Innexin - PFAM28P - GREMLIN Contacts

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Innexin - Innexin

PFAM:	PF00876	Sequences: DDFVDRLHYRYTVIILLAFSLLVTAKQYVGDPIQCWVPAEFTGSWEEYANTYCWIQNTYTVPFDNIPEEYISYYQWVPFVLFFQALLFYLPRYLWKLLEGGRSGINIKALVEGANDPIKSEDPEEREKKIKLLVDYLDRNLHTHREYSGNYLAYLYLFCKLLYLVNVIGQIFLLNRFLGGEFLTYGFEVLKDLLNGQEWTDSMIFPRVTKCDFHKRGSGNIQRHDVQCVLPINIFNEKIYIFLWFWFVFLAILTGLSLLYWLARLLSPSLRVRFLRKRLRLADKLSREDDKDVVKFVVRYLRIDGWFLLRLLAKNAGDLVFRELVAELWKRY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	332 (330)
Sequences:	957 (737)
Seq/√Len:	40.5
META:	0.189

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
164_L	255_G	6.006	1.00
84_Q	240_Y	5.161	1.00
166_N	170_Q	4.186	1.00
59_Y	212_D	3.995	1.00
16_L	247_F	3.910	1.00
80_V	240_Y	3.881	1.00
12_T	246_W	3.793	1.00
54_W	185_Y	3.738	1.00
4_V	253_L	3.413	1.00
210_K	225_D	2.962	1.00
186_G	245_F	2.890	1.00
243_L	247_F	2.736	1.00
169_G	172_F	2.631	1.00
49_A	226_V	2.630	1.00
307_F	311_L	2.620	1.00
161_L	258_L	2.619	1.00
83_F	87_L	2.592	1.00
54_W	231_P	2.524	1.00
88_F	166_N	2.480	1.00
16_L	243_L	2.466	1.00
169_G	173_L	2.457	1.00
186_G	244_W	2.415	1.00
207_R	237_E	2.400	1.00
137_L	324_L	2.383	1.00
77_V	236_N	2.241	1.00
259_L	263_A	2.236	1.00
58_T	209_T	2.226	1.00
188_E	191_K	2.152	0.99
58_T	75_Q	2.122	0.99
75_Q	209_T	2.084	0.99
8_H	254_T	2.061	0.99
204_I	207_R	2.051	0.99
45_W	54_W	1.956	0.99
4_V	257_S	1.944	0.99
174_L	247_F	1.893	0.98
159_C	163_Y	1.876	0.98
60_T	71_I	1.867	0.98
249_F	253_L	1.865	0.98
5_D	160_K	1.825	0.98
179_G	236_N	1.805	0.98
117_P	324_L	1.798	0.98
182_F	186_G	1.789	0.98
164_L	251_A	1.787	0.98
2_D	257_S	1.775	0.98
175_N	182_F	1.745	0.97
1_D	9_Y	1.740	0.97
199_W	203_M	1.735	0.97
54_W	307_F	1.730	0.97
301_L	305_G	1.704	0.97
38_P	41_F	1.661	0.96
87_L	169_G	1.660	0.96
296_F	301_L	1.642	0.96
13_V	92_R	1.610	0.96
167_V	251_A	1.608	0.96
5_D	163_Y	1.589	0.95
8_H	163_Y	1.563	0.95
160_K	261_W	1.545	0.95
31_D	50_N	1.541	0.95
296_F	305_G	1.515	0.94
30_G	238_K	1.490	0.94
169_G	251_A	1.481	0.93
57_N	70_Y	1.477	0.93
309_L	324_L	1.472	0.93
311_L	315_N	1.458	0.93
246_W	250_L	1.457	0.93
84_Q	170_Q	1.442	0.92
9_Y	46_E	1.436	0.92
212_D	225_D	1.432	0.92
16_L	85_A	1.414	0.92
321_F	325_V	1.412	0.92
75_Q	234_I	1.384	0.91
2_D	160_K	1.363	0.90
46_E	50_N	1.359	0.90
9_Y	92_R	1.356	0.90
167_V	247_F	1.347	0.89
185_Y	189_V	1.340	0.89
251_A	255_G	1.338	0.89
279_L	307_F	1.338	0.89
296_F	329_W	1.334	0.89
260_Y	268_P	1.331	0.89
35_C	53_C	1.326	0.89
30_G	77_V	1.324	0.89
12_T	16_L	1.323	0.89
80_V	83_F	1.320	0.89
94_L	159_C	1.319	0.88
8_H	167_V	1.291	0.87
52_Y	56_Q	1.281	0.87
260_Y	264_R	1.280	0.87
41_F	49_A	1.277	0.87
227_Q	232_I	1.276	0.87
6_R	55_I	1.276	0.87
24_T	27_Q	1.264	0.86
62_P	213_F	1.262	0.86
5_D	156_Y	1.254	0.86
190_L	245_F	1.249	0.86
182_F	245_F	1.246	0.85
5_D	159_C	1.245	0.85
175_N	180_G	1.241	0.85
275_L	323_E	1.239	0.85
107_I	308_L	1.232	0.85
6_R	58_T	1.231	0.85
157_L	258_L	1.228	0.85
81_L	239_I	1.226	0.84
163_Y	309_L	1.214	0.84
266_L	330_K	1.210	0.84
37_V	46_E	1.189	0.83
75_Q	79_F	1.174	0.82
160_K	304_D	1.171	0.82
278_R	325_V	1.168	0.81
162_L	169_G	1.167	0.81
80_V	177_F	1.154	0.81
318_D	322_R	1.147	0.80
88_F	254_T	1.139	0.80
184_T	188_E	1.138	0.80
17_L	111_V	1.131	0.79
42_T	45_W	1.130	0.79
86_L	94_L	1.127	0.79
36_W	41_F	1.127	0.79
94_L	98_L	1.120	0.79
166_N	246_W	1.120	0.79
164_L	254_T	1.115	0.78
45_W	185_Y	1.115	0.78
231_P	315_N	1.110	0.78
296_F	300_Y	1.109	0.78
176_R	251_A	1.103	0.78
17_L	85_A	1.102	0.77
77_V	238_K	1.096	0.77
9_Y	89_Y	1.087	0.77
15_I	242_F	1.085	0.76
60_T	235_F	1.078	0.76
126_R	323_E	1.078	0.76
263_A	267_S	1.076	0.76
12_T	81_L	1.074	0.76
49_A	60_T	1.073	0.76
132_L	139_R	1.072	0.75
254_T	257_S	1.071	0.75
23_V	27_Q	1.071	0.75
92_R	163_Y	1.068	0.75
192_D	197_Q	1.063	0.75
81_L	236_N	1.062	0.75
84_Q	315_N	1.059	0.75
27_Q	30_G	1.055	0.74
7_L	250_L	1.052	0.74
320_V	327_E	1.047	0.74
199_W	202_S	1.044	0.74
38_P	229_V	1.036	0.73
95_W	233_N	1.024	0.72
161_L	165_V	1.011	0.71
181_E	188_E	1.008	0.71
135_D	263_A	1.006	0.71
38_P	49_A	1.006	0.71
102_R	140_N	1.005	0.71
57_N	67_P	1.003	0.70
110_L	114_A	1.000	0.70
170_Q	240_Y	1.000	0.70
16_L	19_F	0.995	0.70
192_D	203_M	0.995	0.70
240_Y	250_L	0.995	0.70
174_L	243_L	0.989	0.69
327_E	330_K	0.988	0.69
214_H	223_R	0.988	0.69
88_F	170_Q	0.985	0.69
107_I	128_K	0.978	0.69
165_V	330_K	0.977	0.68
38_P	220_N	0.975	0.68
193_L	241_I	0.975	0.68
106_N	148_S	0.971	0.68
161_L	276_R	0.971	0.68
156_Y	311_L	0.964	0.67
22_L	25_A	0.964	0.67
55_I	58_T	0.963	0.67
138_D	300_Y	0.963	0.67
21_L	55_I	0.961	0.67
28_Y	54_W	0.959	0.67
262_L	266_L	0.951	0.66
115_N	323_E	0.949	0.66
135_D	276_R	0.949	0.66
177_F	240_Y	0.946	0.66
99_E	310_R	0.943	0.66
262_L	324_L	0.939	0.65
165_V	169_G	0.937	0.65
212_D	226_V	0.933	0.65
186_G	207_R	0.930	0.65
135_D	324_L	0.930	0.65
220_N	229_V	0.929	0.64
222_Q	234_I	0.924	0.64
211_C	228_C	0.922	0.64
35_C	228_C	0.922	0.64
62_P	241_I	0.921	0.64
79_F	274_F	0.919	0.64
128_K	131_K	0.918	0.64
33_I	76_W	0.916	0.63
158_F	162_L	0.915	0.63
49_A	235_F	0.913	0.63
8_H	250_L	0.906	0.63
108_K	302_R	0.903	0.62
49_A	213_F	0.902	0.62
76_W	205_F	0.900	0.62
160_K	227_Q	0.900	0.62
176_R	240_Y	0.897	0.62
185_Y	231_P	0.896	0.62
177_F	245_F	0.896	0.62
156_Y	160_K	0.895	0.62
102_R	171_I	0.892	0.61
10_R	31_D	0.886	0.61
275_L	325_V	0.884	0.61
6_R	110_L	0.883	0.61
105_I	152_L	0.881	0.60
79_F	178_L	0.881	0.60
178_L	186_G	0.879	0.60
59_Y	85_A	0.879	0.60
13_V	19_F	0.874	0.60
76_W	206_P	0.872	0.60
165_V	171_I	0.872	0.60
9_Y	13_V	0.871	0.59
136_Y	140_N	0.869	0.59
27_Q	33_I	0.864	0.59
134_V	156_Y	0.863	0.59
150_N	302_R	0.859	0.58
90_L	116_D	0.858	0.58
36_W	227_Q	0.855	0.58
13_V	62_P	0.850	0.58
88_F	174_L	0.848	0.57
209_T	244_W	0.847	0.57
142_H	153_A	0.845	0.57
40_E	224_H	0.841	0.57
13_V	72_S	0.841	0.57
5_D	8_H	0.840	0.57
205_F	233_N	0.840	0.57
171_I	220_N	0.837	0.56
113_G	140_N	0.836	0.56
135_D	252_I	0.827	0.55
34_Q	229_V	0.826	0.55
213_F	226_V	0.823	0.55
203_M	207_R	0.823	0.55
170_Q	317_G	0.822	0.55
79_F	222_Q	0.820	0.55
217_G	224_H	0.818	0.55
21_L	31_D	0.818	0.55
76_W	238_K	0.811	0.54
73_Y	95_W	0.811	0.54
223_R	324_L	0.811	0.54
154_Y	158_F	0.808	0.54
87_L	173_L	0.806	0.54
167_V	254_T	0.804	0.53
14_I	18_A	0.800	0.53
95_W	219_G	0.798	0.53
26_K	31_D	0.797	0.53
53_C	228_C	0.795	0.53
221_I	229_V	0.791	0.52
102_R	109_A	0.787	0.52
6_R	19_F	0.786	0.52
75_Q	236_N	0.785	0.52
11_Y	131_K	0.785	0.52
283_D	302_R	0.784	0.52
81_L	250_L	0.784	0.52
8_H	225_D	0.783	0.51
227_Q	296_F	0.783	0.51
28_Y	242_F	0.782	0.51
38_P	301_L	0.781	0.51
110_L	168_I	0.778	0.51
164_L	258_L	0.777	0.51
36_W	60_T	0.777	0.51
87_L	251_A	0.776	0.51
210_K	217_G	0.776	0.51
4_V	196_G	0.775	0.51
275_L	279_L	0.772	0.50
157_L	313_A	0.770	0.50
216_R	226_V	0.767	0.50
249_F	288_E	0.766	0.50
160_K	305_G	0.764	0.50
268_P	298_V	0.762	0.50
59_Y	62_P	0.761	0.49
168_I	223_R	0.759	0.49
66_I	210_K	0.755	0.49
79_F	83_F	0.755	0.49
112_E	320_V	0.755	0.49
73_Y	238_K	0.750	0.48
58_T	73_Y	0.748	0.48
239_I	254_T	0.748	0.48
41_F	226_V	0.745	0.48
84_Q	166_N	0.743	0.48
5_D	12_T	0.742	0.48
157_L	314_K	0.741	0.48
69_E	259_L	0.740	0.47
24_T	236_N	0.739	0.47
124_E	127_E	0.739	0.47
215_K	226_V	0.738	0.47
106_N	145_R	0.736	0.47
304_D	329_W	0.734	0.47
20_S	28_Y	0.732	0.47
1_D	182_F	0.730	0.47
35_C	211_C	0.730	0.47
20_S	52_Y	0.729	0.46
114_A	324_L	0.727	0.46
74_Y	205_F	0.725	0.46
114_A	317_G	0.724	0.46
2_D	5_D	0.723	0.46
93_Y	240_Y	0.723	0.46
131_K	327_E	0.723	0.46
72_S	222_Q	0.722	0.46
95_W	156_Y	0.722	0.46
66_I	69_E	0.719	0.46
193_L	235_F	0.717	0.45
40_E	217_G	0.717	0.45
69_E	158_F	0.714	0.45
68_E	154_Y	0.708	0.45
157_L	169_G	0.707	0.44
182_F	204_I	0.707	0.44
48_Y	227_Q	0.705	0.44
146_E	280_R	0.705	0.44
56_Q	60_T	0.701	0.44
156_Y	173_L	0.698	0.44
25_A	29_V	0.696	0.43
158_F	258_L	0.695	0.43
108_K	183_L	0.694	0.43
297_V	306_W	0.694	0.43
13_V	47_E	0.693	0.43
95_W	236_N	0.689	0.43
217_G	220_N	0.689	0.43
75_Q	238_K	0.688	0.43
154_Y	324_L	0.686	0.43
210_K	213_F	0.686	0.43
216_R	225_D	0.685	0.42
279_L	296_F	0.683	0.42
206_P	244_W	0.679	0.42
184_T	194_L	0.675	0.42
8_H	219_G	0.674	0.41
7_L	21_L	0.672	0.41
285_L	289_D	0.672	0.41
255_G	259_L	0.672	0.41
34_Q	231_P	0.671	0.41
147_Y	280_R	0.671	0.41
127_E	190_L	0.671	0.41
297_V	312_L	0.668	0.41
80_V	173_L	0.667	0.41
217_G	222_Q	0.664	0.41
10_R	317_G	0.659	0.40
13_V	325_V	0.657	0.40
126_R	236_N	0.657	0.40
175_N	278_R	0.656	0.40
302_R	305_G	0.654	0.40
284_K	291_K	0.654	0.40
60_T	84_Q	0.653	0.40
300_Y	305_G	0.653	0.40
167_V	213_F	0.652	0.40
177_F	189_V	0.652	0.40
293_V	316_A	0.652	0.40
234_I	250_L	0.650	0.39
9_Y	163_Y	0.648	0.39
13_V	25_A	0.647	0.39
111_V	171_I	0.646	0.39
98_L	155_L	0.645	0.39
128_K	187_F	0.644	0.39
252_I	255_G	0.643	0.39
160_K	163_Y	0.642	0.39
316_A	327_E	0.640	0.38
175_N	202_S	0.640	0.38
51_T	185_Y	0.638	0.38
158_F	295_K	0.636	0.38
10_R	239_I	0.635	0.38
208_V	234_I	0.635	0.38
30_G	236_N	0.634	0.38
15_I	19_F	0.633	0.38
9_Y	179_G	0.630	0.38
172_F	263_A	0.624	0.37
124_E	259_L	0.624	0.37
112_E	116_D	0.623	0.37
32_P	156_Y	0.621	0.37
255_G	265_L	0.618	0.37
168_I	187_F	0.618	0.37
43_G	49_A	0.617	0.36
39_A	215_K	0.614	0.36
107_I	131_K	0.614	0.36
301_L	328_L	0.610	0.36
53_C	211_C	0.609	0.36
64_D	250_L	0.608	0.36
73_Y	209_T	0.608	0.36
8_H	166_N	0.607	0.36
165_V	249_F	0.607	0.36
125_E	220_N	0.607	0.36
141_L	255_G	0.607	0.36
219_G	236_N	0.607	0.36
61_V	294_V	0.606	0.36
305_G	329_W	0.606	0.36
36_W	222_Q	0.606	0.36
5_D	261_W	0.604	0.35
107_I	290_D	0.603	0.35
43_G	161_L	0.602	0.35
136_Y	144_H	0.602	0.35
168_I	255_G	0.601	0.35
160_K	257_S	0.600	0.35
169_G	273_R	0.598	0.35
54_W	78_P	0.596	0.35
33_I	71_I	0.594	0.35
67_P	98_L	0.594	0.35
284_K	287_R	0.594	0.35
151_Y	155_L	0.593	0.34
77_V	177_F	0.591	0.34
46_E	49_A	0.589	0.34
4_V	299_R	0.587	0.34
110_L	139_R	0.586	0.34
263_A	270_L	0.584	0.34
236_N	239_I	0.582	0.34
25_A	30_G	0.581	0.33
169_G	177_F	0.580	0.33
153_A	158_F	0.580	0.33
296_F	304_D	0.579	0.33
109_A	116_D	0.577	0.33
152_L	160_K	0.576	0.33
264_R	314_K	0.573	0.33
161_L	288_E	0.572	0.33
36_W	212_D	0.572	0.33
2_D	93_Y	0.571	0.33
52_Y	238_K	0.571	0.33
274_F	310_R	0.571	0.33
87_L	131_K	0.569	0.32
16_L	32_P	0.568	0.32
243_L	249_F	0.566	0.32
45_W	51_T	0.565	0.32
122_D	125_E	0.562	0.32
8_H	80_V	0.560	0.32
112_E	266_L	0.560	0.32
10_R	50_N	0.558	0.32
6_R	174_L	0.557	0.31
182_F	315_N	0.556	0.31
105_I	147_Y	0.555	0.31
256_L	266_L	0.554	0.31
116_D	130_I	0.553	0.31
14_I	83_F	0.553	0.31
210_K	216_R	0.553	0.31
296_F	302_R	0.552	0.31
52_Y	222_Q	0.549	0.31
73_Y	76_W	0.549	0.31
172_F	176_R	0.549	0.31
171_I	268_P	0.549	0.31
71_I	82_F	0.547	0.31
75_Q	244_W	0.547	0.31
36_W	216_R	0.547	0.31
195_N	299_R	0.547	0.31
97_L	115_N	0.546	0.31
147_Y	158_F	0.545	0.31
73_Y	205_F	0.545	0.31
27_Q	32_P	0.544	0.30
17_L	86_L	0.543	0.30
7_L	12_T	0.542	0.30
57_N	209_T	0.541	0.30
250_L	254_T	0.541	0.30
117_P	320_V	0.541	0.30
230_L	239_I	0.540	0.30
102_R	113_G	0.539	0.30
212_D	227_Q	0.538	0.30
16_L	251_A	0.538	0.30
214_H	250_L	0.537	0.30
176_R	275_L	0.535	0.30
218_S	225_D	0.533	0.30
271_R	275_L	0.532	0.30
268_P	288_E	0.531	0.29
92_R	96_K	0.530	0.29
12_T	166_N	0.530	0.29
28_Y	320_V	0.529	0.29
192_D	258_L	0.528	0.29
73_Y	206_P	0.527	0.29
209_T	230_L	0.527	0.29
258_L	290_D	0.523	0.29
6_R	75_Q	0.522	0.29
193_L	199_W	0.522	0.29
70_Y	83_F	0.521	0.29
130_I	310_R	0.520	0.29
7_L	173_L	0.520	0.29
54_W	329_W	0.519	0.29
88_F	163_Y	0.518	0.28
18_A	86_L	0.517	0.28
119_K	128_K	0.517	0.28
127_E	131_K	0.517	0.28
124_E	128_K	0.515	0.28
22_L	185_Y	0.513	0.28
175_N	184_T	0.513	0.28
156_Y	202_S	0.512	0.28
76_W	244_W	0.512	0.28
19_F	247_F	0.511	0.28
270_L	278_R	0.511	0.28
182_F	185_Y	0.510	0.28
38_P	222_Q	0.509	0.28
165_V	252_I	0.508	0.28
47_E	235_F	0.507	0.28
136_Y	219_G	0.507	0.28
231_P	241_I	0.505	0.28
127_E	327_E	0.504	0.27
36_W	49_A	0.504	0.27
241_I	248_V	0.504	0.27
186_G	189_V	0.503	0.27
194_L	326_A	0.502	0.27
276_R	329_W	0.501	0.27
116_D	265_L	0.500	0.27

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4b93A	1	0.244	8.3	0.974	Contact Map
2nutC	1	0.241	7.8	0.975	Contact Map
1dj7A	1	0.1235	6.9	0.975	Contact Map
2o6kA	1	0.1928	3.2	0.979	Contact Map
1vd8A	1	0.0693	2.8	0.979	Contact Map
2fj6A	1	0.2018	2.8	0.979	Contact Map
3gwnA	2	0.1205	2.7	0.98	Contact Map
3gwlA	2	0.1145	2.4	0.98	Contact Map
3kyqA	1	0.3042	2.4	0.98	Contact Map
2i53A	1	0.2018	2.3	0.98	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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