L0.8651.00
103_A106_L0.8571.00
67_S70_S0.8541.00
54_G64_A0.8511.00
116_L120_L0.8511.00
66_S69_T0.8501.00
102_L106_L0.8491.00
56_L59_L0.8431.00
46_S52_Y0.8421.00
156_V159_R0.8421.00
46_S51_N0.8421.00
81_T85_L0.8371.00
83_E86_L0.8371.00
99_G103_A0.8351.00
77_R82_L0.8251.00
114_L118_V0.8231.00
155_A161_A0.8201.00
117_L120_L0.8191.00
86_L89_P0.8191.00
12_K16_R0.8151.00
143_A201_A0.8141.00
109_L138_L0.8131.00
155_A160_D0.8131.00
31_L34_L0.8121.00
88_T93_R0.8111.00
105_L109_L0.8001.00
150_L153_A0.7981.00
53_P56_L0.7951.00
189_L193_A0.7881.00
83_E87_V0.7831.00
38_F41_G0.7821.00
204_A207_A0.7811.00
153_A156_V0.7811.00
137_L205_L0.7751.00
73_L77_R0.7721.00
7_V11_L0.7711.00
84_R88_T0.7661.00
105_L112_L0.7621.00
56_L60_V0.7591.00
53_P65_F0.7571.00
11_L103_A0.7541.00
135_L138_L0.7461.00
160_D163_Q0.7461.00
23_L27_L0.7451.00
53_P61_L0.7371.00
176_S198_L0.7341.00
104_A107_I0.7321.00
138_L142_L0.7311.00
101_V146_G0.7311.00
93_R97_L0.7301.00
177_G180_Y0.7301.00
123_F127_I0.7271.00
119_A122_L0.7261.00
132_L136_L0.7251.00
33_L37_G0.7221.00
58_G64_A0.7191.00
112_L116_L0.7181.00
77_R156_V0.7171.00
110_L113_L0.7151.00
81_T84_R0.7131.00
96_I99_G0.7121.00
111_Q114_L0.7111.00
155_A164_I0.7101.00
58_G63_T0.7081.00
113_L117_L0.7061.00
204_A208_A0.7061.00
37_G41_G0.7041.00
200_Y203_E0.7011.00
98_L102_L0.7001.00
60_V64_A0.6891.00
100_K104_A0.6851.00
146_G150_L0.6851.00
120_L127_I0.6841.00
97_L101_V0.6821.00
34_L37_G0.6801.00
151_L161_A0.6741.00
182_I185_L0.6731.00
86_L93_R0.6721.00
150_L154_L0.6691.00
201_A205_L0.6581.00
121_L124_G0.6581.00
98_L101_V0.6571.00
25_S28_Q0.6551.00
77_R81_T0.6501.00
193_A196_N0.6461.00
146_G153_A0.6451.00
120_L123_F0.6421.00
151_L155_A0.6391.00
61_L65_F0.6341.00
108_A112_L0.6331.00
116_L119_A0.6331.00
170_L173_F0.6321.00
41_G44_G0.6311.00
159_R163_Q0.6311.00
95_A98_L0.6281.00
85_L90_L0.6271.00
79_R83_E0.6261.00
78_E81_T0.6221.00
57_A62_F0.6181.00
146_G149_L0.6141.00
73_L165_V0.6141.00
68_L144_F0.6121.00
61_L64_A0.6111.00
162_Q166_N0.6091.00
65_F69_T0.6091.00
83_E90_L0.6081.00
141_A145_L0.6051.00
24_W29_P0.6041.00
105_L142_L0.5991.00
165_V168_V0.5981.00
15_Y19_V0.5981.00
76_E82_L0.5951.00
106_L109_L0.5941.00
80_G83_E0.5921.00
68_L71_I0.5891.00
95_A99_G0.5881.00
94_P97_L0.5851.00
103_A107_I0.5851.00
184_S187_G0.5831.00
7_V103_A0.5791.00
83_E89_P0.5751.00
136_L205_L0.5731.00
168_V172_L0.5731.00
186_P189_L0.5711.00
53_P63_T0.5691.00
124_G128_S0.5631.00
147_L168_V0.5631.00
159_R162_Q0.5631.00
65_F70_S0.5591.00
60_V63_T0.5591.00
93_R96_I0.5511.00
127_I130_F0.5501.00
64_A141_A0.5491.00
57_A63_T0.5491.00
14_R17_N0.5481.00
53_P60_V0.5471.00
14_R21_G0.5471.00
13_R17_N0.5451.00
163_Q167_F0.5391.00
7_V10_E0.5371.00
90_L93_R0.5371.00
66_S71_I0.5351.00
189_L192_I0.5341.00
151_L165_V0.5331.00
142_L146_G0.5321.00
137_L201_A0.5311.00
125_L128_S0.5291.00
78_E100_K0.5241.00
139_L143_A0.5241.00
81_T86_L0.5241.00
113_L116_L0.5231.00
149_L153_A0.5191.00
104_A108_A0.5191.00
194_Y203_E0.5161.00
74_V162_Q0.5161.00
83_E88_T0.5151.00
96_I100_K0.5141.00
77_R159_R0.5141.00
195_L200_Y0.5141.00
85_L96_I0.5141.00
177_G203_E0.5131.00
45_S51_N0.5121.00
205_L208_A0.5111.00
188_W193_A0.5101.00
69_T73_L0.5071.00
45_S52_Y0.5051.00
59_L64_A0.5041.00
75_S81_T0.5021.00
19_V23_L0.5011.00
185_L190_Q0.5001.00
185_L188_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a65A 2 0.3857 3.2 0.927 Contact Map
2kogA 1 0.1952 0.9 0.946 Contact Map
2m8rA 1 0.1857 0.9 0.948 Contact Map
4b19A 1 0.1429 0.7 0.95 Contact Map
2zy9A 2 0.4952 0.7 0.951 Contact Map
4mbsA 1 0.0571 0.7 0.952 Contact Map
3rqwA 4 0.6286 0.6 0.952 Contact Map
3echC 1 0.0952 0.6 0.952 Contact Map
4i0uA 4 0.3429 0.6 0.953 Contact Map
4ev6A 3 0.3524 0.6 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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