GREMLIN Database
Innexin - Innexin
PFAM: PF00876 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 332 (330)
Sequences: 957 (737)
Seq/√Len: 40.5
META: 0.189

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_L255_G6.0061.00
84_Q240_Y5.1611.00
166_N170_Q4.1861.00
59_Y212_D3.9951.00
16_L247_F3.9101.00
80_V240_Y3.8811.00
12_T246_W3.7931.00
54_W185_Y3.7381.00
4_V253_L3.4131.00
210_K225_D2.9621.00
186_G245_F2.8901.00
243_L247_F2.7361.00
169_G172_F2.6311.00
49_A226_V2.6301.00
307_F311_L2.6201.00
161_L258_L2.6191.00
83_F87_L2.5921.00
54_W231_P2.5241.00
88_F166_N2.4801.00
16_L243_L2.4661.00
169_G173_L2.4571.00
186_G244_W2.4151.00
207_R237_E2.4001.00
137_L324_L2.3831.00
77_V236_N2.2411.00
259_L263_A2.2361.00
58_T209_T2.2261.00
188_E191_K2.1520.99
58_T75_Q2.1220.99
75_Q209_T2.0840.99
8_H254_T2.0610.99
204_I207_R2.0510.99
45_W54_W1.9560.99
4_V257_S1.9440.99
174_L247_F1.8930.98
159_C163_Y1.8760.98
60_T71_I1.8670.98
249_F253_L1.8650.98
5_D160_K1.8250.98
179_G236_N1.8050.98
117_P324_L1.7980.98
182_F186_G1.7890.98
164_L251_A1.7870.98
2_D257_S1.7750.98
175_N182_F1.7450.97
1_D9_Y1.7400.97
199_W203_M1.7350.97
54_W307_F1.7300.97
301_L305_G1.7040.97
38_P41_F1.6610.96
87_L169_G1.6600.96
296_F301_L1.6420.96
13_V92_R1.6100.96
167_V251_A1.6080.96
5_D163_Y1.5890.95
8_H163_Y1.5630.95
160_K261_W1.5450.95
31_D50_N1.5410.95
296_F305_G1.5150.94
30_G238_K1.4900.94
169_G251_A1.4810.93
57_N70_Y1.4770.93
309_L324_L1.4720.93
311_L315_N1.4580.93
246_W250_L1.4570.93
84_Q170_Q1.4420.92
9_Y46_E1.4360.92
212_D225_D1.4320.92
16_L85_A1.4140.92
321_F325_V1.4120.92
75_Q234_I1.3840.91
2_D160_K1.3630.90
46_E50_N1.3590.90
9_Y92_R1.3560.90
167_V247_F1.3470.89
185_Y189_V1.3400.89
251_A255_G1.3380.89
279_L307_F1.3380.89
296_F329_W1.3340.89
260_Y268_P1.3310.89
35_C53_C1.3260.89
30_G77_V1.3240.89
12_T16_L1.3230.89
80_V83_F1.3200.89
94_L159_C1.3190.88
8_H167_V1.2910.87
52_Y56_Q1.2810.87
260_Y264_R1.2800.87
41_F49_A1.2770.87
227_Q232_I1.2760.87
6_R55_I1.2760.87
24_T27_Q1.2640.86
62_P213_F1.2620.86
5_D156_Y1.2540.86
190_L245_F1.2490.86
182_F245_F1.2460.85
5_D159_C1.2450.85
175_N180_G1.2410.85
275_L323_E1.2390.85
107_I308_L1.2320.85
6_R58_T1.2310.85
157_L258_L1.2280.85
81_L239_I1.2260.84
163_Y309_L1.2140.84
266_L330_K1.2100.84
37_V46_E1.1890.83
75_Q79_F1.1740.82
160_K304_D1.1710.82
278_R325_V1.1680.81
162_L169_G1.1670.81
80_V177_F1.1540.81
318_D322_R1.1470.80
88_F254_T1.1390.80
184_T188_E1.1380.80
17_L111_V1.1310.79
42_T45_W1.1300.79
86_L94_L1.1270.79
36_W41_F1.1270.79
94_L98_L1.1200.79
166_N246_W1.1200.79
164_L254_T1.1150.78
45_W185_Y1.1150.78
231_P315_N1.1100.78
296_F300_Y1.1090.78
176_R251_A1.1030.78
17_L85_A1.1020.77
77_V238_K1.0960.77
9_Y89_Y1.0870.77
15_I242_F1.0850.76
60_T235_F1.0780.76
126_R323_E1.0780.76
263_A267_S1.0760.76
12_T81_L1.0740.76
49_A60_T1.0730.76
132_L139_R1.0720.75
254_T257_S1.0710.75
23_V27_Q1.0710.75
92_R163_Y1.0680.75
192_D197_Q1.0630.75
81_L236_N1.0620.75
84_Q315_N1.0590.75
27_Q30_G1.0550.74
7_L250_L1.0520.74
320_V327_E1.0470.74
199_W202_S1.0440.74
38_P229_V1.0360.73
95_W233_N1.0240.72
161_L165_V1.0110.71
181_E188_E1.0080.71
135_D263_A1.0060.71
38_P49_A1.0060.71
102_R140_N1.0050.71
57_N67_P1.0030.70
110_L114_A1.0000.70
170_Q240_Y1.0000.70
16_L19_F0.9950.70
192_D203_M0.9950.70
240_Y250_L0.9950.70
174_L243_L0.9890.69
327_E330_K0.9880.69
214_H223_R0.9880.69
88_F170_Q0.9850.69
107_I128_K0.9780.69
165_V330_K0.9770.68
38_P220_N0.9750.68
193_L241_I0.9750.68
106_N148_S0.9710.68
161_L276_R0.9710.68
156_Y311_L0.9640.67
22_L25_A0.9640.67
55_I58_T0.9630.67
138_D300_Y0.9630.67
21_L55_I0.9610.67
28_Y54_W0.9590.67
262_L266_L0.9510.66
115_N323_E0.9490.66
135_D276_R0.9490.66
177_F240_Y0.9460.66
99_E310_R0.9430.66
262_L324_L0.9390.65
165_V169_G0.9370.65
212_D226_V0.9330.65
186_G207_R0.9300.65
135_D324_L0.9300.65
220_N229_V0.9290.64
222_Q234_I0.9240.64
211_C228_C0.9220.64
35_C228_C0.9220.64
62_P241_I0.9210.64
79_F274_F0.9190.64
128_K131_K0.9180.64
33_I76_W0.9160.63
158_F162_L0.9150.63
49_A235_F0.9130.63
8_H250_L0.9060.63
108_K302_R0.9030.62
49_A213_F0.9020.62
76_W205_F0.9000.62
160_K227_Q0.9000.62
176_R240_Y0.8970.62
185_Y231_P0.8960.62
177_F245_F0.8960.62
156_Y160_K0.8950.62
102_R171_I0.8920.61
10_R31_D0.8860.61
275_L325_V0.8840.61
6_R110_L0.8830.61
105_I152_L0.8810.60
79_F178_L0.8810.60
178_L186_G0.8790.60
59_Y85_A0.8790.60
13_V19_F0.8740.60
76_W206_P0.8720.60
165_V171_I0.8720.60
9_Y13_V0.8710.59
136_Y140_N0.8690.59
27_Q33_I0.8640.59
134_V156_Y0.8630.59
150_N302_R0.8590.58
90_L116_D0.8580.58
36_W227_Q0.8550.58
13_V62_P0.8500.58
88_F174_L0.8480.57
209_T244_W0.8470.57
142_H153_A0.8450.57
40_E224_H0.8410.57
13_V72_S0.8410.57
5_D8_H0.8400.57
205_F233_N0.8400.57
171_I220_N0.8370.56
113_G140_N0.8360.56
135_D252_I0.8270.55
34_Q229_V0.8260.55
213_F226_V0.8230.55
203_M207_R0.8230.55
170_Q317_G0.8220.55
79_F222_Q0.8200.55
217_G224_H0.8180.55
21_L31_D0.8180.55
76_W238_K0.8110.54
73_Y95_W0.8110.54
223_R324_L0.8110.54
154_Y158_F0.8080.54
87_L173_L0.8060.54
167_V254_T0.8040.53
14_I18_A0.8000.53
95_W219_G0.7980.53
26_K31_D0.7970.53
53_C228_C0.7950.53
221_I229_V0.7910.52
102_R109_A0.7870.52
6_R19_F0.7860.52
75_Q236_N0.7850.52
11_Y131_K0.7850.52
283_D302_R0.7840.52
81_L250_L0.7840.52
8_H225_D0.7830.51
227_Q296_F0.7830.51
28_Y242_F0.7820.51
38_P301_L0.7810.51
110_L168_I0.7780.51
164_L258_L0.7770.51
36_W60_T0.7770.51
87_L251_A0.7760.51
210_K217_G0.7760.51
4_V196_G0.7750.51
275_L279_L0.7720.50
157_L313_A0.7700.50
216_R226_V0.7670.50
249_F288_E0.7660.50
160_K305_G0.7640.50
268_P298_V0.7620.50
59_Y62_P0.7610.49
168_I223_R0.7590.49
66_I210_K0.7550.49
79_F83_F0.7550.49
112_E320_V0.7550.49
73_Y238_K0.7500.48
58_T73_Y0.7480.48
239_I254_T0.7480.48
41_F226_V0.7450.48
84_Q166_N0.7430.48
5_D12_T0.7420.48
157_L314_K0.7410.48
69_E259_L0.7400.47
24_T236_N0.7390.47
124_E127_E0.7390.47
215_K226_V0.7380.47
106_N145_R0.7360.47
304_D329_W0.7340.47
20_S28_Y0.7320.47
1_D182_F0.7300.47
35_C211_C0.7300.47
20_S52_Y0.7290.46
114_A324_L0.7270.46
74_Y205_F0.7250.46
114_A317_G0.7240.46
2_D5_D0.7230.46
93_Y240_Y0.7230.46
131_K327_E0.7230.46
72_S222_Q0.7220.46
95_W156_Y0.7220.46
66_I69_E0.7190.46
193_L235_F0.7170.45
40_E217_G0.7170.45
69_E158_F0.7140.45
68_E154_Y0.7080.45
157_L169_G0.7070.44
182_F204_I0.7070.44
48_Y227_Q0.7050.44
146_E280_R0.7050.44
56_Q60_T0.7010.44
156_Y173_L0.6980.44
25_A29_V0.6960.43
158_F258_L0.6950.43
108_K183_L0.6940.43
297_V306_W0.6940.43
13_V47_E0.6930.43
95_W236_N0.6890.43
217_G220_N0.6890.43
75_Q238_K0.6880.43
154_Y324_L0.6860.43
210_K213_F0.6860.43
216_R225_D0.6850.42
279_L296_F0.6830.42
206_P244_W0.6790.42
184_T194_L0.6750.42
8_H219_G0.6740.41
7_L21_L0.6720.41
285_L289_D0.6720.41
255_G259_L0.6720.41
34_Q231_P0.6710.41
147_Y280_R0.6710.41
127_E190_L0.6710.41
297_V312_L0.6680.41
80_V173_L0.6670.41
217_G222_Q0.6640.41
10_R317_G0.6590.40
13_V325_V0.6570.40
126_R236_N0.6570.40
175_N278_R0.6560.40
302_R305_G0.6540.40
284_K291_K0.6540.40
60_T84_Q0.6530.40
300_Y305_G0.6530.40
167_V213_F0.6520.40
177_F189_V0.6520.40
293_V316_A0.6520.40
234_I250_L0.6500.39
9_Y163_Y0.6480.39
13_V25_A0.6470.39
111_V171_I0.6460.39
98_L155_L0.6450.39
128_K187_F0.6440.39
252_I255_G0.6430.39
160_K163_Y0.6420.39
316_A327_E0.6400.38
175_N202_S0.6400.38
51_T185_Y0.6380.38
158_F295_K0.6360.38
10_R239_I0.6350.38
208_V234_I0.6350.38
30_G236_N0.6340.38
15_I19_F0.6330.38
9_Y179_G0.6300.38
172_F263_A0.6240.37
124_E259_L0.6240.37
112_E116_D0.6230.37
32_P156_Y0.6210.37
255_G265_L0.6180.37
168_I187_F0.6180.37
43_G49_A0.6170.36
39_A215_K0.6140.36
107_I131_K0.6140.36
301_L328_L0.6100.36
53_C211_C0.6090.36
64_D250_L0.6080.36
73_Y209_T0.6080.36
8_H166_N0.6070.36
165_V249_F0.6070.36
125_E220_N0.6070.36
141_L255_G0.6070.36
219_G236_N0.6070.36
61_V294_V0.6060.36
305_G329_W0.6060.36
36_W222_Q0.6060.36
5_D261_W0.6040.35
107_I290_D0.6030.35
43_G161_L0.6020.35
136_Y144_H0.6020.35
168_I255_G0.6010.35
160_K257_S0.6000.35
169_G273_R0.5980.35
54_W78_P0.5960.35
33_I71_I0.5940.35
67_P98_L0.5940.35
284_K287_R0.5940.35
151_Y155_L0.5930.34
77_V177_F0.5910.34
46_E49_A0.5890.34
4_V299_R0.5870.34
110_L139_R0.5860.34
263_A270_L0.5840.34
236_N239_I0.5820.34
25_A30_G0.5810.33
169_G177_F0.5800.33
153_A158_F0.5800.33
296_F304_D0.5790.33
109_A116_D0.5770.33
152_L160_K0.5760.33
264_R314_K0.5730.33
161_L288_E0.5720.33
36_W212_D0.5720.33
2_D93_Y0.5710.33
52_Y238_K0.5710.33
274_F310_R0.5710.33
87_L131_K0.5690.32
16_L32_P0.5680.32
243_L249_F0.5660.32
45_W51_T0.5650.32
122_D125_E0.5620.32
8_H80_V0.5600.32
112_E266_L0.5600.32
10_R50_N0.5580.32
6_R174_L0.5570.31
182_F315_N0.5560.31
105_I147_Y0.5550.31
256_L266_L0.5540.31
116_D130_I0.5530.31
14_I83_F0.5530.31
210_K216_R0.5530.31
296_F302_R0.5520.31
52_Y222_Q0.5490.31
73_Y76_W0.5490.31
172_F176_R0.5490.31
171_I268_P0.5490.31
71_I82_F0.5470.31
75_Q244_W0.5470.31
36_W216_R0.5470.31
195_N299_R0.5470.31
97_L115_N0.5460.31
147_Y158_F0.5450.31
73_Y205_F0.5450.31
27_Q32_P0.5440.30
17_L86_L0.5430.30
7_L12_T0.5420.30
57_N209_T0.5410.30
250_L254_T0.5410.30
117_P320_V0.5410.30
230_L239_I0.5400.30
102_R113_G0.5390.30
212_D227_Q0.5380.30
16_L251_A0.5380.30
214_H250_L0.5370.30
176_R275_L0.5350.30
218_S225_D0.5330.30
271_R275_L0.5320.30
268_P288_E0.5310.29
92_R96_K0.5300.29
12_T166_N0.5300.29
28_Y320_V0.5290.29
192_D258_L0.5280.29
73_Y206_P0.5270.29
209_T230_L0.5270.29
258_L290_D0.5230.29
6_R75_Q0.5220.29
193_L199_W0.5220.29
70_Y83_F0.5210.29
130_I310_R0.5200.29
7_L173_L0.5200.29
54_W329_W0.5190.29
88_F163_Y0.5180.28
18_A86_L0.5170.28
119_K128_K0.5170.28
127_E131_K0.5170.28
124_E128_K0.5150.28
22_L185_Y0.5130.28
175_N184_T0.5130.28
156_Y202_S0.5120.28
76_W244_W0.5120.28
19_F247_F0.5110.28
270_L278_R0.5110.28
182_F185_Y0.5100.28
38_P222_Q0.5090.28
165_V252_I0.5080.28
47_E235_F0.5070.28
136_Y219_G0.5070.28
231_P241_I0.5050.28
127_E327_E0.5040.27
36_W49_A0.5040.27
241_I248_V0.5040.27
186_G189_V0.5030.27
194_L326_A0.5020.27
276_R329_W0.5010.27
116_D265_L0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4b93A 1 0.244 8.3 0.974 Contact Map
2nutC 1 0.241 7.8 0.975 Contact Map
1dj7A 1 0.1235 6.9 0.975 Contact Map
2o6kA 1 0.1928 3.2 0.979 Contact Map
1vd8A 1 0.0693 2.8 0.979 Contact Map
2fj6A 1 0.2018 2.8 0.979 Contact Map
3gwnA 2 0.1205 2.7 0.98 Contact Map
3gwlA 2 0.1145 2.4 0.98 Contact Map
3kyqA 1 0.3042 2.4 0.98 Contact Map
2i53A 1 0.2018 2.3 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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