GREMLIN Database
ATP-synt_8 - ATP synthase protein 8
PFAM: PF00895 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 55 (55)
Sequences: 3661 (2152)
Seq/√Len: 290.1
META: 0.004

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_F19_T2.9281.00
17_W54_P2.3241.00
25_Q28_I2.0681.00
38_P41_K1.9201.00
6_P12_I1.8731.00
18_L22_L1.8461.00
43_K46_K1.6151.00
7_S11_A1.5751.00
13_L17_W1.5671.00
41_K46_K1.5101.00
12_I16_S1.4921.00
21_L25_Q1.4841.00
18_L26_P1.4231.00
5_N10_F1.3921.00
4_L17_W1.3541.00
26_P29_L1.3311.00
5_N12_I1.3211.00
20_F25_Q1.3141.00
7_S33_F1.3081.00
51_W54_P1.2591.00
11_A15_F1.2161.00
37_P40_K1.2111.00
36_N41_K1.2091.00
8_P17_W1.1851.00
42_T45_K1.1841.00
5_N8_P1.1611.00
8_P11_A1.1421.00
4_L29_L1.1231.00
34_P40_K1.1201.00
44_T47_K1.1171.00
1_M55_W1.1041.00
35_N41_K1.0951.00
7_S12_I1.0611.00
29_L32_T0.9831.00
35_N38_P0.9691.00
34_P38_P0.9631.00
17_W53_W0.9511.00
23_I48_T0.9031.00
37_P46_K0.8961.00
16_S27_K0.8871.00
37_P41_K0.8601.00
4_L7_S0.8521.00
8_P51_W0.8481.00
22_L25_Q0.8391.00
7_S15_F0.8291.00
17_W21_L0.8251.00
4_L28_I0.8241.00
13_L21_L0.8181.00
43_K52_N0.7980.99
39_S45_K0.7800.99
20_F27_K0.7780.99
8_P19_T0.7680.99
34_P37_P0.7420.99
36_N42_T0.7330.99
13_L25_Q0.7260.99
13_L24_I0.7200.99
13_L16_S0.6960.99
27_K54_P0.6790.98
40_K43_K0.6520.98
34_P42_T0.6400.97
8_P15_F0.6270.97
38_P45_K0.6190.97
13_L20_F0.6130.97
31_H35_N0.6070.97
15_F18_L0.6060.96
6_P10_F0.5980.96
15_F25_Q0.5780.95
10_F27_K0.5620.95
17_W51_W0.5620.95
14_L18_L0.5580.94
20_F31_H0.5550.94
22_L31_H0.5500.94
12_I27_K0.5470.94
7_S16_S0.5350.93
41_K48_T0.5210.92
45_K53_W0.5180.92
6_P53_W0.5140.92
47_K53_W0.5110.92
19_T24_I0.5110.92
33_F42_T0.5080.91
7_S14_L0.5080.91
52_N55_W0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hb3B 1 0.9818 2.8 0.853 Contact Map
2gsmB 1 0.9818 2.5 0.856 Contact Map
2yevB 1 1 2.3 0.86 Contact Map
2znlB 1 0 1.2 0.88 Contact Map
1fftB 1 1 0.8 0.892 Contact Map
3ppuA 2 0 0.6 0.902 Contact Map
2c9lY 2 0.3455 0.6 0.904 Contact Map
1uwyA 1 0 0.6 0.905 Contact Map
4i0uA 4 0.5818 0.5 0.906 Contact Map
4ev6A 3 0.6182 0.5 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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